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47 articles for “bio-toxic analysis”
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Precision Medicine for Neurofibromatosis Type 1: Progress and Prospects in Drug Discovery
Abstract: Objective: The development of neurofibromas, café-au-lait spots, and other neurological problems are the hallmarks of neurofibromatosis type 1 (NF1), a hereditary disorder. The dearth of efficacious pharmaceutical therapies underscores the need for novel therapeutic approaches, even in the face of clinical variability. Through very accurate prediction of the binding affinity of possible therapeutic drugs with the target protein, the computational technique known as “molecular docking” has become a potent tool …
Published in International Journal of Bioinformatics and Computational Biology · Vol. 2, Issue 1, 2024 · pp. 01–15 Read article
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Copper Sulfide Semiconducting Nanoparticles for Antibacterial Applications: Synthesis Strategies, Mechanisms and Performance – A Review
Abstract: Copper sulfide nanoparticles (CuS NPs) have drawn growing attention as a next-generation antibacterial platform, owing to their tunable structural, optical, and catalytic properties. This review consolidates current evidence on CuS NP synthesis, mechanisms, and antibacterial performance, comparing chemical and green synthesis routes alongside the effects of morphology, doping, and surface modification. Mechanistically, CuS NPs act through several overlapping pathways, including reactive oxygen species generation, bacterial membrane disruption, ion release, and …
Published in Journal of Polymer & Composites · Vol. 14, Issue 4, 2026 Read article
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In Silico Exploration of Podophyllum Hexandrum-Derived Phytocompounds as Potential Therapeutics Against Small Cell Lung Cancer (SCLC): A Molecular Docking Approach
Abstract: Small Cell Lung Cancer (SCLC) is a fast-growing and aggressive type of lung cancer that spreads quickly strongly associated with smoking. It is characterized by symptoms, such as persistent cough, breathing difficulties, or hoarseness, though it can sometimes be asymptomatic which makes early detection challenging. The tumor suppressor gene TP53 is critical in regulating the cell cycle and preventing uncontrolled cell division. Mutations in TP53 result in the loss of …
Published in International Journal of Molecular Biotechnological Research · Vol. 3, Issue 1, 2025 · pp. 1–11 Read article
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Self-Healing Polymeric Composites Reinforced with Green Synthesized Nanoparticles
Abstract: The development of sustainable self-healing polymeric materials is critical for enhancing durability and service life in advanced engineering applications. In this study, zinc oxide (ZnO), magnesium oxide (MgO), and ferric oxide (Fe₂O₃) nanoparticles were green-synthesized using Allium cepa extract and incorporated into epoxy-based polymeric composites to improve mechanical, thermal, and self-healing properties. This bio-based synthesis is eco-friendly and safe alternative to harsh chemical techniques, utilizing natural antioxidants to stabilize the …
Published in Journal of Polymer & Composites · Vol. 14, Issue 3, 2026 · pp. 305–314 Read article
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Exploring The Therapeutical Potential Of Pongamia Pinnata For Herpes Simplex Virus Type 1 (HSV-1)
Abstract: Objective: Pongamia pinnata (L.), commonly known as Indian beech or pongam tree, is a tropical plant renowned for its medicinal properties in traditional medicine systems. Extracts derived from various parts of Pongamia pinnata have demonstrated antimicrobial, anti-inflammatory, and immunomodulatory activities. Such attributes make it a compelling candidate for exploring its therapeutic potential against HSV infections. Thymidine kinase is the target protein mostly used in the treatment of HSV1 infections. In …
Published in Research and Reviews: A Journal of Microbiology and Virology · Vol. 15, Issue 1, 2025 · pp. 1–9 Read article
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Determination and Study of The Effect of High Concentrations from Heavy Metals in Environmental Samples
Abstract: This study focused on determining the concentrations of heavy metal ions to assess the environmental pollution levels of five T stations. Based on this, five samples were collected from different environments in Najaf Governorate, and the levels of heavy metal pollution were compared with the permissible values set by the World Health Organization. The research study concerned measurements of the increase and decrease in the concentration of elements and minerals …
Published in Journal of Modern Chemistry & Chemical Technology · Vol. 16, Issue 2, 2025 · pp. 77–84 Read article
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Steam Activated Carbon Material from the Fruit Shells of Sterculia foetida for Energy and Environmental Applications
Abstract: Steam activation of the biochar from Sterculia foetida forms a green route for the synthesis of activated carbon material with high specific surface area (1017 m2/g). The corresponding value with a chemical activating agent (K2CO3) is much lower (596 m2/g). Structural parameters of the activated carbon materials were deduced from XRD studies. Moreover the thermal stability of the activated carbon materials from steam activation is nearly 100°C higher than that …
