Search
92 articles for “metabolic enzymes”
-
Sub-acute Toxicity of β-cyfluthrin in Hepatic Tissue and its Amelioration through Punica granatum in Swiss albino mice
Abstract: β-cyfluthrin, member of synthetic pyrethroid pesticide Type II is broadly used multipurpose insecticide. Widespread and indiscriminate use of β-cyfluthrin leads to environmental contamination and toxicity towards nontarget mammalian systems. The present study was undertaken to examine toxic manifestation of β-cyfluthrin in hepatic tissue of Swiss albino mice and also evaluate possible mitigative potential of pomegranate juice (PJ) in combating pesticide induced hepato-toxicity. Animals were divided into five groups namely, control, …
Published in Research and Reviews: A Journal of Toxicology · Vol. 10, Issue 3, 2020 · pp. 41–52 Read article
-
A Review: A Source of Industrially Important Enzymes from Marine Actinomycetes
Abstract: Actinomycetes are Gram-positive, spore-forming, filamentous actinobacteria which usually contain G+C content of about 57–75% in their DNA. Actinomycetes are considered as a unique group of a microorganism having the characters of the true bacteria and the true fungi. Actinomycetes that have been detected from extreme conditions are considered to be sources of new enzymes of great industrial potential. They produce valuable secondary metabolites and industrially significant enzymes like pectinase, amylase, …
Published in Research and Reviews : A Journal of Biotechnology · Vol. 10, Issue 2, 2020 · pp. 20–25 Read article
-
InSilico Analysis and Homology Modeling of Tetrahydroprotoberberine Oxide involved in the Berberine Biosynthesis
Abstract: Objective: Berberine, a bioactive compound found in various plant species, exhibits diverse pharmacological properties with potential applications in pharmaceutical research. The biosynthesis of berberine involves several enzymatic steps, with (S)-tetrahydroprotoberberine oxidase playing a pivotal role. This study aimed to elucidate the structural and functional characteristics of (S)-tetrahydroprotoberberine oxidase to better understand its role in berberine biosynthesis and its potential biotechnological applications. Methods: Using bioinformatics tools and computational methods, the physicochemical …
Published in Emerging Trends in Metabolites · Vol. 1, Issue 1, 2024 · pp. 7–26 Read article
-
Mercury-induced Biochemical Changes in Perna viridis Exposed in Chronic Toxicity Test
Abstract: In the present study, the Asian green mussel, Perna viridis, was exposed to 50, 75, 113, 160 and 253 µg/L Hg concentrations under chronic toxicity for the assessment of biochemical biomarkers. Higher levels of glutathione S-transferase (GST), reduced glutathione (GSH), lipid peroxidation (LPO) and lower levels of protein, catalase (CAT) and acetylcholinesterase (AchE) were found. The values were found to be significant at P < 0.01. This study suggests that …
Published in Research and Reviews: A Journal of Toxicology · Vol. 2, Issue 1, 2012 · pp. 15–22 Read article
-
Molecular Identification and Characterization of a Rice Field Cyanobacterium for its Possible Use as Biofertilizer in Acidic Environment
Abstract: Normal 0 false false false EN-US X-NONE X-NONE /* Style Definitions */ table.MsoNormalTable {mso-style-name:"Table Normal"; mso-tstyle-rowband-size:0; mso-tstyle-colband-size:0; mso-style-noshow:yes; mso-style-priority:99; mso-style-qformat:yes; mso-style-parent:""; mso-padding-alt:0in 5.4pt 0in 5.4pt; mso-para-margin:0in; mso-para-margin-bottom:.0001pt; mso-pagination:widow-orphan; font-size:11.0pt; font-family:"Calibri","sans-serif"; mso-ascii-font-family:Calibri; mso-ascii-theme-font:minor-latin; mso-fareast-font-family:"Times New Roman"; mso-fareast-theme-font:minor-fareast; mso-hansi-font-family:Calibri; mso-hansi-theme-font:minor-latin; mso-bidi-font-family:"Times New Roman"; mso-bidi-theme-font:minor-bidi;} Initial screening for cyanobacterial diversity in rice fields of Meghalaya revealed presence of a limited number of species predominantly belonging to heterocystous cyanobacteria such as Nostoc and Anabaena. …
Published in Research and Reviews: A Journal of Microbiology and Virology · Vol. 1, Issue 3, 2011 · pp. 1–12 Read article
-
