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1365 articles for “Target”
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Drug Discovery and Design: Focus on computational approaches used in the discovery and design of new drugs
Abstract: Computational approaches have revolutionized the field of drug discovery and design, offering efficient and cost-effective strategies for identifying and developing new therapeutics. This review article explores the application of computational methods in drug discovery, with a focus on virtual screening techniques, molecular docking, molecular dynamics simulations, and quantitative structure-activity relationship (QSAR) models. Virtual screening plays a crucial role in narrowing down large chemical libraries by utilizing ligand-based and structure-based approaches. …
Published in Research and Reviews : Journal of Computational Biology · Vol. 12, Issue 1, 2023 · pp. 26–30 Read article
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Computational Examination of Curcumin Derivatives as Promising Inhibitors for BRCA1 and BRCA2 Proteins in Breast Cancer Treatment
Abstract: Objective: Breast cancer is a major problem for global health and one of the most popular and dangerous diseases. Data from the National Cancer Registry Program (NCRP) of the National Center for Disease Informatics and Research (NCDIR), an arm of the Indian Council of Medical Research (ICMR) in Bangalore, India, shows that an estimated 1,461,427 new cancer cases will occur… Conditions in India by 2022. Among these conditions, breast cancer …
Published in Research and Reviews : Journal of Computational Biology · Vol. 12, Issue 3, 2023 · pp. 68–87 Read article
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Access to Health and Support Systems: Role of NGOs in Facilitation Process among Injecting Drug Users (IDUs) in Bilaspur
Abstract: In Chhattisgarh, Bilaspur has a high prevalence of Injecting Drug Use and it is associated with HIV/AIDS infection, which is fast increasing. There is an urgent need to understand the treatment seeking behaviour of IDUs. Various services and treatment options are in place for IDUs in Bilaspur. Both Government and NGOs are active in spreading awareness and providing necessary support to the drug users. But formulating policies and setting-up establishments …
Published in Research and Reviews: A Journal of Health Professions · Vol. 8, Issue 3, 2018 · pp. 1–6 Read article
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Baseline Assessment of the Knowledge, Attitudes, Belief and Practices (KABP) related to HIV/AIDS in Vasai, Maharashtra, India
Abstract: Despite of decade long national effort to target prevention programs towards the general Indian population, most prevention programs have largely focused on urban populations. Information on semi-urban and rural populations is limited. This study is a baseline assessment of the Knowledge, Attitudes, Belief and Practices (KABP) related to HIV/AIDS, among participants receiving targeted awareness programmes in semi urban regions of Vasai taluka, Maharashtra state, which is identified as one of …
Published in Research and Reviews: A Journal of Health Professions · Vol. 13, Issue 3, 2023 · pp. 7–16 Read article
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Measles Eradication by Vaccination: Opportunities and Challenges
Abstract: Measles is one of the vaccine preventable viral diseases that mainly occur in children. The disease was targeted for elimination by a vaccination program that was initiated three decades back. The measles death rate decreased by 74% from the year 2000 to 2010. This was short of targeted 90% mainly because of low vaccine coverage in some countries. Although, there is marked reduction in measles morbidity and mortality, still it …
Published in Research and Reviews : A Journal of Immunology · Vol. 2, Issue 3, 2012 · pp. 1–7 Read article
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Role of Human Neutrophils in Inflammation and its Modulation by Ixora coccinea
Abstract: Neutrophils are one of the key cells that actively participate in the innate immune reactions. Sequences of event of pathogen elimination by neutrophils are initiated with the activation of resting neutrophils. Pathogen is then eliminated by oxygen-dependent killing mechanism or oxygen-independent killing mechanism. This process includes margination, diapedesis, chemotaxis, phagocytosis and degranulation of neutrophils. Although, these mechanisms of the neutrophils are targeted to eliminate the pathogens and protect the body, …
Published in Research and Reviews : A Journal of Immunology · Vol. 6, Issue 1, 2016 · pp. 32–48 Read article
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Nasal Medication Conveyance Framework: An Approach for Brain Delivery from Essential to Cutting Edge
