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49 articles for “small molecules”
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A Conceptual Framework for AI-Integrated Metabolomics in Predictive Health Systems for Resource-Constrained Environments
Abstract: The increasing prevalence of non-communicable diseases (NCDs) continues to place a significant strain on healthcare systems, particularly in low- and middle-income regions where access to early diagnostic infrastructure is limited. Conventional healthcare approaches remain largely reactive, often detecting diseases at advanced stages when treatment effectiveness is reduced. This challenge underscores the need for predictive, cost-effective, and data-driven healthcare solutions. This study presents a conceptual framework that integrates metabolomics with artificial …
Published in Emerging Trends in Metabolites · Vol. 3, Issue 2, 2026 Read article
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DEVELOPMENT OF POLYMERSOMES AS MACROMOLECULAR PLATFORMS FOR NANOMEDICINE
Abstract: The conventional method of drug delivery is plagued with instability, low targeting and low bioavailability. A solution to these shortcomings is the use of polymer Somes, artificial vesicles that are produced through self-assembly of amphiphilic block copolymer, and they are suggested as universal nanoscale carriers. They have stiff, tunable membranes (thickness = 2-50 nm) due to accurate control of polymer chemistry, chain length, and hydrophilic mass fraction (f), which allows …
Published in Journal of Polymer & Composites · Vol. 14, Issue 5, 2026 Read article
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Analyzing The Mechanisms of Polymerization and The Related Kinetic Pathways Using Refined Analytical Methods.
Abstract: In numerous sectors, polymeric materials play a crucial role, yet effectiveness is largely determined by their molecular structure and the processing parameters utilized. This investigation presents an integrative approach aimed at delineating the connections between polymer structure, properties, and processing through sophisticated characterization methods. With the implementation of small angle X Ray Scattering (SAXS),NMR(Nuclear magnetic resonance( spectroscopy) FM(Atomic Force Microscopy) and rheological analysis, we analyze the complex interplay between molecular …
Published in Journal of Polymer & Composites · Vol. 13, Issue 2, 2025 · pp. 86–94 Read article
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Molecular Docking Studies of Wildtype P53 with Damnacanthal and Scopoletin- Phytochemicals Derived from Morinda Citrifolia
Abstract: Cancer is a prominent cause of mortality globally, and it has the potential to impact any region of the body. The tumor suppressor protein P53 plays a significant role in inhibiting tumor growth by regulating DNA repair, inducing cell cycle arrest, promoting senescence, and triggering apoptosis when confronted with genotoxic stress. P53 is found mutated in 50% of cancers where it loses its tumor suppressive properties and gains oncogenic properties …
Published in International Journal of Molecular Biotechnological Research · Vol. 1, Issue 2, 2023 · pp. 20–31 Read article
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Exploring Abies grandis phytocompounds potential by in silico analysis targeting on the 5P9J Protein
Abstract: Blood Cancer, also popular with name ‘Hematologic cancer’ have variety of types: Leukaemia, Lymphoma, Myeloma, uncontrolled multiplication of blood cells mainly affecting to bone marrow and blood cells (White Blood Cells). Lymphoma, originating from lymphatic system resulted in uncontrolled growth and instead of normal apoptosis development of tumor. Myeloma, uncontrolled formation of malignant plasma cells leads disrupting production of healthy blood cells. This situation creates variety of diseases like anaemia, …
Published in International Journal of Molecular Biotechnological Research · Vol. 3, Issue 2, 2025 Read article
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Non-Small Cell Lung Cancer: Types, Pathogenesis, Diagnosis, and Novel Therapeutic Strategies
Abstract: Non-small cell lung cancer (NSCLC) is the most prevalent type of lung cancer, accounting for over 85% of all cases globally. It remains one of the primary causes of cancer-related death due to its rapid progression, few early symptoms, and late detection. The three main forms of non-small cell lung cancer (NSCLC) are adenocarcinoma, squamous cell carcinoma, and giant cell carcinoma; each has a unique histology, prognosis, and response to …
Published in Research and Reviews: A Journal of Pharmacology · Vol. 16, Issue 2, 2026 Read article
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MicroRNAs in Animal Behavior: Regulation of Memory and Decision-Making in Mammals
Abstract: MicroRNAs are small, non-coding RNA molecules that play a crucial role in post-transcriptional regulation of gene expression. In recent years, their significance has extended beyond cellular development and disease regulation, as emerging evidence suggests they are critical mediators in complex behavioral processes, including learning, memory, and decision-making. This article explores the role of miRNAs in regulating neural plasticity and cognitive functions in mammals, emphasizing their involvement in memory formation and …
