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308 articles for “Method validation”
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Effect of Sinusoidal and Inverse sinusoidal Load on the Vibration and Buckling Behaviour of Laminated Composite Symmetrical and Unsymmetrical Trapezoidal Panels
Abstract: Using finite element (FE) techniques, this work analyzes the influence of sinusoidal and invers sinusoidal stresses on the buckling behavior of trapezoidal laminated composite panels (also known as trapezoidal laminated composite panels). The discretization of the composite panel is accomplished by the use of an eight-noded iso-parametric plate element, which has five degrees of freedom for each node. Due to the incorporation of Higher Order Shear Deformation Theory (HOSDT) into …
Published in Journal of Polymer & Composites · Vol. 13, Issue 3, 2025 Read article
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Effect Of Sinusoidal and Inverse Sinusoidal Load on The Vibration and Buckling Behaviour of Laminated Composite Symmetrical and Unsymmetrical Trapezoidal Panels
Abstract: Using finite element (FE) techniques, this work analyzes the influence of sinusoidal and inverse sinusoidal stresses on the buckling behavior of trapezoidal laminated composite panels (also known as trapezoidal laminated composite panels). The discretization of the composite panel is accomplished by the use of an eight-noded iso-parametric plate element, which has five degrees of freedom for each node. Due to the incorporation of Higher Order Shear Deformation Theory (HOSDT) into …
Published in Journal of Polymer & Composites · Vol. 13, Issue 3, 2025 · pp. 72–84 Read article
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Experimental and Numerical Investigation of Corrosion-Induced Failures in Copper-Tin Alloy (Cu-Sn) and Aluminum-Magnesium Alloy (Al-Mg) Connectors: A Stress–Corrosion Coupling Analysis
Abstract: The utilization of an integrated experimental and finite element modelling (FEM) methodology, this study investigates the degradation and failure mechanisms in polymer composite electrical connectors exposed to aggressive environmental conditions. Epoxy- and polyamide-based composites, reinforced with carbon and glass fibers, were subjected to accelerated salt spray and humidity–temperature cycles to simulate prolonged outdoor exposure. Electrochemical and environmental aging experiments revealed that chloride ions and moisture ingress were responsible for matrix …
Published in Journal of Polymer & Composites · Vol. 14, Issue 2, 2026 · pp. 366–379 Read article
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AI-Enhanced Interpretation of Cardiac Troponins: Toward Predictive Precision in Myocardial Injury
Abstract: Background: Cardiac troponins (cTn) represent the gold standard biomarkers for myocardial injury detection, yet their interpretation remains challenging due to various confounding factors and clinical contexts. Artificial intelligence (AI) technologies provide remarkable possibilities to improve the interpretation of troponin levels by utilizing pattern recognition, predictive modeling, and clinical decision-making support. Objective: This review examines the current state and future potential of AI-enhanced cardiac troponin interpretation, focusing on machine learning applications, …
Published in Research and Reviews: A Journal of Medicine · Vol. 15, Issue 3, 2025 · pp. 1–9 Read article
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Molecular Docking and Interaction of Anthocyanin Derivatives in Regulating Hippo-taz Pathway for Renal Injuries
Abstract: Introduction: The Hippo pathway plays a pivotal role in renal disease, with Yes-associated protein (YAP) exhibiting promise for combined treatments. The crucial evaluation of YAP-targeted drug safety and efficacy through preclinical studies is imperative. Additionally, α-SMA and SMAD3 emerge as potential therapeutic targets in renal fibrosis, driving ongoing research toward innovative interventions. Materials and Methods: In the systematic identification of therapeutic secondary metabolites, Anthocyanin derivatives were methodically retrieved from the …
Published in International Journal of Genetic Modifications and Recombinations · Vol. 2, Issue 1, 2024 · pp. 23–38 Read article
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InSilico Analysis and Homology Modeling of Tetrahydroprotoberberine Oxide involved in the Berberine Biosynthesis
Abstract: Objective: Berberine, a bioactive compound found in various plant species, exhibits diverse pharmacological properties with potential applications in pharmaceutical research. The biosynthesis of berberine involves several enzymatic steps, with (S)-tetrahydroprotoberberine oxidase playing a pivotal role. This study aimed to elucidate the structural and functional characteristics of (S)-tetrahydroprotoberberine oxidase to better understand its role in berberine biosynthesis and its potential biotechnological applications. Methods: Using bioinformatics tools and computational methods, the physicochemical …
Published in Emerging Trends in Metabolites · Vol. 1, Issue 1, 2024 · pp. 7–26 Read article
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Solar Spin: BLDC Motor Integration for Sun powered Cycling
Abstract: This project focuses on the integration of a Brushless DC (BLDC) motor into an E-Solar Cycle to enhance its power generation efficiency. The aim is to design and implement a sustainable transportation solution that harnesses solar energy to supplement the electric power generated by the BLDC motor, thereby extending the cycle's range and reducing its dependence on external charging sources. A BLDC motor is used as the propulsion in the …
Published in Journal of Alternate Energy Sources & Technologies · Vol. 15, Issue 2, 2024 · pp. 30–36 Read article
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Gene prioritization of colorectal cancer using computational approach
