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412 articles for “PKA/CREB pathway”
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Marine Fungi – An Expandable Source for Production of Novel Bioactive Metabolites: A Comprehensive Review
Abstract: The marine environment, representing the largest and most extreme biome on Earth, serves as an unparalleled reservoir of biodiversity. Within this vast ecosystem, marine fungi have emerged as a prolific source of structurally diverse and pharmacologically active secondary metabolites. Dwelling in habitats characterized by extreme high salinity, high hydrostatic pressure, and low temperatures, these microorganisms have evolved unique biochemical and metabolic pathways to synthesize novel compounds, including pyrrole-imidazole alkaloids, cyclic …
Published in International Journal of Fungi · Vol. 3, Issue 1, 2026 · pp. 30–37 Read article
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Bridging the Gap Between Product Development and Entrepreneurship in Engineering Curriculum: A Framework-Based Approach Aligned with NEP 2020
Abstract: Despite advancements in technical education, Indian engineering graduates frequently enter the workforce lacking critical competencies in product development (PD) and entrepreneurship. This imbalance has drawn scrutiny from industry and policymakers alike, with national directives such as the National Education Policy (NEP 2020) emphasizing a shift toward “experiential, holistic, integrated and inquiry-driven” learning models. Similarly, the All-India Council for Technical Education (AICTE) has embedded innovation labs, internship mandates and entrepreneurship courses …
Published in International Journal of Education Sciences · Vol. 3, Issue 1, 2026 · pp. 87–100 Read article
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Marine Microbial Ecology: A Comprehensive Review of Interactions, Symbiosis, and Bioprospecting.
Abstract: Marine microorganisms constitute the largest and most dynamic fraction of Earth's biodiversity, governing vital ecosystem functions ranging from global biogeochemical cycling to host-specific symbiotic associations. This review provides a comprehensive synthesis of the complex interaction networks within marine microbial communities. We first explore the theoretical foundations of microbial niche construction and evolutionary dynamics in the ocean. Subsequent sections dissect micro-scale interactions within the phycosphere, where chemical gradients dictate cross-kingdom mutualisms …
Published in International Journal of Marine Life · Vol. 3, Issue 1, 2026 · pp. 6–16 Read article
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Damage Evolution and Delamination Resistance in Polymer Matrix Functionally Graded Laminates
Abstract: Functionally graded laminates (FGLs) in polymer-matrix systems represent a promising pathway to enhance damage tolerance and delay delamination in advanced structural composites. In this study, we explore the mechanisms of damage initiation, propagation, and delamination resistance in polymer matrix functionally graded laminates (PM-FGLs) through a combined experimental–computational approach. Laminates with linear, exponential, and bio-inspired gradation profiles were fabricated using vacuum-assisted resin transfer molding (VARTM) and additive manufacturing techniques. Comprehensive mechanical …
Published in Journal of Polymer & Composites · Vol. 14, Issue 2, 2026 · pp. 321–337 Read article
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A Review on Evolution of Aircraft Fuselage Materials: From Wood to Composites & Functionally Graded Materials
Abstract: This article presents a comprehensive overview of the evolution of materials for construction of aircraft fuselages, with a focus on the expanding use of polymer composites and functionally graded materials (FGMs) in modern aerostructures. The baseline fuselage design is thought to be from wood, to be followed by metallic systems such as aluminum, titanium, and nickel alloys. All systems improved manufacturability, strength, and longevity, but there was a substantial revolution …
Published in Journal of Polymer & Composites · Vol. 14, Issue 2, 2026 · pp. 447–455 Read article
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Exploring the Intersection of AI Network Pharmacology and Ayurveda: Innovations in Traditional Medicine
Abstract: Integrative frameworks that integrate traditional medicine and modern computer research are increasingly important for advancing evidence-based, individualized healthcare. One interesting strategy is the combination of Ayurveda, network pharmacology, and artificial intelligence (AI). AI expands the capability by allowing for the quick analysis of biomedical big data, the identification of therapeutic trends, and the optimization of treatment plans. Ayurveda, with its long-standing emphasis on individualized care, holistic balance, and natural remedies, …
Published in Journal of AYUSH: Ayurveda, Yoga, Unani, Siddha and Homeopathy · Vol. 14, Issue 3, 2025 · pp. 92–98 Read article
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Mapping A Contextualized Southern Africa's Innovation Ecosystem: The Emerging Role of Higher Education in Promoting Inclusive Innovation and Rural Industrialization
Abstract: Higher education institutions (HEIs) are increasingly recognized as strategic actors in shaping innovation ecosystems that can respond to persistent socio-economic inequalities in the Global South. In Southern Africa, where rural underdevelopment, youth unemployment, weak industrial bases, and uneven innovation capacities remain pressing concerns, universities are under growing pressure to move beyond their traditional teaching and research mandates and contribute more directly to inclusive development. This paper examines the emerging role …
