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55 articles for “Pharmacokinetic study”
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Molecular Docking Analysis of Phytocompounds from Ficus hispida Aagainst Epidermal Growth Factor Receptor Kinase Domain
Abstract: The Epidermal Growth Factor Receptor (EGFR) kinase domain plays a key role in cancer, as it promotes tumour growth and helps cancer cells survive, making it an important focus for developing treatments. Through comprehensive computational analysis, this study investigates the anticancer potential of phytocompounds from Ficus hispida, a medicinal plant renowned for its diverse bioactive compounds, as novel EGFR inhibitors. Molecular docking techniques using Py Rx software were employed to …
Published in International Journal of Cell Biology and Cellular Functions · Vol. 3, Issue 2, 2025 Read article
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Molecular Docking Analysis of Phytocompounds from Ficus hispida Against Epidermal Growth Factor Receptor Kinase Domain
Abstract: The Epidermal Growth Factor Receptor (EGFR) kinase domain plays a key role in cancer, as it promotes tumour growth and helps cancer cells survive, making it an important focus for developing treatments. Through comprehensive computational analysis, this study investigates the anticancer potential of phytocompounds from Ficus hispida, a medicinal plant renowned for its diverse bioactive compounds, as novel EGFR inhibitors. Molecular docking techniques using Py Rx software were employed to …
Published in International Journal of Cell Biology and Cellular Functions · Vol. 3, Issue 2, 2025 · pp. 48–62 Read article
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Graphs and Their Real-Life Applications in Pharmaceutical Research
Abstract: This study provides a comprehensive overview of the role of graphs in pharmacy research, emphasizing their significance as powerful tools for data visualization, interpretation, and communication. In the field of pharmacy, research often generates large volumes of complex data related to drug development, pharmacokinetics, pharmacodynamics, medication safety, and patient outcomes. Graphs serve as an essential medium to translate these data into accessible, interpretable, and actionable insights, supporting evidence-based practice and …
Published in Research & Reviews : Journal of Statistics · Vol. 14, Issue 3, 2025 · pp. 01–08 Read article
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Pharmacokinetic Profiling and Molecular Docking of Carvacrol and Structural Analogs: Targeting Quorum Sensing Proteins to Disrupt Biofilm-Mediated Antimicrobial Resistance in Multidrug-Resistant Bacterial Pathogen
Abstract: Antibiotic resistance, particularly in Pseudomonas aeruginosa, has become a major global health threat, exacerbated by the organism's ability to form biofilms and regulate virulence through quorum sensing (QS). The LuxR and LasR receptors are key regulators in this process, influencing both pathogenicity and antibiotic resistance. This study investigates potential QS inhibitors targeting these receptors as a strategy to mitigate antibiotic resistance. The primary objective was to identify novel ligands that …
Published in International Journal of Biochemistry and Biomolecule Research · Vol. 3, Issue 2, 2025 · pp. 43–61 Read article
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Targeting Papain-Like Protease of Re-Emerging Coronaviruses
Abstract: Re-emerging Corona viruses (CoVs), including SARS-CoV (S-CoVs), and SARS-CoV-2 (S-CoV-2), continue to pose a global health threat due to their high mutation rates, zoonotic spillover potential, and capacity for immune evasion. The global pandemic of year 2019, caused by S-CoV-2, has highlighted the importance for robust antiviral strategies beyond vaccines and RNA polymerase or main protease inhibitors, which are susceptible to resistance. One promising therapeutic target is the S-CoV-2 papain-like …
Published in Research and Reviews : A Journal of Life Sciences · Vol. 15, Issue 3, 2025 · pp. 46–62 Read article
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Molecular Docking and Pharmacokinetic Profiling of the Phytocompounds of Jatropha curcas as Antagonist for Salmonella typhi
Abstract: Background: Typhoid is an infection caused by the Gram-negative bacterium, Salmonella enterica serovar typhi. The study assessed the potential use of Jatropha curcas as a typhoid fever therapy alternative to traditional medications. The ability to uncover novel drug indications for currently available medications using in silico methods has increased thanks to the wealth of pharmacological and biological knowledge that is available. Objective: In this study, we assessed the potential inhibitory …
Published in International Journal of Cell Biology and Cellular Functions · Vol. 1, Issue 1, 2023 · pp. 67–81 Read article
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Molecular Docking Analysis of Berberis aristata Phytocompounds as Potential Growth Factor Receptor Blockers in Cancer Therapy
Abstract: Middle-aged and older women are susceptible to breast cancer (BC), a potentially fatal condition. When breast cancer is diagnosed, the median age is 62. Breast cancer diagnoses in women under 45 are comparatively uncommon, whereas the bulk of breast cancer diagnoses occur in women 62 and older. Growth factor receptors are interesting therapeutic targets because of their critical role in the pathophysiology of cancer. Vascular endothelial growth factor receptors (VEGFR-2) …
