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1365 articles for “Target”
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The Renaissance and Resilience of CB1 Reverse Agonists: From Central Liabilities to Peripheral Promise
Abstract: Building upon these foundational insights, current research has increasingly focused on refining the pharmacological profile of CB1 reverse agonists to maximize therapeutic benefit while minimizing central adverse effects. The adverse neuropsychiatric outcomes associated with first-generation agents such as Rimonabant including anxiety, depression, and suicidal ideation highlighted the critical role of central CB1 receptors in mood regulation. Consequently, drug development strategies have shifted toward peripherally restricted CB1 reverse agonists that exhibit …
Published in International Journal of Cheminformatics · Vol. 4, Issue 1, 2026 · pp. 30–35 Read article
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Molecular Dynamics and Therapeutic Architectures of Cannabinoid Receptors: A Comprehensive Review
Abstract: Expanding on these foundations, recent structural biology studies using cryo-electron microscopy have provided high-resolution insights into the conformational dynamics of CB₁ and CB₂ receptors. These findings have enabled a more precise understanding of ligand–receptor interactions, particularly how agonists, antagonists, and reverse agonists stabilize distinct receptor states. Such knowledge is critical for rational drug design, allowing researchers to selectively modulate downstream signaling pathways. For instance, CB₁ receptors primarily couple to Gi/o …
Published in International Journal of Cheminformatics · Vol. 4, Issue 1, 2026 · pp. 36–40 Read article
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Circadian Regulation of Lipid Peroxidation in the Brain: Linking Ferroptosis to Neurodegenerative Vulnerability
Abstract: The human brain operates through highly coordinated physiological and biochemical processes that regulate cognition, behavior, and neural adaptability. Central to these processes are mechanisms governing brain function, neurophysiology, and neuroplasticity, which are increasingly recognized to be influenced by circadian rhythms. Recent advances in cognitive neuroscience, neuroimaging, and behavioral neuroscience have revealed that disruptions in circadian regulation can significantly impact oxidative balance within the brain, particularly through enhanced lipid peroxidation. Lipid …
Published in International Journal of Brain Sciences · Vol. 3, Issue 2, 2026 · pp. 1–14 Read article
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Nutrient Sensing and Microbiota Crosstalk: Driving Determinants Shaping Metabolic Stability and Adaptive Physiology for Animal Health
Abstract: Nutrient sensing is a fundamental cellular process that enables animals to adapt to fluctuating dietary inputs while maintaining metabolic homeostasis and health. Recent advances reveal that the gut microbiota functions as an active metabolic partner, producing bioactive metabolites that directly influence host nutrient-sensing pathways and downstream cellular responses. This review synthesizes current knowledge on the integration of key signalling networks, including adenosine monophosphate activated protein kinase (AMPK), mechanistic target of …
Published in International Journal of Molecular Biotechnological Research · Vol. 4, Issue 2, 2026 Read article
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Gene Edited Livestock for Enhanced Feed Efficiency and Metabolic Adaptation Through Precision Genomic Interventions
Abstract: Advances in gene editing technologies have transformed the landscape of livestock production by enabling precise manipulation of genetic material associated with productivity, health, and environmental adaptability. Tools such as CRISPR Cas9 and emerging next generation editors allow targeted modifications that improve feed efficiency, growth performance, nutrient utilization, and stress tolerance in farm animals. This review highlights the genetic basis of feed efficiency and metabolic regulation, focusing on key genes and …
Published in Research and Reviews : A Journal of Biotechnology · Vol. 16, Issue 2, 2026 · pp. 1–10 Read article
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Molecular Docking, QSAR Modeling, and ADMET Evaluation of Novel Pyrazolo-Pyrimidine Derivatives as Potential CDK-2 Inhibitors for Cancer Therapy
Abstract: Cyclin-dependent kinase-2 (CDK-2) is an essential regulator in cell cycle progression and is an important therapeutic target in cancer drug development. In the present study, an integrated computational approach involving molecular docking studies, QSAR modeling, ADMET prediction, and artificial intelligence-based analysis was used to identify pyrazolo-pyrimidine derivatives as potential CDK-2 inhibitors. Based on the molecular docking results, it was found that selected compounds exhibited high binding affinity towards the ATP …
Published in Research and Reviews: A Journal of Pharmacology · Vol. 16, Issue 2, 2026 Read article
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Phosphorescence of Carbon Nanodots – The Phenomena and the Applications
