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332 articles for “randomization”
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GLP-1 Receptor Agonists: A Dual Therapeutic Strategy for the Management of Type 2 Diabetes Mellitus and Obesity
Abstract: For the treatment of obesity and type 2 diabetes mellitus (T2DM), glucagon-like peptide-1 receptor agonists (GLP-1 RAs) have become a revolutionary class of pharmaceutical drugs. These drugs were first created as glucose-lowering treatments, but they have now shown other advantages, such as notable weight loss, better cardiovascular results, and general metabolic control. The objective of this narrative review is to assess the pharmacological mechanisms, clinical efficacy, safety profile, and therapeutic …
Published in Research and Reviews: A Journal of Pharmacology · Vol. 16, Issue 1, 2026 · pp. 69–75 Read article
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The Hidden Struggle: Premenstrual Depression its Impact on Women’s Health and Management Strategies: A Narrative Review.
Abstract: Background: Premenstrual depression, including Premenstrual Syndrome (PMS) and Premenstrual Dysphoric Disorder (PMDD), represents a significant yet underrecognized contributor to women’s mental health burden. Hormonal fluctuations during the luteal phase interact with neurotransmitter systems, particularly serotonin and GABA, leading to affective and somatic symptoms that impair daily functioning. Objective: This systematic review synthesizes evidence on the prevalence, pathophysiology, psychological impact, and management strategies of premenstrual depression among reproductive-aged women, with particular …
Published in International Journal of Nutritions · Vol. 3, Issue 1, 2026 · pp. 21–32 Read article
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AI-Driven Prediction of Square-Hole Laser Trepanning Performance in AA7075/15%SiC/15% Glass Fiber Hybrid Composites Using Taguchi–ANOVA and Deep Neural Networks
Abstract: Hybrid AA7075 composites reinforced with 15% silicon carbide (SiC) and 15% glass fiber were fabricated via the stir casting technique to improve machining and structural performance. The addition of dual reinforcements into the aluminum matrix was aimed at enhancing hardness, thermal stability, and surface quality during non-traditional drilling operations. Square-hole drilling was performed using a laser trepanning process, and the key responses—hole size accuracy, surface roughness, and taper angle—were systematically …
Published in Journal of Polymer & Composites · Vol. 14, Issue 1, 2026 · pp. 1932–1943 Read article
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Challenges And Constraints Affecting Female-Owned Rural Farm Businesses in Plateau State, Nigeria
Abstract: This study examined the challenges and constraints affecting female-owned rural farm businesses in Plateau State, Nigeria. No prior study had conducted a comprehensive, quantitative, state-wide investigation covering all 17 local government areas (LGAs) of the state, and this study addressed that gap. The objectives were to identify the challenges faced by female-owned rural farm businesses, assess their relationship with business performance, and determine how strongly these challenges predicted performance outcomes. …
Published in International Journal of Rural and Regional Development · Vol. 4, Issue 1, 2026 · pp. 1–13 Read article
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A Study on Measures to Improve Digital Education and Technological Advancement Towards Tribal Community Enrichment and Life Satisfaction - Nilgiri District – TN
Abstract: This study examines measures to enhance digital education and technological advancement for the enrichment of tribal communities and life satisfaction in the Nilgiri district, Tamil Nadu. The research aims to assess the current state of digital education accessibility, identify challenges faced by tribal populations, and propose strategies to bridge the digital divide. Using a structured questionnaire, primary data was collected from 60 respondents, including students, educators, and community members, selected …
Published in Recent Trends in Social Studies · Vol. 3, Issue 1, 2026 · pp. 1–5 Read article
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The Use of Digital Tools in Assessing Language and Literacy Development in Early Childhood Centres in Tamale Nanton District, Ghana
Abstract: The study investigated the use of digital tools in assessing language and literacy development in early childhood centres in the Tamale Nanton-district, Ghana. Specifically, the study examined the extent to which facilitators integrate digital tools in teaching practices, assessed facilitators’ levels of digital literacy skills, and explored the factors influencing the successful integration of digital tools in teaching. A total of 113 facilitators (39 males and 74 females) were selected …
Published in International Journal of Children · Vol. 3, Issue 1, 2026 · pp. 17–29 Read article
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SGLT2 Inhibitors in Heart Failure and Chronic Kidney Disease: Expanding Therapeutic Horizons beyond Glycemic Control
