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42 articles for “Randomized Clinical Trial”
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An Analysis of Machine Learning Models for Early Cardiac Risk Stratification
Abstract: The paper shows an in-depth study of machine learning and artificial intelligence solutions to early cardiac risk stratification which has a crucial necessity because cardiovascular disease (CVD) prediction remains a significant issue that needs to be improved beyond the conventional risk score. Since CVD is the most serious disease killer in the world, claiming 17.9 million deaths every year, there is a strong need to get the most sophisticated predictive …
Published in Research & Reviews: A Journal of Bioinformatics · Vol. 13, Issue 2, 2026 Read article
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Clinical Evaluation of Lekhaniya Effect of Vacha (Acorus calamus) and Musta (Cyperus rotundus) in Medoroga w.s.r. to Obesity: A Comparative Study
Abstract: Present clinical study was designed to assess the lekhaniya effect of Vacha and Musta in reducing sign and symptoms of Medoroga. Lekhaniya effect can be correlates with antiobesity drug action. Total 40 patient of Medoroga were registered in the OPD of Pakwasa, (Shri Ayurved Mahavidyalaya, Nagpur). Total patients were divided equally into 2 groups: A and B. Study was done by using randomized single blind method. The trial drugs were …
Published in Research & Reviews: A Journal of Pharmacognosy · Vol. 3, Issue 1, 2016 · pp. 1–8 Read article
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Effect of Ultrasound and Low Level Laser Therapy on Nerve Conduction Studies in Patients with Carpal Tunnel Syndrome
Abstract: Carpal tunnel syndrome is a common entrapment neuropathy resulting from median nerve compression with the symptoms of pain, numbness and tingling in the hand and fingers. There are many conservative treatment options available for carpal tunnel syndrome. Ultrasound and low level LASER therapy are found to be one of the effective conservative treatments. The purpose of this study is to find the effect of ultrasound and low level LASER therapy …
Published in Research and Reviews: A Journal of Neuroscience · Vol. 3, Issue 2, 2013 · pp. 9–14 Read article
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Evaluation of Effect of Rasayana Ghana Tablet (An Ayurvedic Formulation) in Management of Akala jara (Premature Ageing)
Abstract: In the present era of stress, when lifestyle disorders are on the rise, premature ageing is also one of the most prevalent disorders. Ayurvedic Rasayana (rejuvenator) drugs can provide solution for this. The present study was aimed to evaluate the efficacy of Rasayana Ghana tablet (RGT) in management of premature ageing. In this placebo-controlled randomized prospective clinical study, Rasayana Ghana tablet based upon the classical combination of Gokshura (Tribulus terestris …
Published in Journal of AYUSH: Ayurveda, Yoga, Unani, Siddha and Homeopathy · Vol. 1, Issue 1-3, 2012 · pp. 77–88 Read article
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Study on the Effect of Rohitaka Sharapunkha Churna and Kunjal Kriya on Mukhadushika
Abstract: The present clinical trial was conducted to evaluate the efficacy of Kunjal Kriya and Rohitaka Sharapunkha Churna in the management of Mukhadushika (Acne Vulgaris). The subjects were randomly divided into three groups. A total 30 patients were selected for the study and all the patients completed the study. The efficacy was determined by finding out the difference between the base line data of parameters with the after treatment data. The …
Published in Journal of AYUSH: Ayurveda, Yoga, Unani, Siddha and Homeopathy · Vol. 3, Issue 2, 2014 · pp. 48–57 Read article
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Novel plasma therapy for covid-19: A Perspective
Abstract: Coronavirus disease (COVID-19) is an induced disease caused by the coronavirus-19 that causes acute respiratory syndrome (SARS COVID-19). In the month of December 2019, the first case was recorded in Wuhan, China. No specific medications have yet been approved for their treatment; convalescent plasma therapy is projected to boost the survival rate. Early in the twentieth century, convalescent plasma therapy was developed. Convalescent plasma therapy is widely utilized around the …
Published in Research and Reviews: Journal of Oncology and Hematology · Vol. 10, Issue 3, 2021 · pp. 30–34 Read article
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Sudarshan Kriya Intervention and Rise of Protective Prostaglandins in Advanced-Stage Breast Cancer: Double-Blind, Randomized, Controlled Trial
Abstract: Background: Breast cancer patients in advanced stages of cancer are managed by palliative care. This study reports important prostaglandin changes observed with added intervention of Sudarshan Kriya in their ongoing palliative care. Level of Prostaglandin A₂ (PGA₂) indicates tumor growth suppression; its level rises if person’s general condition is good, physically fit and active while PGE₂ and D₂ are considered pro-inflammatory. Quantitative assessment of Prostaglandins was done pre and post …