Published in International Journal of Rural and Regional Development · Vol. 4, Issue 1, 2026 · pp. 14–27 Read article
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Sustainable Architecture for Rural Communities: The Tanzanian Family House Model
Abstract: Sustainable rural housing in East Africa must respond simultaneously to climatic stress, water scarcity, sanitation challenges, and socio-cultural practices. This article presents the Tanzanian Family House as a climate-responsive and resource-efficient housing model developed specifically for rural Tanzanian communities. The project integrates low embodied energy materials, passive environmental strategies, and decentralized infrastructure systems to create a durable and culturally grounded dwelling that can be constructed using local skills and materials. …
Published in International Journal of Rural and Regional Development · Vol. 4, Issue 1, 2026 · pp. 1–12 Read article
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Atmospheric Determinants of Feed, Fodder, and Forage Contamination in a Changing Climate: Emerging Challenges for Sustainable Livestock Production
Abstract: Feed, fodder, and forage contamination represents a growing constraint to sustainable livestock production under a changing climate. Atmospheric determinants such as rising temperature, altered precipitation patterns, increased humidity, elevated carbon dioxide concentration, and enhanced aerosol and pollutant loads are increasingly recognized as critical drivers of contamination risks across feed supply chains. These atmospheric factors directly and indirectly influence crop growth, fungal proliferation, mycotoxin biosynthesis, microbial survival, and the deposition of …
Published in International Journal of Atmosphere · Vol. 3, Issue 1, 2026 · pp. 1–14 Read article
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Corn Husk Fiber–Reinforced PLA Biocomposites: Mechanical, Thermal, and Biodegradation Performance
Abstract: The increasing environmental burden caused by conventional petroleum-based plastics has driven significant interest in the development of sustainable polymer composites reinforced with renewable natural fibers. In the present work, corn husk fiber (CHF), an agricultural waste by-product, was utilized as a reinforcing phase in a polylactic acid (PLA) matrix to fabricate eco-friendly biocomposites. Composite samples with varying fiber loadings (0–40 wt.%) were produced through twin-screw melt blending followed by compression …
Published in Journal of Polymer & Composites · Vol. 14, Issue 2, 2026 · pp. 312–327 Read article
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AI-Enabled Optimization of Additively Manufactured Composite Materials for Enhanced Mechanical and Thermal Performance
Abstract: This paper discusses the optimization of multi-objective optimization of enhanced coupling of heat and mechanical properties of 3D printed polymer composite materials by artificial intelligence (AI), as a component of a multi-objective optimization framework. It aims at development of nonlinear printing parameters and material properties relationships to achieve maximum tensile strength and thermal conductivity in polymer composites produced through fused deposition modeling (FDM). Short carbon fiber reinforcement was used to …
Published in Journal of Polymer & Composites · Vol. 14, Issue 2, 2026 · pp. 867–891 Read article
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Deep Learning for Real-Time Monitoring and Defect Detection in Additive Manufactured Polymer Composites
Abstract: Additives Fiber-reinforced polymer composite ADDs have high utility in making lightweight structural components, but due to process-related defects (interlayer delamination and reinforcement stacking) the integrity of consolidation during extrusion-based deposition is frequently compromised. This paper has presented a physics-informed deep learning framework that is applicable to real-time measurements of reinforced thermoplastic composite fabrication. Multimodal sensing was provided with thermal gradient, optical morphology, and acoustics emission signals being used to assess …
Published in Journal of Polymer & Composites · Vol. 14, Issue 2, 2026 · pp. 974–999 Read article
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AI-Driven Prediction of Square-Hole Laser Trepanning Performance in AA7075/15%SiC/15% Glass Fiber Hybrid Composites Using Taguchi–ANOVA and Deep Neural Networks
Abstract: Hybrid AA7075 composites reinforced with 15% silicon carbide (SiC) and 15% glass fiber were fabricated via the stir casting technique to improve machining and structural performance. The addition of dual reinforcements into the aluminum matrix was aimed at enhancing hardness, thermal stability, and surface quality during non-traditional drilling operations. Square-hole drilling was performed using a laser trepanning process, and the key responses—hole size accuracy, surface roughness, and taper angle—were systematically …
Published in Journal of Polymer & Composites · Vol. 14, Issue 1, 2026 · pp. 1932–1943 Read article
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Renewable-Powered HVAC Systems: Advances in Solar, Bioenergy, and Heat Pump Technologies