Published in Research and Reviews : Journal of Veterinary Science and Technology · Vol. 13, Issue 3, 2024 · pp. 21–25 Read article
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Recent Advances & Prospects of Transferosomes for Transdermal Delivery: Trends in Drug Delivery
Abstract: There have been several non-invasive administrations that have emerged recently to replace conventional needle injections. With its minimal rejection rate, remarkable ease of administration, and remarkable patient comfort and perseverance, the transdermal drug delivery system (TDDS) is the most attractive of them all. The skincare industry, which includes cosmetics, may also find use for TDDS in addition to the pharmaceutical industry. As this strategy mainly entails local drug administration, it …
Published in Trends in Drug Delivery · Vol. 11, Issue 3, 2024 · pp. 01–21 Read article
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Applications of Nanotechnology in Advanced Cosmeceuticals
Abstract: Nanotechnology is the study and manipulation of atoms and molecules on the nanoscale, which is approximately 80,000 times smaller than the width of a human hair. By 2015, the global market for products incorporating nanomaterials is projected to reach $2.6 trillion. This field showcases significant progress in research and development by improving product performance and introducing innovative solutions.The usage of cosmetics has increased significantly throughout time, and they are thought …
Published in Recent Trends in Cosmetics · Vol. 2, Issue 1, 2025 · pp. 8–16 Read article
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The Next Era of Solid-State Innovation: Beyond Silicon
Abstract: The semiconductor industry is getting close to the physical and economic boundaries of silicon-based technology. A new era of solid-state innovation is beginning. Beyond Silicon: The Next Era of Solid-State Innovation looks at the materials, device layouts, and manufacturing methods that are about to change the way electronics and energy work. The article talks about improvements in wide- and ultra-wide-bandgap semiconductors, two- dimensional materials, and quantum and neuromorphic systems that …
Published in International Journal of Solid State Innovations & Research · Vol. 3, Issue 2, 2025 · pp. 19–23 Read article
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Development of a Novel Therapeutic Approach Using RNA Interference for Targeting Viral Genes
Abstract: RNA interference (RNAi) is a ground breaking therapeutic strategy that holds immense promise for targeting viral genes in the treatment of viral infections. This approach leverages the natural gene-silencing mechanisms of RNAi to inhibit viral replication and expression at the molecular level, providing a precise and adaptable method to counteract viral pathogens, including influenza, HIV, and hepatitis viruses. Recent advancements in RNAi technology have enabled the development of highly specific …
Published in International Journal of Virus Studies · Vol. 1, Issue 2, 2024 · pp. 12–22 Read article
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Paternal Pre-Pubertal Smoking: Small RNAs, Lasting Marks, and the Hidden Legacy of Early Exposure
Abstract: While the negative effects of maternal smoking during pregnancy are well-established, the lasting and transgenerational impact of paternal pre-pubertal smoking remains a critical, underexplored area. Emerging evidence in sperm epigenetics suggests that cigarette exposure during early male development may create persistent molecular imprints that can affect the health of future offspring. This phenomenon is rooted in the fact that heredity extends beyond the DNA sequence. Sperm carry a complex epigenetic …
Published in Emerging Trends in Personalized Medicines · Vol. 3, Issue 1, 2026 · pp. 1–5 Read article
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In Silico Molecular Docking of Indigofera tinctoria Phytocompounds to Target EGFR/ERK and FGFR/FGF Pathway Proteins Involved in Prostate Cancer
Abstract: Objective: Prostate cancer being the second major cause of cancer-related deaths in males, affects the small walnut-shaped gland below the bladder called the prostate gland. The epidermal growth factor protein (EGFR), cascade protein (ERK), and fibroblast growth factor proteins (FGFR and FGF) are involved in the different signaling pathways that lead to the formation of different products, that are responsible for the progression of cancer and thus can be considered …
Published in International Journal of Molecular Biotechnological Research · Vol. 1, Issue 1, 2023 · pp. 34–56 Read article
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RNA- Based Drug Delivery, Current Advances, Pharmaceutical Applications, and Future Perspectives
