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1363 articles for “Pre-clinical”
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RoseRAG-Based Clinical Decision Support System for Precision Medication Safety
Abstract: Medication-related errors remain a major challenge in healthcare, contributing to adverse drug events, increased hospitalization rates, and substantial healthcare costs. Conventional Clinical Decision Support Systems (CDSS) primarily rely on rule-based mechanisms for identifying drug-related problems (DRPs), including drug–drug interactions, contraindications, dosing errors, therapeutic duplication, and medication omissions. Although effective in structured environments, these systems frequently generate excessive context-insensitive alerts, leading to alert fatigue and reduced clinical acceptance. Recent developments in …
Published in Journal of Artificial Intelligence Research & Advances · Vol. 13, Issue 3, 2025 Read article
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A Study of Clinical Education Practice of Clinical Instructors Accompanying Nursing Students of Kashmir Division, Deployed for Clinical Posting in SKIMS Soura
Abstract: Introduction: Clinical education also called clinical teaching, is one of the practical based approaches whereby the students are exposed to natural and practical settings. Clinical education refers to the process of educating and training healthcare professionals, such as medical students, nurses, or other allied health professionals, in a real-world clinical setting. This form of teaching is crucial for translating theoretical knowledge into practical skills and fostering the development of clinical …
Published in Journal of Nursing Science & Practice · Vol. 14, Issue 2, 2024 · pp. 32–38 Read article
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Women’s Satisfaction with Care Providers Interaction and Associated Factors among Pregnant Women Attending Antenatal Clinic in Tiyo District, Arsi Zone, Ethiopia, 2016: Institutional Based Cross-Sectional Study
Abstract: Background: Health care provider-client interaction during antenatal care is an effective strategy to improve maternal health care seeking behavior. When clients are informed and involved in decision making, they are more adherent to medical recommendation and carry out more health related behavioral changes. However, the unsatisfactory interaction between health care providers and women pose a significant challenge in the health care service utilization.Objective: This study is aimed to assess women’s …
Published in Research and Reviews : A Journal of Medical Science and Technology · Vol. 6, Issue 1, 2017 · pp. 30–38 Read article
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Predictive value of Systemic Inflammatory Response Syndrome score in assessing the clinical outcomes in patients with acute pancreatitis
Abstract: Background: The role of various clinical scoring systems to assess the severity and outcomes of acute pancreatitis is attracting a lot of attention to the experts. Purpose: We aimed to objectively reconfirm the predictive value of systemic inflammatory response syndrome (SIRS) score for predicting the various clinical outcomes of acute pancreatitis and also to evaluate the significance of monitoring SIRS score on day 1 and its duration. Methods: We retrospectively …
Published in Research and Reviews : A Journal of Medical Science and Technology · Vol. 11, Issue 1, 2022 · pp. 34–42 Read article
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THE BURDEN OF EMPIRICAL THERAPY: ANALYZING THE PREDOMINANCE OF BROAD-SPECTRUM ANTIBIOTIC USAGE IN LOWER RESPIRATORY TRACT INFECTIONS
Abstract: Lower respiratory tract infections (LRTIs) remain one of the leading causes of morbidity and hospitalization worldwide, particularly among older adults, immunocompromised individuals, and patients with chronic respiratory disorders. These infections include conditions such as community-acquired pneumonia, hospital-acquired pneumonia, bronchitis, and acute infective exacerbations of chronic lung disease, all of which often require rapid clinical intervention. Because microbiological confirmation of the causative pathogen frequently takes 48–72 hours, clinicians generally initiate empirical …
Published in International Journal of Antibiotics · Vol. 3, Issue 2, 2026 Read article
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A Study and Report on Role And Impact Of Clinical Pharmacist in assessment of Prescribing Cascades In Antibiotics Usage For Infectious Diseases in Promotion of Rational Drug Usage
Abstract: ABSTRACT:A Prescription cascade occur when the healthcare providers fail to recognise that the new symptoms are actually the side effects of the medications under treatment. The study was based on the role and impact of clinical pharmacist in assessment of prescribing cascades in antibiotics usage for infectious diseases in department of general medicines and paediatric department at ESI hospital, Indiranagar, Bangalore, Karnataka, India. The main motto of the study was …
Published in Research & Reviews: A Journal of Drug Formulation, Development and Production · Vol. 9, Issue 3, 2022 · pp. 1–14 Read article
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An Open Labelled Parallel Arm Randomized Clinical Trial of Tuvaraka Oil Prepared By Two Different Method In The Management of Pama
