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349 articles for “amines”
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In silico Analysis of nsSNPs in the Human ACTN4 Gene associated with a Steroid-Resistant Nephrotic Syndrome
Abstract: The main motive of this study is to discover nsSNPs of ACTN4 gene through various insilico views. ACTN4 is one of the proteins that play a leading role in cellular pathways by altering cytoskeletal behaviour associated with steroid-resistant nephrotic syndrome. Data of ACTN4 was collected from NCBI dbSNP and Uniport KB and further used to explore adverse outcome using SIFT, PolyPhen, PROVEAN and SNAP2.Out of 11 nsSNPs selected in this …
Published in Research and Reviews: A Journal of Health Professions · Vol. 8, Issue 3, 2018 · pp. 43s–52s Read article
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Smoking and Body Weight: Is There Any Relation?
Abstract: Tobacco is a tall, green leafy plant, originally grown in South and Central America, but now cultivated throughout the world. The link between smoking and body weight is evident as early as adolescence. Nicotine acts on nicotinic cholinergic receptors in the brain and autonomic ganglia. The binding of nicotine to the nicotinic receptors opens ion channels, allowing entry of sodium and calcium, thereby; augment the release of various neurotransmitters. This …
Published in Research and Reviews: A Journal of Health Professions · Vol. 3, Issue 3, 2013 · pp. 33–36 Read article
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Gir Cow Milk: The Wealthy Nutrition for Human Health
Abstract: It protects the consumer from all the types of lifestyle disorders. Gir cow milk is with amino acid that helps human being to fight with diseases (examples: pains in joints; asthma; obesity; insomnia). Gir cow milk protects the cells of colon from causing cancer. It helps human body to develop strong immunity. Gir cow milk has the properties of antioxidation. Gir cow milk is a rich source of calcium that …
Published in Research and Reviews: A Journal of Health Professions · Vol. 11, Issue 2, 2021 · pp. 30–33 Read article
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Pharmacological, Characterization and Utilization of Ginger
Abstract: Ginger also known as Zingiber is the most important species used here, as India is the largest producer of it. Rhizome is the most important part of this plant which is used, having 50% carbohydrates, 6–8% free fatty acids and volatile oils like palmitic, oleic, linoleic acids as well as oleo resins, other amino acids and proteins. It is most important flavouring agent which is used worldwide. Ginger has many …
Published in Research and Reviews: A Journal of Health Professions · Vol. 13, Issue 2, 2023 · pp. 27–30 Read article
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Isolation and Characterization of “Heavy Chain Antibody” Variable Domain Gene of Indian Desert Camel (Camelus dromedarius, L.)
Abstract: Camelids have “heavy chain antibodies” (HCAbs) of IgG isotype (IgG2 and IgG3 subtypes) and lack light chains and heavy chain constant domain 1 (CH1) in their structure. The molecular biological features of VHH (i.e., antigen binding variable domain of HCAbs) gene isolated from Indian desert camel were examined as a prelude to construct VHHs-phage display library. VHH cDNA was synthesized by reverse transcription-polymerase chain reaction (RT-PCR) from B lymphocyte mRNA, …
Published in Research and Reviews : A Journal of Immunology · Vol. 3, Issue 1, 2013 · pp. 22–31 Read article
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Cloning and Expression of LPS-Binding Single Domain Antibody Clones Selected from Phage Display Library of Indian Desert Camel
Abstract: Despite the absence of light chains in their structure, camelid and shark “heavy chain antibodies” (HCAbs) variable domains (designated as VHH) are able to make functional paratopes. The authors have selected lipopolysaccharide (LPS)-binder “single-domain antibodies” (dAb) clones from the previously constructed phage display library of (LPS)-immunized Indian desert camel. This study was undertaken to make available large amounts of some LPS-binder dAb clones by using a suitable expression vector-host system …
Published in Research and Reviews : A Journal of Immunology · Vol. 4, Issue 1, 2014 · pp. 1–7 Read article
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Molecular Identification of Common Bacterial Infection in Chronic Otitis Media in an Outpatient Department of Tertiary Care Hospital
Abstract: Chronic otitis media (COM) is a chronic inflammation of the mucoperiosteum of the middle ear left which leads to profuse discharge from the ear and hearing impairment that may have a serious long-term effect on language, auditory and cognitive development and on educational progress. In the present study, the prevalence of culture-positive cases of an active mucosal variety of COM was 92.65%. Pseudomonas aeruginosa (41.2%) was the predominant aerobic bacterial …
Published in Research and Reviews : A Journal of Medical Science and Technology · Vol. 8, Issue 1, 2019 · pp. 18–24 Read article