Published in Journal of Water Pollution & Purification Research · Vol. 11, Issue 1, 2024 · pp. 23–33 Read article
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Synthesis, characterization, and antibacterial activity of silver nanoparticles with expired minocycline as reducing agent: proposed as a recycling technique
Abstract: In this research, expired minocycline, a broad-spectrum tetracycline antibiotic, was employed as both a reducing and stabilizing agent for the eco-friendly synthesis of silver nanoparticles. This sustainable method avoids the use of toxic chemical reducing agents, providing a greener alternative for nanoparticle production. The synthesized silver nanoparticles were analyzed using several characterization techniques, such as UV-Vis’s spectroscopy, scanning electron microscopy, transmission electron microscopy, and Edex analysis, to assess their structural, …
Published in Journal of Nanoscience, NanoEngineering & Applications · Vol. 16, Issue 1, 2026 · pp. 30–43 Read article
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In Silico Docking Analysis to Identify Therapeutic Benzoic Acid Derivatives for Acute Myeloid Leukaemia
Abstract: Background: The study is anchored to initiate subjugation against modern cancer therapy for Acute Myeloid Leukaemia (AML) which involves natural therapeutics as an alternative therapy that would degrade the prospect of adverse side effects along with anti-cancer properties. Objectives: Collate the various characteristics of Giltertinib with natural benzoic acid derivative phytochemicals for a disquisition regarding their similarities and differences in the context of providing adverse side effects. Methods: ADME toxicity …
Published in International Journal of Cell Biology and Cellular Functions · Vol. 1, Issue 2, 2023 · pp. 50–63 Read article
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A Comparative Review on Abelmoschus palianus and Barleria mysorensis: Phytochemical Constituents, Pharmacological Potentials, and Ethnobotanical Significance
Abstract: Medicinal plants have long served as invaluable resources for treating human ailments, with countless species still awaiting scientific exploration and validation. Abelmoschus palianus and Barleria mysorensis are two such botanicals with rich ethnomedicinal heritage but limited pharmacological characterization. This review presents a detailed comparative analysis of these two species, examining their botanical descriptions, geographic distribution, traditional applications, phytochemical constituents, pharmacological properties, toxicological profiles, and therapeutic potential. Abelmoschus palianus, native to …
Published in Research & Reviews : Journal of Herbal Science · Vol. 14, Issue 3, 2025 · pp. 7–13 Read article
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Bio Materials and Nanotechnology: Green Tea (Waste)– Aluminium Nanoparticles (Gt-Al Nps) For Methylene Blue Adsorption
Abstract: This study examines the adsorption of Methylene Blue (MB) dye from aqueous solutions using Aluminium Nanoparticles synthesized with green tea powder as a biological reducing agent. Methylene Blue, an aromatic phenothiazine dye, is widely applied in medical diagnostics and various industrial processes, but its uncontrolled release into water bodies leads to environmental pollution due to its intense colour, stability, and potential toxicity. Therefore, identifying an efficient and eco-friendly adsorbent for …
Published in Journal of Materials & Metallurgical Engineering · Vol. 15, Issue 3, 2025 · pp. 96–107 Read article
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The Clinical Landscape of Wogonin: Advancing Targeted Treatments for Chronic Diseases
Abstract: The traditional Chinese medicinal herb Scutellaria baicalensis Georgi, commonly known as Chinese skullcap or Huang-Qin, has long been used to treat a variety of conditions, including cancer, viral infections, and seizures. Its pharmacological effects are largely attributed to the high concentration of flavones, particularly wogonoside, and its aglycone derivative, wogonin. Among the bioactive compounds found in S. baicalensis, wogonin has garnered the most scientific attention due to its potent therapeutic …
Published in Research & Reviews: A Journal of Pharmacognosy · Vol. 12, Issue 1, 2025 · pp. 46–52 Read article
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Assay of the Antitrypanosomal Activity of Ziingiber Officinale Extract in Wister Rats
Abstract: This research investigated the antitrypanosomal effects of Zingiber officinale in rats infected with Trypanosoma brucei brucei. Twelve adult rats, 7 weeks old and of both sexes, were randomly divided into six groups (1 through 6), with each group consisting of two rats. All six groups (1–6) were intraperitoneally injected with 0.1 ml of blood containing 10⁶ Trypanosomes/ml. Groups 1–4 received daily intraperitoneal doses of the plant extract at concentrations of …
Published in Research and Reviews : Journal of Veterinary Science and Technology · Vol. 14, Issue 1, 2025 · pp. 32–37 Read article
