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238 articles for “Clinical Safety”
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Kisunla (Donanemab): A Novel Breakthrough Illuminating a Path to Better Alzheimer’s Outcomes
Abstract: Background: Alzheimer’s disease (AD) is a progressive neurodegenerative condition marked by cognitive decline, memory loss, and loss of independence. Despite decades of extensive research, disease-modifying treatments have been limited in success. Recent therapeutic advancements have led to the development of monoclonal antibodies targeting amyloid-beta (Aβ) plaques, particularly the pyroglutamate-modified variant, a key pathological hallmark of AD. Objectives: This review aims to explore the therapeutic potential of Donanemab (Kisunla), a novel …
Published in Research and Reviews: A Journal of Neuroscience · Vol. 15, Issue 3, 2025 · pp. 37–45 Read article
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Pharmacological Comparison of Turmeric and Non-Steroidal Anti-Inflammatory Drugs in Pain Relief
Abstract: Pain is one of the most frequently encountered clinical symptoms affecting millions globally and is typically treated pharmacologically with nonsteroidal anti-inflammatory drugs (NSAIDs). However, long-term use of NSAIDs is associated with adverse effects such as gastrointestinal, renal, and cardiovascular issues. In recent years, turmeric and its main active compound, curcumin, have received considerable attention for their reported anti-inflammatory, analgesic, and antioxidant properties as natural therapeutic options. This review seeks to …
Published in Research & Reviews: A Journal of Pharmacognosy · Vol. 13, Issue 1, 2026 · pp. 19–28 Read article
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Switch Movement: Overview of Various Key Attributes on Regulatory Scenario of OTC Legislations in U.S.
Abstract: The Rx-to-OTC switch was a phenomenal success in USA, which was based on risk/benefit ratio of all scientific evidences in collaboration with FDA, manufacturer and consumers. Different surveys speak about the success stories of Rx-to-OTC movement as consumers experience the benefit from self-care in terms of empowerment, convenience, savings of money and time, etc. OTC perspective of scientific and regulatory bodies is based upon a valid procedure and just not …
Published in Research & Reviews: A Journal of Drug Formulation, Development and Production · Vol. 4, Issue 2, 2017 · pp. 24–31 Read article
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TO STUDY THE IMPACT OF CLINICAL PHARMACIST IN EMPOWERMENT OF FIRST AID PRACTICE AMONG PUBLIC IN MANAGEMENT OF EMERGENCY CONDITIONS- A COMMUNITY BASED HEALTH AND SAFETY RELATED STUDY.
Abstract: Background:There is inadequacy in knowledge required for handling emergency situations without a hospitalsetting in India as the people lack knowledge and practice in first aid and this happens becausethere are very few means of first aid education and training.Aim and Objectives: Aim to study the impact of clinical pharmacist in empowerment of Firstaid practices among public in management of emergency conditions: a community-based healthandsafety related Study. The main objective of …
Published in Research and Reviews: A Journal of Pharmaceutical Science · Vol. 13, Issue 3, 2022 · pp. 27–40 Read article
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GLP-1 Receptor Agonists: A Dual Therapeutic Strategy for the Management of Type 2 Diabetes Mellitus and Obesity
Abstract: For the treatment of obesity and type 2 diabetes mellitus (T2DM), glucagon-like peptide-1 receptor agonists (GLP-1 RAs) have become a revolutionary class of pharmaceutical drugs. These drugs were first created as glucose-lowering treatments, but they have now shown other advantages, such as notable weight loss, better cardiovascular results, and general metabolic control. The objective of this narrative review is to assess the pharmacological mechanisms, clinical efficacy, safety profile, and therapeutic …
Published in Research and Reviews: A Journal of Pharmacology · Vol. 16, Issue 1, 2026 · pp. 69–75 Read article
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A General Review of Mucuna Pruriens W.S.R to its effect on Parkinson’s Disease.