Abstract: Heart failure (HF) and chronic kidney disease (CKD) are closely related clinical diseases that significantly increase morbidity and death worldwide. The co-occurrence of both conditions is frequently referred to as the "cardio-renal syndrome," in which the failure of one organ hastens the decline of the other. The original purpose of sodium–glucose cotransporter-2 (SGLT2) inhibitors was to treat type 2 diabetic mellitus (T2DM) by reducing blood sugar levels. Nevertheless, new data …
Published in Research and Reviews: A Journal of Pharmacology · Vol. 16, Issue 2, 2026 Read article
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The Importance of Self-Care for Healthcare Professionals in North India: A Regional Analysis of Burnout, Resilience and Institutional Support
Abstract: Background: Burnout in healthcare professionals is described using the framework of Occupational Health and Resilience Theory, where self-care is an individual-level coping mechanism and institutional support is an organizational-level moderator. However, there is a lack of regional data from North India on the structural and contextual factors influencing burnout. Healthcare workers (HCWs) in North India face mounting pressures due to high patient loads, limited mental health resources, and overlapping professional …
Published in International Journal of Behavioral Sciences · Vol. 3, Issue 1, 2026 · pp. 24–29 Read article
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A Comparative Study of the Optimum Health and Health-Related Physical Fitness Level of State Level Players Boys and Girls at MBSPSU, Patiala
Abstract: The study’s goal was to compare state-level player girls’ and boys’ optimal health and health-related physical fitness. Thirty individuals, including male and female state-level players from the Patiala district of Punjab, India, were chosen via purposeful random sampling. There were two distinct groups formed: There were fifteen participants in each group (15 females and 15 boys), with Group 1 being made up of girls and Group 2 being made up …
Published in Recent Trends in Sports · Vol. 3, Issue 1, 2026 · pp. 22–27 Read article
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Adaptive Drift Correction in Polymer-Based Wearable Biosensors via Data-Driven Signal Modeling
Abstract: Polymer-based wearable biosensors have emerged as a promising technology for continuous health monitoring due to their mechanical flexibility, biocompatibility, and suitability for long-term physiological interfacing. However, prolonged exposure to biofluids, environmental variability, and mechanical deformation introduces signal drift, which significantly degrades measurement accuracy and limits clinical reliability. This paper presents a data-driven methodology for compensating signal drift in polymer-based wearable biosensors using adaptive signal processing and machine learning techniques. The …
Published in Journal of Polymer & Composites · Vol. 14, Issue 3, 2026 · pp. 131–139 Read article
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Physicochemical Transitions and Polymerization Dynamics in Multi-Generational Dentin Adhesives: A Critical Review of the Resin-Dentin Composite Interface
Abstract: Adhesive dentistry has undergone a transformative refinement over the past three decades, transitioning from technique-sensitive, multi-step etch-and-rinse protocols to streamlined universal formulations. This narrative review critically synthesizes evidence from thirty peer-reviewed investigations to evaluate the evolution of dentin bonding agents from the fourth through the eighth generations. The analysis places particular emphasis on the physicochemical dynamics of the resin-dentin interface, including interfacial bond strength metrics, marginal integrity, and microleakage behavior. …
Published in Journal of Polymer & Composites · Vol. 14, Issue 3, 2026 · pp. 209–228 Read article
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Enhanced Sustainable Concrete Mix Design Using LLMs and Advanced Machine Learning Techniques
Abstract: Large Language Models (LLMs) are emerging as transformative tools in materials science, offering human-like reasoning, zero-shot problem solving, and the ability to integrate fuzzy laboratory knowledge with structured data. This study extends and reinterprets the original systematic benchmark for using LLMs in sustainable concrete design, particularly for Alkali-Activated Concrete (AAC). We introduce an enhanced, multi-model framework combining LLM-based inverse design, Random Forest regression, Gaussian Process Regression (GPR), and a lightweight …
Published in Recent Trends in Civil Engineering & Technology · Vol. 16, Issue 2, 2026 Read article
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Machine Learning Assisted Timing Violation Prediction in Sub-7nm VLSI Physical Design
Abstract: The continuous scaling of semiconductor technology into the sub-7nm regime has introduced significant challenges in timing closure due to process variability, interconnect delay, power density, and manufacturing uncertainties. Conventional static timing analysis techniques often require extensive computational resources and iterative optimization cycles, resulting in increased design complexity and longer turnaround time. This research proposes a Machine Learning Assisted Timing Violation Prediction framework for sub-7nm VLSI physical design to improve early-stage …
