Search
42 articles for “oral dosage”
-
To Investigate Hormonal Fluctuations in Male Rattus norvegicus after Treatment with 50% Methanolic Extract of Acacia arabica
Abstract: The use of medicinal plants in traditional and modern medicine has garnered significant interest for their therapeutic potential. Acacia arabica, commonly known as babul, is renowned for its bioactive compounds and diverse pharmacological properties. This study investigates the hormonal fluctuations induced by 50% methanolic extract of Acacia arabica in male Rattus norvegicus, aiming to explore its potential as a male contraceptive. Male contraception remains limited primarily to condoms and vasectomy, …
Published in Research & Reviews : Journal of Herbal Science · Vol. 13, Issue 3, 2024 · pp. 28–38 Read article
-
Oral Thin Films of Ondanetron Hcl: Formulation and Performance Evaluation
Abstract: This study had the goal to formulate oral polymeric thin film that would dissolve and disintegrate instantly, while also having high mechanical features. These are the most advanced forms of solid dosage forms. Solvent casting was the technique employed to create oral thin films. These are additionally referred to as buccal films/strip, mouth dissolving films, oral thin films, as well as oral strips of paper. These films are suitable for …
Published in Research & Reviews: A Journal of Drug Design & Discovery · Vol. 11, Issue 3, 2024 · pp. 1–6 Read article
-
Design and Development of Self Microemulsyfying Drug Delivery System of Olmesartan Medoxomil
Abstract: Olmesartan Medoxomil is poorly water soluble drug. It comes into the BCS II drug. Hence oral bioavailability of Olmesartan Medoxomil is less (26%). The purpose of this study is to develop novel dosage form of the self-microemulsifying drug delivery systems (SMEDDS) for the Olmesartan Medoxomil for enhancing its solubility hence the oral bioavailability. Before the formulation of SMEDDS, solubility study was performed in different excipients and select excipients on basis …
Published in Research and Reviews: A Journal of Pharmacology · Vol. 3, Issue 3, 2013 · pp. 1–14 Read article
-
Design and Development of Self Microemulsyfying Drug Delivery System of Olmesartan Medoxomil Smita D Patel*, M R Patel, K R Patel
Abstract: Olmesartan Medoxomil is poorly water soluble drug. It comes into the BCS II drug. Hence oral bioavailability of Olmesartan Medoxomil is less (26%). The purpose of this study is to develop novel dosage form of the self-microemulsifying drug delivery systems (SMEDDS) for the Olmesartan Medoxomil for enhancing its solubility hence the oral bioavailability. Before the formulation of SMEDDS, solubility study was performed in different excipients and select excipients on basis …
Published in Research and Reviews: A Journal of Pharmacology · Vol. 3, Issue 3, 2013 · pp. 1–15 Read article
-
Exprimental Study on the Protective Action of rhGM-CSF for Acute Lung Injury
Abstract: Anti-cancer agents and radiation therapies result in various complications on respiratory systems like interstitial pneumonia, acute lung damage, bacterial pneumonia and pneumomycosis in clinical oncology. Recently it is being interested in variable rolls of GM-CSF to protect the lungs. We infuse the ethyl alcohol and lipopolysaccharide (LPS) to damage lung orally, and then inject GM-CSF subcutaneously at the same time and then observe the changes of lung tissue. As a …
Published in Research and Reviews : A Journal of Medical Science and Technology · Vol. 8, Issue 3, 2019 · pp. 4–8 Read article
-
Formulation and Characterization of sublingual film strip of Antiemetic drug Ondansetron hydrochloride
Abstract: Orally fast dissolving sublingual film gives fast patients compliance over other conventional dosage forms. It gives quick onset of action, ease of administration. This formulation is suitable for anti-emetic formulation since it released the drug fast and this sort of formulation does not need water to take formulation ultimately it acts as boon as antiemetic formulation. It gives immediate action. It places in the oral cavity and dissolved in the …
Published in Research and Reviews: A Journal of Pharmaceutical Science · Vol. 10, Issue 2, 2019 · pp. 1–8 Read article
-
Fast Dissolving Oral Thin Films: A Review
Abstract: Fast-dissolving oral thin films (FDOFs) represent a significant advancement in drug delivery technology, offering advantages over traditional solid dosage forms, especially for patients with swallowing difficulties. FDOFs dissolve rapidly in the mouth, releasing the active ingredient without the need for water or chewing. They have picked up ubiquity due to their comfort, taste veiling capabilities, and progressed persistent compliance. Ideal drugs for FDOFs should possess characteristics such as solubility, stability, …