Abstract: Mucuna Pruriens is a very famous drug prescribed in classical ayurvedic science in various disorder of Nervous System including Kampavata .In Clinical Practice ,Physician used Levadopa as a Dopamine replacement agent in controlling bradykinetic symptoms apparent in Parkinson disease so used successfully in treatment of Parkinson disease.Kapikacchu(Mucuna Pruriens) is having Balya, Brimhanaha, Vrishya, and Vatahara properties and is a natural source of L-dopa. So, keeping in views of the degenerative …
Published in Research & Reviews : Journal of Herbal Science · Vol. 13, Issue 1, 2024 · pp. 1–6 Read article
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Formulation And Evaluation of Vyadhikshamatva Vardhak Giloy Ghanvatis
Abstract: The product of Kalka Kalpana, one of the five essential ayurvedic medicinal preparations, is vati Kalpana. Because of its many advantages, such as its tasty nature, ease of administration, ease of dispensing, and ease of transportation, vati kalpana is a vital part of the ayurvedic formulation. A pharmaceutical technique called vati kalpana uses powder of unprocessed medications (herbal or herbo minerals) and is triturated using juice, honey, or kassayam, and …
Published in Research & Reviews : Journal of Herbal Science · Vol. 13, Issue 2, 2024 · pp. 7–13 Read article
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Electroconvulsive Therapy in the Management of Schizophrenia: A Systematic Review in Emergency Nursing Practice
Abstract: Electroconvulsive therapy (ECT) is a well-established treatment for various psychiatric disorders, including schizophrenia, particularly in cases where patients are resistant to conventional treatments. Schizophrenia, a chronic and severe psychiatric disorder, often presents with a combination of positive symptoms (such as hallucinations and delusions), negative symptoms (such as social withdrawal and emotional blunting), and cognitive impairments. While antipsychotic medications are the primary treatment, approximately 20–30% of individuals with schizophrenia do not …
Published in International Journal of Emergency and Trauma Nursing and Practices · Vol. 3, Issue 1, 2025 · pp. 43–48 Read article
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Gastro Retentive Drug Target System: Its Needs, Advantages, Limitation and Approaches
Abstract: Background: Gastro retentive drug delivery systems (GRDDS) address limitations of oral therapy for drugs with poor solubility, instability at intestinal pH, or narrow absorption windows by prolonging gastric residence and increasing contact with the gastric mucosa. Objectives: To review GRDDS approaches—floating systems, mucoadhesive systems, and super porous hydrogels—with emphasis on formulation strategies and polymer–excipient selection to enhance gastric retention, modulate buoyancy/swelling/adhesion, and ultimately improve oral bioavailability and therapeutic outcomes for …
Published in Trends in Drug Delivery · Vol. 13, Issue 2, 2026 · pp. 47–58 Read article
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Formulation and Evaluation of Herbal Cream from Ethanolic Extract of Panfuti (Bryophyllum pinnatum) Leaves
Abstract: Bryophyllum pinnatum, commonly referred to as the "miracle leaf" or "life plant," is a succulent medicinal plant widely valued in traditional medicine. It is well known for its broad range of pharmacological activities, including wound-healing, anti-inflammatory, and antioxidant properties, making it an important species in natural and herbal therapeutics. This study aimed to formulate a topical cream incorporating Bryophyllum pinnatum extract and evaluate its physicochemical properties, stability, and potential for …
Published in Research & Reviews: A Journal of Drug Formulation, Development and Production · Vol. 13, Issue 3, 2026 Read article
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Development of an Active Catheter Mechanism using IPMC for in vivo Inspection
Abstract: An active catheter mechanism designed and developed for body parts (interiors, oral) inspection using active polymeric actuator i.e. ionic polymer metal composite (IPMC). The first step is achieved by fabricating the low cost silver (Ag) electrode IPMC following the chemical decomposition method. When a voltage is applied, the catheter yields a transverse movement; at the same time can exhibit forward and backward motion enables it to inspect wide range of …
Published in Journal of Mechatronics and Automation · Vol. 1, Issue 1, 2014 · pp. 60–69 Read article
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Navigating the Horizon: Current Trends in Elevating Quality Assurance in Clinical Research
Abstract: The landscape of clinical research quality management has evolved significantly in recent years, driven by stringent regulatory frameworks and globalization of trials. This evolution underscores the importance of integrating quality into all aspects of the clinical trial process from design to postresearch activities. Concepts such as Good Clinical Practice (GCP) and Quality by Design (QbD) are central to ensuring the reliability and accuracy of trial data while safeguarding patient safety …
Published in Research & Reviews: A Journal of Drug Design & Discovery · Vol. 11, Issue 1, 2024 · pp. 1–8 Read article
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Comparative Efficacy and Safety of Safinamide and Rasagiline in the Treatment of Parkinson’s Disease: A Meta-Analysis and Systematic Review
Abstract: Background: Recent studies have suggested Rasagiline and Safinamide monotherapy as potential management options for Parkinson’s disease. Parkinson’s disease, a neurological disorder characterized by tremors and movement difficulties, necessitates treatments aimed at managing clinical symptoms. Levodopa remains the primary effective treatment for Parkinson’s disease symptoms; however, its long-term use often leads to motor complications in many patients. Additional therapeutic drugs, such as dopamine agonists and monoamine oxidase B inhibitors, including Safinamide …
