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191 articles for “Pharmaceutical activities.”
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Nutraceutics: Opening the Debate for a Framework for the Safety and Efficacy of Nutraceuticals Formulations
Abstract: As of right now, there is no precise definition for nutraceuticals that distinguishes them from other food-based categories such herbal products, dietary supplements, pre- and probiotics, functional foods, and fortified foods. Several studies have shed light on the possible mechanisms of action of pharmaceutically active ingredients in food, emphasizing their ability to improve health, lower the risk of disease, and promote general wellbeing. However, Nutraceuticals confront difficulties in substantiating safety …
Published in Recent Trends in Infectious Diseases · Vol. 1, Issue 1, 2024 · pp. 27–33 Read article
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A Research on Formulation and Evaluation of Clove Gel for Treatment of Scabies
Abstract: Scabies remains a pervasive global health issue, with a need for more effective topical treatments. This research focuses on the formulation and evaluation of a clove oil-based gel containing eugenol, the primary bioactive component, for the treatment of scabies. Eugenol’s well-documented antimicrobial, anti-inflammatory, and ant parasitic activities make it an ideal candidate for targeting Sarcoptes scabiei, the mite responsible for scabies. The formulation was prepared by incorporating clove oil and …
Published in Research & Reviews: A Journal of Drug Formulation, Development and Production · Vol. 11, Issue 3, 2024 · pp. 22–31 Read article
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Advancing Capsule Technology: A Comprehensive Review of Formulation Strategies
Abstract: Capsules are a popular and versatile oral dosage form used in drug delivery, offering benefits such as ease of swallowing, taste masking, and improved stability of active pharmaceutical ingredients (APIs). They can be made from gelatin or non-gelatin materials like Hydroxypropyl Methylcellulose (HPMC), Polyvinyl Alcohol (PVA), and starch, catering to dietary, cultural, and sustainability needs. Capsules can be engineered for controlled, sustained, or targeted release, enhancing bioavailability, particularly for poorly …
Published in International Journal of Antibiotics · Vol. 2, Issue 1, 2025 · pp. 44–56 Read article
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Nitrosamine: The Carcinogenic Impurity in Angiotensin Receptor Blockers
Abstract: Angiotensin II Receptor Blockers (ARBs), commonly known as the Sartans, are used in the treatment of hypertension for a long time. Currently, seven Sartan drugs, i.e. Valsartan, Losartan, Candesartan, Irbesartan, Telmisartan, Olmesartan, and Eprosartan, are in use. Recently, Nitroso impurity was detected in Valsartan active pharmaceutical ingredient, which led to the recall of batches of products containing it. Even in trace amounts, the impurity is said to be a probable …
Published in Research and Reviews: Journal of Oncology and Hematology · Vol. 9, Issue 3, 2020 · pp. 36–43 Read article
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Supergenerics Regulation in India and US: A Comparative Review
Abstract: ‘Supergenerics’, a new form of generic drugs with improved properties such as safety, efficacy, stability or improved commercial attractiveness such as taste or route of administration. Those drugs are most often based on an incremental re-formulation of a generic API (active pharmaceutical ingredient) or the combination of multiple generic APIs. Process of forming supergeneric molecule need not to be complex all the time. A supergeneric may be as simple as …
Published in Research & Reviews: A Journal of Drug Formulation, Development and Production · Vol. 3, Issue 1, 2016 · pp. 30–38 Read article
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Formulation Development, Characterization and in-vitro Evaluation of Nano-Lipid Carriers of Ropinirole HCl for Persistent Parkinsonian Management
Abstract: According to a report of World Health Organization (WHO) 2014, Parkinson's Disease (PD) is the second-most neurodegenerative dysfunction of the central nervous system (CNS) of human being effecting 7–10 million people worldwide. It is primarily due to the death of dopamine-generating cells in the substantia-nigra of midbrain. It is symptomatized by tremor, rigidity, bradykinesia, dementia, depression and falls or emerges with the progression of the disease. Ropinirole HCl is a …
Published in Trends in Drug Delivery · Vol. 6, Issue 1, 2019 · pp. 14–23 Read article
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Comparison of Photocatalytic activity of Various Metallic and Non-metallic doped TiO2 Nano Particles for Treatment of Pharmaceutical Effluent
Abstract: The use of semiconductor oxide particles such as TiO2 as photo catalysts has shown great utility in the complete mineralization of organic compounds present in effluent. The dopant maximize the electron trapping for further inhibiting excitation recombination and thereby enhancing the oxidation of organic compounds. A pilot scale synthesis of TiO2 nano particles has been carried out using the Sol-gel method with various metallic dopants like Iron, Copper, Cobalt, Vanadium, …
