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618 articles for “Drug–protein interactions (DPIs)”
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Development of an Innovative Nanotransdermal Formulation Utilizing an Optimal Combination of Acyclovir and Omeprazole to Improve Antiviral Efficacy
Abstract: The study effectively created nanogel formulations of Acyclovir and Omeprazole using the solvent diffusion technique. Among the various formulations (F1–F9), F9 was identified as the most suitable for gel preparation based on its pH evaluation. Drug content analysis, performed using UV-spectroscopy, confirmed the homogeneity of the prepared nanogels, which appeared opaque, free of lumps, particles, or aggregates. The spreadability assessment of F9 demonstrated excellent spreadability, while viscosity values for all …
Published in International Journal of Biomedical Innovations and Engineering · Vol. 2, Issue 1, 2024 · pp. 19–35 Read article
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Development and Formulation of Chocolate-coated Seeds Bar
Abstract: Vitamins E, D, and B6 minerals like zinc and selenium and amino acids like glutamine all play a role in the body's immune system development. Edible seeds are a great source of protein, healthy fats, fiber, and important minerals like magnesium, potassium, calcium, iron, and zinc in addition to vitamins B1, B2, B3, and E. Examples of edible seeds include pumpkin, flax, sesame, sunflower, mustard, amaranth, oat, barley, black rice, …
Published in International Journal of Nutritions · Vol. 1, Issue 1, 2024 · pp. 1–12 Read article
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Millet Bran: Unveiling Its Potential Health Benefits
Abstract: Millet bran, derived from various millet grains, has emerged as a potent nutritional source, rich in fiber, vitamins, minerals, antioxidants, and omega-3 and omega-6 fatty acids. Its rising popularity is driven by its gluten-free nature, nutrient density, and sustainability. This review aims to explore the potential health benefits of millet bran, focusing on its digestive health, blood sugar control, heart health, antioxidant properties, and fatty acid composition. The Millet brand …
Published in International Journal of Nutritions · Vol. 1, Issue 2, 2024 · pp. 11–19 Read article
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Real Time Characterization of BA.2.86 and Its Variant (JN.1) in Senegal Using Midnight Protocol
Abstract: During the week ending August 13th, 2023, the most prevalent variant of interest (VOI), uploaded to GISAID, was the BA.2.86 variant. This SARS-CoV-2 Omicron lineage was described as the first phylogenetically distinct from the currently circulating SARS-CoV-2 Omicron XBB lineages, including EG.5.1 and HK.3. Compared to the XBB and BA.2 lineages, the BA.2.86 possesses more than 30 mutations in the Spike (S) protein, suggesting a significant potential for immune evasion. …
Published in International Journal of Vaccines · Vol. 1, Issue 2, 2024 · pp. 16–21 Read article
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Multiple Sclerosis: A Brief Overview of the Disease, Its Pharmacotherapy
Abstract: Multiple Sclerosis is an autoimmune disorder mostly affecting individuals aged between 20-40. In this disorder, the optic, vertebral, and central nervous system nerves are primarily impacted. It is a neurological condition that worsens over time and is characterized by inflammation and the breakdown of the sheath that surrounds and shields the nerve fiber. Common symptoms may include muscle weakness, numbness, tingling, fatigue, vertigo, tremor, vision complications, pain, Lhermitte sign, sexual …
Published in International Journal of Brain Sciences · Vol. 1, Issue 1, 2024 · pp. 13–18 Read article
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Navigating the Digital Frontier: An In-depth Analysis of Classroom Digitalization
Abstract: When we talk about the Internet, we think about the likes of social media, or platforms like Google which has an unfathomable archive of information which is available for any and every individual to use up to their own likings. However, there are several challenges and complexities associated with the Internet's impact on social interactions. The issues of online harassment, privacy, and the addictive nature of social media have become …
Published in International Journal of Electrical and Communication Engineering Technology · Vol. 1, Issue 2, 2023 · pp. 14–20 Read article
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Real-time Voice-over Translation
Abstract: The real-time voice-over translation project stands as a pioneering endeavor poised to reshape the landscape of cross-cultural communication. In response to the escalating demand for fluid interaction amidst linguistic diversity, this initiative sets out to engineer a transformative solution. Its core objective lies in the seamless mediation of language barriers during real-time exchanges. Through the fusion of cutting-edge speech recognition and machine translation technologies, the project endeavors to fabricate a …