Published in Journal of AYUSH: Ayurveda, Yoga, Unani, Siddha and Homeopathy · Vol. 15, Issue 1, 2026 · pp. 62–68 Read article
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Integrative Therapeutics for Antimicrobial Resistance and Autoimmune Disease: Evidence and Pathways
Abstract: Background: Antimicrobial resistance (AMR) is accelerating globally, while autoimmune diseases and adverse drug reactions (ADRs) continue to rise. Ayurveda offers immunomodulatory, antimicrobial, and detoxification‑oriented interventions that may complement biomedical strategies. Objective: To propose a hypothesis‑driven integrative model combining Ayurvedic phytotherapy, panchakarma detoxification, and personalized dosha‑based care with evidence‑based medical management to mitigate AMR emergence, modulate autoimmunity, and reduce ADR incidence. Methods: A synthesis of mechanistic literature on Ayurvedic herbs with …
Published in Research and Reviews : A Journal of Immunology · Vol. 16, Issue 2, 2026 · pp. 25–30 Read article
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Clinical Trial to Find the (Asbab) Aetiology and (Ilaj) Treatment of (Marz-e-Akyās Khusyat-ur-Rahim) Polycystic Ovarian Syndrome (PCOS)
Abstract: Introduction: Polycystic Ovarian Syndrome (PCOS) is common endocrine disorder. It is clinically defined as the syndrome characterized by amenorrhoea, hirsutism and obesity associated with polycystic ovaries. Diagnosis is made on the Rotterdam criteria, established in 2003. The criteria require the presence of 2 of the following 3 criteria: 1. Oligo-ovulation or an ovulation. 2. Hyperandrogenism. 3. Polycystic ovaries through ultrasound evaluation. Methods: Diagnosed patients were enrolled in the trial into …
Published in Research & Reviews : A Journal of Unani, Siddha and Homeopathy · Vol. 12, Issue 3, 2025 · pp. 30–37 Read article
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Prime Editing and Base Editing in Human Hematopoietic Stem Cells Toward Scarless Correction of Monogenic Blood Disorders
Abstract: Monogenic hematological disorders – such as sickle cell disease (SCD), β-thalassemia, and X-linked chronic granulomatous disease (X-CGD) – affect >400, 000 newborns worldwide each year, with a considerable burden in low-resource settings . Although donor-derived allogeneic hematopoietic stem-cell transplantation (HSCT) is widely regarded as curative, its application is limited due to issues of donor availability and graft-versus-host disease (GVHD) and conditioning-related toxicity. DSB-based conventional CRISPR-Cas9 strategies are limited by inefficient …
Published in International Journal of Genetic Modifications and Recombinations · Vol. 4, Issue 1, 2026 · pp. 15–22 Read article
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SGLT2 Inhibitors in Heart Failure and Chronic Kidney Disease: Expanding Therapeutic Horizons beyond Glycemic Control
Abstract: Heart failure (HF) and chronic kidney disease (CKD) are closely related clinical diseases that significantly increase morbidity and death worldwide. The co-occurrence of both conditions is frequently referred to as the "cardio-renal syndrome," in which the failure of one organ hastens the decline of the other. The original purpose of sodium–glucose cotransporter-2 (SGLT2) inhibitors was to treat type 2 diabetic mellitus (T2DM) by reducing blood sugar levels. Nevertheless, new data …
Published in Research and Reviews: A Journal of Pharmacology · Vol. 16, Issue 2, 2026 Read article
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A Clinical Study on Itrifal Shahatra and Sharbat Unnab to Evaluate the Mechanisms of Action and Unani Principles in Buthūr (Acne)
Abstract: The current study assesses the possible mechanisms of action of Itrifal shahatra and sharbat unnab in Buthūr (Acne) with the support of Unani principles and evidence of the trial. The skin eruptions like macules, papules and pastules are described in the Unani classical literature as Buthūr. The main cause of Buthūr is khilt e Raddi (Morbid Humour) due to derangement of Akhlat (body humor). Musaffi-e-khoon (Blood purifier), Muhallil-e-auram (anti-inflammatory), Dāfi‘-i-Ta‘affun …
Published in Research & Reviews : A Journal of Unani, Siddha and Homeopathy · Vol. 9, Issue 3, 2022 · pp. 9–16 Read article
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Guidelines for Withdrawal of Anti-Epileptic Drugs in Seizure-Free Patients
Abstract: The ultimate goal of epilepsy treatment is to become seizure free and live a healthy life without the need to take antiepileptic drugs may cause several tricky and sometimes serious side-effects. There is no class I evidence that is based on randomized double-blind trials for withdrawal of antiepileptics in adults who become seizure-free while taking such drugs. Whether or not antiepileptic drugs should be withdrawn after a patient has been …
Published in Research and Reviews: A Journal of Health Professions · Vol. 4, Issue 1, 2014 · pp. 5–8 Read article
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Development of Cost-Effective Nanocarriers for Targeted Drug Delivery in Cancer Therapy in India
