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185 articles for “immune T cells”
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Beyond Chemotherapy: The Promise of Immunotherapy in Cancer Care and Advancements in Cancer Therapy
Abstract: Recent advances in cancer immunotherapy harness the immune system to precisely target cancer. These include the use of immunosuppressive agents, NK cell recovery, changes in tumor microenvironment metabolic, and aging to achieve a positive tumor response The article explores how the body development of the immune system in the late 19th century, highlighting milestones such as the discovery and FDA approval of IL2. Different categories of immunology are explored, from …
Published in Research and Reviews : A Journal of Immunology · Vol. 13, Issue 2, 2023 · pp. 22–37 Read article
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Wiskott-Aldrich Syndrome: A Comprehensive Guide
Abstract: Wiskott-Aldrich Syndrome (WAS) is an uncommon genetic disorder inherited through the X chromosome, marked by a combination of immune system deficiencies, eczema, and low platelet counts. This syndrome primarily affects males, leading to significant morbidity and mortality due to recurrent infections, bleeding complications, and autoimmune diseases. Mutations in the WAS gene disrupt the production of the Wiskott-Aldrich Syndrome protein (WASp), crucial for the functioning of immune cells and platelet formation. …
Published in Research and Reviews : A Journal of Immunology · Vol. 14, Issue 2, 2024 · pp. 39–46 Read article
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Glial Cells in Viral and Bacterial Infections
Abstract: The Central nervous system consists of neurons and glial cells. Neurons constitute about half the volume of the CNS and glial cells make up the rest. They are also known as supporting cells of the nervous system. The three types of CNS supporting cells are Astrocytes, Oligodendrocytes and microglia. The supporting cells of Peripheral Nervous System are known as Schwann cells. The main functions of glial cells are to surround …
Published in Research and Reviews : A Journal of Immunology · Vol. 10, Issue 3, 2020 · pp. 13–21 Read article
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Orbital Cellular Angiofibroma: One of the Rarest Tumor in Pandora’s Box
Abstract: Orbital cellular angiofibroma is one of the rarest benign mesenchymal tumors and only two cases have been reported. It typically originates from the lower reproductive tract and does not show a gender or race preference. Total surgical resection is the suggested modality of treatment. Diagnosing tumors in rare anatomical locations can pose considerable challenges, especially when they share common histopathological characteristics with more common tumors. In such cases, achieving an …
Published in Research and Reviews: Journal of Oncology and Hematology · Vol. 12, Issue 2, 2023 · pp. 22–27 Read article
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Clone-Specific Drug Delivery Systems: Targeted Approaches and Future Clinical Applications
Abstract: Clone-specific drug delivery systems represent a transformative frontier in personalized medicine, addressing the longstanding challenge of clonal heterogeneity within diseases such as cancer, infectious diseases, and autoimmune disorders. Traditional drug delivery platforms often fail to discriminate between pathogenic and healthy cells, leading to systemic toxicity and reduced therapeutic efficacy. In contrast, clone-specific systems aim to selectively target and eliminate disease-driving cellular clones based on unique molecular signatures, thereby improving treatment …
Published in Research & Reviews: A Journal of Drug Design & Discovery · Vol. 12, Issue 2, 2025 · pp. 21–29 Read article
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Exploring the Dynamics of Eye Fluid: Lymphatics, Aqueous Humor, and Intraocular Pressure
Abstract: Lymphatic vessels are essential for regulating interstitial fluid balance, facilitating immune cell transport, supporting lipid absorption, and playing significant roles in tumor development and metastasis. Recent findings have expanded their recognized functions, particularly in pathological contexts. One notable discovery is the involvement of lymphatics in draining aqueous humor from the eye, a process closely linked to the regulation of intraocular pressure (IOP) and its implications for glaucoma progression. This review …
Published in Emerging Trends in Personalized Medicines · Vol. 2, Issue 2, 2025 · pp. 31–44 Read article
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Crispr Cas – Revolutionizing Modern Therapies and Beyond
Abstract: CRISPR-Cas technology has emerged as a transformative tool in modern molecular biology, revolutionizing both fundamental research and clinical applications. This RNA-guided gene-editing system enables precise and efficient genomic modifications, offering unprecedented potential for addressing genetic disorders, infectious diseases, and oncological conditions through innovative therapeutic interventions. The inherent specificity and programmability of CRISPR-Cas systems have facilitated breakthroughs in diverse fields, including precision medicine, regenerative therapies, and immuno-oncology. Beyond its therapeutic applications, …
