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1901 articles for “ADMET lab 2.0” (ranking capped at the first 2,000 matches — narrow the search to see the rest)
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Structure and Origin Insight of Recent Coronavirus with Ongoing Therapeutic Approach
Abstract: Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) is highly transmissible zoonotic virus that was initially reported in late 2019 in Wuhan, China. Presently, it has infected approximately 1.5 million person and responsible for more than 0.1 million death across the world. It is likely evolved from bats and pangolin and genetically different from SARS-CoV-1, responsible for SARS disease. In present review, we have discussed the recent finding of its origin from …
Published in Research and Reviews : A Journal of Life Sciences Read article
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Molecular Characterization of Circulating Rota Viral Strain causing infantile diarrhoea in Tripura, North East India
Abstract: Introduction: North Eastern India is geographically distinct from rest of India and the trend of Rota viral diarrhoea among children below 5 years of age group is not well studied yet. The Government of India introduced the oral rotavirus vaccine (ROTAVAC) in 2016 as part of the Universal Immunization Programme in different parts of India. Objective: (1). To determine the proportion of circulating Rotavirus strains causing acute viral gastroenteritis (AGE) …
Published in Research and Reviews: A Journal of Microbiology and Virology · Vol. 11, Issue 3, 2021 · pp. 6–13 Read article
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Molecular Docking Evaluation of Cedrus deodara Secondary Metabolites as a Potent Anti-ovarian Cancer Agent
Abstract: Objective: According to the statistics for the year 2022 it was seen that cancer total cases is 14,61,427. After breast cancer, ovarian cancer is the second most frequent cancer among women. The estrogen receptor (PDB ID: 1X7E), progesterone receptor (PDB ID: 1A28), and Phosphoinositide 3-kinases (PDB ID: 4FJY) can be considered as target protein for ovarian cancer. The plant Cedrus deodara and its phytochemicals were chosen in this study to …
Published in International Journal of Molecular Biotechnological Research · Vol. 1, Issue 1, 2023 · pp. 77–93 Read article
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Enhanced Thermal Stability and Thermophysical Properties of High Density Polyethylene Based Polymer Composite Synthesized Through Compression Moulding Route
Abstract: Polymer composite materials attract researchers as polymers can be filled with different fillers to get desired properties. Thermophysical properties of HDPE-silicon composite is reported in the present study. HDPE-Si composite was synthesized by hot compression and molding technique for different silicon volumetric ratio. Thermal conductivity as well as thermal diffusivity was found to be enhanced significantly on increasing the filler volumetric ratio. Thermal conductivity value for 20 volume % composite …
Published in Journal of Polymer & Composites · Vol. 11, Issue 5, 2023 · pp. 1–16 Read article
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Analysis of Fibre Reinforced Beams
Abstract: There has been research into the flexural behaviour of composite beams with a variety of fibre layer depths, all of which were designed using the balancing section and the limit state design idea. The fibre depth is estimated to be 112 mm (d = 112 mm), with the first three dimensions being 94.44 mm (d1 = 94.44 mm), 46.12 mm (d2 = 22.35 mm), and 22.35 mm (d3) respectively. The …
Published in Journal of Polymer & Composites · Vol. 11, Issue 4, 2023 · pp. 53–59 Read article
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Lamivudine And Dolutegravir Simultaneous Dosage Forms Determined and Validated Using The RP-UPLC Method
Abstract: RP-UPLC has been used to produce a straightforward, precise, and accurate approach for the simultaneous estimation of dolutegravir and lamivudine in a pharmaceutical dose form. A HSS C18 column of 2.8 x 50 mm and featuring particles with a size of 1.6 μm was used to process the chromatogram. A mixture of 70:30 Buffer Na2HPO4 and methanol made up the mobile phase, which was pushed across the column at a …
Published in Emerging Trends in Personalized Medicines · Vol. 1, Issue 1, 2024 · pp. 5–13 Read article
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Red Cell Distribution in Pregnancy Associated with Preeclampsia Patients in Worldwide: A Brief Review
Abstract: Introduction: Preeclampsia (PE) is a major obstetric problem contributing considerably to maternal and prenatal morbidity and mortality worldwide. Preeclampsia varies in incidence in India from 5% to 15%. The role of this hematological parameter in clinical assessment, differential diagnosis, and prognosis evaluation of PE remains unclear. Thus, the purpose of the current review was to investigate the red cell distribution width (RDW) in preeclampsia, analyze its importance for early diagnosis, …
Published in Research and Reviews : A Journal of Life Sciences · Vol. 14, Issue 1, 2024 · pp. 6–12 Read article
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Physicochemical Analysis of Groundwater Quality In Owerri Municipal, Imo State, Nigeria Using MATLAB and ANN Models.
