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1260 articles for “CTLA-4”
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Molecular Docking and Pharmacokinetic Profiling of the Phytocompounds of Jatropha curcas as Antagonist for Salmonella typhi
Abstract: Background: Typhoid is an infection caused by the Gram-negative bacterium, Salmonella enterica serovar typhi. The study assessed the potential use of Jatropha curcas as a typhoid fever therapy alternative to traditional medications. The ability to uncover novel drug indications for currently available medications using in silico methods has increased thanks to the wealth of pharmacological and biological knowledge that is available. Objective: In this study, we assessed the potential inhibitory …
Published in International Journal of Cell Biology and Cellular Functions · Vol. 1, Issue 1, 2023 · pp. 67–81 Read article
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Radix Entomolaris: A Clinical Case Report of Endodontic Treatment on Tooth #46
Abstract: Radix entomolaris (RE) is a rare anatomical variation characterized by the presence of an extra root, most often occurring in mandibular molars. This anatomical anomaly can present significant challenges during endodontic treatment, as it alters the traditional root canal morphology, making diagnosis and treatment more complex. In particular, RE is typically found in the mandibular first molar and can complicate canal identification, cleaning, and shaping. This case report describes the …
Published in Research and Reviews : Journal of Surgery · Vol. 13, Issue 3, 2024 · pp. 11–16 Read article
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Investigation of Residual Stress, and corrosion behavior of AA6082/Al 2 O 3 /C/ Si 3 N 4 Composite Material
Abstract: The main objective of the current study was to create AA6082/ Al2O3/C/Si3N4 Composite Material by the use of stir casting. The properties of the AA6082/ Al2O3/C/ Si3N4 Composite Material shown a significant improvement, with a micro-hardness rise of 13.5% and a residual stress decrease of 60%. As the testing parameters were increased, the residual stress of the AA6082/ Al2O3/C/ Si3N4 Composite Material rapidly decreased from -65MPa to -15MPa. An electromagnetic …
Published in Journal of Polymer & Composites · Vol. 13, Issue 1, 2025 · pp. 1104–1109 Read article
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Effect of Solution Heat Treatment and Aging on the tensile Properties of Ti-6Al-4V Alloy Component Manufactured by Wire Arc Additive Manufacturing
Abstract: Wire Arc Additive Manufacturing (WAAM) is a cost-effective technique for fabricating components from the Ti-6Al-4V alloy, known for its high strength and utility in demanding applications. To maximize its strength, the alloy undergoes Solution Treating and Aging heat treatment, comprising three key steps: (i) Solution Treating: The alloy is heated to 950°C (just below the β transus) and held for 1 hour, increasing the β phase proportion. This step sets …
Published in International Journal of Machine Systems and Manufacturing Technology · Vol. 3, Issue 2, 2025 · pp. 1–6 Read article
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Advancements in Smart Manufacturing: A Review of Industry 4.0 Technologies and Integration Strategies
Abstract: A new era of production known as “Smart Manufacturing,” which is primarily motivated by the ideas of Industry 4.0, has been brought about by the quick development of digital technologies. The goal of this technology revolution is to develop intelligent, adaptive, and networked production systems that react instantly to shifting supply, demand, and operating circumstances. The Internet of Things (IoT), artificial intelligence (AI), machine learning (ML), cyber-physical systems (CPS), big …
Published in International Journal of Manufacturing and Production Engineering · Vol. 3, Issue 1, 2025 · pp. 31–36 Read article
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Human-in-the-Loop AI in HR Decision-Making: Insights from Big 4 AI Governance Reports
Abstract: The integration of artificial intelligence (AI) in human resource (HR) decision-making has transformed recruitment, performance evaluations, and talent management. However, biases embedded in AI-driven HR systems present significant ethical and operational challenges. Human-in-the-Loop (HITL) AI offers a hybrid approach that combines AI efficiency with human oversight to enhance fairness and accountability. This paper systematically analyses HITL AI in HR decision-making using qualitative analysis of AI governance reports from Big 4 …
Published in Current Trends in Information Technology · Vol. 16, Issue 1, 2025 · pp. 43–50 Read article
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Synthesis of Magnetically Recoverable Nickel (II) Complex-Functionalized Fe 3 O 4 @ISNA (ISNA= Isonicotinic acid) Nanomaterials: Catalytic Studies on Nitrophenol Reduction and TD- DFT Studies
Abstract: In this study, we aimed to develop a novel, environmentally sustainable, and magnetically separable heterogeneous nanocatalyst, denoted as Fe 3 O 4 @ISNA@NiL (where L represents the ligand). The synthesis involved a two-step process, first, isonicotinic acid was chemically grafted onto the surface of iron oxide nanoparticles (Fe 3 O 4 ) to introduce functional groups capable of further chemical modification. Subsequently, a nickel(II) Schiff base monomeric complex was anchored …