Abstract: In Ayurveda, all skin diseases have classified mainly into two groups i.e., Mahakushtha (major skin diseases) and Kshudrakushtha (minor skin diseases). Tuvaraka [Hydnocarpus laurifolia (Dessnt).Sleumer] is one among the most useful drugs for the treatment of Kushtha (Various skin diseases) and Madhumeha (Diabetes Melitus). Pama is described under Kshudra Kushtha. which can be correlates with scabies. Aim: To evaluate the clinical efficacy of Tuvaraka oil prepared by modified method and …
Published in Research & Reviews : Journal of Herbal Science · Vol. 13, Issue 1, 2024 · pp. 29–36 Read article
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Comparison between two severity classificaitons in patients with acute cholecystitis
Abstract: Background and objective: Assessment severity helps clinicians to guide appropriate treatment and minimumize adverse outcome. The objective of our study was to comparison between TG13 severity system and EGS grade system for predicting clinical outcomes in acute cholecystitis. Patients and method: This is a retrospective single-center study which enrolled patients who were admitted to pyongsong medical university hospital between February 2020 and October 2021. Tokyo 2013(TG 13) severity classification and …
Published in Research and Reviews : Journal of Surgery · Vol. 12, Issue 2, 2023 Read article
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Navigating the Principles and Practice of Oral Anticoagulant Therapy: A Comprehensive Healthcare Guide
Abstract: Oral anticoagulant therapy plays a critical role in the prevention and treatment of thromboembolic disorders, including atrial fibrillation (AF), venous thromboembolism (VTE), and mechanical heart valve replacement. This research article aims to provide a comprehensive overview of the principles and practice of oral anticoagulant therapy, focusing on the mechanisms of action, pharmacokinetics, clinical indications, monitoring, and management of associated complications. The cornerstone of oral anticoagulant therapy includes vitamin K antagonists …
Published in Research and Reviews: A Journal of Pharmacology · Vol. 15, Issue 1, 2025 · pp. 76–82 Read article
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Association of Metabolic Syndrome with Cholelithiasis in Female Patients and Its Impact on Clinical Management and Surgical Outcome
Abstract: Background: Metabolic syndrome (MetS) is associated with obesity, insulin resistance, dyslipidemia, and hypertension, which may predispose to gallstone formation. This study aimed to evaluate the association between MetS and cholelithiasis in female patients and to assess its impact on clinical presentation, surgical difficulty, and postoperative outcomes. Methods: A prospective observational study was conducted on 88 female patients with ultrasonography-confirmed cholelithiasis. Patients were divided into two groups: MetS (n=44) and non-MetS …
Published in Research and Reviews : Journal of Surgery · Vol. 14, Issue 3, 2025 · pp. 1–7 Read article
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A Comparative Machine Learning Framework for Early Prediction of Liver Cancer Using Clinical Attributes
Abstract: One of the main causes of cancer-related death globally is liver cancer, and improving patient outcomes depends heavily on early detection. However, low contrast, noise, organ similarity, and tumor shape and size variability make it difficult to accurately identify and segment liver tumors from medical imaging. Automated liver cancer diagnosis, segmentation, and prognosis have been greatly improved by recent developments in artificial intelligence (AI), especially deep learning. This work presents …
Published in Research and Reviews: Journal of Oncology and Hematology · Vol. 15, Issue 2, 2026 · pp. 39–47 Read article
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Leveraging Genome-Wide Association Studies for Precision Medicine in Cardiovascular Diseases
Abstract: Cardiovascular diseases (CVDs) are the leading cause of death globally, with complex etiologies involving genetic, environmental, and lifestyle factors. Genome-wide association studies (GWAS) have significantly advanced the understanding of genetic underpinnings of CVDs by identifying numerous risk loci and variants associated with various cardiovascular conditions. This review explores the potential of GWAS to drive precision medicine in cardiovascular diseases by linking genetic data with clinical outcomes, providing insights into disease …
Published in Research and Reviews : Journal of Computational Biology · Vol. 14, Issue 1, 2025 · pp. 35–39 Read article
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Unmasking Human Metapneumovirus: The Emerging Threat to Vulnerable Populations
Abstract: Human Metapneumovirus (HMPV) is a contagious respiratory virus that commonly spreads among individuals. It can cause serious infections, especially in high-risk groups like infants, older adults, and individuals with weakened immune systems.It is a major contributor to acute respiratory illnesses. Since its discovery in 2001, HMPV has been identified as a common cause of both upper and lower respiratory tract illnesses, with clinical presentations ranging from mild symptoms to severe …
Published in International Journal of Virus Studies · Vol. 2, Issue 1, 2025 · pp. 16–24 Read article
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Jaundice: Etiology, Clinical Manifestations, Diagnosis, Management, Nursing Care, and Prevention