Published in International Journal of Computer Science Languages · Vol. 2, Issue 1, 2024 · pp. 24–32 Read article
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Gene prioritization of colorectal cancer using computational approach
Abstract: Colorectal cancer (CRC) continues to be a major worldwide health issue, underscoring the need to pinpoint crucial genetic elements influencing its initiation and advancement. In this investigation, we utilize sophisticated computational methods to prioritize potential genes linked to CRC development. Through the utilization of various bioinformatics tools and comprehensive methodologies, we systematically examine extensive microarray datasets to identify potential genetic contributors. Initially, a vast amount of CRC microarray data (approximately …
Published in International Journal of Bioinformatics and Computational Biology · Vol. 2, Issue 1, 2024 · pp. 39–52 Read article
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Smart Door Lock System Using IOT
Abstract: The Internet of Things (IoT) represents a revolution in the way we interact with technology and the world around us. It incorporates a network of interconnected devices, sensors, and systems that collect, share, and analyze information to be effective, enhance decision-making, and improve every aspect of our lives. This content aims to provide an indepth look at the evolution, current state and future potential of the Internet of Things. The …
Published in International Journal of Satellite Remote Sensing · Vol. 1, Issue 2, 2023 · pp. 10–13 Read article
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Smart Lane Following and Mobile Controlled Robotic Car
Abstract: One major development in autonomous vehicle technology is the emergence of mobile-controlled robotic cars and smart lane-following vehicles. To improve user control and vehicle autonomy, these systems integrate mobile technology, computer vision, and machine learning. This review work highlights the potential of mobile-controlled and smart lane-following robotic automobiles to transform transportation and related sectors by examining their design, functioning, applications, and obstacles. Autonomous driving relies heavily on smart lane-following technology, …
Published in International Journal of Advanced Control and System Engineering · Vol. 2, Issue 1, 2024 · pp. 36–47 Read article
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Assessment of exacerbation of Depression in pulmonary tuberculosis patients by using PHQ-9 scale at Tertiary Care Hospital
Abstract: Context: Depression leads to more dysfunction and stress, which could affect the patient's life condition. Tuberculosis is a leading cause of comorbidity with depression. Those suffering from tuberculosis and depression are at higher risk of bad health-seeking nature, resulting in higher morbidities, drug resistance, and mortality. The relationship is not well established. Aims: To identify multiple variables/ dependent factors affecting depression respectively in tuberculosis patients and check the medication adherence …
Published in International Journal of Pathogens · Vol. 1, Issue 2, 2024 · pp. 24–31 Read article
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Student Academic Achievement Forecast Based on Emotional Intelligence, Personality, Demographic Characteristics and Attitude Towards Education and Future Career
Abstract: This study was aimed at predicting students' academic achievement based on emotional intelligence of personality traits, attitudes to education and future career. The present study was a correlational-analytical study. The statistical population of Zanjan University students in the academic year of 1395-1395 was the sample of 489 people selected by cluster random sampling method. Academic Resilience Scale (ARI) and Schotte Emotional Intelligence Questionnaire and Researcher Attitude Questionnaire were used to …
Published in International Journal of Education Sciences · Vol. 1, Issue 2, 2024 · pp. 25–36 Read article
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“Evaluation of superoxide Dismutase (SOD) enzyme level and some indicators in people exposed to smoke”
Abstract: The aim of this study is to assess the level of SOD enzyme and its impact in people who are exposed to smoking, in addition to measuring C-interactive protein, and finally measure a complete picture of blood samples taken from patients. The results of the current study showed there is a significant differences (p<0.05) in the activity of the SOD. The mean of SOD activity in patient was 127.9 U/ml …
Published in International Journal of Toxins and Toxics · Vol. 1, Issue 2, 2024 · pp. 52–55 Read article
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Total Lipids and Storage Quality of Oil Seeds and Nuts as Influenced by Yeast Fermentation
