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543 articles for “(DoS)”
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Dasatinib Induced Pulmonary Hypertension
Abstract: Dasatinib (Das) is a second-generation tyrosine kinase inhibitor that is used in the treatment of chronic myelogenous leukemia (CML) in patients who are resistant or intolerant to imatinib, as well as in Philadelphia chromosome-positive acute lymphoblastic leukemia (Ph+ ALL) patients. Dasatinib-induced pulmonary arterial hypertension (PAH) is a known but rare adverse effect of dasatinib and is grouped under Group-1 PAH. The mechanism of PAH development is not fully known, but …
Published in Research and Reviews: A Journal of Pharmacology · Vol. 14, Issue 3, 2024 · pp. 92–95 Read article
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Advancing Capsule Technology: A Comprehensive Review of Formulation Strategies
Abstract: Capsules are a popular and versatile oral dosage form used in drug delivery, offering benefits such as ease of swallowing, taste masking, and improved stability of active pharmaceutical ingredients (APIs). They can be made from gelatin or non-gelatin materials like Hydroxypropyl Methylcellulose (HPMC), Polyvinyl Alcohol (PVA), and starch, catering to dietary, cultural, and sustainability needs. Capsules can be engineered for controlled, sustained, or targeted release, enhancing bioavailability, particularly for poorly …
Published in International Journal of Antibiotics · Vol. 2, Issue 1, 2025 · pp. 44–56 Read article
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Herbal Frontiers: The Role of Alternative Remedies in Combating Typhoid Fevers
Abstract: Typhoid fever, caused by Salmonella typhi, remains a major health challenge, particularly in developing regions where sanitation and healthcare resources are limited. With an estimated global incidence of 17 million cases annually, the disease poses a significant public health burden. The growing resistance to conventional antibiotics, such as fluoroquinolones and third-generation cephalosporins, exacerbates treatment challenges. This has spurred interest in alternative remedies, including herbal and homeopathic treatments.Herbal medicine offers a …
Published in Recent Trends in Infectious Diseases · Vol. 2, Issue 1, 2025 Read article
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Impact of Polypropylene Fibres on the Properties of Concrete
Abstract: This review paper explores the effects of polypropylene fibres on the mechanical and structural properties of concrete. The integration of short, discontinuous fibres into plain concrete enhances its post-cracking behavior and overall performance, with notable improvements in tensile strength, fracture strength, toughness, impact resistance, and flexural strength. These fibres effectively control crack propagation, increase energy absorption, and improve durability under varying loading conditions. A comprehensive analysis of prior research highlights …
Published in Journal of Construction Engineering, Technology & Management · Vol. 14, Issue 3, 2024 · pp. 55–60 Read article
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Review on Clinical Safety and Efficacy of Giant Calotropis in the 21st Century
Abstract: Calotropis gigantea, a highly valued plant in traditional Indian pharmacology, has emerged as a promising candidate for therapeutic innovation. This review delves into the clinical safety and efficacy of C. gigantea in the 21st century, examining its historical use, phytochemical composition, and pharmacological properties. While traditional medicine has long utilized C. gigantea for various ailments, modern research has sought to validate these claims through scientific investigation. This review critically analyzes …
Published in Research and Reviews: A Journal of Pharmacology · Vol. 15, Issue 1, 2025 · pp. 26–34 Read article
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Comprehending and Managing Restless Leg Syndrome
Abstract: An need to move that arises during rest or is made worse by rest, that happens in the evening or at night, and that goes away or gets better with movement is the hallmark of restless legs syndrome (RLS), a frequent sensorimotor disease. The degree, frequency, and age of start of symptoms vary greatly; severe types can impair mood, quality of life, and sleep. Periodic leg movements are common in …
Published in Research and Reviews: A Journal of Neuroscience · Vol. 15, Issue 1, 2025 · pp. 1–6 Read article
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Formulation Development and Evaluation Technique for Immediate and Modified Release Capsule
Abstract: The development and evaluation of formulations for immediate-release (IR) and modified-release (MR) capsules represent a critical aspect of pharmaceutical dosage form design, offering distinct advantages in terms of drug release profiles and therapeutic outcomes. This study focuses on the formulation strategies, techniques, and evaluation methods used to develop both IR and MR capsules. Immediate-release capsules are designed to disintegrate quickly in the gastrointestinal tract, ensuring rapid drug absorption, while modified-release …
