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61 articles for “Parkinson’s”
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Non-Enzymatic Glycation in Alzheimer’s and Parkinson’s Disease: A Molecular Approach to Pathology and Recent Advances
Abstract: Non-enzymatic glycation, a biochemical process by which reducing sugars spontaneously bind to proteins, leads to the formation of advanced glycation end-products (AGEs), which have emerged as critical contributors to the pathogenesis of several neurodegenerative diseases, particularly Alzheimer’s disease (AD) and Parkinson’s disease (PD). The accumulation of AGEs can significantly alter protein structure, stability, and function, triggering a cascade of detrimental effects, including increased oxidative stress, heightened neuroinflammation, and the promotion …
Published in International Journal of Molecular Biotechnological Research · Vol. 2, Issue 2, 2024 · pp. 36–41 Read article
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Parkinson’s Disease Detection on Spiral Images Using CNN with Meta-Classifiers
Abstract: In this work, we provide a detailed method for identifying Parkinson’s Disease (PD) by integrating Convolutional Neural Network (CNN) and meta-classifiers. Through the utilization of a varied dataset consisting of handwritten spiral images, our methodology demonstrates commendable accuracy across a range of models. Specifically, our CNN model with meta-classifiers surpasses alternative approaches, achieving an impressive accuracy rate of 95.07%. By utilizing pre-established VGG16 and ResNet50 architectures as bases, the region-based …
Published in Journal of Computer Technology & Applications · Vol. 16, Issue 1, 2025 · pp. 55–66 Read article
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Pseudodysphagia in a Person with Parkinson’s Disease: A Case Report
Abstract: Pseudodysphagia is a psychosomatic fear of choking and is an unusual type of dysphagia encountered by a Speech Language and Swallow Pathologist (SLP). The patients presenting this illness are afraid of swallowing as they fear that swallowing will lead to choking. The assessment and rehabilitation of pseudodysphagia is challenging and requires an SLP to work with a multidisciplinary team comprising An SLP, Psychologist, Neurologist, ENT specialist, Radiologist, Gastroenterologist, and a …
Published in Research and Reviews: A Journal of Neuroscience · Vol. 11, Issue 3, 2021 · pp. 15–21 Read article
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Neurodiversity Revolution: Advancing Autism Therapies and Treating Comorbid Neurodegeneration
Abstract: The purpose of this study is to describe all about autism and for that it covered all the data included introduction, history, symptoms, diagnosis, treatment along with non-pharmacology therapies like play therapy, Behaviour therapy, ABA therapy, Occupational therapy, Speech therapy, Physiotherapy, and Sensory integration therapy. The neurodiversity movement recognizes autism as a natural variation of human neurodevelopment rather than a disorder to be cured or eliminated. Future approaches will likely …
Published in Research and Reviews: A Journal of Neuroscience · Vol. 13, Issue 1, 2023 · pp. 1–12 Read article
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Rotenone effects on the human body with reference to neurological disorder
Abstract: It has been claimed that the well–known neurotoxic pesticide rotenone, which is known to block the mitochondrial complex I, is strongly linked to the pathophysiology and etiology of Parkinson's disease (PD) in humans. There have been numerous analyses in the past and are still being conducted to establish a relationship between the two in order to completely comprehend the level of harm brought on by rotenone. Numerous laboratory studies shown …
Published in International Journal of Toxins and Toxics · Vol. 2, Issue 1, 2025 · pp. 21–27 Read article
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Kapikacchu (Mucuna pruriens): A Promising Indigenous Herbal Drug and Its Effect on Different Disease Conditions
Abstract: Mucuna pruriens is widely known as “velvet bean,” which originally belongs to eastern part of India and China where it is cultivated as vegetable crop. It has been shown that its seeds are potentially of substantial medicinal importance. Kapikacchu belongs to Fabaceae family and it is widely used for aphrodisiac purpose as well as for Parkinson disease. It has lots of pharmacological properties such as hypoglycemic activity, antioxidant activity, aphrodisiac …
Published in Research and Reviews: A Journal of Toxicology · Vol. 7, Issue 3, 2017 · pp. 1–5 Read article
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Exploring the Therapeutic Potential of Grapeseed Phytoconstituent Through Molecular Docking Analysis for Multiple System Atrophy Treatment
Abstract: Objective: Alpha-synuclein (α-Syn) aggregates are a common neurodegenerative disorder associated with Parkinson’s disease and multiple system atrophy (MSA). As a fruit that is extensively grown, grapes have several pharmacological advantages when it comes to reducing oxidative stress. Research has indicated that grape seed phytoconstituents have a major effect on α-Syn. The objective of this study is to inquire into the pharmacological characteristics and potential therapeutic applications of grape seed derivatives …