Abstract: Oilseeds and the products made from them have a role in a healthy balanced diet, even though they are energy dense and contain a high proportion of fat. Most oilseeds are made up of protein and oil. In general, fat is 18–45% by weight of oilseeds and protein is about 16–40%. Fluctuations in oil yields can cause significant fluctuations in their rates. The oils contain fat-soluble vitamins and unsaturated fats …
Published in International Journal of Fungi · Vol. 1, Issue 2, 2024 · pp. 29–35 Read article
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Insect Hymnenopteran Parasitoids of Sugarcane Pest and Role As Biological Control Agents
Abstract: The present study is short communication of insect parasitoids belongs to order Hymenoptera. Sugarcane crop attract number of insect pests that flourish on it, and cause about 15- 20% yield loss and minimize the productivity, this reduction in yield increase when the insect parasitoids attack on pest. There are some major parasitoids Orders that attack on the number of crops pest, like Dipteran, Lepidopterans, Neuropteran etc. and one of the …
Published in International Journal of Insects · Vol. 1, Issue 1, 2024 · pp. 18–21 Read article
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Design and Implementation of a Smart Healthcare Communication Bot
Abstract: Healthcare has proved to be one of the core factors that lead us to a magnificent life. Moreover, going to a professional for every small health issue is complicated and difficult task. To aid users with health issues, this paper describes the creation and deployment of a multifunctional healthcare assistance application. The application encompasses: The first task of the application involves a chatbot interface that gives in- depth drug information …
Published in International Journal of Robotics and Automation in Mechanics · Vol. 2, Issue 1, 2024 · pp. 14–20 Read article
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Heterocyclic Substituted Flavones: Bridging Natural Products and Medicinal Chemistry
Abstract: Heterocyclic substituted flavones represent a unique and promising class of flavonoid derivatives, gaining significant attention in recent years due to their diverse and enhanced biological activities. These compounds are characterized by the incorporation of heterocyclic moieties such as quinoline, pyridine, thiazole, imidazole, oxazole, and pyrazole into the flavone structure, which significantly alters and often enhances their bioactive properties. This structural modification has made heterocyclic flavones particularly appealing as candidates for …
Published in International Journal of Tropical Medicines · Vol. 2, Issue 1, 2025 · pp. 23–30 Read article
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Advanced Document Query System
Abstract: For knowledge-intensive businesses, large document libraries contain a plethora of information. Massive, chaotic, collections of documents that are unstructured have emerged from this rapid increase. Even if accessing or storing these documents has become easier, finding the required critical information in these vast document collections has become more difficult. NLP (natural language processing) is one of the techniques used to retrieve the information that is required from a huge chunk …
Published in International Journal of Computer Science Languages · Vol. 2, Issue 2, 2024 · pp. 26–35 Read article
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Strategy to Accelerate the Biopharmaceuticals Production Using Komogataella phaffii (Pichia pastoris)
Abstract: Revenue generation has been the primary goals for nations as well as the industries worldwide. Biopharmaceutical verticals have become potential revenue generators as they are the industrial workhorses and the economic engines that drive the upcoming biopharmaceutical industries with advances in DNA recombinant technology. A breakthrough in the indusrial biotechnology for the production of biopharmaceuticals using Pichia pastoris is awaited. Ablynx NV, Recombinant proteins (RP), HSA-pFSH beta, antibodies, borosin, N-glycoprotein, …
Published in International Journal of Advance in Molecular Engineering · Vol. 2, Issue 2, 2024 · pp. 1–7 Read article
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Malaria Diagnosis through Conventional Methods: A Comprehensive Review
Abstract: The incidence of drug-resistant parasite strains is rising, there is an apparent increase in the number of cases of malaria worldwide, and in a small number of cases and there has been a dramatic rise in international migration and travel. Over 1 million people die from malaria every year; 90% of these deaths are in African children, who live in tropical and subtropical regions. Although there are now efficient techniques …
Published in International Journal of Pathogens · Vol. 1, Issue 2, 2024 · pp. 8–14 Read article