Published in Journal of Polymer & Composites Read article
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Effect of 4-Week Protocol of Kegel Exercise on Pelvic Floor Strength on a Patient with Ovarian Endometriosis—A Case Report
Abstract: Purpose: The purpose of this case study was to describe the effects of Kegel exercise in a 4-week protocol for a patient with endometriosis associated with urinary incontinence. Case description: A 23-year-old female patient presented with chronic low back pain and also complained of difficulty in holding urine and leakage while doing forceful activities like lifting heavy objects, coughing, and sneezing in the past 6 months. She also complained of …
Published in International Journal of Women's Health Nursing And Practices · Vol. 3, Issue 1, 2025 · pp. 9–14 Read article
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4D Printing in Drug Delivery: Application of Shape- Morphing Materials in Controlled Drug Release
Abstract: Four-dimensional printing technology has transformed the pharmaceutical landscape, offering unprecedented opportunities for innovation in drug development and delivery. This emerging technology enables the creation of complex geometries and customized structures, facilitating the design of personalized medications tailored to individual patient needs. Personalized dosing and drug release profiles, customized pill shapes and sizes for improved swallowability. Enhanced drug solubility and bioavailability, rapid prototyping and testing of pharmaceutical products. Development of complex …
Published in Trends in Drug Delivery · Vol. 12, Issue 3, 2025 · pp. 08–16 Read article
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A Decade of Research on Polymer Manufacturing and Industry 4.0 Integration: A Comprehensive Bibliometric Review of Industry
Abstract: The advent of Industry 4.0 has brought a transformative revolution to the manufacturing sector by integrating advanced polymer technologies with intelligent, interconnected, and data-driven production systems. These developments have significantly reshaped industrial operations by improving efficiency, enhancing production flexibility, and enabling innovative manufacturing practices. Smart polymer processing, supported by automation, artificial intelligence, the Internet of Things (IoT), and real-time data analytics, allows manufacturers to optimize resource utilization, reduce waste, and …
Published in Journal of Polymer & Composites · Vol. 14, Issue 1, 2026 · pp. 1897–1905 Read article
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Design and Simulation of Full Adder-Based CMOS 4-2 Compressor using CMOS XOR-XNOR Logic
Abstract: This study utilizes the recent development of CMOS transistors to construct an energy-efficient Full adder-based CMOS 4-2 compressor. The CMOS Exclusive-OR-Exclusive-NOR component and multiplexer used in the transmission logic of the novel CMOS compressor include eight transistors. The XOR-XNOR logic style is the most efficient and effective due to its speed and reduced power consumption. Utilizing an operational supply voltage of 0.7 V and 90nm CMOS technology, the Cadence Virtuoso …
Published in Recent Trends in Electronics Communication Systems · Vol. 12, Issue 3, 2025 · pp. 1–8 Read article
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Strategic Opportunities in Implementing Industry 4.0 for Natural Fiber- Reinforced Polymer Composites
Abstract: Cyber-physical systems (CPS) lie at the heart of the fourth industrial revolution, more widely recognized as Industry 4.0. This emerging paradigm is characterised by the seamless and instantaneous integration of physical and digital systems, creating an interconnected environment where machines, data, and human intelligence work in close collaboration. The proposition behind Industry 4.0 suggests that the fusion of advanced digital technologies with traditional industrial processes will fundamentally transform the nature …
Published in Journal of Polymer & Composites · Vol. 13, Issue 6, 2025 · pp. 451–466 Read article
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Mathematical Modelling and Experimental Analysis of a 3D Printed PLA UAV Propeller using NACA 4412 Airfoil
Abstract: The usage of unmanned aerial vehicles (UAVs) has grown significantly because they are cost-effective and easy to availability for many applications. However, researchers have focused on the designing for various UAV propeller/rotors geometries, including their aerodynamic performance and structural examination. An elegant, designed propeller can enhance the UAV's endurance limit and its reliability. This research focuses on designing of UAV propeller and its fabrication using Polylactic acid (PLA) material using …
Published in Journal of Polymer & Composites · Vol. 14, Issue 3, 2026 · pp. 825–832 Read article
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Computational Molecular Docking Studies to Design Novel 2, 3-Substituted-1-(4-(Piperidin-1-yl) butyl)-1H- indol-5-ol Derivatives for Estrogen Receptor Alfa in AF-2 Domain
Abstract: The present manuscript describes the designing of novel 2, 3-Substituted-1-(4-(Piperidin-1-yl) butyl)- 1H-indol-5-ol derivatives as specific estrogen receptor alfa modulators and their screening by docking studies to determine the binding interaction for the best-fit conformations in the binding site of the ERα receptor. Based on the results of docking studies, the selected ligands reveal the all- important functional groups of the ligands that interact with active amino acid residues in the …