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Taxonomic Assessment of Thermostable Amylase Producer from the Unkeshwar Hot Spring, Nanded
Abstract: Total 42 thermophiles were isolated from the Unkeshwar hot spring of Maharashtra, India. Of these 23 thermostable amylase producers were identified as Bacillus alvei APP1, Bacillus brevis APP2, Bacillus sterothermophilus APP3, Bacillus subtilis APP4, Bacillus farraginis APP5, Bacillus firmus APP6, Bacillus licheniformis APP7, Bacillus megaterium APP8, Lysinibacillus sphaericus APP10, Paenibacillus alvei APP11, Bacillus simplex APP12, Staphylococcus cohnii APP15, Streptococcus thermophilus APP16, Bacillus cereus APP18, Bacillus atrophaeus APP19, Bacillus lentus APP24, …
Published in Research and Reviews: A Journal of Microbiology and Virology · Vol. 9, Issue 1, 2019 · pp. 113–126 Read article
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Possible Risk Factors Associated with Tuberculosis Treatment Failure Among Patients Attending Tuberculosis Treatment Centers in Kano State, Nigeria
Abstract: The widespread failure of tuberculosis chemotherapy has led to an increase in mortality and morbidity associated with tuberculosis infection. This study was aimed at assessing the possible risk factors associated with tuberculosis treatment failure in patients attending Aminu Kano Teaching Hospital (AKTH) and Infectious Disease Hospital (IDH), Kano State. Treatment outcomes of the 436 tuberculosis patients attending selected hospitals in 2018 were obtained using a retrospective study (review of the …
Published in Research and Reviews: A Journal of Microbiology and Virology · Vol. 13, Issue 2, 2023 · pp. 1–9 Read article
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Human Arginase I (Arg I)—A Potential Broad-spectrum Anti-cancer Agent: Perspectives and the Road Ahead
Abstract: Cancer is the second leading cause of morbidity and mortality globally. A variety of effective regimens are available for the treatment of different cancers, however, there is still a need for the development of safe and effective broad-spectrum anti-cancer agent(s). Towards this, amino acid-depleting enzymes have proven to be effective in the treatment of certain auxotrophic cancers. In this review, we have briefly discussed arginine metabolism and arginine depletion as …
Published in Research and Reviews: Journal of Oncology and Hematology · Vol. 9, Issue 3, 2020 · pp. 23–35 Read article
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Arsenic Induced Oxidative Stress and Its Possible Reversal by Chelation Therapy
Abstract: Arsenic (As) is a metalloid listed in group Va of the periodic chart. It exists in nature in the oxidation states +V (arsenate), +III (arsenite), 0 (arsenic) and −III (arsine). In the aqueous environment inorganic arsenic appears commonly in the oxidation states +V and +III as arsenous acid (As (III)), arsenic acid (As (V)), and their salts. Chronic and acute exposures of arsenic leads to cancer, cardiovascular disease (hypertension and …
Published in Research and Reviews: A Journal of Toxicology · Vol. 2, Issue 2, 2012 · pp. 16–37 Read article
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Effects of Sub Chronic Dermal Exposure of Gasoline Blended with Varying Concentration of Benzene on Hepatic Mixed Function Oxidases in Rats
Abstract: Interaction of chemicals in a mixture, their biotransformation and adverse impact, if any, on environment and workroom atmosphere needs to be evaluated to identify the nature of potential toxic effects elicited by constituent chemical(s) in a mixture. The nature of chemical interaction(s) through which an individual chemical in a mixture undergoes metabolism and/or biotransformation in the target tissue could be helpful in evaluation of its toxic potential. Gasoline is a …
Published in Research and Reviews: A Journal of Toxicology · Vol. 3, Issue 1, 2013 · pp. 1–5 Read article
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A Review of Toxicity, Genotoxicity and Teratogenicity of Formaldehyde
Abstract: Formaldehyde (FA) is important chemical found outdoor and indoor source, it is commonly used in the production of industrial, laboratories and household fule. Most FA exposure occurs by inhalation or by skin or eye contact. It is rapidly absorbed by lungs, gastrointestinal tract and skin. FA easily reacts with amino group in molecular compounds such as proteins and nucleic acid; these reactions caused alterations in tissues and leading to toxicity …
Published in Research and Reviews: A Journal of Toxicology · Vol. 10, Issue 3, 2020 · pp. 9–18 Read article
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Environmental and Toxicological Implications of Dyes: A Mini Review
Abstract: Synthetic dyes are extensively used in industries – such as textiles, leather, paper, and food processing – due to their vibrant colors and high chemical stability. However, the large-scale release of dye-containing wastewater has become a significant environmental and health concern. Owing to their complex chemical structures, most synthetic dyes are highly resistant to biodegradation, resulting in their long-term persistence in aquatic and terrestrial ecosystems. Their accumulation in water bodies …