Published in Journal of Nanoscience, NanoEngineering & Applications · Vol. 8, Issue 2, 2018 · pp. 7–14 Read article
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Development Aspects, Physiochemical Characteristics, Pharmaceutical Requirements and Different Manufacturing Procedures for Dry Powder Inhalation Formulations
Abstract: Dry Powder Inhalation (DPI) products are combination of pharmacologic activity and pharmaceutical properties including procedure used to manufacture. Desirable performance features of DPI are physical and chemical stability, ease of handling, accurate and reproducible delivery to the target organ and availability of drug at the site of action. The physical stability of DPI is of utmost importance as it results in ultimate deposition of drug through various dispersion mechanisms into …
Published in Research & Reviews: A Journal of Drug Formulation, Development and Production · Vol. 8, Issue 1, 2023 · pp. 40–48 Read article
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Modulation of Receptor Proteins: A Recent Paradigm in Drug Discovery and Target
Abstract: The main aim in drug discovery is to design different ligands those work on specific drug targets. However, various effective drugs work through the modulation of many proteins than single target. Advancement in system biology are establishing a phenotypic strength and a network structure, which suggests that, the excellent selective compounds may be performed less than desired clinical efficacy in comparison to multi-target drugs. In this new appreciation of the …
Published in Research & Reviews: A Journal of Drug Design & Discovery · Vol. 5, Issue 1, 2018 · pp. 14–24 Read article
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Cosmeceuticals Unveiled Innovation and Efficacy in Skincare Science
Abstract: By combining the terms "Cosmeceuticals" and "pharmaceuticals," the phrase refers to goods that combine the medicinal benefits of pharmaceuticals with the aesthetic benefits of cosmetics. These innovative products do not strictly fall into the categories of either cosmetics or pharmaceuticals but serve as a bridge between the two, offering a unique combination of beauty enhancement and health improvement. Similar to pharmaceuticals, Cosmeceuticals contain active ingredients and compounds that are scientifically …
Published in Recent Trends in Cosmetics · Vol. 1, Issue 2, 2024 · pp. 1–7 Read article
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Antibacterial Activity of Seed Extracts of Okra (Abelmoschus esculentus) against Selected Pathogens
Abstract: The aim of the study was to determine the antibacterial potency of aqueous and ethanoic extracts of Abelmoschus esculentus seeds. Antibacterial activity of aqueous and ethanoic extracts of A. esculentus seeds were evaluated against selected foodborne pathogens; Listeria monocytogenes, Bacillus cereus, Salmonella enterica, Staphylococcus aureus and Escherichia coli) using agar well diffusion method by measuring the clear zone of inhibition diameter in (mm). It was observed that the aqueous and …
Published in Research & Reviews : Journal of Food Science & Technology · Vol. 6, Issue 1, 2017 · pp. 1–5 Read article
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An Overview of GMP Requirements for Drug Product in China
Abstract: Good manufacturing practice (GMP) is a tool which facilitates the innovation and continual improvement throughout the lifecycle of products and strengthens the link between pharmaceutical development and manufacturing activities. It also helps in increasing the process efficiency and product quality by adopting the current, risk-based manufacturing approach and in turn optimizes manufacturing process and improves quality of the end product which improves the health of the individual patient and the …
Published in Research & Reviews: A Journal of Drug Formulation, Development and Production · Vol. 3, Issue 2, 2016 · pp. 1–6 Read article
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HPTLC: An Important Tool for Estimation of Phytoconstituents
Abstract: AbstractHPTLC (High-performance thin layer chromatography) technique is widely employed in pharmaceutical industry for the process development, identification and estimation of adulterants in herbal formulations and helps in estimation and identification of pesticide content, mycotoxins and in quality control of nutraceuticals. For the herbal extracts and especially for the botanical drugs, the issue of stability is of exceptional importance. Standardization is required for the development of an accurate biological activity and …
Published in Research and Reviews: A Journal of Pharmaceutical Science · Vol. 7, Issue 1, 2016 · pp. 28–33 Read article
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In silico PASS-Assisted Biological Activity Predictions of a Phytoconstituent Astilbin isolated from Thelypteroid fern Sphaerostephanos arbuscula (Willd.) Holttum
