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73 articles for “genetic variation”
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Pharmacogenomics in Anesthesia: Case Studies and Clinical Applications for Personalized Care
Abstract: Pharmacogenomics, the study of how genetic variability influences individual responses to medications, is transforming anesthetic practice by enabling personalized care. This case study collection explores the integration of pharmacogenomic insights into anesthesia management, highlighting its impact on safety, efficacy, and patient outcomes. Adverse reactions to anesthetics often arise from genetic polymorphisms that alter drug metabolism or sensitivity. For instance, patients with RYR1 mutations are susceptible to malignant hyperthermia (MH) when …
Published in Research and Reviews: A Journal of Pharmacology · Vol. 15, Issue 2, 2025 · pp. 85–91 Read article
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Pharmacogenetics: A Marvel!
Abstract: Normal 0 MicrosoftInternetExplorer4 Pharmacogenetics is a new paradigm in the field of medical research and therapeutics which is set to revolutionize the current scenario of drug prescribing in health care. It can identify the genetic variations responsible for differences in drug efficacy and safety among individuals by employing pharmacogenomic tools and hence result in lowering of the chances of therapeutic failures and adverse effects. Clinical practitioners will also need to …
Published in Research and Reviews: A Journal of Pharmacology · Vol. 2, Issue 2, 2012 · pp. 12–20 Read article
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Pharmacovigilance And Drug-Induced Toxicities: A Clinical Perspective
Abstract: Pharmacovigilance, which aims to detect, assess, and prevent medication-induced toxicities and adverse drug reactions (ADRs), is a crucial part of healthcare. This study examines the several kinds of drug-induced toxicities, such as idiosyncratic, dose-dependent, and allergic reactions, and emphasizes the function of clinical pharmacists in the tracking and treatment of these illnesses. Pharmacovigilance systems are crucial because they can identify and handle drug-related safety issues that might not surface during …
Published in Research and Reviews: A Journal of Toxicology · Vol. 14, Issue 3, 2024 · pp. 17–30 Read article
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Adverse Drug Reactions: A Global Health Challenge
Abstract: Adverse drug reaction (ADR) is an unfavorable event with a causal connection to the medication. It is an undesirable event occurred by a pharmacological substance. They are a major cause of Mortality all over, they are classified into augmented, chronic, bizarre, Delayed based on the severity of the damage they caused The primary causes of adverse drug reactions (ADRs) are drug overdose, drug– drug interactions, genetic variations, and individual characteristics …
Published in Research and Reviews: A Journal of Pharmacology · Vol. 16, Issue 2, 2026 · pp. 01–06 Read article
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Identification and Characterization of Genetic Predictors of Sickle Cell Anemia in Bilaspur District, Chhattisgarh, India
Abstract: In the present decades, sickle cell anemia (SCA) is a challenging task for control of hereditary syndrome in Bilaspur district of Chhattisgarh state, India. The present study aims to identify and characterize genetic predictors of SCA from Bilaspur district (CG) in 2024. A total of 3000+ individuals were screened and categorized into carriers, positive (screening), and diseased cases. Fetal hemoglobin (HbF) level is determined by several genetic factors including genetic …
Published in International Journal of Genetic Modifications and Recombinations · Vol. 4, Issue 2, 2026 · pp. 1–9 Read article
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Advances in Lung Cancer Detection and Diagnosis: An Integrative Approach Using Computational Chemistry, Statistics, Bioinformatics, Artificial Intelligence, and Machine Learning
Abstract: Lung cancer is still one of the most common and lethal cancers globally, accounting for more than a million deaths each year. Prompt detection is important, and imaging techniques like chest X-rays, MRIs, PETs, CTs, and molecular imaging have become important tools. But still, even though all these techniques do not provide an accurate classification of the lesion, they have led to the development of computer-based high-resolution image analysis. Computer …
Published in Research & Reviews: A Journal of Bioinformatics · Vol. 13, Issue 2, 2026 Read article
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RAPD–PCR Analysis of An Important Medicinal Plant Tinospora cordifolia (Willd.) Miers ex Hook. F. & Thoms Collected from Western Ghats of South India
