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113 articles for “Animal models”
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Toxicological Evaluation Of Two Nigerian Refinery Effluents Using Natural Biomonitors
Abstract: Abstract The present study aimed to evaluate the toxic effects of two Nigerian refineries’ effluents using natural bio-monitors. Standard physicochemical analysis, toxi-chromo test using mutant E. coli and sub-chronic animal toxicity testing with emphasis on tissue heavy metal accumulation, biochemical parameters and histopathology, were adopted during the study. The physicochemical results revealed that the two effluent samples are highly polluted although PH sample was more polluted than the Warri sample. …
Published in Research and Reviews: A Journal of Toxicology · Vol. 10, Issue 2, 2020 · pp. 22–31 Read article
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Clinical Utility of Black Tea Polyphenols in Chemoprevention and Therapeutics Against Cancer
Abstract: Tea is the second-most preferred beverage produced from Camellia sinesis. It is cultivated in more than 30 countries. Several scientific studies have specified that polyphenolic compounds in tea may reduce the risk of a variety of infirmity including cancer. Most of the research evidences are available from green tea but limited information is available from black tea. Several studies have investigated both in vitro and in vivo models including rats, …
Published in Research and Reviews : A Journal of Life Sciences · Vol. 11, Issue 3, 2021 · pp. 7–14 Read article
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Epstein-Barr virus A Review
Abstract: The unravelling of the molecular pathogenesis of malignancy that had its beginnings in the last third of the twentieth century was, in many ways, sparked by the discovery of virus-associated tumors and oncogenic viruses. Epstein Barr virus (EBV) and other viruses that soon followed were not only exciting stories in themselves but provided models with starting points and outcomes, which, since they were specific, could be dissected and generalized. In …
Published in Research and Reviews : A Journal of Immunology · Vol. 1, Issue 1-3, 2011 · pp. 10–15 Read article
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Potential Source of Mesenchymal Stem Cell (MSCs) in Veterinary Medicine
Abstract: Stem cells serve a vital function in veterinary care in a variety of ways. Several stem cell treatments for animal patients are now being developed, and some, such as the treatment of horse tendinopathies using mesenchymal stem cells (MSCs), have already successfully hit the market. Furthermore, animal models are routinely employed to explore the qualities and potential of stem cells for future uses in human health. Furthermore, bovine ES cells …
Published in Research and Reviews : Journal of Veterinary Science and Technology · Vol. 11, Issue 1, 2022 · pp. 1–3 Read article
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Ivermectin: Its Therapeutic Efficacy in the Treatment of COVID-19
Abstract: Over past 35 years the most commonly used anti-helminthic drug is ivermectin. It has showed good impact in treating the parasitic infections. The drug provides an evidence of immune modulatory and anti-inflammatory actions in vitro animal model. Ivermectin belongs to the class of ivermectin and most widely used as an anti-parasitic agent. It is also used in the treatment of internal nematode infections like onchocerciasis, filariasis, and strongloidiasis. For the …
Published in Research and Reviews: A Journal of Microbiology and Virology · Vol. 11, Issue 3, 2021 · pp. 1–5 Read article
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A Perspective Review on Role of Environmental Pollutants in Developing Neurodegenerative Diseases
Abstract: As human society progresses towards industrialization, an excess number of environmental pollutants are released to our ecosystem, which significantly contribute in causing various health issues primarily associated with neurodegenerative diseases such as cognitive disorder, dementia, anxiety, Alzheimer, Parkinson etc. Because of their high global occurrence, these diseases have attracted attention in recent decades, however, the etiology of these diseases remains unclear. Pollutants are discharged into the environment by natural events …
Published in Research and Reviews : A Journal of Life Sciences · Vol. 14, Issue 2, 2024 · pp. 1–18 Read article
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An Insilico Study of Isobutrin and Phosphorylase Kinase - A Ray of Hope for Psoriasis Patients – Clinical Hypothesis
Abstract: Psoriasis is a chronic, hyper-proliferative and inflammatory skin disease. Increased levels of the calmodulin-containing enzyme, namely, phosphorylase kinase (PhK), were observed in the human epidermis of the active psoriasis cases. Thus PhK is a potential biomarker for the diagnosis and progression of the skin disease, namely, psoriasis. The search for the potential molecules that could supress the over expression of PhK is underway and any break-through in this direction leads …