Abstract: The physicochemical analysis of groundwater quality in Owerri Municipal council, Imo state, Nigeria was carried out. Fifteen water samples were randomly selected from the five villages that make up Owerri municipal council were anlayzed for physicochemical parameters using standard methods. The results from the study area showed that the temperature ranged between 26.5-28.0oC; рH ranged between 4.80-5.32. Electrical conductivity ranged between 77-166 µЅ/cm. The total dissolved solids were between 35.4-168.4mg/l; …
Published in Emerging Trends in Chemical Engineering · Vol. 11, Issue 1, 2024 Read article
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Simultaneous Determination And Stability Indicating Method For Telmisartan, Metoprolol Succinate And Cilnidipine In Tablet Dosage Form.
Abstract: There are several medicinal agents available for antihypertensive activity. Telmisartan, metoprolol and cilnidipine are among them. Quantitative and qualitative analysis plays a pivotal role in safeguarding patients. Here, the estimation of these drugs was performed by using the chromatographic technique RP-HPLC. It was conducted with Phosphate buffer (pH 3.5 ± 0.01): Methanol (50:50 v/v) mobile phase. The system was operated at 1 ml/min. Drug volume to the system was 20μl. …
Published in Research & Reviews: A Journal of Drug Design & Discovery · Vol. 11, Issue 1, 2024 · pp. 32–38 Read article
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Effects of Soil and Water Conservation Measures on Selected Physico-Chemical Properties of Soil in Qenshiben Watershed Central Ethiopia Regional State
Abstract: One of the main causes of declining soil resources in Ethiopia has been identified as soil erosion, which in turn negatively affects the agricultural productivity of the country. In order to alleviate the problem of soil erosion, numerous soil and water conservation measures have been implemented during the past ten years in numerous parts of the country through community mass mobilization. In spite of the fact that conservation measures had …
Published in Research & Reviews : Journal of Agricultural Science and Technology · Vol. 13, Issue 1, 2024 · pp. 23–32 Read article
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Computational Screening of Vitex negundo Compounds for Potential Arthritis Therapies in India
Abstract: Objective: Arthritis is a pervasive medical condition that manifests as inflammation and discomfort within the joints. As of September 2021, arthritis has affected an estimated 180 million people in India, making it a substantial public health concern with a considerable impact on individuals' quality of life and healthcare systems. Therefore, using molecular docking, drug-likeness prediction, and ADME analysis, an effort was made to identify natural compounds from Vitex negundo, which …
Published in Research and Reviews : Journal of Computational Biology · Vol. 13, Issue 1, 2024 · pp. 01–18 Read article
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Environmental Impact of Ghaf Tree (Prosopis cineraria) on Heavy Metals Concentration in Atmosphere
Abstract: The Ghaf is a hardy tree, drought-resistant, and can grow up to ten meters in height, it tree produces small, yellow flowers which attractive to many habitats, like bees, insects, and birds. The leaves and pods of the Ghaf tree have significant antioxidant and anti-inflammatory properties and can be used in new drug development. Ghaf trees can adapt to changing environmental conditions and planting Ghaf trees could be an effective …
Published in International Journal of Minerals · Vol. 1, Issue 1, 2024 · pp. 1–7 Read article
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Estimation of Alogliptin and Dapagliflozin in Synthetic Mixture by RP-HPLC Method
Abstract: The primary objective of the proposed research was to develop and validate analytical methods for the simultaneous quantification of Alogliptin and Dapagliflozin in a synthetic mixture. Alogliptin and Dapagliflozin are medications used for managing diabetes, with Alogliptin inhibiting the enzyme Dipeptidyl peptidase-4 and Dapagliflozin belonging to the class of sodium-glucose cotransporter 2 inhibitors. High-performance liquid chromatography method development was conducted using a C18 column (250 mmX4.6 mm, 5 μm particle …
Published in Research and Reviews: A Journal of Pharmaceutical Science · Vol. 15, Issue 2, 2024 · pp. 37–46 Read article
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Heavy Metals Contamination in Groundwaters of Punjab: A Man-made Curse and its Mitigation
Abstract: The curse of heavy metal contamination in groundwaters of Punjab state is causing health hazards for the population of Punjab. It is not so much a natural disaster as its origin can be traced to a man-made crisis in Punjab. Potentially toxic elements, including high levels of Uranium (U) contamination in the Malwa belt of Punjab, Arsenic contamination in the Majha belt, and Selenium contamination in the Doaba belt of …