Published in International Journal of Genetic Modifications and Recombinations · Vol. 3, Issue 1, 2025 · pp. 25–38 Read article
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Molecular Docking Studies of Nyctanthes arbor-tristis Phytochemicals for Targeting TNF Receptor in Arthritis
Abstract: Rheumatoid Arthritis is an autoimmune disorder which results in inflammation. Tumor necrosis factor-alpha (TNF-α) is responsible for the progression of inflammatory arthritis by promoting immune cell activation and cytokine release. The present study explores the potential of bioactive compounds derived from Nyctanthes arbor-tristis (Parijat) in modulating TNF receptor activity through molecular docking. Computational methods were employed to evaluate the binding affinity of selected phytocompounds from N. arbor-tristis against the extracellular …
Published in International Journal of Cell Biology and Cellular Functions · Vol. 3, Issue 2, 2025 · pp. 11–21 Read article
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Molecular Dynamics and Therapeutic Architectures of Cannabinoid Receptors: A Comprehensive Review
Abstract: Expanding on these foundations, recent structural biology studies using cryo-electron microscopy have provided high-resolution insights into the conformational dynamics of CB₁ and CB₂ receptors. These findings have enabled a more precise understanding of ligand–receptor interactions, particularly how agonists, antagonists, and reverse agonists stabilize distinct receptor states. Such knowledge is critical for rational drug design, allowing researchers to selectively modulate downstream signaling pathways. For instance, CB₁ receptors primarily couple to Gi/o …
Published in International Journal of Cheminformatics · Vol. 4, Issue 1, 2026 · pp. 36–40 Read article
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Next-Generation mRNA Vaccines: Applications Beyond COVID-19
Abstract: Messenger RNA (mRNA) vaccine technology has become a paradigm shift in contemporary medicine and, with remarkable success in the COVID-19 pandemic, has opened the door to a new wave of vaccines development. In contrast to the traditional vaccine methods, mRNA vaccines are based on the synthetic genetic code that allows host cells to express target antigens, thus eliciting strong humoral and cellular immunity. The speed of development, efficacy, scalability of …
Published in International Journal of Vaccines · Vol. 3, Issue 2, 2026 · pp. 15–26 Read article
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Concept of Ojas with Relevancy of Physiological Properties
Abstract: In the human body, metabolic activity is performed by Tridosha (functional entity and vitiating substances), Sapta Dhatus (seven tissue levels) and Malas (waste products). In addition to this, Ojas is considered as Dhatu & the essence of all Dhatus, which is present in every compartment of the body. Its quality is homologous to Kapha (lubricating and protective substance). Strength and body protecting phenomenon are governed by certain substances. It lies …
Published in Journal of AYUSH: Ayurveda, Yoga, Unani, Siddha and Homeopathy · Vol. 4, Issue 1, 2015 · pp. 30–38 Read article
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Progress from the Traditional Vaccines to Novel Rational Vaccine Designs
Abstract: Vaccines are among the most valuable assets for saving human and animal lives. The vaccines discovered and designed on the Pasteurian principles laid the foundations of the traditional vaccine regime during the late-19th century. Some traditional vaccine designs proved remarkably successful, while others had safety or efficacy problems, and still others failed- particularly those against diseases caused by non-cultivable, hyper-variable or opportunist pathogens, or those requiring cellular immunity. The problems …
Published in Research and Reviews : A Journal of Immunology · Vol. 6, Issue 3, 2016 · pp. 17–31 Read article
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Effects of Chlorpyrifos as Inducer for Oxidative Stress in Liver, Kidney and Spleen of Freshwater Fish, Pseudetroplus maculatus (Bloch, 1795)
Abstract: Chlorpyrifos is one of the most common organophosphate insecticides found abundantly in freshwater ecosystems and has been detected in agricultural and fishery products worldwide. The study focused to determine the effect of chlorpyrifos on the induction of oxidative stress in freshwater fish Pseudetroplus maculatus. Fish were exposed to sublethal concentrations (0.661 and 1.32 μg/l) of chlorpyrifos for 15 and 30 days. Activities of antioxidant enzymes and the levels of hydrogen …
Published in Research and Reviews: A Journal of Toxicology · Vol. 8, Issue 1, 2018 · pp. 20–29 Read article
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KVS Approach for IoT Network Security: A Novel Approach to IoT Network Security With B-Cell Inspired Models