Interaction of Mosquito’s hppd Enzyme with Lansoprazole Sulfide A New Hope to Tackle the Mosquito Menace – an in-Silico Study
Abstract: Tyrosine detoxification is an important physiological process that helps blood-feeding insects, such as mosquitoes that transmit Plasmodium parasites causing malaria, digest their blood meals. An enzyme known as 4-hydroxyphenylpyruvate dioxygenase (HPPD), which is part of the tyrosine detoxification pathway, helps in removing excess tyrosine in a high-protein blood meal. Excess tyrosine can be lethal to the insects, and hence, the role of HPPD enzyme is very critical. Inhibitors of HPPD …
Published in International Journal of Insects · Vol. 3, Issue 1, 2026 · pp. 1–11 Read article
-
Toxicity of Alpha-Cypermethrin on Fish
Abstract: Alpha-cypermethrin is a type II synthetic pyrethroid. Synthetic pyrethroids are used extensively for the control of insect pest and public health purpose. A fresh water fish was exposed to lethal concentration and sub lethal concentration of alpha-cypermethrin, respectively to observe the enzyme activity in functionally two different tissues—gills and liver. The present article focusses on non-target organism in fresh water environment and critically evaluates the toxicity of these pyrethroids in …
Published in Research and Reviews : Journal of Veterinary Science and Technology · Vol. 10, Issue 2, 2021 · pp. 33–38 Read article
-
Study the Effect of Antioxidant and Antidiabetic Property of the Selective Indian Herbal Plant Extract (A. indicum) on Type II Diabetes Mellitus
Abstract: Abutilon indicum (A. indicum) is a traditional Indian phytomedicine plant used for the treatment of several diseases such as diabetes mellitus, cardiac diseases and anti-inflammatory diseases. The aim of the study was to evaluate whether A. indicum improves insulin sensitivity and determine its active role in bioactive secondary metabolites. Aldose reductase is an enzyme which contains lower affinity towards glucose and helps in converting glucose to sorbitol and slightly catalyzed. …
Published in Research and Reviews : A Journal of Life Sciences · Vol. 9, Issue 1, 2019 · pp. 53–63 Read article
-
Fenvalerate Toxicity on Fish: A Review
Abstract: As a new class of agricultural insecticides, synthetic pyrethroids are widely used to control insect pests. Synthetic pyrethroids have shown to enter the aquatic environment from agricultural runoff or drift from aerial and ground-based spraying applications posing threat to fishes, which are less tolerant to pesticides through direct exposure. These insecticides interfere with the sodium channel of the nervous system resulting in prolonged sodium tail current. Widespread application of these …
Published in Research and Reviews : Journal of Veterinary Science and Technology · Vol. 9, Issue 2-3, 2020 · pp. 6–13 Read article
-
Screening of Newer Phytoconstituents on Novel Enzymes for their Biological Activity
Abstract: Background: Hyperlipidemia and gout are prevalent metabolic disorders significantly impacting global health. The xanthine oxidase and HMG-CoA reductase pathways play pivotal roles in the pathophysiology of these conditions. This study explores the potential of natural phytoconstituents—daidzein, resveratrol, and genistein—as dual inhibitors for these enzymatic targets, offering insights into innovative therapeutic strategies. Aim: To evaluate the potential of natural phytoconstituents—daidzein, resveratrol, and genistein—as dual inhibitors of xanthine oxidase and HMG-CoA reductase …
Published in Research and Reviews: A Journal of Pharmaceutical Science · Vol. 16, Issue 1, 2025 · pp. 81–86 Read article
-
Buccal Drug Delivery System: A Review
Abstract: The occurrence of interfacial molecular attracting force into the surface of biologically known substrates and naturally or synthetically occurring polymer, that in turn permits the polymer to cling to the biologically known surfaces for a prolonged length of time, is known as bio adhesion. Bio adhesive polymerizing system has employed into creation of goods for a variety of biomedical applicability, including surgical glue and denture adhesive, for a long time. …
Published in Trends in Drug Delivery · Vol. 9, Issue 2, 2022 · pp. 16–27 Read article
-
Production and Partial Purification of Tannase from Bacillus sp.