Published in Journal of Water Pollution & Purification Research · Vol. 11, Issue 1, 2024 · pp. 6–22 Read article
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Analysis of C45 Steel Machining with Differentiated Tool Bits
Abstract: The tool material may be coated or uncoated, and cutting inserts are typically situated along the covered contact region. Work piece remains fixed while tool revolves for cutting and machining. Objective: A NABL-accredited metallurgical evaluation laboratory (machining) assessed two specimens. Machining profile and materials determine insert selection. Analytical results show material composition. The surface qualities of samples 1 and 2 were examined. As DOC, cutting speed and tool tip temperature …
Published in Journal of Polymer & Composites · Vol. 12, Issue 5, 2024 · pp. 244–252 Read article
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A New Separation Technique for Method, Development and Validation of Aclidinium Bromide and Formoterol Fumarate in Its Pure and Pharmaceutical Dosage Form by Using Rp-HPLC
Abstract: A new simple, precise, selective and accurate, a new method of development and validation using Rp-HPLC for the estimation of Aclidinium bromide and Formoterol Fumarate in its pure and pharmaceutical dosage form. Chromatogram was run through DIKMA Spursil, C18 segment (4.6×150 mm, 5µ0). Mobile phases contain 0.1% OPA: Acetonitrile (30:70) with the use of the 0.1% OPA buffer, stream rate of 1 ml/min and measured in 280 nm. The run …
Published in Research and Reviews: A Journal of Pharmaceutical Science · Vol. 15, Issue 3, 2024 · pp. 18–36 Read article
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Diabetic Risk Prediction Using Machine Learning
Abstract: The global prevalence of Type 2 diabetes has risen dramatically in recent years, posing a serious public health risk. Long-term risk prediction is an important technique for evaluating who is most likely to develop type 2 diabetes. Early detection and response can lead to better management and prevention of diabetes complications. Developing a user-friendly Windows program for long-term Type 2 diabetes risk prediction could revolutionize preventive healthcare due to technological …
Published in International Journal of Satellite Remote Sensing · Vol. 2, Issue 1, 2024 · pp. 11–17 Read article
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Nano-Enhanced Biosensors: Bridging the Gap in Early Disease Detection and Diagnosis
Abstract: This article provides an in-depth examination of nano-enhanced biosensors, a groundbreaking technology that combines nanotechnology and biosensing techniques to transform disease detection and diagnosis. These advanced sensors boast exceptional sensitivity, specificity, and rapid response times, enabling early detection and treatment of various medical conditions. The article covers the fundamental principles, current applications, and prospects of nano-enhanced biosensors in multiple medical domains, including recent research, experimental investigations, and case studies. It …
Published in Journal of Nanoscience, NanoEngineering & Applications · Vol. 14, Issue 2, 2024 · pp. 10–17 Read article
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Evaluating the Effect of NPSB Fertilizers on Barely (Hordeum vulgare L.) Production and Productivity at Tocha Woreda, Southwest Ethiopia.
Abstract: A number of blended fertilizers (BFs) were formulated and introduced but site and crop specific rate was not identified. A research was conducted in Tocha woreda to evaluate the rate of NPSB fertilizer to improve barely yield during main cropping season of 2019 and 2020. The experiment consists of seven treatment such as control(0) , recommended NP (69kg N and 20kg P), NPSB: 18.9-37.7-6.95-0.1 (100kg NPSB), NPSB: 41.9-37.7-6.95-0.1(100kg NPSB + …
Published in Research & Reviews : Journal of Botany · Vol. 13, Issue 3, 2024 · pp. 39–45 Read article
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NPSB Fertilizer Effect on Yield of Wheat (Triticum aestivum L.) At Wolaita Zone Sodo Zuria Woreda, South Ethiopia
Abstract: Wheat (Triticum aestivum) is one of most important cereal crop in Ethiopia. The major obstacle for farmer to produce wheat in Ethiopia was low soil fertility status and nutrient imbalance. The experiment was conduct during 2019 and 2020 ‘meher’ cropping season at Kokate substation of Areka agricultural research center at sodo zuria woreda wolaita zone south Ethiopia with objectives of evaluating the effect of NPSB fertilizers rate on yield and …
Published in Research & Reviews : Journal of Botany · Vol. 13, Issue 3, 2024 · pp. 46–52 Read article