Published in Research and Reviews: A Journal of Toxicology · Vol. 16, Issue 2, 2026 · pp. 70–77 Read article
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Face Recognition Techniques: A Critical Review
Abstract: Humans have the ability to identify each other. Identification of a person by his facial image is known as face recognition. To identify a person by comparing image data or live capture with stored data is the biometric method of face recognition. A set of measureable and unique characteristics of a person can be used to recognize an individual automatically. To recognize a person automatically is one of the challenging …
Published in Recent Trends in Programming languages · Vol. 5, Issue 2, 2018 · pp. 24–30 Read article
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Direct ELISA-based Reagentless Amperometric Immunosensor for Cancer Antigen 125
Abstract: The authors propose a direct electrochemistry-based reagentless, separation-free, immunosensor for quantification of cancer antigen 125 (CA125) based on direct ELISA technique. HRP-conjugated monoclonal anti-CA125 antibody, helps in direct electron transfer from electroctalytic center of enzyme to electrode on immunocomplex formation via covalent linkage between immobilized tagged antibodies, amino acid coated colloidal gold nanoparticles and electrode. Optimum temperature, pH and incubation time for efficient electron transfer and hence amperometric response of …
Published in Nano Trends – A Journal of Nano Technology & Its Applications · Vol. 16, Issue 2, 2014 Read article
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Synthesis, Structural Characterization and Biological Studies of Schiff Base Complexes Bearing Indole Moiety
Abstract: Schiff base complexes of N2O2 type derived from indole-3-carboxaldehyde(ind) and amino acids such as glycine(gly), L-valine(val), and L-tryptophan(try) with Cu(II), Ni(II), Zn(II), Co(II) and Mn(II) were synthesized and characterized by physical and analytical techniques. The complexes are of non-electrolytic nature having 1:2 (metal:ligand) ratio. The geometry of the complexes was predicted with the combined data obtained from electronic spectral and magnetic susceptibility measurements. The mode of coordination of the Schiff …
Published in Journal of Modern Chemistry & Chemical Technology · Vol. 4, Issue 1, 2013 · pp. 31–42 Read article
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BVM: A Promising Agent for Future HIV-1 Treatment
Abstract: Normal 0 false false false EN-US X-NONE X-NONE MicrosoftInternetExplorer4 /* Style Definitions */ table.MsoNormalTable {mso-style-name:"Table Normal"; mso-tstyle-rowband-size:0; mso-tstyle-colband-size:0; mso-style-noshow:yes; mso-style-priority:99; mso-style-qformat:yes; mso-style-parent:""; mso-padding-alt:0in 5.4pt 0in 5.4pt; mso-para-margin:0in; mso-para-margin-bottom:.0001pt; mso-pagination:widow-orphan; font-size:11.0pt; font-family:"Calibri","sans-serif"; mso-ascii-font-family:Calibri; mso-ascii-theme-font:minor-latin; mso-fareast-font-family:"Times New Roman"; mso-fareast-theme-font:minor-fareast; mso-hansi-font-family:Calibri; mso-hansi-theme-font:minor-latin; mso-bidi-font-family:"Times New Roman"; mso-bidi-theme-font:minor-bidi;} More than 20 individual and fixed-dose combinations of anti-HIV drugs are available for the treatment of human immunodeficiency virus (HIV) infection. However, owing to the development of …
Published in Research and Reviews: A Journal of Pharmaceutical Science · Vol. 2, Issue 1, 2011 · pp. 11–21 Read article
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Design, Synthesis and Evaluation of Antitubercular Activity of Mannich Bases of Isoniazid-Containing Thiazolidin-4-one Rings
Abstract: Isoniazid (INH), the established antitubercular drug was selected as the lead for the design and development of antitubercular agents by many researchers. 4-thiazolidinones are well known heterocyclic compounds for their spectrum of biological activities such as antibacterial, antifungal [1], anticancer [2], antitubercular, anthelmintic, anti-inflammatory [3], analgesic [4], antithyroid, local anaesthetic, monoamine oxidase inhibition, anti-Toxoplasma gondii activity etc [5]. Modification of thiazolidinones via Mannich reaction to improve biological activity is also …
Published in Research and Reviews: A Journal of Pharmaceutical Science · Vol. 7, Issue 1, 2016 · pp. 1–12 Read article
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Potentiality of Bacteriocins as the Attachment Inhibitors of HIV-1 gp120
Abstract: It is postulated that some bacteriocin derivatives are consummate candidates to inhibit the binding of HIV gp120 to CD4 T-cell. From the discovery of bacteriocin compounds in 1925 and forth, nearly 300 bacteriocins have been identified. Of various bacteriocins, there are some which have been used successfully for inhibiting both animal and human pathogens. Unfortunately, no large extent research has been found in the development of various bacteriocins as HIV …
Published in Research and Reviews: A Journal of Microbiology and Virology · Vol. 5, Issue 3, 2015 · pp. 18–23 Read article