Published in International Journal of Molecular Biotechnological Research · Vol. 2, Issue 2, 2024 · pp. 14–26 Read article
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Neurodegeneration and Cognitive Decline: Causes, Consequences, and Treatment Approaches
Abstract: Neurodegenerative diseases gradually destroy nerve cells, often leading to fatal outcomes. The phrase includes a wide range of clinical problems, such as a variety of Neurological conditions include movement disorders, like Parkinson’s disease (PD) and progressive cognitive impairments, with Alzheimer’s disease (AD) being the most common among them. A loss of neurones and synaptic connections, typically in later life, is a prevalent feature of Usually, the onset and development of …
Published in International Journal of Cell Biology and Cellular Functions · Vol. 3, Issue 1, 2025 · pp. 47–59 Read article
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A Combined Molecular Docking Analysis of The Phytochemicals of Ginkgo biloba against The Parkin Protein Target (Autoinhibited Parkin Catalytic Domain)
Abstract: This study's goal is to evaluate the specific therapeutic targets for Parkinson's disease (PDB ID: 4BM9) using molecular docking simulation and ADME analysis against bilobalide, quercetin, ginkgolide B, and protocatechuic acid (3,4-Dihydroxybenzoic acid). The Protein Data Base was used to extract theprotein's three-dimensional structure, and the PubChem database was used to retrieve the ligands. Using Auto-Dock Tools-1.5.7, a molecular docking simulation of the compounds was carried out. Since none of …
Published in Journal of Catalyst & Catalysis · Vol. 10, Issue 1, 2023 · pp. 1–9 Read article
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Case Control Analysis on Neurodegeneration Disorders and Autism in Familial Context
Abstract: Neurodegenerative disorders such as Parkinson's and Alzheimer's co-occur with autism spectrum disorder (ASD), indicating shared genetic factors. Oxidative stress and inflammation play roles, with an elevated risk of Parkinson's and dementia in individuals with autism spectrum disorder. Antioxidant levels are linked to language and behaviour in autistic children. In the present study, a systematic review and meta-analysis was done following the PRISMA guidelines, reviewing English articles (2002- 2022) on familial …
Published in Research and Reviews: A Journal of Neuroscience · Vol. 13, Issue 2, 2023 · pp. 31–39 Read article
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Integrating Network Pharmacology and Molecular Docking to Assess Rutin’s Pharmacological Properties
Abstract: Objectives: In the present research, the network pharmacology process was applied to determine the underlying mechanism of the pharmacological properties of Rutin. Network pharmacology was utilized to reveal the interactions between medications and the targets of illnesses, and it is capable of completely articulating the complexity between diseases and medications. The identification of diverse drug-target interactions using network pharmacology may be utilized to discover novel medications for difficult conditions like …
Published in International Journal of Molecular Biotechnological Research · Vol. 1, Issue 1, 2023 · pp. 20–33 Read article
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IoT Based Pill Dispenser System
Abstract: Real-time data collection and patient database recording have been facilitated by the Internet of Things. One of the most common reasons a treatment plan does not work for a patient is that the drug is not taken at the prescribed time. People 50 years of age and beyond are more likely to suffer from diabetes, high blood pressure, Alzheimer's disease, Parkinson's disease, and other illnesses. For a patient like this, …
Published in Journal of Microelectronics and Solid State Devices · Vol. 11, Issue 1, 2024 · pp. 18–24 Read article
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A Perspective Review on Role of Environmental Pollutants in Developing Neurodegenerative Diseases
Abstract: As human society progresses towards industrialization, an excess number of environmental pollutants are released to our ecosystem, which significantly contribute in causing various health issues primarily associated with neurodegenerative diseases such as cognitive disorder, dementia, anxiety, Alzheimer, Parkinson etc. Because of their high global occurrence, these diseases have attracted attention in recent decades, however, the etiology of these diseases remains unclear. Pollutants are discharged into the environment by natural events …
Published in Research and Reviews : A Journal of Life Sciences · Vol. 14, Issue 2, 2024 · pp. 1–18 Read article
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Development of Spanish Version of Home-Based Video Module of Balance Exercises for Peripheral Vestibular Disordered Patients