Abstract: RNA-based therapeutics have emerged as a transformative approach in modern medicine due to their ability to regulate gene expression with high specificity and precision. Advances in molecular biology, RNA chemistry, and nanotechnology have accelerated the development of diverse RNA modalities, including messenger RNA (mRNA), small interfering RNA (siRNA), microRNA (miRNA), antisense oligonucleotides (ASOs), and RNA aptamers. These therapeutics offer promising strategies for the treatment of cancer, genetic disorders, infectious diseases, …
Published in Research & Reviews: A Journal of Drug Design & Discovery · Vol. 13, Issue 2, 2026 Read article
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A Review on Unmasking Merkel Cell Polyomavirus: From Discovery to Cancer Driver
Abstract: Merkel cell polyomavirus (MCPyV) is a small, non-enveloped, circular double-stranded DNA virus belonging to the Polyomaviridae family, first characterized in 2008. Epidemiological data suggest widespread exposure, with seroprevalence rates approaching 80% in adults. While primary infection is typically asymptomatic, rare integration events in Merkel cells can initiate oncogenesis, yielding Merkel cell carcinoma (MCC), a neuroendocrine skin cancer with a five-year survival rate under 60%. This review integrates findings from six …
Published in International Journal of Virus Studies · Vol. 2, Issue 2, 2025 · pp. 6–11 Read article
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Health Hazards of Nanoparticles and Environmental Pollutants
Abstract: The exponential growth in the use of nanoparticles and the prevalence of environmental pollutants have raised significant concerns regarding their health hazards. Nanoparticles, owing to their unique physicochemical properties—such as small size, high surface areatovolume ratio, and chemical reactivity—can penetrate biological barriers, including the bloodbrain barrier, and interact at the cellular and molecular levels. This can lead to oxidative stress, inflammation, and cellular dysfunction, ultimately resulting in potential toxicity. Similarly, …
Published in Research and Reviews: A Journal of Toxicology · Vol. 15, Issue 1, 2025 · pp. 1–9 Read article
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Looking into new ideas in green chemistry
Abstract: Green chemistry has become a revolutionary way to change chemical processes such that they have less of an effect on the environment while still being efficient and cost-effective. This article looks at new developments in green chemistry that go beyond small changes and offer completely new ways to build chemicals that are good for the environment. There is a lot of focus on innovative catalytic systems, sustainable feedstocks, reaction pathways …
Published in Journal of Modern Chemistry & Chemical Technology · Vol. 17, Issue 1, 2026 · pp. 10–18 Read article
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Advancements in Nanotechnology and Biosensor Integration for Detection and Treatment of Alice in Wonderland Syndrome
Abstract: Alice in Wonderland Syndrome (AIWS) is an uncommon neurological condition characterized by profound distortions in perception. Individuals with AIWS experience altered body image and spatial awareness, often perceiving objects, surroundings, or even their own body as being unusually large, small, or distorted. The condition presents a unique challenge for both diagnosis and management due to its elusive and varied symptoms. This paper explores how advancements in nanotechnology and biosensor integration …
Published in Nano Trends – A Journal of Nano Technology & Its Applications · Vol. 26, Issue 3, 2024 · pp. 1–12 Read article
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Gold Nanoparticle Size, Biodistribution, and Toxicity: Insights from DualEnergy CT
Abstract: Dual-energy and spectral computed tomography (CT) have emerged as powerful platforms for noninvasive, quantitative mapping of nanoparticle biodistribution in vivo. By exploiting the energy-dependent attenuation profiles of high-atomic-number (high-Z) materials, these systems enable material decomposition and element-specific imaging, thereby distinguishing nanoparticle signals from those of soft tissues and conventional iodinated contrast agents. Photon-counting spectral CT further enhances this capability by binning individual photons into multiple energy channels, improving spatial resolution, …
Published in Nano Trends – A Journal of Nano Technology & Its Applications · Vol. 28, Issue 2, 2025 Read article
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The Role of Cholesterol in Biological Membranes
Abstract: Cholesterol plays the role of a regulator that ensures the correct packaging of the lipid part of the membrane, which is necessary for its normal operation, by influencing on the mobility of the fatty acid tails of membrane lipids: if the membrane is too rigid and there is a danger of "freezing" of fatty acid chains, cholesterol causes it to liquefy, since the chains in its presence become more mobile; …
Published in International Journal of Cell Biology and Cellular Functions · Vol. 1, Issue 1, 2023 Read article