Abstract: Herbal drug technology is the emerging area in pharmaceutical industries. The molecular-based quality control is need of the hour to find out the adulterant. DNA-based techniques have been widely used for authentication of plant species of medicinal importance. The present study investigates the RAPD-PCR analysis of Tinospora cordifolia using RAPD-PCR techniques between five populations. A total of 44 polymorphic bands were observed. The genetic distance between the population ranged from …
Published in Research and Reviews : A Journal of Biotechnology · Vol. 6, Issue 1, 2016 · pp. 1–5 Read article
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CRISPR-Cas System: Next Generation Genome Editing Tool
Abstract: CRISPR-Cas system provides sequence specific adaptive immunity against phages and mobile genetic elements. Resistance is acquired following phage infection or plasmid uptake when short specific sequence is added into CRSIPR array. This complex guides cRNA to target complementary DNA fragments and target its degradation. CRISPR array is then transcribed and processed into cRNA which forms complex with cas protein. The ability of CRISPR-Cas system to induce site specific DNA breaks …
Published in Research and Reviews : A Journal of Biotechnology · Vol. 6, Issue 2, 2016 · pp. 10–16 Read article
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Efficient Identification of Complex Diseases Through Epistasis Computational Models: A Review
Abstract: AbstractGenome-Wide Association Studies (GWAS) identify and characterize the genes that are associated with human diseases. One of the significant ongoing researches in GWAS is to identify the disease susceptible genes through Epistasis. The gene that masks the effects of other genes is called Epistasis. The gene interacts with another gene is known as epistatic or genetic interactions (GGIs). GWAS identifies the genetic variants of Single Nucleotide Polymorphism and also the …
Published in Research & Reviews: A Journal of Bioinformatics · Vol. 7, Issue 2, 2020 · pp. 21–32 Read article
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Biodiversity and Conservation of Plant Species
Abstract: Plant biodiversity stands as a cornerstone of the intricate web of life on Earth, encompassing the staggering variety of plant species that grace our planet. This review delves into the nuanced realms of plant biodiversity, unraveling its definition in the context of species diversity, genetic variation, and ecological roles. The importance of this biodiversity resonates across ecosystems, permeating into the fabric of human well-being and maintaining the delicate equilibrium of …
Published in Research & Reviews : Journal of Botany · Vol. 12, Issue 2, 2023 · pp. 22–27 Read article
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DNA Barcoding and Sequence Analysis of Annona reticulata Linn.
Abstract: AbstractDNA barcoding is the use of short DNA sequences (~650 bp) of the standard segment of genome for large scale species identification. The Consortium for the Barcode of Life (CBOL) plant-working group recommended 2-locus combination of rbcL and matK as the standard plant barcode. These two regions of chloroplast DNA were chosen due to efficient recovery of quality sequences and high levels of species discrimination. In this study, seven samples …
Published in Research & Reviews : Journal of Herbal Science · Vol. 7, Issue 3, 2018 · pp. 24–32 Read article
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Estimation of Genetic Diversity in Some Species of Meliaceae Family through RAPD Technique
Abstract: Random amplified polymorphic DNA (RAPD) analysis has proved to be useful in determining genetic relationship and variation in many plant species, result of RAPD analysis can be used to determine genetic distances and relatedness within or among species, which can then be utilized in construction of phytogenetic. RAPD analysis could also provide useful insights into the phylogenetic relationship. RAPD is a polymerase chain reaction (PCR), which is based on dominant …
Published in Research and Reviews : A Journal of Biotechnology · Vol. 5, Issue 3, 2015 · pp. 11–17 Read article
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In vitroAntioxidant and Antidiabetic Activity of Regional Chemotypes of three Curcuma species from Chhattisgarh
Abstract: Phytoconstituents and nutritional rich Curcuma species playsan important role in medication. In the present study rhizomes of Curcuma longa, Curcuma caesia and Curcuma aromatica from different regions of Chhattisgarh, Indiawere chosen for best chemotype identification on the basis of antioxidant and antidiabetic potential. Curcuminoids found in Curcuma rhizomes vary often with varieties, locations, sources, and cultivation conditions, while there are significant variations in varieties and geographical locations as well as …
Published in Research & Reviews : Journal of Herbal Science · Vol. 7, Issue 1, 2018 · pp. 13–22 Read article
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Hydroponics Culture Regulated Metabolic Variations in Plants of Medicinal Value