Published in International Journal of Cheminformatics · Vol. 2, Issue 1, 2024 · pp. 1–8 Read article
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Role of Centella asiatica in Alzheimer’s Disease: A Comprehensive Review
Abstract: Alzheimer's disease (AD) is a progressive neurological illness that causes cognitive decline and memory loss and affects millions of people worldwide. As synthetic medications often prove ineffective or cause severe side effects, natural remedies are gaining attention. This review explores the potential of Centella asiatica, a herb traditionally used in oriental medicine, in the treatment of Alzheimer's disease. Triterpenoids, asiaticoside, and madecassoside are among the bioactive substances found in Centella …
Published in International Journal of Brain Sciences · Vol. 1, Issue 2, 2024 · pp. 1–7 Read article
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Edible Mushrooms: Management of Diabetes Mellitus and Phytochemical Screening of Agaricus Bisporus
Abstract: A metabolic disease characterized by elevated blood glucose levels; diabetes mellitus affects millions of people. If not treated on time, it causes problems, damage organs, and even life-threatening. Studies have shown that diabetes can be avoided and controlled with a healthy lifestyle that incorporates exercise and a balanced diet. While there are several synthetic medications available to treat this illness using them over an extended period of time is linked …
Published in International Journal of Cell Biology and Cellular Functions · Vol. 3, Issue 1, 2025 · pp. 1–13 Read article
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Nanorobots: The Fight against Cholesterol
Abstract: Cardiovascular disease (CVD) rests leading reason of death globally, with atherosclerosis, the buildup of plaque in arteries, playing a central role. Current treatment strategies, including lifestyle changes and medications, often fall short in completely reversing or preventing the progression of atherosclerosis. This has spurred the exploration of innovative approaches, with nanorobotics emerging as a promising avenue for targeted plaque control and high-density lipoprotein (HDL) enhancement. This article discusses how nanorobots …
Published in Nano Trends – A Journal of Nano Technology & Its Applications · Vol. 27, Issue 2, 2025 · pp. 23–32 Read article
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Unani Medicine Approaches To Liver Diseases :Therapeutic Principles and Review
Abstract: Background: For centuries, the Unani system of medicine has addressed liver diseases through principles that recommend specific therapies tailored to each ailment. Purpose: To analyze the therapeutic principles and Unani medications recorded for the treatment of liver diseases. Data Sources: Unani literary books in both Urdu and English were consulted, along with original e-research papers serving as databases. Limitation: This paper primarily focuses on the therapeutic principles related to liver …
Published in Research & Reviews : A Journal of Unani, Siddha and Homeopathy · Vol. 12, Issue 2, 2025 · pp. 25–29 Read article
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Pathways in Drug Discovery and Development: From Molecular Targets to Market Approval
Abstract: A complicated, multidisciplinary, and resource-intensive process, the discovery and development of new pharmacological drugs is essential to the advancement of contemporary medicine. Finding and optimising lead chemicals comes after a disease-relevant biological target has been identified and validated. Through preclinical research in animal models, these leads are thoroughly assessed for toxicity, pharmacokinetics, safety, and efficacy. Clinical trials, which are carried out in several stages to evaluate safety, efficacy, ideal dosage, …
Published in Research & Reviews: A Journal of Drug Design & Discovery · Vol. 13, Issue 1, 2026 · pp. 01–04 Read article
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In Vitro Evaluation of Analgesic Activity of the Methanol Extract of Pileamicrophylla (L.) Liebm. in Swiss Albino Mice
Abstract: Due to the availability of the plant Pileamicrophylla (L.) Liemb in Bangladesh, the present study was aim to investigatein vitroanalgesic activity of the methanol extract of Pileamicrophylla (L.) Liebm. analgesic activity was conducted at the doses of 200 and 400 mg/kg body weight usingSwiss albino mice as animal model by two thermal (hot plate and tail immersion test) methods. Overall, the extract showed significant analgesic activity compared to standard drug …
Published in Research and Reviews : Journal of Computational Biology · Vol. 6, Issue 3, 2017 · pp. 12–15 Read article
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Therepi: A Replenishable Implanted Epicardial Reservoir