Abstract: The growing challenge of cancer in India demands the development of novel treatment approaches that are efficient and less expensive in alleviating disparities related to healthcare access and optimizing outcomes. Among the possible options, the drug delivery systems utilizing nanocarriers have been developed and they provide greater therapeutic targeting, reduced systemic toxicity, and decreased treatment costs over time. In this research, we assess the degrees of awareness, affordability, and acceptability …
Published in Journal of Nanoscience, NanoEngineering & Applications · Vol. 15, Issue 3, 2025 · pp. 1–7 Read article
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Comparative Efficacy and Safety of Safinamide and Rasagiline in the Treatment of Parkinson’s Disease: A Meta-Analysis and Systematic Review
Abstract: Background: Recent studies have suggested Rasagiline and Safinamide monotherapy as potential management options for Parkinson’s disease. Parkinson’s disease, a neurological disorder characterized by tremors and movement difficulties, necessitates treatments aimed at managing clinical symptoms. Levodopa remains the primary effective treatment for Parkinson’s disease symptoms; however, its long-term use often leads to motor complications in many patients. Additional therapeutic drugs, such as dopamine agonists and monoamine oxidase B inhibitors, including Safinamide …
Published in Research and Reviews: A Journal of Pharmacology · Vol. 14, Issue 3, 2024 · pp. 74–91 Read article
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Randomized Clinical Study on Dissolution of Urinary Catheters and Stents Encrustation by an Ayurvedic Compound
Abstract: Encrustation, a crust or hard coating on the surface of urinary catheter and stents, is developed due to the formation of biofilm. Encrustation causes blockage of urinary catheter and leads to reflux of urine, increases renal pressure and ultimately damages renal parenchyma tissues. Present clinical study was designed to evaluate the dissolution activity of an Ayurvedic compound on catheter and stent encrustation and to study the changes seen in serum …
Published in Research and Reviews : A Journal of Medical Science and Technology · Vol. 2, Issue 3, 2013 · pp. 12–24 Read article
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A Clinical Study of Manahshiladi Lepa in Psoriasis
Abstract: Skin is the largest organ of the body which protects the body from the outer environment. It is the organ that reflects many internal diseases by changing its character. Psoriasis is an autoimmune papulosquamous disorder that represents an inflammation pattern of the skin to various stimuli. It is characterized by sharply demarcated erythematous plaque/patches/papules covered with silvery scaling. Psoriasis is a common dermatological problem affecting up to 2.5% of the …
Published in Journal of AYUSH: Ayurveda, Yoga, Unani, Siddha and Homeopathy · Vol. 3, Issue 2, 2014 · pp. 68–79 Read article
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Evaluating the Role of Apple Cider Vinegar in Managing Semaglutide-Induced Gastrointestinal Disturbances: A Systematic Review
Abstract: Background: Semaglutide, a glucagon-like peptide-1 (GLP-1) receptor agonist, is highly effective in treating type 2 diabetes and obesity. However, its use is often associated with gastrointestinal side effects, including nausea, vomiting, and diarrhea, which may impact patient compliance. Objective: This systematic review aims to evaluate the evidence regarding the management of semaglutide-induced GI symptoms and assess the potential role of apple cider vinegar (ACV) as a complementary treatment. Methods: A …
Published in Research and Reviews: A Journal of Medicine · Vol. 15, Issue 1, 2025 · pp. 25–31 Read article
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Progressive Muscle Relaxation and Anxiety Reduction among Cardiac Surgery Patients
Abstract: Heart surgery is a stressful life event. Progressive muscle relaxation (PMR) can be implementing in nursing practice as an effective, complimentary therapy. Present study was undertaken with the objective of assessing the effect of PMR on anxiety level of valvular heart surgery patients. A randomized controlled trial was done and 65 adult patients were enrolled and randomly assigned 33 into the experimental group and 32 into control group. Hamilton anxiety …
Published in Journal of Nursing Science & Practice · Vol. 8, Issue 3, 2018 · pp. 38–47 Read article
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Breathing for Brains: Yoga's Cognitive Transformation in College Students
Abstract: This study investigates the potential cognitive-enhancing effects of meditation and pranayama practices in young adults aged 18–25. A randomized controlled trial was conducted, with one group undergoing a two-month, meditation and pranayama intervention, while the other served as a control with no intervention. Various physiological parameters were assessed, including blood pressure, pulse rate, lung capacity, and oxygen levels. The intervention group practiced mindfulness, Om meditation, focus meditation, body scan meditation, …
Published in OmniScience: A Multi-disciplinary Journal · Vol. 13, Issue 3, 2023 · pp. 1–10 Read article