A Clinical Study on Itrifal Shahatra and Sharbat Unnab to Evaluate the Mechanisms of Action and Unani Principles in Buthūr (Acne)

Md Manzar Alam; Mahboob Ussalam; Anirban Goswami; Md Ishtiyaque Alam; Mumtaz Ahmad; Rajesh .; Md Hashmat Imam; Shaista Bano

Abstract

The current study assesses the possible mechanisms of action of Itrifal shahatra and sharbat unnab in Buthūr (Acne) with the support of Unani principles and evidence of the trial. The skin eruptions like macules, papules and pastules are described in the Unani classical literature as Buthūr. The main cause of Buthūr is khilt e Raddi (Morbid Humour) due to derangement of Akhlat (body humor). Musaffi-e-khoon (Blood purifier), Muhallil-e-auram (anti-inflammatory), Dāfi‘-i-Ta‘affun (anti-septic/antibiotic) and Moaddilat-e-dam (alterative) are used in Unani System of Medicine for the management of Buthūr. Several clinical studies support this trial. There is a need to develop different therapeutic options for the treatment of Buthūr-e-Jild with possible mechanisms of action according to Unani principles. An open level study was conducted in RRIUM, Patna, Bihar for a period of 2 years. 128 subjects were randomly selected; among them, 100 cases completed the course of study. All the subjects were given Sharbat e Unnab 20ml and Itrifal Shahatra 5 grams twice a day for three weeks. The levels of improvements were recorded in terms of percentage efficacy as calculated from improvement in the signs and symptoms in the visual analog scale. The results were statistically analyzed and it showed that the Unani Pharmacopoeial formulations Sharbat-e-Unnab and Itrifal shahtra were significantly effective in the management of Buthūr and possible mechanisms of action are also evaluated.

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