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143 articles for “method development and validation”
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Toxicology-Focused Development and Validation of an RP-HPLC Technique for Quantifying Bempefoic Acid and Rosuvastatin in a Fixed-Dose Combination
Abstract: A straightforward, precise method was developed to simultaneously assess Bempedoic acid and Rosuvastatin in both bulk and tablet forms. Utilizing a DIKMA Spursil C18 column (4.6 mm x 250 mm, 3.0 μm), chromatography was conducted with a mobile phase comprising 30% phosphate buffer and 70% acetonitrile, flowing at 1 ml/min. Operating at ambient temperature, the optimized wavelength for detection was set at 240 nm, revealing retention times of 4.418 min …
Published in Research and Reviews: A Journal of Toxicology · Vol. 14, Issue 2, 2024 · pp. 1–9 Read article
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Analytical Technique Optimization and ICH-Directed Verification of a Reverse Phase HPLC Approach for Quantification of Bupropion Hydrochloride
Abstract: This method was developed for retention time, peak resolution and baseline response using Bupropion Hydrochloride under optimized conditions as validation. The method resulted in two well separated, well defined peaks, a minor peak at 7.5 minutes 12 mV and a main peak at 11.52 minutes 150 mV. At the same time, the baseline has remained stable during the chromatographic run and the fluctuations of noise are very small (0.5 ± …
Published in Research & Reviews: A Journal of Drug Formulation, Development and Production · Vol. 12, Issue 2, 2025 · pp. 47–54 Read article
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RP-HPLC method for simultaneous determination of Drospirenone and Ethinylestradiol in Bulk and their Pharmaceutical dosage form
Abstract: Oral contraceptive is used to prevent the pregnancy which is contain hormones to block the release of eggs from the ovaries. Most of them contain estrogen and progesterone. Nowadays, usage of hormonal contraceptive is sharply enhancing; around 100 million of women worldwide are taking these drugs. With this drug fertility rate can be supressed as long as they want or plan their activity along with these drugs provide efficacy, reliability, …
Published in Trends in Drug Delivery · Vol. 11, Issue 3, 2024 · pp. 46–67 Read article
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Polymer-Based Acousto-Optic Ultrasonic Sensor for Non-Destructive Evaluation of Dielectric Insulation
Abstract: A dual-polymer fiber-optic sensor for monitoring partial discharge (PD) activity in high-voltage polymeric insulation is presented in this work for non-destructive evaluation and dielectric testing applications. Dielectric weakness within polymeric insulation leads to partial discharge activity, generating ultrasonic acoustic waves that propagate through the medium. The developed sensing assembly comprises a conical polymer-based horn that gathers and concentrates the ultrasonic acoustic emission energy generated by dielectric weakness, and a single-mode …
Published in Journal of Polymer & Composites · Vol. 14, Issue 1, 2026 · pp. 11–24 Read article
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Epilert: Epilepsy Tracker and Detector
Abstract: Epilepsy, affecting over 50 million individuals worldwide, necessitates innovative solutions for effective monitoring and intervention. Current systems face challenges such as inaccuracy, limited accessibility, and discomfort, leaving patients and caregivers vulnerable. Epilert, a wearable device, addresses these gaps by employing advanced sensors and machine-learning algorithms for real-time epilepsy detection and monitoring. The device integrates electromyography (EMG) and motion sensors to capture and analyze physiological and movement data. Preprocessing techniques ensure …
Published in Recent Trends in Sensor Research & Technology · Vol. 12, Issue 1, 2025 · pp. 1–8 Read article
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Integrating Human-Centric Principles into Machine Design: Ergonomic and Safety Enhancements in Mechanical Systems
Abstract: The integration of human-centric design (HCD) principles into mechanical systems has become increasingly critical in contemporary machine design. As machines become more complex and operate within high-interaction environments, the need for design strategies that prioritize human safety, usability, and comfort has intensified. This review explores how ergonomic insights, safety standards, and user experience (UX) considerations influence the physical configuration, control mechanisms, and operational safety of mechanical systems across industrial, healthcare, …
Published in Trends in Machine design · Vol. 12, Issue 2, 2025 · pp. 33–37 Read article
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Chemical Reactor Design and Analysis: A Review
Abstract: Chemical reactors play a critical role in industries such as oil and gas, chemical processing, and power generation, where they operate under extreme pressure and handle highly toxic, compressible fluids. The growing need for alternative energy sources has led to an increased demand for vessels capable of withstanding high pressure and temperature, especially in the chemical and petroleum industries. Recent innovations in chemical reactor technology have concentrated on creating new …