Abstract: The global demand for refrigeration, air conditioning, heating, and ventilation (HVAC) systems has increased rapidly due to population growth, urbanization, industrialization, and rising expectations for indoor thermal comfort. These systems account for a substantial share of global energy consumption and greenhouse gas emissions, primarily because they rely heavily on fossil-fuel-based electricity and thermal energy. Consequently, the decarbonization of HVAC and refrigeration sectors has become a critical component of global climate …
Published in Journal of Refrigeration, Air conditioning, Heating and ventilation · Vol. 13, Issue 1, 2026 · pp. 26–33 Read article
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Comparative Study of Structural and Optical Properties of Bismuth Ferrite Nanoparticles for Photovoltaic Applications Synthesized via Different Sol-Gel Methods
Abstract: Pure multiferroic bismuth ferrite (BiFeO3) nanoparticles were successfully synthesized using an energy-efficient, low-temperature sol-gel method, comparing two distinct approaches: auto-combustion and non-auto-combustion. To ensure phase stability, the precursor solution's pH was strictly maintained between 1 and 2 using ammonia solution (NH4OH), while ethylene glycol (C2H6O2) was employed as a chelating agent for the Fe3+ and Bi3+ cations. All samples underwent a final annealing process at 500 °C to promote crystallization. …
Published in Journal of Materials & Metallurgical Engineering · Vol. 16, Issue 1, 2026 · pp. 83–94 Read article
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Nutrient–Xenobiotic Crosstalk in Dairy Cattle: Implications for Metabolism, Immunity, Health, and Productivity in Resilient Dairy Development
Abstract: Dairy cattle are routinely exposed to a wide range of xenobiotics, including mycotoxins, heavy metals, pesticides, residues from veterinary drugs, and plant secondary metabolites, through feed, water, and environmental sources. These xenobiotics, being foreign to biological systems, can interfere with the absorption, metabolism, and utilization of essential nutrients, while also compromising immune function, organ health, and overall physiological performance. Chronic or subclinical exposure can reduce feed efficiency, disrupt energy and …
Published in Research and Reviews: A Journal of Neuroscience · Vol. 16, Issue 1, 2026 · pp. 37–46 Read article
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Thermo–Electrical Performance Enhancement of a Lightweight Polymer–Metal Hybrid Electrostatic Precipitator Using Epoxy-Based Composite Housing for Industrial Particulate Control
Abstract: Airborne particulate emissions, particularly PM₁₀ and PM₂.₅ produced by industrial activities and combustion processes, they continue to pose a significant threat to both the environment and public health. Electrostatic precipitators (ESPs) are widely recognized for their ability to achieve high collection efficiencies; however, conventional metallic constructions often lead to increased system weight, higher fabrication costs, and long-term corrosion-related challenges. In this study, a lightweight hybrid material approach is proposed by …
Published in Journal of Polymer & Composites · Vol. 14, Issue 2, 2026 · pp. 652–668 Read article
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Metagenome-Informed Engineering of Monoclonal Antibodies: Mining Microbial Immunoglobulin-Like Domains for Ultra-Stable Therapeutics
Abstract: Metagenome-informed engineering represents an emerging strategy for improving the stability and functionality of monoclonal antibodies (mAbs) by leveraging the vast diversity of microbial immunoglobulin-like (Ig-like) domains (10,24). These domains, derived from uncultured bacteria and bacteriophages, exhibit exceptional thermostability, protease resistance, and structural resilience due to adaptation to extreme environments (29,30). This review highlights advances in metagenomic mining, structural characterization, and protein engineering that enable the integration of microbial Ig-like scaffolds …
Published in Research and Reviews : A Journal of Biotechnology · Vol. 16, Issue 1, 2026 Read article
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Looking into new ideas in green chemistry
Abstract: Green chemistry has become a revolutionary way to change chemical processes such that they have less of an effect on the environment while still being efficient and cost-effective. This article looks at new developments in green chemistry that go beyond small changes and offer completely new ways to build chemicals that are good for the environment. There is a lot of focus on innovative catalytic systems, sustainable feedstocks, reaction pathways …
Published in Journal of Modern Chemistry & Chemical Technology · Vol. 17, Issue 1, 2026 · pp. 10–18 Read article
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Early Life Nutrition as a Determinant of Long-Term Vaccine Immunogenicity in Livestock: Mechanisms, Practical Strategies, and Species-Specific Considerations
Abstract: Early life represents a critical period for immune system development in livestock, during which nutritional exposures can exert long lasting effects on vaccine immunogenicity. Although vaccination is a cornerstone of infectious disease control in food producing animals, marked variability in vaccine induced immune responses is frequently observed under commercial conditions. Growing evidence suggests that this variability is partly driven by differences in early nutritional status, which can influence immune maturation, …
Published in International Journal of Vaccines · Vol. 3, Issue 1, 2026 · pp. 15–26 Read article