Abstract: Photoluminescence has emerged as a fundamental phenomenon in modern biomedical science, enabling advanced diagnostic, therapeutic, and theranostic applications through light–matter interactions at the nanoscale. The ability of photoluminescent materials to absorb electromagnetic radiation and emit light at distinct wavelengths has been widely exploited in bioimaging, biosensing, drug delivery tracking, and photodynamic therapy. Among various photoluminescent nanomaterials, carbon nanodots have attracted significant attention due to their strong emission intensity, tunable fluorescence, …
Published in International Journal of Photochemistry and Photochemical Research · Vol. 4, Issue 1, 2026 · pp. 01–05 Read article
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RNA- Based Drug Delivery, Current Advances, Pharmaceutical Applications, and Future Perspectives
Abstract: RNA-based therapeutics have emerged as a transformative approach in modern medicine due to their ability to regulate gene expression with high specificity and precision. Advances in molecular biology, RNA chemistry, and nanotechnology have accelerated the development of diverse RNA modalities, including messenger RNA (mRNA), small interfering RNA (siRNA), microRNA (miRNA), antisense oligonucleotides (ASOs), and RNA aptamers. These therapeutics offer promising strategies for the treatment of cancer, genetic disorders, infectious diseases, …
Published in Research & Reviews: A Journal of Drug Design & Discovery · Vol. 13, Issue 2, 2026 · pp. 27–41 Read article
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Overcoming Obstacles to an HIV-1 Cure: Advances in Genome Editing, Immune System Reprogramming, and Viral Reservoir Elimination
Abstract: Human immunodeficiency virus type-1 (HIV-1) continues to represent a major global health challenge despite the remarkable success of antiretroviral therapy (ART). Although ART effectively suppresses viral replication and prolongs survival, it cannot eradicate the virus due to the persistence of long-lived latent reservoirs. In recent years, innovative therapeutic strategies have been explored with the aim of achieving either a functional remission or complete viral elimination. Advances in genome-editing technologies, particularly …
Published in International Journal of Virus Studies · Vol. 3, Issue 2, 2026 Read article
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Toxicological Profiling and Safety Assessment of NASAT 2.0: A Conceptual Framework for Adaptive Nanoparticle Therapy in Rabies
Abstract: Rabies, caused by the highly neurotropic Rabies lyssavirus, remains one of the most enigmatic and universally lethal infectious diseases known to modern medicine. Once clinical symptoms manifest following successful neuroinvasion, the fatality rate approaches absolute certainty (approximately 99.9%), a staggering statistic that has remained largely unchallenged despite massive, concurrent advances in modern virology, critical care medicine, and cellular immunology. Current late-stage therapeutic protocols, most notably the widely debated Milwaukee Protocol, …
Published in Research and Reviews: A Journal of Toxicology · Vol. 16, Issue 2, 2026 · pp. 1–19 Read article
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Constrained Online Non Negative Matrix Factorization (CONMF) for Visual Tracking
Abstract: Visual tracking is the process of locating a moving object (or multiple objects) over time using a camera. It is one of the most important components in numerous applications such as military, secure control, crime prevention systems, access control and biometric identification etc. of computer vision. In visual tracking, holistic and part-based representations are both popular choices to model target appearance. The former is known for great efficiency and convenience …
Published in Current Trends in Signal Processing · Vol. 7, Issue 1, 2017 · pp. 8–18 Read article
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Heterogeneous Teleoperation Model for Controlling 3D Printed Humanoid Robot Arm with 5 DOF using 3 DOF Exoskeleton
Abstract: The main objectives of the present work are to model and implement a control system of five degrees of freedom (5 DOF) humanoid arm by using an exoskeleton system with 3 DOF. The exoskeleton system is used to transport the movements of the human’s arm to the controller to control the humanoid arm by using sensors at each target joint to measure the angular displacement of it. To achieve this …
Published in Journal of Control & Instrumentation · Vol. 10, Issue 2, 2019 · pp. 1–15 Read article
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Bioenergy and Biomass Conversion for Sustainable Energy Production
Abstract: This study delves deeply into the essential role that bioenergy derived from biomass conversion plays in achieving sustainable energy production. The primary aims of this research encompass exploring a diverse range of biomass resources, and their availability, evaluating different biomass conversion technologies (including both thermochemical and biochemical processes), analyzing the sustainability of these conversion methods, and elucidating their significant contribution towards realizing renewable energy targets. This investigation relies on an …