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Silver Nanoparticles Loaded Polyurethane Composites for Antibacterial Medical devices
Abstract: Polyurethane (PU) polymer is widely used in biomedical application. In our study we have combined polyurethane with silver nanoparticles to develop a nanocomposite material for antibacterial medical applications. Such combination has antibacterial properties and control the toxicity too. In current research we have mixed the different sizes and types of silver nanoparticles into the polyurethane matrix. The result was their antibacterial activity, mechanical strength, and biocompatibility. The antibacterial performance of …
Published in Journal of Polymer & Composites · Vol. 14, Issue 4, 2026 Read article
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Detection and Control of Adulterants in Milk
Abstract: Milk is one of the most essential and widely consumed staple foods, valued for its rich nutritional composition, including proteins, fats, vitamins, and minerals necessary for human growth and health. However, the increasing demand for milk, coupled with economic incentives, has led to the widespread issue of milk adulteration, posing serious concerns for food safety and public health. Adulteration involves the addition of harmful or inferior substances to milk, either …
Published in Research and Reviews : Journal of Dairy Science and Technology · Vol. 15, Issue 1, 2026 · pp. 1–6 Read article
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Harnessing Honeybee Venom For Cancer Treatment: A Natural Remedy In Oncology
Abstract: Honeybee venom (HBV) has harvested significant attention as a promising natural compound with therapeutic potential in cancer treatment. This review investigates deeply into the current scientific understanding of honeybee venom, focusing on its anticancer mechanisms, molecular interactions, and potential clinical applications. Honeybee venom comprises various bioactive components, including melittin, apamin, phospholipase A2, and other peptides, which exhibit a wide range of biological activities. Recent research has demonstrated its ability to …
Published in Research and Reviews: A Journal of Toxicology · Vol. 15, Issue 1, 2025 · pp. 10–14 Read article
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Exploring Antimalarial Activity of Chalcone Derivatives through QSAR
Abstract: Background: The core structure of chalcones contains a reactive α,β-unsaturated system within the aromatic rings, which plays a key role in mediating various biological effects. These effects include enzyme inhibition, anticancer activity, anti-inflammatory properties, as well as antibacterial, antifungal, antimalarial, antiprotozoal, and anti-filarial actions.Modifying the structure by introducing substituent groups to the aromatic ring can enhance potency, reduce toxicity, and expand their range of pharmacological actions. Methods: A total of …
Published in International Journal of Bioinformatics and Computational Biology · Vol. 3, Issue 2, 2025 · pp. 1–6 Read article
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Investigations Into the Potential for Anthracene Decomposition of Novel Soil Bacterium, Pseudomonas putida P7
Abstract: Bioremediation of hazardous contaminants holds immense importance for the preservation of a clean and healthy environment. Conversely, the accumulation of toxicants can be mitigated with the assistance of microorganisms capable of breaking down these harmful substances into benign molecules. Anthracene is frequently used as a model molecule for studies on PAH pollution because it is found in many carcinogenic PAHs. Therefore, the hunt for new microorganisms with the ability to …
Published in Research and Reviews : A Journal of Biotechnology · Vol. 14, Issue 2, 2024 · pp. 29–44 Read article
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Biopolymer Hydrogels: Patent Insights and Emerging Technological Trends
Abstract: Hydrogel biopolymers have become a valuable resource for next-generation functional materials due to their inherent properties, including compatibility with biological systems, environmental degradability, and minimal toxicity. Intelligent gels that respond to changes in temperature, pH, or ionic strength have various applications across industries like pharmaceuticals, biomedical engineering, and the food sector. This review systematically compiles findings from patent disclosures and non-patent literature to highlight recent trends in biopolymer-based hydrogel research, …
Published in Journal of Polymer & Composites · Vol. 14, Issue 2, 2026 · pp. 916–924 Read article
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Preparing Chitosan Hybrid Nanocomposites by Novel Additives for Wound Healing
Abstract: Biomaterials made from chitosan have been discovered to be particularly unique marine polysaccharides (or polycarbohydrates) with a wide range of physico-chemical and biological characteristics suitable for biomedicine field. Due to net positive charge of chitosan, it is essentially capable of chemically binding with negatively charged surfaces A biodegradable blend of chitosan nanoparticles (CHT), poly vinyl alcohol (PVA) and polyethylene glycol (PEG) hybridized with metal oxides nanopowders were prepared and used …
Published in Journal of Polymer & Composites · Vol. 11, Issue 2, 2023 · pp. 9–23 Read article