Published in Recent Trends in Fluid Mechanics · Vol. 12, Issue 2, 2025 · pp. 49–59 Read article
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Website Usability Using AI
Abstract: This article introduces a comprehensive framework that leverages artificial intelligence (AI), automated tools, and APIs to enhance the evaluation of website usability. The proposed framework integrates AI-driven models with traditional usability assessment techniques to create a more dynamic and effective evaluation process. Specifically, it utilizes Google Lighthouse to conduct in-depth audits on website performance, search engine optimization (SEO), and accessibility. Additionally, chatbot APIs are incorporated to gather real-time user feedback, …
Published in Journal of Web Engineering & Technology · Vol. 12, Issue 2, 2025 · pp. 19–27 Read article
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Vibrational Wind Turbine Design
Abstract: This work focuses on the study and analysis of bladeless wind turbines (BWT) as an alternative to operating vertical-axis wind turbines (VAWT) and horizontal-axis wind turbines (HAWT). A mathematical analysis of the BWT oscillation under wind force allows the development of specific mathematical expressions for the oscillation speed and BWT mast displacement at any height. The oscillation movement is submitted to a Strouhal constant number condition, resulting in an algorithm …
Published in Journal of Offshore Structure and Technology · Vol. 11, Issue 3, 2024 · pp. 32–45 Read article
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High-Definition Electroencephalography: A New Horizon in Neurological Pathology Research
Abstract: The advent of high-density electroencephalography (HD-EEG) has catalyzed a paradigm shift in the exploration of neurological pathologies. This editorial underscore its transformative potential in elucidating brain dynamics and refining diagnostic approaches for a spectrum of conditions, spanning from epilepsy and dementia to cognitive impairments in preterm infants. Our objective is to optimize the utility of HD-EEG by emphasizing the imperative for methodological homogenization and fostering collaborative endeavors. The remarkable spatial …
Published in Research and Reviews: A Journal of Neuroscience · Vol. 14, Issue 2, 2024 · pp. 15–21 Read article
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Optimizing Antibiotic Analysis: A Comprehensive Guide to HPLC Process of Assessment and Quantification
Abstract: The history and uses of chromatography are thoroughly covered in this work, with an emphasis on the use of High-Pressure Liquid Chromatography (HPLC) in pharmaceutical analysis. Since its discovery by Russian botanist Mikhail Tswett in the 19th century, chromatography has undergone tremendous developments that have given rise to a variety of chromatography types and applications. The story follows the evolution historically, emphasizing Tswett's groundbreaking breakthrough in plant color classification and …
Published in International Journal of Antibiotics · Vol. 1, Issue 2, 2024 · pp. 27–44 Read article
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Environmental Impact of Chlorantraniliprole in Bell Peppers: Residue Dynamics and Sustainable Practices
Abstract: Bell peppers (Capsicum annuum) are integral to global agriculture and nutrition due to their rich nutrient profile and culinary uses. To protect these crops from pest infestations, Chlorantraniliprole, a widely employed insecticide, has gained prominence. This research investigates the environmental fate of Chlorantraniliprole in bell pepper ecosystems, emphasizing its effects on soil, water quality, and overall ecological health. The study employs a multifaceted approach, conducting field experiments in the Sangli …
Published in OmniScience: A Multi-disciplinary Journal · Vol. 14, Issue 3, 2024 · pp. 1–7 Read article
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Experimental Investigation and Optimization of Machining Parameters for Al6351 Alloy Using a Modified Taguchi Approach
Abstract: Machining processes encompass both conventional and non-conventional techniques and optimizing machining parameters is crucial for achieving high-quality outcomes. However, simplifying these processes remains a significant challenge. This study focuses on determining the optimal machining parameters—cutting speed, feed rate, and depth-of-cut to enhance performance characteristics in Al6351 alloy plates. The parameters evaluated include surface roughness (Ra), material removal rate (MRR), resultant forces (RF), and temperature at the tool- workpiece interface (Temp). …
Published in Journal of Polymer & Composites · Vol. 14, Issue 2, 2026 · pp. 1463–1481 Read article
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Authentication of a Rapid RP-HPLC technique for Quantification of Remogliflozin and Metformin in Medicinal Formulations