Published in Journal of Energy, Environment & Carbon Credits · Vol. 13, Issue 2, 2023 · pp. 1–16 Read article
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THE FACTORS THAT SHOULD INFLUENCE THE EFFECTIVENESS OF POVERTY ALLEVIATION PROGRAMS ACROSS THE GLOBE
Abstract: World is in a state of a long fight with poverty since technology advancement’s and automation came into existence, various policies and poverty alleviation programs mutually by many of the governing governments and policymakers have been put in place with the goal to eradicate poverty which however they have not yielded the expected result. The goal of this qualitative study was to investigate the claim by beneficiaries & policy lawmakers …
Published in Journal of Production Research & Management · Vol. 8, Issue 3, 2018 · pp. 1–9 Read article
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Efficient Analysis and Minimization of Glitches using Threshold Swapped Combinational Clock Gating
Abstract: Nowadays design of electronic circuits to meet requirements like high speed, better functionality and low power is a tedious task. Power dissipation in any circuit comprises mainly two components: static power and dynamic power. The dynamic power heavily depends on the switching activity of the circuit. During the transistor switching transitions some spikes may occur, which are called as glitches. These glitches contribute 20–70% of the dynamic power and 20% …
Published in Journal of VLSI Design Tools and Technology · Vol. 5, Issue 2, 2015 · pp. 29–37 Read article
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MODELING EARLY COMPRESSIVE STRENGTH OF CONCRETE PARTIALLY REPLACED WITH HETEROGENEOUS PALM KERNEL SHELL INFLUENCED BY VOID RATIO AND PERMEABILITY
Abstract: The study monitored the partial replacement of palm kernel shell as an aggregate for concrete production, this was carried out using modelling and simulation techniques, such condition were applied to determine other parameters that their significance impact may have not determined its growth rates in terms of compressive strength. The study observed the void and permeability of the material, including heterogeneity, to influence the increase and decrease of compressive growth …
Published in Recent Trends in Civil Engineering & Technology · Vol. 13, Issue 3, 2023 · pp. 24–38 Read article
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Modern perspectives on composite armor
Abstract: This article is study of garment oriented schemes to learn composite armor. Bulletproof armor has been developed to protect humans from destructive weapon. Assess has been to develop low-cost, easy in fabricate originated easy wearable biocompatible bulletproof garment. Suggestive estimation has scriptive issued competence between variations in plate thickness and amount of energy absorbed by lamination of armor. Henceforth, observation has been 12mm thickness of composite plate lying to be …
Published in Trends in Machine design · Vol. 8, Issue 3, 2021 · pp. 14–20 Read article
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Clustering based Model to Provide Defense against DDoS attacks in MANETs
Abstract: AbstractSecurity of MANETs is the part of extensive issue of research in past years. MANET is liable to DDoS attacks because of its no fixed infrastructure, changing topology, open medium, cooperative and trust-based algorithms and absence of a well-defined line of defense. DDoS attack is a synchronized attack created by attackers to overflow the target network with big quantity of information in the form of packets such that the resources …
Published in Journal of Communication Engineering & Systems · Vol. 9, Issue 1, 2019 · pp. 7–13 Read article
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Power Estimation Approach for Artix 7 FPGA using Machine Learning Technique
Abstract: Abstract This paper presents the power estimation approach using a suitable machine learning technique. Artix7 FPGA has been chosen as the target FPGA (Field Programmable Gate Arrays) platform for understanding the methodology of power estimation. There are various approaches of power estimation for FPGAs that have been given in the literature viz. probabilistic, statistical, and LUT-based, etc. In the past few years, the demand for hand-handled devices like smartphones, tabs, …
Published in Research & Reviews: A Journal of Embedded System & Applications · Vol. 9, Issue 1, 2021 · pp. 1–5 Read article
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The Contextual Effect of Vowels on Correct Production of Retroflex in Kannada Speaking Children with Speech Sound Disorder: A Case Study
Abstract: Contextual based interaction of speech sounds, coarticulation, is the main component of intelligible continuous speech. This interaction between speech sounds within and across the words is affected in children with speech sound disorders (SSD). Literature reports on certain contexts facilitating the production of different speech sounds. Thus, these contextual considerations are vital for the selection of target stimuli during articulation therapy for faster learning. As phonotactics and coarticulation are language …
Published in Research and Reviews : Journal of Computational Biology · Vol. 7, Issue 2, 2018 · pp. 46–66 Read article