Published in International Journal of Cell Biology and Cellular Functions · Vol. 3, Issue 2, 2025 · pp. 1–10 Read article
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Neuroprotective Effects of Curcuma longa: A Review of Its Role in Neurodegenerative Diseases
Abstract: Curcuma longa (turmeric), a perennial herb notably utilized in traditional medication, has garnered big clinical attention due to its major bioactive compound, curcumin. Curcumin, well-known shows a couple of organic activities, together with antioxidant, anti-amyloidogenic, and neurodegenerative effects, making it a promising candidate for the management of neurodegenerative diseases (NDDs), which include Alzheimer’s illness, Parkinson’s disorder (PD), Huntington’s sickness (HD), and amyotrophic lateral sclerosis (ALS). This evaluate consolidates current findings …
Published in Research & Reviews: A Journal of Pharmacognosy · Vol. 12, Issue 3, 2025 · pp. 24–32 Read article
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A Computational Study to Elucidate the Phytochemicals as An Antagonist Against Pruritis in Psoriasis
Abstract: Objective: Psoriasis is a chronic, non-contagious, auto-immune skin disorder that causes inflammation, pain, and itching in the affected areas. The etiology of this condition is not entirely understood, and while there are treatments available to manage the symptoms, there is currently no cure. The Transient receptor potential cation channel, subfamily Vanillin, member 3 (TRPV3), present in keratinocytes, allegedly had a part in the development of psoriasis-related pain and itching. Specifically, …
Published in International Journal of Bioinformatics and Computational Biology · Vol. 1, Issue 2, 2023 · pp. 49–61 Read article
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In Silico Analysis and Molecular Docking Studies of COX-2 Inhibitors for Anti-Inflammatory Activity
Abstract: Although nonsteroidal anti-inflammatory drugs (NSAIDs) are frequently used to treat pain, lower fevers, and control inflammation, they frequently cause gastrointestinal side effects because they inhibit the COX-1 and COX-2 enzymes. Despite their effectiveness and lack of gastrointestinal side effects, selective COX-2 inhibitors have been linked to cardiovascular risks. To find new COX-2 inhibitors that are safer and more effective, this study uses in silico techniques, such as molecular docking and …
Published in International Journal of Molecular Biotechnological Research · Vol. 3, Issue 1, 2025 · pp. 38–55 Read article
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Drugs Design and Process Chemistry: A Factuality Study of Recent Advance in Drug Delivery Systems – A Comprehensive Review
Abstract: Recent years have seen significant advances in drug design and process chemistry, mostly due to breakthroughs in drug delivery technologies. This study provides a thorough examination of current developments in drug delivery, emphasizing strategies that improve therapeutic efficacy, reduce adverse effects, and maximize pharmacokinetic profile. The effects of several strategies on drug stability, solubility, and bioavailability are examined, including controlled-release systems, targeted delivery methods, and nanoparticle-based delivery. This review also …
Published in Research and Reviews : A Journal of Biotechnology · Vol. 15, Issue 1, 2025 · pp. 26–35 Read article
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Space Pharmacy for Human Space Exploration: Overcoming Drug Stability, Packaging Challenges, Pharmacokinetic Variations, and Developing Innovative On-Demand Therapeutic Solutions for Long- Duration Missions Beyond Earth
Abstract: As humankind prepares for prolonged space exploration and the establishment of lunar and Martian habitats, ensuring reliable access to safe and effective medicines has emerged as a critical challenge. The evolving discipline of space pharmacy addresses the unique pharmaceutical needs of astronauts in microgravity and radiation-rich environments, where drug stability, packaging, and pharmacokinetics are markedly different from conditions on Earth. Traditional dosage forms often undergo accelerated degradation, while altered fluid …
Published in Trends in Drug Delivery · Vol. 13, Issue 1, 2026 · pp. 32–47 Read article
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Pharmacokinetics and Stability of Polymer-Encapsulated Drugs
Abstract: Making drugs that are covered by plastics is a fresh and useful way to make medicines work better, last longer, and treat diseases better. Putting drugs inside polymer materials helps them breakdown better, stays in the body longer, and lowers the number of side effects they cause. This is necessary to slowly release the drug and help people stick to their treatment plan. Polymers are used to wrap drugs. This …
Published in Journal of Polymer & Composites · Vol. 13, Issue 4, 2025 · pp. 349–361 Read article
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Molecular Docking Studies of Nyctanthes arbor-tristis Phytochemicals for Targeting TNF Receptor in Arthritis