Abstract: For the past few years, nasal drug delivery has provided attractive niche to the formulation scientists. It is the first choice as targeted drug delivery when one requires it for brain targeting. In addition, absorption of drug at the olfactory region of the nose provides a potential for a pharmaceutical compound to be available to the central nervous system. The nasal delivery of vaccines is another very attractive application in …
Published in Research and Reviews: A Journal of Medicine · Vol. 6, Issue 1, 2016 · pp. 14–27 Read article
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An Overview on the Management cum Treatment of Nephropathy in Type-1 Diabetes Mellitus
Abstract: The motive of this review is to keep updated with the medical nonfictions, the projected early natural arrangement of diabetic nephropathy, the theories behind the root of its pathogenesis pathophysiology, diagnosis and its supervision. Type 1 diabetes is an autoimmune disease characterized by advanced destruction of pancreatic beta cells by genetic and environmental factors which primes to an absolute necessity of insulin for survival and conservation of health; while Diabetic …
Published in Research and Reviews : A Journal of Medical Science and Technology · Vol. 9, Issue 3, 2020 · pp. 19–38 Read article
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A Review Drug and Biochemical Pharmacology Discovery
Abstract: The development of new therapeutic approaches and our understanding of disease mechanisms have both benefited ground-breaking medications as they are advanced and show the value of contemporary technologies, methodologies, and genetics in drug discovery. The synthesis, design, and application of these molecules have become a focal point in drug discovery efforts. The present research paper provided a comprehensive study of the recent developments in the field of biochemical pharmacology and …
Published in Research and Reviews : A Journal of Medical Science and Technology · Vol. 12, Issue 3, 2024 · pp. 27–31 Read article
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Are the Words in the Lexicon arranged in a pattern?
Abstract: Words are arranged in a specific pattern in the lexicon. The lexical arrangement is studied by employing a word association task. Each stimulus is known to elicit different kind of responses including taxonomic responses (which includes a response belonging to the same category), thematic (which includes a response common to the same theme as the target word). The lexical semantic organization would vary as a function of stimulus type, The …
Published in Research and Reviews: A Journal of Neuroscience · Vol. 9, Issue 1, 2019 · pp. 19–23 Read article
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A Short Review on Mucormycosis/Black fungus
Abstract: The present article provides an outline regarding the mucormycosis, an angio invasive infection and an opportunistic condition with fungal infection that mainly targets the people who are with weaker immunity unable to fight with environmental pathogens due to other health related problems and people who are on long term medication and the present paper has been covered with all the information regarding the Predisposing factors, suspected diseased conditions, Targeted organs/tissues …
Published in Research and Reviews: Journal of Oncology and Hematology · Vol. 10, Issue 1, 2021 · pp. 12–15 Read article
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Graph Neural Networks for Molecular Scale Property Prediction and Inverse Design of Thermoset Polymer Nanocomposites: A Computational Framework
Abstract: Thermoset polymer nanocomposites exhibit properties that are highly sensitive to molecular scale formulation decisions, yet the vast design space remains largely unexplored because of the high cost of experimental characterisation and fully atomistic simulation. This paper presents TNC GNN, a dual mode graph neural network framework developed for the computational design of thermoset nanocomposite formulations. The forward module employs an attention augmented Message Passing Neural Network with 3D geometric encoding …
Published in Journal of Polymer & Composites · Vol. 14, Issue 4, 2026 Read article
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CRISPR-Based Enhancement of Secondary Metabolites in Artemisia annua: Focus on Artemisinin Biosynthesis
Abstract: Medicinal plants are natural biofactories producing secondary metabolites with significant therapeutic value, including terpenoids, alkaloids, and phenolics. Among these, artemisinin, a sesquiterpene lactone from Artemisia annua L. is the cornerstone of global antimalarial therapy along with additional anticancer, antiviral, and antimicrobial activities. However, artemisinin content in the native plants is inherently low (typically 0.01–0.8% dry weight), restricting affordable and consistent supply. Conventional approaches to increase production include classical breeding, singlegene …
Published in Research and Reviews : A Journal of Biotechnology · Vol. 16, Issue 2, 2026 · pp. 23–35 Read article
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Intelligent Paradigms in Subsea Connectivity: A Comprehensive Review of Artificial Intelligence in Underwater Communications