Abstract: Micro-organisms tannase is industrial-important enzymatic enzymes can, through oxidation with secondary metabolites including such tannins, catalyze that production of Gallic acid or glucose. Tannase are commonly used in the production, drink, food processing and brewing and chemical industries. Tannic acid with low-value agro-industrial waste was also commonly used in manufacturing besides tannase production. Tannase also have huge 124–310 KDa variety with molecular weights as well as a great deal with …
Published in Research & Reviews: A Journal of Drug Formulation, Development and Production · Vol. 8, Issue 2, 2023 · pp. 42–51 Read article
-
Versatile Application of Tannase: A Review
Abstract: Micro - organisms tannase is industrial-important enzymatic enzymes can, through oxidation with secondary metabolites including such tannins, catalyze that production of Gallic acid or glucose. Tannase are commonly used in the production, drink, food processing and brewing and chemical industries. Tannic acid with low-value agroindustrial waste was also commonly used in manufacturing besides tannase production. Tannase also have huge 124-310 KDa variety with molecular weights as well as a great …
Published in Research & Reviews: A Journal of Pharmacognosy · Vol. 8, Issue 2, 2023 · pp. 13–17 Read article
-
Nutrient–Xenobiotic Crosstalk in Dairy Cattle: Implications for Metabolism, Immunity, Health, and Productivity in Resilient Dairy Development
Abstract: Dairy cattle are routinely exposed to a wide range of xenobiotics, including mycotoxins, heavy metals, pesticides, residues from veterinary drugs, and plant secondary metabolites, through feed, water, and environmental sources. These xenobiotics, being foreign to biological systems, can interfere with the absorption, metabolism, and utilization of essential nutrients, while also compromising immune function, organ health, and overall physiological performance. Chronic or subclinical exposure can reduce feed efficiency, disrupt energy and …
Published in Research and Reviews: A Journal of Neuroscience · Vol. 16, Issue 1, 2026 · pp. 37–46 Read article
-
Lab Reagents and Their Importance in Bio-chemistry
Abstract: Biochemical reagents are essential substances in the study of life at the molecular level. These reagents help scientists detect, identify, and quantify bio-molecules such as proteins, carbohydrates, nucleic acids, and enzymes in biological systems. They play a vital role in understanding metabolic reactions and physiological processes within living organisms. Biochemical reagents are generally classified into analytical, diagnostic, enzymatic, chromogenic, and buffer reagents, each serving a specific purpose in laboratory and …
Published in Research and Reviews : A Journal of Biotechnology · Vol. 16, Issue 1, 2026 · pp. 1–4 Read article
-
The Multifaceted Vitamin B6: Metabolism, Cardiovascular Health, Cognition, and Cancer
Abstract: Vitamin B6 is hydrophilic and plays a crucial role in various metabolic processes. It acts as a cofactor in different enzymatic reactions. Vitamin B6 exists in various forms, including pyridoxal 5'-phosphate (PLP), the most active form. Vitamin B6 is essential for amino acid metabolism, such as PLP is essential for transamination, the process of transferring amino groups between amino acids. This is vital for synthesizing non-essential amino acids and breaking …
Published in Research & Reviews : Journal of Food Science & Technology · Vol. 14, Issue 2, 2025 · pp. 33–39 Read article
-
Human Arginase I (Arg I)—A Potential Broad-spectrum Anti-cancer Agent: Perspectives and the Road Ahead
Abstract: Cancer is the second leading cause of morbidity and mortality globally. A variety of effective regimens are available for the treatment of different cancers, however, there is still a need for the development of safe and effective broad-spectrum anti-cancer agent(s). Towards this, amino acid-depleting enzymes have proven to be effective in the treatment of certain auxotrophic cancers. In this review, we have briefly discussed arginine metabolism and arginine depletion as …
Published in Research and Reviews: Journal of Oncology and Hematology · Vol. 9, Issue 3, 2020 · pp. 23–35 Read article
-
Modulation of Receptor Proteins: A Recent Paradigm in Drug Discovery and Target
Abstract: The main aim in drug discovery is to design different ligands those work on specific drug targets. However, various effective drugs work through the modulation of many proteins than single target. Advancement in system biology are establishing a phenotypic strength and a network structure, which suggests that, the excellent selective compounds may be performed less than desired clinical efficacy in comparison to multi-target drugs. In this new appreciation of the …
Published in Research & Reviews: A Journal of Drug Design & Discovery · Vol. 5, Issue 1, 2018 · pp. 14–24 Read article
-
The Specificity of Purine Derivatives towards Xanthine Oxidase Enzyme and the Factors Affecting the Enzyme Catalyzed Reaction
Abstract: Xanthine oxidase (XO) is a molybdenum-containing enzyme catalyzing the hydroxylation of a sp2-hybridized carbon in a broad range of aromatic heterocycles and aldehydes. Further, it is a key enzyme in the last two steps of purine metabolism. Thus, the need for an understanding and developing unified reaction mechanism to minimize the amount of accumulated uric acid inside human body has led us to the present detailed study of the reaction …
Published in Research and Reviews : A Journal of Life Sciences · Vol. 6, Issue 2, 2016 · pp. 28–44 Read article
-
Functional Biomolecules in Animal Nutrition: Biochemical Mechanisms and Their Impacts on Growth Performance and Health Outcomes
Abstract: Functional biomolecules have emerged as critical modulators of animal nutrition, extending beyond conventional nutrient supply to regulate biochemical and physiological processes that determine growth performance and health outcomes. This review synthesizes current knowledge on diverse classes of bioactive compounds, including amino acids, peptides, fatty acids, vitamins, minerals, phytochemicals, and microbial-derived metabolites, and their roles in livestock systems. Emphasis is placed on underlying biochemical mechanisms such as enzyme activation, nutrient signaling …
Published in International Journal of Nutritions · Vol. 3, Issue 2, 2026 · pp. 26–36 Read article