Abstract: Internet of Things (IoT) is rapidly expanding, connecting billions of devices that collect, process, and transmit data. This interconnectedness, while offering immense opportunities, also presents significant security challenges. Customary security mechanisms often scuffle to retain stride with the vibrant and assorted form of IoT environments. In response, innovative security concepts are being explored, and one promising approach is the B-Cell concept called as KVS approach for IoT security. In immunology, …
Published in Journal Of Network security · Vol. 13, Issue 2, 2025 · pp. 16–25 Read article
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Advancing Cancer Vaccine Development through CRISPR/Cas9 Technologies and Future Opportunities
Abstract: The advent of CRISPR/Cas9 genome editing has revolutionized the cancer immunotherapy market, offering unprecedented precision and versatility in the development of next-generation cancer vaccines. This review examines how CRISPR technologies are being integrated into various stages of cancer vaccine development including neoantigen discovery, dendritic cell engineering, cancer cell reprogramming, and tumor microenvironment modulation. In the area of neoantigen discovery, CRISPR enables rapid identification and validation of tumor-specific mutations, thereby supporting …
Published in International Journal of Vaccines · Vol. 2, Issue 2, 2025 Read article
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A Rare Case of Signet-Ring Cell Stromal Tumor (SRST) of the Ovary
Abstract: Signet Ring-Cell Stromal Tumor (SRST) of the ovary is a rare nonfunctioning distinctive stromal neoplasm and is characterized by a proliferation of stromal and signet-ring cells. To date, only 11 cases have been reported in English literature. The tumor is characterized by a proliferation of stromal spindle cells in the form of a typical fibroma, admixed with various amounts of stromal cells with a single large vacuole and eccentric nuclei, …
Published in Research and Reviews: Journal of Oncology and Hematology · Vol. 4, Issue 2, 2015 · pp. 4–7 Read article
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Cathodoluminescence method to scheme optical remains
Abstract: Cathodoluminescence (CL) microscopy replaces light generation by a focused electron-beam so as to visualize optical information at resolution of electron microscope. High-resolution imaging has pursued on strongly cathodoluminescent substrates, such as glass. Method has been applicable for bio- and nano-sciences, said as CL identification of bio-markers within cells as well as ceramic character interpret to describe plasmon components from glass supported devices, given by, sensors, waveguides, plasmonic tweezers, and thin-film …
Published in Journal of Microelectronics and Solid State Devices · Vol. 8, Issue 2, 2021 · pp. 7–14 Read article
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An Immunohistochemical Study to Assess the Role of Myofibroblasts in Diagnosing and Predicting the Outcome of Oral Squamous Cell Carcinoma
Abstract: Background: Squamous cell carcinoma (SCC) accounts for approximately 94% of all oral malignancies, hence establishing oral squamous cell carcinoma (OSCC) as one of the top 10 most prevalent malignant tumors. Cells with several functions, such as macrophages and myofibroblasts, play a vital role in the biological behavior of tumors. This study aimed to assess and evaluate the prevalence of myofibroblasts (MF) and macrophages in SCCs occurring in the oral region. …
Published in International Journal of Cell Biology and Cellular Functions · Vol. 2, Issue 1, 2024 · pp. 13–17 Read article
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Understanding Programmed Cell Death
Abstract: Recent studies emphasize the critical role of various types of programmed cell death (PCD) such as apoptosis, autophagy, pyroptosis, and necroptosis, as well as their respective signaling pathways. These processes are essential for regulating cellular balance, responding to stress, and triggering immune defenses. Apoptosis, commonly known as "cellular suicide," is a tightly controlled mechanism that allows cells to die without inducing inflammation. This process is key for tissue development, immune …
Published in Research and Reviews : A Journal of Life Sciences · Vol. 14, Issue 3, 2024 · pp. 42–50 Read article
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Immunotherapy Advancements in Cancer Treatment
Abstract: Immuno-oncology has been one of the more exciting developments in the field of cancer treatment since about a century ago, with William B. Coley's work in the late 19th century, which really gave the field its beginnings with "Coley's toxin." In an initial effort that proved unsuccessful, early immunotherapy approaches utilizing bacterial mixtures to induce immune responses against tumors nonetheless laid some groundwork for this field. It wasn't until over …
Published in Research and Reviews: A Journal of Pharmacology · Vol. 14, Issue 3, 2024 · pp. 22–28 Read article