Abstract: Underwater wireless communication (UWC) plays a critical role in ocean exploration, environmental monitoring, offshore energy operations, disaster management, and naval defense. However, the underwater environment presents significant communication challenges, including severe signal attenuation, multipath propagation, Doppler effects, limited bandwidth, high latency, and energy constraints. Recent advancements in Artificial Intelligence (AI) and Machine Learning (ML) have emerged as promising solutions to address these limitations and enhance the efficiency, reliability, and adaptability …
Published in Journal of Artificial Intelligence Research & Advances · Vol. 13, Issue 3, 2025 Read article
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Personalization in E-Commerce and Its Impact on Customer Satisfaction
Abstract: In e-commerce, personalization is the process of customizing online shopping experiences based on each customer’s preferences, past purchases, and behavior. E-commerce platforms are increasingly using tailored content, targeted ads, and personalized recommendations to improve the user experience due to the rapid development of digital technologies and data analytics. Providing customers with pertinent goods and services is the primary goal of personalization, which increases convenience and engagement. By improving the efficiency …
Published in E-Commerce for Future & Trends · Vol. 13, Issue 2, 2026 · pp. 33–44 Read article
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Surveillance Patrol Robot for People Tracking in Indoor Environments
Abstract: There is a great challenge that a mobile robot reliably and continuously tracks a specific person in indoor environments. In this paper, a novel method is presented, which can effectively recognize and reliably track a target person based on mobile robot vision. Such a robot is equipped with a camera which senses a moving object and starts tracking the object. The on-board camera develops a computer vision system for detection …
Published in Journal of Advancements in Robotics · Vol. 1, Issue 3, 2014 · pp. 17–23 Read article
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Active Vision Approach for Controlling Educational Robotic Arm with Autonomous Object Manipulation
Abstract: This research presents an autonomous robotic framework for academic, vocational and training purpose. The platform is centred on a six-degree-of-freedom (DOF) serial robotic arm. Two on-board cameras developed a computer vision system for detection and autonomous object/target manipulation placed randomly on a target surface and controlling an educational robotic arm (ERA) to pick it up and move it to a predefined destination. Force sensitive resistor (FSR) has been used as …
Published in Journal of Advancements in Robotics · Vol. 1, Issue 3, 2014 · pp. 1–10 Read article
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SQL Injection: A Hazard to Databases Security via Web Application
Abstract: Databases are the first target of the hackers. Weak authentication is one of biggest reason for which we lose our confidential data. We usually share our sensitive information such as debit/credit card numbers, SSN etc. without caring for the fact that when our system will interact in the internet through the WWW environment, huge amount of data is being created which may have user’s personal information. It may cause a …
Published in Journal of Advanced Database Management & Systems · Vol. 3, Issue 1, 2016 · pp. 30–36 Read article
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A Steady on Quality Update in New Austrian Tunneling Method (NATM) Technology for Safe Underground Shortest Path in Road Transportation Networks
Abstract: Metro train project is a combination of many related engineering fields as civil engineering, computer engineering, mechanical engineering and electrical engineering etc. But here, we discus about civil engineering and computer engineering related project report. Firstly we start from railway track/road. A railway track network can be considered as a graph (a graph is an ordered pair G=(V, E) comprising a set V of vertices or nodes or points together …
Published in Journal of Open Source Developments · Vol. 3, Issue 2, 2016 · pp. 20–26 Read article
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GPS and GSM Based VTS Using Web Based Mapping Application
Abstract: AbstractNowadays GPS is used in large number of applications. One of the applications is tracking vehicles and getting exact locations of your vehicles. This tracking system is used to get you the location and route traveled by the vehicle, and that information can be observed from any other remote location. It also includes the use of web application, generally a mapping application that provides you exact location of target by …
Published in Journal of Software Engineering Tools & Technology Trends · Vol. 3, Issue 3, 2016 · pp. 18–21 Read article