Published in Research and Reviews: A Journal of Pharmacology · Vol. 14, Issue 3, 2024 · pp. 74–91 Read article
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Pathways in Drug Discovery and Development: From Molecular Targets to Market Approval
Abstract: A complicated, multidisciplinary, and resource-intensive process, the discovery and development of new pharmacological drugs is essential to the advancement of contemporary medicine. Finding and optimising lead chemicals comes after a disease-relevant biological target has been identified and validated. Through preclinical research in animal models, these leads are thoroughly assessed for toxicity, pharmacokinetics, safety, and efficacy. Clinical trials, which are carried out in several stages to evaluate safety, efficacy, ideal dosage, …
Published in Research & Reviews: A Journal of Drug Design & Discovery · Vol. 13, Issue 1, 2026 · pp. 01–04 Read article
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Clinical Trials: A Brief Review
Abstract: Clinical trials, according to the World Health Organization, are used to test new medicinal entities on humans after they have been studied in animals. Clinical studies are usually divided into five stages. Clinical pharmacologists study phase I pharmacokinetics, safety, and gross effects on human volunteers. If the drug passes the test, it moves on to phase II testing, where pharmacokinetics, safety, and therapeutic efficiency are studied on a small number …
Published in Research & Reviews: A Journal of Drug Design & Discovery · Vol. 9, Issue 1, 2022 · pp. 1–7 Read article
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Fungal-derived Nutraceuticals & Bioactive Compounds with Physiotherapeutic and Health- promoting Properties: A Comprehensive Review
Abstract: Fungal-derived nutraceuticals represent a rapidly expanding field in biomedical research, offering a rich source of bioactive compounds with diverse therapeutic applications. This comprehensive review examines the physiotherapeutic and health-promoting properties of fungal metabolites, including polysaccharides, terpenes, proteins, peptides, alkaloids, fatty acids, vitamins, and minerals. Fungi produce over 9,000 bioactive compounds from approximately 22,500 microbial metabolites, with less than 5% of the fungal kingdom explored [1] . The major bioactive constituents …
Published in International Journal of Fungi · Vol. 2, Issue 2, 2025 Read article
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Preparation of a Novel Polyherbal Hair Dye Formulation: Better Coloring and Protection Offered as Compared to Marketed Products
Abstract: Synthetic dyes contain permanent coloring agents such as aromatic diamine, amino compounds (4-amino-2-hydrosytoluene, meta-aminophenol, etc.), hydric phenols, polycompounds (para-phenylenediamine) which results in many side effects such as skin irritation, erythrema, loss or damage of hair, and even skin cancer. Dyes obtained from various plant sources are simply available, economical, safe, competent, and rarely have side-effects. In traditional systems of medicines such as Ayurveda, Unani, Siddha, and Homeopathy, the prescribed dyes …
Published in Research & Reviews: A Journal of Drug Formulation, Development and Production · Vol. 7, Issue 1, 2020 · pp. 11–15 Read article
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Recent Advances in Nanotechnology-Assisted Liquid Crystal Biosensors for Sensitive and Naked-Eye Detection of Antibiotics
Abstract: The widespread use of antibiotics in healthcare, veterinary medicine, agriculture, and aquaculture has resulted in increasing levels of antibiotic residues in food products and environmental samples, posing significant risks to human health and contributing to antimicrobial resistance. Conventional analytical methods, including high-performance liquid chromatography (HPLC), liquid chromatography–mass spectrometry (LC–MS), enzyme-linked immunosorbent assay (ELISA), and electrochemical techniques, offer excellent sensitivity but require sophisticated instrumentation, skilled personnel, and extensive sample preparation. In …
Published in International Journal of Crystalline Materials · Vol. 3, Issue 2, 2026 Read article
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Monoclonal antibodies in targeted cancer therapy advances, resistance mechanisms, and next-gen formats (Bispesifics, ADCs)
Abstract: Breast cancer is one of the leading causes of cancer-related morbidity and death worldwide, which emphasizes the need for more effective and focused treatment strategies. antibody-mediated drug delivery techniques. Specifically, antibody–drug conjugates (ADCs) have emerged as a potential approach that combines the specificity of monoclonal antibodies with the potent cytotoxicity of anticancer drugs. By selectively targeting tumor-associated antigens, ADCs enhance drug accumulation within cancer cells while minimizing systemic toxicity associated …
Published in Research and Reviews: A Journal of Pharmaceutical Science · Vol. 17, Issue 2, 2026 · pp. 62–79 Read article
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Clinical Evaluation of Vaginal Contraceptive Cream of Sapindus mukorossi, CONSAP: A Pilot Study
Abstract: Sapindus mukorossi also known as reetha is well known herb in ancient Ayurveda. The fruits of this herb contain saponins which showed excellent spermicidal activity in vitro and in vivo animal experiments. The formulation in the form of cream was prepared for human application. The safety and tolerability pilot clinical study was organized. The aim of the present study was to evaluate the contraceptive safety and efficacy of 2.5% cream …
Published in Trends in Drug Delivery · Vol. 2, Issue 3, 2015 · pp. 22–24 Read article