Abstract: The healthcare technology has been advancing at such a high pace which was not expected some years back. This paper is an attempt to introduce not so known, still existing and in-development phase, techniques which can revolutionize the healthcare industry in different domains. The recent technological development in coronary therapies have shown a great promise in restoring the abnormalities present in the heart after the patient experiences heart attack; certain …
Published in Research and Reviews: A Journal of Health Professions · Vol. 9, Issue 2, 2019 · pp. 12–16 Read article
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Pathogenesis, Immune Response and Vaccine Development in Amoebiasis
Abstract: Worldwide, approximately fifty million cases of invasive E histolytica disease occur each year and resulting in more than 100,000 deaths. It is the second leading cause of mortality due to a protozoan parasitic infection after malaria. Entamoeba histolytica infection is associated with considerable morbidity and mortality in the form of intestinal and extra-intestinal amoebiasis especially in developing countries. Recent molecular studies have conclusively proved that there are morphologically similar species …
Published in Research and Reviews : A Journal of Immunology · Vol. 5, Issue 3, 2015 · pp. 30–35 Read article
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A Study for the Presence of Enterococcal Virulence Factors Gelatinase, Haemolysin among Clinical Isolates in a Tertiary Care Hospital
Abstract: Enterococcus, considered a normal commensal of intestinal tract, is fast emerging pathogen causing serious infection. Despite the increasing importance of Enterococcus as opportunistic pathogens, their virulence factors are still poorly understood. The potential virulence factors of Enterococci include production of enterococcal surface protein (Esp), gelatinase, and haemolysin. Gelatinase- and haemolysin-producing strains of Enterococcus faecalis have been shown to be virulent in animal models of enterococcal infections. This study was undertaken …
Published in Research and Reviews: A Journal of Microbiology and Virology · Vol. 7, Issue 3, 2017 · pp. 14–18 Read article
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Activity of Cannabinoids in Type II Diabetes
Abstract: The present research is a theoretical study of the medicinal use of Cannabis (cannabinoids) compounds in Type II Diabetes based on literature citing animal models and available clinical evidence from human studies. The study emphasizes the positive physiological actions and benefits of cannabinoid compounds in Type II Diabetes. The pharmacological activities of cannabinoid compounds in Type II Diabetes have been studies only in limited human clinical trials that were often …
Published in Research and Reviews: A Journal of Neuroscience · Vol. 7, Issue 2, 2017 · pp. 1–5 Read article
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Up-Regulation of TNF-α by Ethanol Extract of Moringa Oleifera in Benzene-Induced Leukemic Wister Rat: A Possible Mechanism of Anticancer Property
Abstract: Ethanol extract of Monringa oleifera (EMO) has been shown to possess anti-cancer properties in animal models. The mechanisms of action of its anticancer properties have not been fully demonstrated. We induced leukemia in two groups of seven rats each by intravenous injection of benzene chromasolv solution (0.2 mL) 48 hourly for 4 weeks. EMO (0.2 ml of 100 mg/mL) was administered orally by gavage, after leukemia induction, daily for 4 …
Published in Research and Reviews: Journal of Oncology and Hematology · Vol. 3, Issue 3, 2014 · pp. 16–21 Read article
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Induction of Apoptosis using Gene Therapy in the Treatment of Cancer
Abstract: Gene therapy is the treatment of a genetic disease through the insertion of normal or genetically altered genes into cells in order to replace or make up for the non-functional or missing genes. A major application of gene therapy is the induction of apoptosis to inhibit metastases or cure cancer. Besides the identification of the target site, the choice of a suitable vector system for gene delivery is also critical …
Published in Research and Reviews: Journal of Oncology and Hematology · Vol. 2, Issue 3, 2013 · pp. 6–10 Read article
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Anti-nociceptive Potential of Scurrula parasitica: An Unexploited Parasitic Plant
Abstract: Scurrula parasitica (Loranthaceae) is an herbaceous growing shrub parasitic on Dendrophthoe falcata (Loranthaceae) which is itself parasitic on Mangifera indica (Anacardiaceae). Scurrula parasitica is distributed throughout the western ghat region of Maharashtra, some parts of Uttar Karnataka and Tamil Nadu. Genus Scurrula comprising of around 91 species, however, only S. ferruginea, S. atropurpurea, S. fusca have been investigated systematically. No such pharmacological and phytochemical data are available on the plant …
Published in Research and Reviews: A Journal of Pharmacology · Vol. 3, Issue 1, 2013 · pp. 4–8 Read article