Published in International Journal of Biochemistry and Biomolecule Research · Vol. 3, Issue 1, 2025 · pp. 1–9 Read article
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Controlled Drug Delivery of Furosemides Using Floating Tablet System
Abstract: The development of gastroretentive drug delivery systems (GRDDS) has gained interest, particularly for drugs like furosemide with narrow absorption windows in the upper gastrointestinal (GI) tract. Furosemide, a commonly used diuretic, faces challenges due to limited bioavailability and rapid elimination, requiring frequent dosing and affecting patient compliance. This review highlights the formulation and evaluation of floating furosemide tablets as an effective strategy to enhance therapeutic efficacy. Floating tablets allow prolonged …
Published in International Journal of Membranes · Vol. 2, Issue 1, 2025 · pp. 23–31 Read article
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A Review on the Magical Plant : Shatavari (Asparagus racemosus)
Abstract: Shatavari (Asparagus racemosus) is a revered medicinal herb in Ayurveda, recognized for its diverse health benefits, particularly for women’s health. The chemical makeup, pharmacological characteristics, and therapeutic uses of shatavari are thoroughly examined in this review. Key active compounds include saponins, flavonoids, and phytoestrogens, which contribute to its adaptogenic, antioxidant, and hormone-regulating effects. These properties make Shatavari effective in addressing female reproductive issues, such as infertility, irregular menstrual cycles, and …
Published in Recent Trends in Cosmetics · Vol. 2, Issue 1, 2025 · pp. 32–43 Read article
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A Single Case Study on Ayurvedic Therapeutic Management for Increasing Growth Hormone in Pre-Pubertal Girl
Abstract: Human growth hormone, commonly referred to as HGH and somatotropin, is a naturally occurring hormone released by the pituitary gland that promotes growth in children by acting on various body regions. The pituitary gland produces the polypeptide hormone known as human growth hormone (hGH), or somatotropin, which is made up of 191 amino acids. A lack of human growth hormone (hGH) in children can result in growth failure, low stature …
Published in Journal of AYUSH: Ayurveda, Yoga, Unani, Siddha and Homeopathy · Vol. 14, Issue 1, 2025 Read article
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Personalized Medicines in Pharmaceutics: Drug Delivery System
Abstract: Pharmaceutics personalized medicine is a developing area that seeks to customize medical interventions for specific patients. Instead of a one-size-fits-all approach, personalized medicine focuses on developing treatments that consider a person’s unique characteristics, such as their genetic makeup, environment, and lifestyle. This allows for more effective treatment outcomes, as drugs are specifically designed to work best for each patient, reducing side effects and improving therapeutic results. In pharmaceutics, this involves …
Published in Emerging Trends in Personalized Medicines · Vol. 2, Issue 1, 2025 · pp. 11–22 Read article
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Molecular Mechanisms of Drug Metabolism in Anesthesia: A Pharmacogenomic Perspective
Abstract: Pharmacogenomics studies how a person’s genetic profile affects their reaction to drugs, which is vital in anesthesia. Anesthetic pharmacology depends significantly on drug metabolism, which involves complex biochemical processes that manage the absorption, distribution, metabolism, and excretion (ADME) of anesthetic drugs. The cytochrome P450 (CYP) enzyme family plays a critical role in the metabolism of various anesthetic drugs, with genetic polymorphisms leading to inter-individual variability in drug responses. Specific CYP …
Published in Research & Reviews: A Journal of Drug Formulation, Development and Production · Vol. 12, Issue 1, 2025 · pp. 90–95 Read article
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Pharmacogenomics in Anesthesia: Individualized Drug Responses
Abstract: Pharmacogenomics is the study of how a person’s genes influence how they react to medications. Pharmacology, the study of medications, and genomics, the examination of genes and their functions, merge in this field to develop safe, effective drugs that can be prescribed based on an individual’s genetic makeup. Pharmacogenomics examines how an individual’s unique genetic makeup can influence their responses to certain drugs. In anesthesia, where individual responses to pain …
Published in Research and Reviews: A Journal of Pharmacology · Vol. 15, Issue 1, 2025 · pp. 83–95 Read article
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Authentication of a Rapid RP-HPLC technique for Quantification of Remogliflozin and Metformin in Medicinal Formulations