Published in Research & Reviews: A Journal of Drug Design & Discovery · Vol. 11, Issue 1, 2024 · pp. 24–31 Read article
-
A Literature Review on Extrusion/Spheronisation-A Pelletization Technology
Abstract: Extrusion-spheronization is a leading pelletization technology, widely favored for its economic and commercial viability. It is a cost-effective method suitable for large-scale production, making it the most efficient approach for oral drug delivery. This process provides multiple benefits, such as improved flow characteristics, lower friability, a narrow particle size range, easier coating, consistent packing, reduced likelihood of dose dumping, and more predictable gastric emptying. Pellets usually measure between 0.5 and …
Published in Research and Reviews: A Journal of Pharmaceutical Science · Vol. 16, Issue 1, 2025 · pp. 61–71 Read article
-
Pharmacokinetic Study of Iron Absorption from Unani Compound Formulation in Animals
Abstract: Background: Iron is an indispensable element for survival and normal functioning of the human cells. It is required for a large number of biochemical reactions in the cells. It is a vital component of haemoglobin, myoglobin, cytochromes, catalases and many other enzyme systems like Krebs cycle. It is essential for oxygen transport and oxidation reactions in cells. Iron deficiency is the most prevalent deficiency disorders of human beings in the …
Published in Research & Reviews : A Journal of Unani, Siddha and Homeopathy · Vol. 10, Issue 1, 2023 · pp. 1–5 Read article
-
European Regulatory Perspective on Super-Generics: Antacid Orally Disintegrating Tablets (ODT)
Abstract: Super-generic is the general form of nomenclature for hybrid medicinal product in European Union (EU). The super-generic form of the medicinal product is one that considers changes in the form of active substance, therapeutic indications, strength, pharmaceutical form or route of administration. They rely partly on results of preclinical tests and clinical trials of an innovator product and also on new data with appropriate bioavailability and bioequivalence studies. Marketing authorization …
Published in Trends in Drug Delivery · Vol. 3, Issue 1, 2016 · pp. 31–37 Read article
-
A Review on: Oral Thin Films: A New Approach to Effective and Easy Drug Delivery
Abstract: Oral Thin Film (OTF) is an advance drug delivery system in which drug is incorporated into dissolvable strip and place in oral cavity for rapid absorption. OTF is useful for patient such as pediatric and geriatric who have difficulty swallowing pills. It provides rapid action, precise dosage and improved bioavailability. OTFs consist of fast-dissolving films, extended-release films, and mucoadhesive films for various therapeutic applications. The manufacturing processes of OTFs such …
Published in Trends in Drug Delivery · Vol. 11, Issue 3, 2024 · pp. 22–41 Read article
-
Child-Friendly Innovation: A New Era in Pediatric Drug Delivery Systems
Abstract: Pediatric formulations are becoming more and more popular as a result of advancements in pharmaceutical delivery technology. For young patients, there isn't a safe and effective drug delivery system in place. Since children's pharmacokinetics and pathophysiologic profiles differ from those of adults, it is imperative to design and develop an innovative and appropriate delivery system to provide accurate and dependable medicine administration to pediatric patients. Discussions will be held under …
Published in Trends in Drug Delivery · Vol. 13, Issue 2, 2026 · pp. 26–34 Read article
-
The Utilization of Oil Entrapped Floating Alginate Beads in a Gastroretentive Delivery System is Intended to Improve the Bioavailbility of Telmisartan Incorporating Principles of Bioinformatics
Abstract: Oil entrapped floating calcium alginate beads of Telmisartan were successfully prepared using sodium alginate as polymer and two different oil phases of mineral oil and olive oil by emulsion gelation method. The FT-IR spectra of final optimized formulation confirms no drug- polymer incompatibility. The floating time of beads was found to be more than 12 hrs suggesting that the method used for prepration was effective. The floating time of optimized …
Published in Research & Reviews: A Journal of Bioinformatics · Vol. 11, Issue 1, 2024 · pp. 21–38 Read article
-
RP-HPLC Analytical Method Development and Validation for Quantitative Estimation of Metoclopramide Hydrochloride in Solid Oral Formulations