Abstract: Jaundice is a significant clinical condition marked by a yellow discoloration of the skin, sclera, and mucous membranes resulting from increased bilirubin levels in the bloodstream. Rather than being a disease itself, jaundice represents an underlying disorder involving the liver, biliary system, or hematological processes. Hyperbilirubinemia develops when there is excessive bilirubin production, impaired hepatic uptake, defective conjugation, or obstruction in bile excretion. Jaundice remains a major global health concern …
Published in Research and Reviews: A Journal of Medicine · Vol. 16, Issue 1, 2026 · pp. 32–39 Read article
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Clinicopathological Study of Oral Malignant and Premalignant Lesions with p53 and p16 Immunostaining
Abstract: Oral cancer is a global problem, more in India. A study of 50 cases of oral lesions were conducted in a tertiary care hospital in Kolkata, India. Detailed clinical history was taken. Cytology, punch biopsy with histopathology and immunostaining with p53 and p16 were done in all the cases. A total of 31 cases (62.0%) were benign, 19 cases (38.0%) were malignant, with an age range of 26–69 years (mean …
Published in Research and Reviews: Journal of Oncology and Hematology · Vol. 8, Issue 2, 2019 · pp. 20–24 Read article
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Prevalence and Distribution of Staphylococcus Aureus in Clinical Samples Across Age Groups
Abstract: The bacteria that cause everything from ordinary skin infections to serious illnesses is called Staphylococcus aureus. It is now known that Staphylococcus aureus may develop resistance to a variety of drugs. Staphylococcus aureus has been displaying an unusual kind of resistance to antibiotics, especially to those based on β-lactum. As a result, Methicillin Resistant Staphylococcus Aureus (MRSA) is the new name for the resistant strain of Staphylococcus aureus. The prevalence …
Published in Research and Reviews: A Journal of Pharmacology · Vol. 14, Issue 2, 2024 · pp. 15–19 Read article
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AI-Enhanced Interpretation of Cardiac Troponins: Toward Predictive Precision in Myocardial Injury
Abstract: Background: Cardiac troponins (cTn) represent the gold standard biomarkers for myocardial injury detection, yet their interpretation remains challenging due to various confounding factors and clinical contexts. Artificial intelligence (AI) technologies provide remarkable possibilities to improve the interpretation of troponin levels by utilizing pattern recognition, predictive modeling, and clinical decision-making support. Objective: This review examines the current state and future potential of AI-enhanced cardiac troponin interpretation, focusing on machine learning applications, …
Published in Research and Reviews: A Journal of Medicine · Vol. 15, Issue 3, 2025 · pp. 1–9 Read article
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A Study for the Presence of Enterococcal Virulence Factors Gelatinase, Haemolysin among Clinical Isolates in a Tertiary Care Hospital
Abstract: Enterococcus, considered a normal commensal of intestinal tract, is fast emerging pathogen causing serious infection. Despite the increasing importance of Enterococcus as opportunistic pathogens, their virulence factors are still poorly understood. The potential virulence factors of Enterococci include production of enterococcal surface protein (Esp), gelatinase, and haemolysin. Gelatinase- and haemolysin-producing strains of Enterococcus faecalis have been shown to be virulent in animal models of enterococcal infections. This study was undertaken …
Published in Research and Reviews: A Journal of Microbiology and Virology · Vol. 7, Issue 3, 2017 · pp. 14–18 Read article
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Vitamin-Aspirin-Prednisolone Therapy for Miscarriage Associated with Anticardiolipin Antibody: Clinical Study
Abstract: Objective: To find pathogenesis of miscarriage associated with anticardiolipin antibody and to make reasonable therapy for the diseases. Methods: Blood coagulation findings, malondialdehyde volume are evaluated and those variations were observed with Vitamin–Aspirin–Prednisolone therapy. And clinical and laboratory findings, pregnancy outcomes were analyzed and relationship between medicine combined therapy and other factors (ages, attack period of disease, miscarriage times, and body mass index) is observed. Results: In anticardiolipin antibody positive …
Published in Research and Reviews : A Journal of Medical Science and Technology · Vol. 12, Issue 1, 2024 · pp. 37–48 Read article
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Protagonist of Aspirin in Primary Treatment of Cardiovascular Disease: An Overview
Abstract: AbstractAspirin (ASA) is the most used medication on the globe. The benefits of aspirin therapy for the secondary prevention of cardiovascular disease clearly outweigh the risks of bleeding, and low- dose aspirin is uniformly recommended in this condition. While the clinical use of aspirin in secondary cardiovascular disease (CVD) prevention remains undisputed, its role in primary prevention is controversial. Recently, three trials of primary prevention reported neutral net benefit results …
Published in Research and Reviews : A Journal of Medical Science and Technology · Vol. 9, Issue 2, 2020 · pp. 12–30 Read article