Published in International Journal of VLSI Circuit Design & Technology · Vol. 4, Issue 1, 2026 Read article
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Assessing Taila Bindu Pariksha as a Diagnostic and Prognostic test for Diabetes Mellitus
Abstract: Ayurveda has consistently emphasised on not just treatment of a disease but also how to diagnose it and further assess the prognosis. Ayurveda is blessed with different diagnostic tests which is broadly classified into Roga and Rogi Pariksha such as Ashtavidha Pariksha, Dashavidha Pariksha and Dwadashavidha Pariksha. These tests are used very rarely by just few Ayurvedic practioners as an important diagnostic and prognostic methods in different diseases. Taila Bindu …
Published in Journal of AYUSH: Ayurveda, Yoga, Unani, Siddha and Homeopathy · Vol. 15, Issue 2, 2026 Read article
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An Overview on VLSI based Hardware Security in IoT Node
Abstract: In the coming era, security will not be a feature we add to an IoT device; it will be a property inherent to its transistor-level design. By encoding security into the VLSI architecture, we move away from the fragile "software-only" paradigm and toward a future where the identity of the device is as immutable as the laws of physics. The rapid proliferation of Internet of Things (IoT) devices has transformed …
Published in International Journal of VLSI Circuit Design & Technology · Vol. 4, Issue 1, 2026 Read article
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Wear and Tribological Characteristics of Novel Metal Matrix Composites
Abstract: The development of advanced metal matrix composites (MMCs) with enhanced tribological performance has become increasingly important due to the premature failure of critical engineering components operating under severe wear conditions in automotive, aerospace, marine, defense, and power generation systems. Conventional composites such as Copper–Alumina and Aluminium–Silicon Carbide have demonstrated improved mechanical and wear characteristics; however, their widespread application is often limited by issues including particle agglomeration, non-uniform reinforcement distribution, porosity …
Published in Journal of Polymer & Composites · Vol. 14, Issue 2, 2026 · pp. 1326–1346 Read article
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Machine Learning Based Sentiment Analysis of Student Feedback in Higher Education
Abstract: Educational institutions routinely collect feedback from students to understand their perceptions of academic programs, infrastructure, and campus facilities, to improve the overall quality of the college environment. In current practice, feedback is often gathered using numerical or grade-based rating systems, which tend to oversimplify student opinions and may overlook important details related to their level of satisfaction. In contrast, open-ended textual feedback allows students to clearly express their views, concerns, …
Published in International Journal of Data Structure Studies · Vol. 4, Issue 1, 2026 · pp. 01–10 Read article
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A Lightweight Cost-Sensitive Explainable Ensemble Framework for Early Heart Disease Risk Prediction
Abstract: Cardiovascular disease is still one of the leading causes of death, and hence, the early prediction of risk is a very important task in preventive medicine. Although recent studies have shown encouraging results in the application of machine learning algorithms to the prediction of heart disease, it has been noticed that most of the algorithms are more concerned with accuracy-driven optimization than the concerns of safety and false negatives. In …
Published in International Journal of Bioinformatics and Computational Biology · Vol. 4, Issue 2, 2026 Read article
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Molecular Docking, QSAR Modeling, and ADMET Evaluation of Novel Pyrazolo-Pyrimidine Derivatives as Potential CDK-2 Inhibitors for Cancer Therapy
Abstract: Cyclin-dependent kinase-2 (CDK-2) is an essential regulator in cell cycle progression and is an important therapeutic target in cancer drug development. In the present study, an integrated computational approach involving molecular docking studies, QSAR modeling, ADMET prediction, and artificial intelligence-based analysis was used to identify pyrazolo-pyrimidine derivatives as potential CDK-2 inhibitors. Based on the molecular docking results, it was found that selected compounds exhibited high binding affinity towards the ATP …
Published in Research and Reviews: A Journal of Pharmacology · Vol. 16, Issue 2, 2026 Read article
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Resilience, Secular attitude and Forgiveness among indian men & women
Abstract: The present study investigates the relationship among forgiveness, resilience, and secular attitude among adults living in Pune, India. The primary objectives of the study were to examine the interrelationship between these three variables, evaluate the influence of secular attitude on forgiveness and resilience, and identify differences based on gender and region. 113 adults were selected through a simple random sampling method and were assessed using the Bharathiar University Resilience Scale …
Published in International Journal of Behavioral Sciences · Vol. 3, Issue 1, 2026 · pp. 112–120 Read article