Published in Research and Reviews: A Journal of Pharmaceutical Science · Vol. 12, Issue 3, 2025 · pp. 15–49 Read article
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Evaluation of Coping Strategies Adapted to Overcome Psychosocial Problems in Adults Residing at Residential Home: A Descriptive Study
Abstract: Coping strategies refer to intentional actions taken to address and resolve personal or interpersonal challenges, aiming to manage, reduce, or tolerate stress or conflicts. Emotional-focused techniques specifically target the reduction of negative emotional responses caused by stressors. Some examples of coping strategies focused on emotions involve participating in activities to keep oneself busy and divert attention from stressors, seeking support, encouragement, empathy, and understanding from others. Objectives: (1) to assess …
Published in International Journal of Community Health Nursing And Practices · Vol. 1, Issue 1, 2023 Read article
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Grid based docking study of some 2-(4-methylsulfonyl phenyl) pyrimidine derivatives (designed after QSAR studies) with Cyclooxygenase
Abstract: Molecular docking helps in studying drug/ligand or receptor/ protein interactions by identifying the suitable active sites in protein, obtaining the best geometry of ligand-receptor complex and calculating the energy of interaction for different ligands to design more effective ligands. In Grid based docking, after unique conformers of the ligand are generated, the receptor cavity of interest is chosen and a grid is generated around the cavity. Cavity points are found …
Published in International Journal of Antibiotics · Vol. 1, Issue 1, 2024 · pp. 23–41 Read article
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Delay Analysis of HS-14T 45nm CMOS SRAM with Different SRAM Techniques for Improvement in Speed
Abstract: This paper presents a novel HS-14T design aimed at significantly improving read and write delays compared to conventional 6T and other memory cells RHRD-12T, SEUH-12T, and NHRC-14T. As technology scales, the demand for faster and more stable memory cells becomes increasingly critical. Our proposed HS-14T incorporates additional transistors to enhance stability and reduce access times, resulting in notable performance gains. Comprehensive simulations reveal that the HS-14T SRAM cell substantially reduces …
Published in Journal of VLSI Design Tools and Technology · Vol. 14, Issue 2, 2024 · pp. 1–13 Read article
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Synthesis, spectroscopic, crystal structure, Hirshfeld surface, computational, and biological investigations on Isophorone derivatives: 3-(3,4-dimethoxystyryl)-5,5-dimethylcyclohex-2-en-1-one
Abstract: FT-IR, 1H NMR, and 13C NMR spectroscopy were among the spectroscopic methods used to synthesize and analyze 3-(3,4-dimethoxystyryl)-5,5-dimethylcyclohex-2-en-1-one, a new isophorone derivative. Single-crystal X-ray diffraction (SCXRD) was used to determine the crystal structure, which showed that the molecule crystallizes in a monoclinic system (space group P121/c1) with packing configurations and intermolecular interactions. To learn more about the non-covalent interactions influencing the crystal packing, Hirshfeld surface analysis was used. In order …
Published in Journal of Modern Chemistry & Chemical Technology · Vol. 16, Issue 2, 2025 · pp. 51–69 Read article
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Use of NMR and Other Spectroscopy Techniques in Heterocyclic Oxadiazole Derivatives Studies: A Review
Abstract: It was possible to create a number of novel symmetrical 2,5-dialkyl-1,3,4-oxadiazoles with substituents including carboxymethylamino, isopropyloxycarbonylmethylamino, and bromine at the terminal positions of the alkyl groups. The multistep process that was devised used hydrazine hydrate, phosphorus oxychloride, and commercially available acid chlorides that varied in alkyl chain length and terminal substituent.Diisopropyliminodiacetate was an easy way to substitute the intermediate bromine-containing 2,5-dialkyl-1,3,4-oxadiazoles. This was followed by hydrolysis in an aqueous methanol …
Published in International Journal of Photochemistry and Photochemical Research · Vol. 2, Issue 1, 2024 · pp. 07–13 Read article
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Investigations On Use of Poly(3,4-Ethylenedioxythiophene): Poly (Styrene Sulfonic Acid) (PEDOT: PSS) Conductive Polymers for Design of Improved EEG Based Brain Computer Interface for Seizure Control and Analysis
Abstract: This research explores the application of Poly(3,4-ethylenedioxythiophene):poly(styrene sulfonic acid) (PEDOT:PSS) conductive polymers in the design of an enhanced Electroencephalography (EEG)-based Brain-Computer Interface (BCI) for seizure control and analysis. PEDOT: PSS, known for its high conductivity, flexibility, and biocompatibility, is employed to improve the efficiency and sensitivity of EEG electrodes, addressing challenges such as signal noise, skin-electrode impedance, and user comfort. The study evaluates the material’s properties, including its electrical conductivity, …
Published in Journal of Polymer & Composites · Vol. 13, Issue 3, 2025 · pp. 223–241 Read article