Abstract: Pteridophytes are the most important land plants with enormous medicinal properties. The medicinal properties of this group of plants mainly depend upon the numerous phytoconstituents present inside the plants. In the present study, the biological activity spectra of a phytoconstituent Astilbin isolated from Thelypteroid fern Sphaerostephanos arbuscula was predicted using computer-aided program—Prediction of Activity Spectra for Substances (PASS). The PASS predicted activity of Astilbin exhibited its various probable activities (Pa). …
Published in Research and Reviews : A Journal of Biotechnology · Vol. 6, Issue 2, 2016 · pp. 24–29 Read article
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Studies on the antioxidant content and antimicrobial activity of cucumber (cucumissativus) peel collected from bagmari, kolkata, west bengal, india
Abstract: Cucumber (Cucumis sativus) is widely consumed across the globe, yet its peels are commonly discarded as waste, despite possessing a wealth of bioactive compounds. Recent studies have highlighted that these peels contain substantial amounts of antioxidants, antibacterial, anti-inflammatory, and anti-carcinogenic properties, making them a promising candidate for value-added applications. In this study, methanolic extracts (80% v/v) of cucumber peels were systematically analyzed to assess their total phenolic content (TPC), total …
Published in Emerging Trends in Metabolites · Vol. 2, Issue 2, 2025 Read article
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Molecular Docking Technique Assisted Discovery of Some Hydroxylated Chalcone Molecules as α-glucosidase Inhibitors
Abstract: The present study involved exploration of the inhibitory potential of some A-ring hydroxylated chalcone compounds against PDB ID: 2QMJ file (Maltase-glucoamylase in complex with acarbose) with the assistance of iGEMDOCK (Genetic Evolutionary Method for Molecular Docking) software. The present study highlighted the immense potentials of several unexplored hydroxyl group (in ring-A) containing chalcones in successfully inhibiting the one of the most effective anti-hyperglycemic based enzymatic target α-glucosidase. The research has …
Published in Research & Reviews: A Journal of Drug Design & Discovery · Vol. 6, Issue 1, 2019 · pp. 34–38 Read article
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Studies on the Antioxidant Content and Antimicrobial Activity of Cucumber (Cucumis sativus) Peels Collected from Bagmari, Kolkata, West Bengal, India
Abstract: Cucumber (Cucumis sativus) is widely consumed across the globe, yet its peels are commonly discarded as waste, despite possessing a wealth of bioactive compounds. Recent studies have highlighted that these peels contain substantial amounts of antioxidants, antibacterial, anti-inflammatory, and anticarcinogenic properties, making them a promising candidate for value-added applications. In this study, methanolic extracts (80% v/v) of cucumber peels were systematically analyzed to assess their total phenolic content (TPC), total …
Published in Emerging Trends in Metabolites · Vol. 2, Issue 2, 2025 · pp. 6–14 Read article
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Study on Effect of Some Bangladeshi Medicinal Plant Extracts on in vitro Thrombolysis: An Assessment using Statistical Test
Abstract: An in vitro thrombolytic model was used to check the clotlysis effect of seven aqueous herbal extracts, viz., Cassia hirsuta, Clausena suffruticosa, Litsea glutinosa, Leea indica, Leucas aspera, Achyranthes aspera and Paederia foetida along with Streptokinase as a positive control and water as a negative control using statistical analysis. Statistical analysis such as Friedman test is a powerful tool for the characterization of the pharmaceutical process by studying the activity …
Published in Research and Reviews : A Journal of Biotechnology · Vol. 3, Issue 1, 2013 · pp. 41–44 Read article
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Regulatory Requirement for Supergenerics in Saudi Arabia, Brazil and Malaysia
Abstract: Supergeneric is the general form of nomenclature for value-added generics globally, which is coined suitably in different regulatory authorities. The supergeneric form of the medicinal product is one that considers changes, which may not be limited to, form of active substance, therapeutic indications, strength, pharmaceutical form or route of administration. They rely partly of results of preclinical tests and clinical trials of an innovator product and also on new data …
Published in Research & Reviews: A Journal of Drug Design & Discovery · Vol. 3, Issue 1, 2016 · pp. 38–45 Read article
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European Regulatory Perspective on Super-Generics: Antacid Orally Disintegrating Tablets (ODT)
Abstract: Super-generic is the general form of nomenclature for hybrid medicinal product in European Union (EU). The super-generic form of the medicinal product is one that considers changes in the form of active substance, therapeutic indications, strength, pharmaceutical form or route of administration. They rely partly on results of preclinical tests and clinical trials of an innovator product and also on new data with appropriate bioavailability and bioequivalence studies. Marketing authorization …
Published in Trends in Drug Delivery · Vol. 3, Issue 1, 2016 · pp. 31–37 Read article