Abstract: A new, precise, and stability-assessing advanced liquid chromatography (HPLC) technique for simultaneous quantification of Remogliflozin and Metformin in fixed dose pharmaceutical formulations was designed and verified. Optimization of the technique was carried out on flowing phase composed of ethanenitrile and buffer, under isocratic conditions, the resolution of peak being sharp with retention times of 3.24 min and 4.89 min for Remogliflozin and Metformin, respectively. Technology suitability was confirmed by the …
Published in Trends in Drug Delivery · Vol. 12, Issue 2, 2025 · pp. 70–77 Read article
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Evaluate the Impact of a First Aid Module on the Knowledge and Skills Related to First Aid Management Among Nursing Students at Gian Sagar College of Nursing, Ramnagar, Rajpura, Punjab
Abstract: Introduction: First aid refers to the immediate and temporary care provided to individuals who are injured, ill, or wounded before professional medical assistance becomes available. Since accidents can occur unexpectedly, having fundamental first aid knowledge is invaluable. It enables individuals to deliver prompt, lifesaving assistance and prevent complications until expert care arrives. Training nursing students in first aid is particularly important, as it equips them to preserve life, prevent further …
Published in International Journal of Emergency and Trauma Nursing and Practices · Vol. 3, Issue 2, 2025 · pp. 42–55 Read article
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Literature Review and Research Gaps in Power Quality Enhancement: From Conventional Methods to Intelligent Solutions
Abstract: Power quality (PQ) has become a critical concern in modern electrical power systems due to the rapid integration of renewable energy sources, proliferation of power electronic devices, and increasing sensitivity of loads. This paper presents a comprehensive literature review and research gap analysis of power quality enhancement techniques, ranging from conventional approaches to emerging intelligent solutions. Traditional methods, including passive filters, capacitor banks, and synchronous condensers, have been widely employed …
Published in International Journal of Electrical Machine Analysis and Design · Vol. 4, Issue 1, 2026 · pp. 38–80 Read article
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Lamivudine And Dolutegravir Simultaneous Dosage Forms Determined and Validated Using The RP-UPLC Method
Abstract: RP-UPLC has been used to produce a straightforward, precise, and accurate approach for the simultaneous estimation of dolutegravir and lamivudine in a pharmaceutical dose form. A HSS C18 column of 2.8 x 50 mm and featuring particles with a size of 1.6 μm was used to process the chromatogram. A mixture of 70:30 Buffer Na2HPO4 and methanol made up the mobile phase, which was pushed across the column at a …
Published in Emerging Trends in Personalized Medicines · Vol. 1, Issue 1, 2024 · pp. 5–13 Read article
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Next-Gen Techniques for Bottleneck Detection in High-Performance Computing
Abstract: Modern computing systems face new challenges in bottleneck detection and mitigation due to their increasing complexity which stems from multi-core architectures alongside distributed platforms and real-time processing needs. Traditional methods like hardware profiling and static analysis which used to work well now struggle to keep up with the changing conditions of dynamic system behaviors and diverse computing environments along with variable workload patterns. The current limitations restrict their capability to …
Published in Recent Trends in Parallel Computing · Vol. 12, Issue 2, 2025 · pp. 09–14 Read article
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Electromagnetic Propulsion Train for Future Transportation
Abstract: The Electromagnetic Propulsion Train project focuses on the development and analysis of a prototype system that achieves linear motion through the application of controlled electromagnetic forces. Unlike conventional railway systems that rely primarily on mechanical drive mechanisms such as wheels, axles, and traction motors, this project explores an alternative propulsion approach based on electromagnetic interaction. In this system, a sequence of electromagnets is strategically positioned along the track to generate …
Published in International Journal of Electro-Mechanics and Material Behaviour · Vol. 3, Issue 2, 2025 · pp. 25–31 Read article
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Synthesis and Characterization of Polymer-Based Benzamide Derivatives with Potential Biomedical Applications
Abstract: The present study explores the synthesis and characterization of polymer-supported benzamide derivatives, focusing on their potential biomedical applications. The use of polymer-supported synthesis offers several advantages, including improved reaction efficiency, ease of purification, and reusability of the support material, making it an environmentally friendly and cost-effective approach. The synthesis involved a stepwise reaction sequence, with polymeric supports facilitating controlled functionalization and ensuring high product purity. These materials have been widely …
Published in Journal of Polymer & Composites · Vol. 13, Issue 5, 2025 Read article