Abstract: RP-HPLC technique formulated for the numerical assessment of Metoclopramide Hydrochloride in tablet formulation has been confirmed for reliability. A C18 column facilitated the chromatographic separation using a mobile phase comprising 60:40 (v/v) potassium dihydrogen phosphate buffer: meth anol mixture. Such method was used to detect, where the retained time was 6.78 minutes and Metoclo pramide Hydrochloride produced a clear peaked at 273 nm. Results were in agreement with ICH Q2 …
Published in Research & Reviews: A Journal of Drug Formulation, Development and Production · Vol. 12, Issue 2, 2025 · pp. 07–15 Read article
-
Research Insight: Toxicology
Abstract: Toxicology is an apprehensive study of the antagonistic effects of chemicals on living entities. It also studies the detrimental special effects of chemical, biological and physical proxies in biological systems that inaugurate the extent of loss in living organisms. The association between dose and its effects on the wide-open entity is of prodigious implication in toxicology. The factors that sway chemical toxicity include dosage, the route of exposure, the species, …
Published in Research and Reviews: A Journal of Toxicology · Vol. 5, Issue 2, 2015 · pp. 23–26 Read article
-
An Effective & Novel Approach as Gastro-retentive Drug Delivery Systems
Abstract: Researcher’s curiosity about gastro-retentive drug delivery system increased so high in recent years because of its excellent drug releasing properties to the target site. The delivery system's residence time in the stomach can be extended with the usage of gastro-retentive drug delivery system by using a number of natural and synthetic polymers such as guar gum, hydoxy propyl methyl cellulose which can be used to improve the bioavailability of a …
Published in Research and Reviews: A Journal of Pharmaceutical Science · Vol. 15, Issue 2, 2024 · pp. 47–54 Read article
-
Design and Development of Novel Floating Drug Delivery Systems
Abstract: Recent advances in science and technology have greatly aided in the creation of novel drug delivery methods, especially in addressing physiological issues including irregular stomach emptying times and brief stomach residence periods. Long-term stomach absorption is the goal of gastro-retentive dosage forms (GRDF). Floating drug delivery systems, expanding or swelling systems, polymer-based bioadhesive systems, high-density systems, and other ways that postpone stomach emptying are just a few of the techniques …
Published in International Journal of Membranes · Vol. 1, Issue 2, 2024 · pp. 1–22 Read article
-
Gastro Retentive Drug Target System: Its Needs, Advantages, Limitation and Approaches
Abstract: Background: Gastro retentive drug delivery systems (GRDDS) address limitations of oral therapy for drugs with poor solubility, instability at intestinal pH, or narrow absorption windows by prolonging gastric residence and increasing contact with the gastric mucosa. Objectives: To review GRDDS approaches—floating systems, mucoadhesive systems, and super porous hydrogels—with emphasis on formulation strategies and polymer–excipient selection to enhance gastric retention, modulate buoyancy/swelling/adhesion, and ultimately improve oral bioavailability and therapeutic outcomes for …
Published in Trends in Drug Delivery · Vol. 13, Issue 2, 2026 · pp. 47–58 Read article
-
Rivaroxaban: A Comprehensive Review of an Anticoagulant Revolution
Abstract: Rivaroxaban, a prominent direct oral anticoagulant (DOAC), has garnered attention for its pivotal role in preventing and treating thromboembolic diseases. Its introduction into clinical practice has marked a significant advancement in anticoagulant therapy. The mechanism of action of rivaroxaban involves selective inhibition of factor Xa, a crucial component in the coagulation cascade. This targeted approach distinguishes it from traditional anticoagulant and contributes to its efficacy. The significance of rivaroxaban lies …
Published in Research & Reviews: A Journal of Drug Design & Discovery · Vol. 10, Issue 3, 2023 · pp. 17–23 Read article
-
Comparative Study of Natural and Synthetic Humectants Present in Calamine Lotion
Abstract: Lotions are defined as monophasic liquid dosage form. Lotions are designed to be applied to the skin without friction [1]. Lotions may contain humectants, so that moisture is retained on the skin after the lotions are applied [2]. Humectants are the substance that prevents the skin from drying. In this research work, the natural and synthetic humectants are used in order to prevent the water loss and to keep the …
Published in Trends in Drug Delivery · Vol. 4, Issue 1, 2017 · pp. 18–21 Read article