Abstract: Rheumatoid Arthritis is an autoimmune disorder which results in inflammation. Tumor necrosis factor-alpha (TNF-α) is responsible for the progression of inflammatory arthritis by promoting immune cell activation and cytokine release. The present study explores the potential of bioactive compounds derived from Nyctanthes arbor-tristis (Parijat) in modulating TNF receptor activity through molecular docking. Computational methods were employed to evaluate the binding affinity of selected phytocompounds from N. arbor-tristis against the extracellular …
Published in International Journal of Cell Biology and Cellular Functions · Vol. 3, Issue 2, 2025 · pp. 11–21 Read article
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In Silico Analysis and Docking Study of the Active Phytocompounds of Bacopa monnieri Against Alzheimer Disease
Abstract: Objective: Alzheimer’s is a neurodegenerative disease and is the cause of 60–70% of cases of dementia. It infected a million people worldwide. An effort was undertaken to explore the potential of natural compounds found in Bacopa monnieri, a plant renowned for its extensive medicinal properties in Indian Ayurveda, to combat the disease. This was achieved through molecular docking studies, evaluation of drug-likeness, and comprehensive ADME (absorption, distribution, metabolism, and excretion) …
Published in Research and Reviews : Journal of Computational Biology · Vol. 13, Issue 2, 2024 · pp. 1–13 Read article
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Exploring Azadirachta indica’s Potential to Combat Visceral Leishmaniasis Through GP63 Inhibition
Abstract: Objectives: Millions of people worldwide suffer from the parasite disease visceral leishmaniasis. Determine the naturally occurring active ingredients in Azadirachta indica, which are employed as a disease-prevention agent and have several uses in medicine. To choose the best ligand to use as a medication, absorption, distribution, metabolism, and excretion (ADME) studies and molecular docking are employed. Methods: To obtain the GP63 protein, the Protein Data Bank (PDB) database was accessed. …
Published in International Journal of Genetic Modifications and Recombinations · Vol. 2, Issue 2, 2024 · pp. 1–12 Read article
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Pharmacological Comparison of Turmeric and Non-Steroidal Anti-Inflammatory Drugs in Pain Relief
Abstract: Pain is one of the most frequently encountered clinical symptoms affecting millions globally and is typically treated pharmacologically with nonsteroidal anti-inflammatory drugs (NSAIDs). However, long-term use of NSAIDs is associated with adverse effects such as gastrointestinal, renal, and cardiovascular issues. In recent years, turmeric and its main active compound, curcumin, have received considerable attention for their reported anti-inflammatory, analgesic, and antioxidant properties as natural therapeutic options. This review seeks to …
Published in Research & Reviews: A Journal of Pharmacognosy · Vol. 13, Issue 1, 2026 · pp. 19–28 Read article
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CB₁ Reverse Agonists: A Cheminformatic and Patent Landscape Study
Abstract: The endocannabinoid system plays a crucial role in numerous physiological functions, making cannabinoid receptor 1 (CB1) an attractive target for therapeutic development. This review provides a systematic analysis of patent filings from 2019 to 2023 that focus on small-molecule CB1 reverse agonists. It begins with an overview of the endocannabinoid system, highlighting CB1’s involvement in energy balance, pain regulation, and neuroinflammatory processes The main section of the review examines fifteen …
Published in International Journal of Cheminformatics · Vol. 3, Issue 2, 2025 · pp. 33–36 Read article
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Screening Phytocompounds of Tinospora cordifolia to Find Potential Drug Targets for Cystic Fibrosis
Abstract: This study aimed to evaluate the therapeutic potential of phytocompounds derived from Tinospora cordifolia in treating cystic fibrosis (CF), a genetic disorder caused by mutations in the CFTR gene that lead to severe respiratory and digestive complications. Phytocompounds were retrieved from the IMPPAT database and subjected to molecular docking simulations using PyRx to assess their binding affinity to the CFTR protein. The top-scoring compounds – sterol, magnoflorine, tembetarine, kaempferol, and …
Published in International Journal of Genetic Modifications and Recombinations · Vol. 3, Issue 1, 2025 · pp. 16–24 Read article
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Comparison of Recovery Profile for Total Intravenous Anaesthesia (TIVA) Using Propofol And Remifentanil in Laparoscopic Surgeries
Abstract: Total Intravenous Anaesthesia (TIVA) has become an increasingly preferred technique in modern anaesthetic practice due to advantages such as reduced postoperative nausea and vomiting (PONV), improved hemodynamic stability, minimal environmental impact, and faster recovery compared to conventional inhalational anesthesia. Propofol in combination with remifentanil is widely used for TIVA because of its rapid onset and offset of action, which supports quick postoperative awakening and enhanced patient satisfaction. Target Controlled Infusion …
Published in Research and Reviews : A Journal of Life Sciences · Vol. 16, Issue 1, 2026 · pp. 39–50 Read article