Abstract: Any disturbances affecting one or more of the balance organs lead to imbalance difficulties and as a consequence, the quality of life of the affected individuals can be seriously affected, especially if the episodes end with injuries or even fatal accidents. Bal Ex is the first home-based video guided workout that was created by Zainun and her colleagues in 2009. Ten languages are currently supported by Bal Ex, including Cantonese, …
Published in International Journal of Brain Sciences · Vol. 1, Issue 2, 2024 · pp. 33–41 Read article
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High-Definition Electroencephalography: A New Horizon in Neurological Pathology Research
Abstract: The advent of high-density electroencephalography (HD-EEG) has catalyzed a paradigm shift in the exploration of neurological pathologies. This editorial underscore its transformative potential in elucidating brain dynamics and refining diagnostic approaches for a spectrum of conditions, spanning from epilepsy and dementia to cognitive impairments in preterm infants. Our objective is to optimize the utility of HD-EEG by emphasizing the imperative for methodological homogenization and fostering collaborative endeavors. The remarkable spatial …
Published in Research and Reviews: A Journal of Neuroscience · Vol. 14, Issue 2, 2024 · pp. 15–21 Read article
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Aquatic Ecosystems: A Review on Prospecting of Anticancer Molecules from Fungi & Other Microbes
Abstract: Marine biota; namely, actinomycetes, bacteria, fungi, microalgae, green algae, oceanic weeds, mangroves, and other extremophiles constitute about 90% of the oceanic biomass. The organisms are taxonomically diverse, biologically productive/active, and biochemically unique. These unique biochemiques may act as a great source for the discovery of new bioactive molecules, including anticancer drugs. The marines produce medicinally potent biochemicals; namely, sulfated saccharides, polyphenols, and, sterols. Only a few of these alkaloids have …
Published in International Journal of Fungi · Vol. 1, Issue 2, 2024 · pp. 1–22 Read article
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MicroRNAs in Animal Behavior: Regulation of Memory and Decision-Making in Mammals
Abstract: MicroRNAs are small, non-coding RNA molecules that play a crucial role in post-transcriptional regulation of gene expression. In recent years, their significance has extended beyond cellular development and disease regulation, as emerging evidence suggests they are critical mediators in complex behavioral processes, including learning, memory, and decision-making. This article explores the role of miRNAs in regulating neural plasticity and cognitive functions in mammals, emphasizing their involvement in memory formation and …
Published in Research and Reviews : Journal of Veterinary Science and Technology · Vol. 13, Issue 3, 2024 · pp. 21–25 Read article
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Analysis of White Matter, Gray Matter, and Cerebrospinal Fluid Alterations in Neurological Disorders: A Deep Learning Approach
Abstract: This paper investigates the role of white matter (WM), gray matter (GM), and cerebrospinal fluid (CSF) alterations in the pathophysiology of neurological disorders, including Alzheimer’s disease, Parkinson’s disease, schizophrenia, and epilepsy. By leveraging advanced deep learning methodologies, we aim to automate the segmentation and analysis of brain structures from MRI scans, enabling a more detailed and precise evaluation of their roles in disease progression. These techniques allow for the identification …
Published in Research and Reviews: A Journal of Neuroscience · Vol. 14, Issue 3, 2024 · pp. 21–27 Read article
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Assessing the Clinical Efficacy and Safety of Semaglutide: A Comprehensive Study
Abstract: Semaglutide, a glucagon-like peptide-1 receptor agonist (GLP-1RA), has emerged as a versatile therapeutic agent with significant potential in managing a range of diseases. Extensive research has demonstrated its efficacy in treating obesity, type 1 and type 2 diabetes, and even neurodegenerative disorders like Parkinson’s disease. This comprehensive review examines the principal outcomes derived from clinical trials that incorporate semaglutide alongside other GLP-1 agonists, with particular emphasis on the mechanisms underlying …
Published in Research and Reviews: A Journal of Pharmacology · Vol. 14, Issue 3, 2024 · pp. 96–104 Read article
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A Review Article on Nutraceuticals – An Impact on Conventional Health Care
Abstract: Nutraceuticals, combining nutrition and pharmaceuticals, have transformed healthcare. This review explores their classification, scope, benefits, and challenges. Nutraceuticals, including dietary supplements, functional foods, herbal products, and fortified foods, promote health and prevent diseases. The global market, valued at $117 billion, is expanding rapidly, fueled by the growing focus on health. Key benefits are boosted health benefits, fewer side effects, natural options improved nutrition. Classification is traditional (conventional) nutraceuticals (e.g., lycopene, …
Published in International Journal of Nutritions · Vol. 2, Issue 1, 2025 · pp. 9–23 Read article