Abstract: The current review chiefly brings to light the importance of alternative cultivation strategies for medicinal plants about the effective enhancement of the bioactive substances. The fast-paced society is favoring the need for its cost-effective cultivation and studying the effects thereafter. The mis-steps while collecting the plant from the wild lead to identification issues, genetic and phenotypic variations, variable bioactive substances/secondary metabolites, and toxic compounds. So, cultivation happening in controlled environments, …
Published in Research & Reviews : Journal of Herbal Science · Vol. 13, Issue 2, 2024 · pp. 14–20 Read article
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Role of Genetics in Improving Fitness and Sports Performance
Abstract: Research indicates that variations in specific genes affects sports performance, comparing athletes with nonathletes. The genes that have been examined the most in relation to athletic performance are ACE and ACTN3. Strength and endurance have been associated with these genes, which also affect the type of fiber that makes up muscles. Sports performance factors primarily affected by genes are intrinsic motivation to exercise, power and endurance potential, training response to …
Published in Recent Trends in Sports · Vol. 1, Issue 2, 2024 · pp. 28–34 Read article
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Unilateral Ventriculomegaly or Congenital Unilateral Ventricular Dilatation
Abstract: The lateral ventricles may be larger than normal in one side or both sides. Usually it is 10 mm or less in normal foetus during routine antenatal ultrasonogram at the level of atrium. Atrium is the larger central area in lateral ventricle where the three horns anterior, posterior and inferior horns meet together. The present case is having unilateral dilated right ventricle in the mid trimester which is followed upto …
Published in Research and Reviews: A Journal of Health Professions · Vol. 3, Issue 2, 2013 · pp. 16–19 Read article
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Systematic Hydroponic Review and Cultivation Strategies for Bacopa Monnieri
Abstract: Bacopa monnieri (L.) Wettst. (Brahmi; Plantaginaceae) is a medicinally important herb whose nootropic, antioxidant and anti-inflammatory properties derive largely from a group of triterpenoid saponins known as bacosides. Rising global demand for such compounds has made reliable, high-yield production a research priority and has prompted a search for cultivation systems superior to conventional field cultivation. This review compares field cultivation, in vitro micropropagation, bioreactor culture, hydroponics and elicitation for their …
Published in International Journal of Trends in Horticulture · Vol. 3, Issue 2, 2026 · pp. 23–28 Read article
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Advanced Techniques in Filler Layering for the Malar Region: Implications for Cellular Integrity and Long-Term Outcomes
Abstract: Objective: This review investigates advanced filler layering techniques for the malar region, focusing on cellular integration, collagen remodeling, hydration dynamics via aquaporin channels, genetic responses, and filler performance over time. Emphasis is placed on high-density HA fillers (Lyft, Voluma, Volift, and Volux), examining cellular-level mechanisms, genetic interactions, and the role of key pathways (TGF-β, ERK/MAPK, AQP3) in long-term outcomes. Methods: A systematic review was conducted, focusing on genetic, cellular, and …
Published in International Journal of Biochemistry and Biomolecule Research · Vol. 3, Issue 1, 2025 · pp. 10–19 Read article
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Population Genetics and Diversity of Human Adenovirus in Two Tertiary Hospitals in Southern Nigeria
Abstract: The study of dynamic changes in genetic heterogeneity can shed light on the evolution of viruses because it is known that the genetic variety of viral populations within their hosts affects disease progression, treatment outcome, medication resistance, cell tropism, and transmission risk. Our study's primary goal is to identify trends in the genetic makeup and variety of human adenoviruses using samples taken from children who attend two distinct tertiary hospitals …
Published in Research and Reviews : A Journal of Immunology · Vol. 12, Issue 3, 2022 · pp. 37–44 Read article
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Calf Mortality in the Tropics: Multidimensional Challenges and Implications for Sustainable Dairy Development
Abstract: Calf mortality remains a significant challenge in tropical dairy farming, posing threats to productivity and sustainability. This review explores the multifactorial factors contributing to calf mortality in the tropics, including environmental stress, infectious diseases, nutritional deficiencies, management practices, genetic factors, and social dynamics. Tropical climates, characterized by extreme temperature variations, humidity, and poor shelter, exacerbate stress and compromise calf health. Infectious diseases, such as bacterial, viral, and parasitic infections, coupled …
Published in Research and Reviews : Journal of Veterinary Science and Technology · Vol. 14, Issue 3, 2025 · pp. 7–23 Read article