Abstract: A new, precise, and stability-assessing advanced liquid chromatography (HPLC) technique for simultaneous quantification of Remogliflozin and Metformin in fixed dose pharmaceutical formulations was designed and verified. Optimization of the technique was carried out on flowing phase composed of ethanenitrile and buffer, under isocratic conditions, the resolution of peak being sharp with retention times of 3.24 min and 4.89 min for Remogliflozin and Metformin, respectively. Technology suitability was confirmed by the …
Published in Trends in Drug Delivery · Vol. 12, Issue 2, 2025 · pp. 70–77 Read article
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Review on Sustained Released Matrix Tablet
Abstract: Pharmaceuticals often use sustained release dose forms to prolong the therapeutic agent’s presence in the bloodstream and maintain a consistent plasma profile. The matrix governs the drug’s release rate. Hydroxypropyl methyl cellulose, a release retardant, is a key excipient in formulations due to its ability to promote sustained release. Techniques that include wet granulation, direct compression, or the dispersion of solid particles within a porous matrix, integrating polymers, like polymethyl …
Published in Trends in Drug Delivery · Vol. 12, Issue 2, 2025 · pp. 60–69 Read article
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Enhancing Mechanical and Thermal Performance of M30 Concrete with Carbon Fibre Reinforcement
Abstract: This study examines the influence of carbon fibre incorporation on the mechanical properties of M30-grade concrete. A series of experimental investigations were conducted to assess the effects of varying carbon fibre content on compressive, split tensile, and flexural strengths. The results indicate a significant enhancement in mechanical performance with the inclusion of carbon fibres, with the optimum fibre dosage identified as 0.75%. At this content, the concrete achieved a peak …
Published in Journal of Polymer & Composites · Vol. 13, Issue 3, 2025 · pp. 252–260 Read article
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A Study on the Impact of Paracetamol on Male Reproductive System: A Mini Review
Abstract: Paracetamol, a widely used analgesic and antipyretic, has been studied for its potential effects on the male reproductive system. Paracetamol is a medication commonly used to relieve mild to moderate pain. Research suggests that prolonged or high-dose use of paracetamol may adversely affect male fertility by disrupting hormone regulation, impairing sperm production, and reducing testosterone levels. Studies have shown that paracetamol can interfere with the hypothalamic-pituitary-gonadal axis, leading to changes …
Published in Research and Reviews: A Journal of Pharmacology · Vol. 15, Issue 2, 2025 · pp. 43–51 Read article
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Physical and Mechanical Properties of GGBS Based Geopolymer Concrete with the Inclusion of Metakaolin
Abstract: The use of ecologically friendly materials in the production of concrete is a significant and pertinent development in the global movement for sustainable construction. Geopolymer concrete (GPC) has gained popularity as an alternative to conventional Portland cement (OPC)-based concrete due to its utilisation of ground granulated blast furnace slag (GGBS), fly ash, and metakaolin, among other industrial by-products. The production of geopolymer concrete addresses serious environmental problems and contributes to …
Published in Journal of Polymer & Composites · Vol. 13, Issue 3, 2025 · pp. 261–266 Read article
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Role of Polymeric Composites in Controlled Drug Release Systems
Abstract: In the realm of controlled drug release systems, polymeric composites have attracted a lot of interest as they possess several diverse characteristics that enable exact control of the drug delivery rate. This lowers adverse effects and increases the efficacy of treatment. Usually composed of biocompatible polymers combined with functional fillers like nanoparticles, ceramics, or hydrogels, these composites help to get the desired drug release patterns. Stable, biodegradable, and bioactive materials …
Published in Journal of Polymer & Composites · Vol. 13, Issue 4, 2025 · pp. 453–465 Read article
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Effect of Bacteria on Crude Oil Degradation in Loamy and Clay Soil for Water and Ethanol Biostimulant Extraction from Bryophylum pinnatum Leaf
Abstract: The effect of bacteria on crude oil degradation in loamy and clay soil for water and ethanol biostimulant extraction from Bryophylum pinnatum leaf was investigated to ascertain the potential of the bacteria counts in the bioreactors sampled. At the progressive phase, the bacteria counts were more with bioreactors induced with ethanol solvent extract as the volume of the dosage increases compared to the bioreactors induced with the water extract. The …
Published in Research and Reviews : Journal of Crop science and Technology · Vol. 14, Issue 2, 2025 · pp. 19–25 Read article