Abstract: Colorectal cancer (CRC) continues to be a major worldwide health issue, underscoring the need to pinpoint crucial genetic elements influencing its initiation and advancement. In this investigation, we utilize sophisticated computational methods to prioritize potential genes linked to CRC development. Through the utilization of various bioinformatics tools and comprehensive methodologies, we systematically examine extensive microarray datasets to identify potential genetic contributors. Initially, a vast amount of CRC microarray data (approximately …
Published in International Journal of Bioinformatics and Computational Biology · Vol. 2, Issue 1, 2024 · pp. 39–52 Read article
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Phase – Field Modeling of Brittle and Ductile Fracture Under Complex Loading Conditions
Abstract: Phase-field modeling has emerged as a powerful computational framework for predicting fracture behavior in engineering materials, offering a unified description of crack initiation, propagation, branching, and coalescence without the need for explicit crack tracking. This study presents an in-depth examination of phase-field modeling applied to both brittle and ductile fracture under complex loading conditions, including multiaxial stress states, cyclic loading, thermal gradients, and dynamic impact. The phase-field approach regularizes the …
Published in International Journal of Fracture Mechanics and Damage Science · Vol. 3, Issue 2, 2025 · pp. 13–18 Read article
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Analyzing the Role of Fiber Composition in Drying Behavior: A Comparative and Predictive Approach
Abstract: This research presents a comprehensive analysis of the drying behavior and thermal response of three distinct fabric types: 100% Cotton, 100% Polyester, and a Polyester blend (65/35), under meticulously controlled environmental conditions. The Polyester blend (65/35) consists of 65% Polyester and 35% Cotton, combining characteristics of both fibers. The investigation focuses on understanding how fiber composition impacts drying time, moisture retention, and thermal characteristics. Experimental trials were conducted using standardized …
Published in Journal of Polymer & Composites · Vol. 13, Issue 5, 2025 · pp. 1–11 Read article
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AI-Designed Functionally Graded Polymer Composites for Multifunctional Thin Films
Abstract: The design of multifunctional polymer composite thin films requires simultaneous optimization of mechanical, optical, barrier, and thermal properties—objectives often in conflict when using conventional homogeneous materials. This study presents an artificial intelligence-driven framework for designing functionally graded material (FGM) architectures in polymer nanocomposite thin films. We integrated machine learning with physics-based modeling to optimize compositional gradients across film thickness, achieving superior performance compared to homogeneous and discrete multilayer alternatives. A …
Published in Journal of Polymer & Composites · Vol. 14, Issue 2, 2026 · pp. 1026–1041 Read article
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Early Alzheimer's Disease Detection Using Deep Ensemble Learning and MRI Image Analysis
Abstract: Early detection of Alzheimer's disease (AD) is crucial to slowing cognitive decline and enabling timely clinical interventions. Traditional diagnostic methods, including cognitive tests and single-model classifiers, have limited sensitivity during early stages of the disease. This paper presents a deep ensemble learning approach that integrates multiple convolutional neural networks (CNNs) for accurate Alzheimer's disease detection using structural Magnetic Resonance Imaging (MRI) data. The proposed framework utilizes ResNet50, VGG16, and DenseNet121 …
Published in Research and Reviews : Journal of Computational Biology · Vol. 15, Issue 1, 2026 Read article
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Design and Research of Thermoelectric Energy Harvesting Methods for Instantaneous Use
Abstract: In today’s consumer-oriented market, researchers are attempting to harness energy from ambient sources for sustainable energy generation leading to reduction of dependency on conventional energy sources. Energy harvesting methods offers enormous opportunities to derive energy from our natural surroundings to directly operate self-powered devices or storing it for later use. Generating energy from our nearby environment seems to be a promising solution to address the growing concerns of powering small …
Published in Trends in Machine design · Vol. 13, Issue 1, 2026 · pp. 1–16 Read article
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Assessment of Chlorides In The Water Samples And Its Absorption By Thermosetting Polymer Phenol Formaldehyde Resin
Abstract: Assessing chloride levels in water samples is critical for monitoring water quality and ensuring environmental and public health protection. This study presents a comprehensive methodology for estimating chloride concentrations in water samples through various analytical techniques, including titration. Results obtained from each method were compared and discussed to evaluate their accuracy, and applicability in different environmental settings. The data shows that the samalkot drinking water sample has a relatively high …
Published in Journal of Polymer & Composites · Vol. 12, Issue 2, 2024 · pp. 91–98 Read article
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A Comprehensive Review on the Miniaturized Analytical Techniques for Sustainable Pharmaceutical Testing
Abstract: Miniaturized analytical techniques are revolutionizing pharmaceutical testing by offering sustainable and efficient alternatives to traditional methods. These techniques are designed to reduce sample and reagent consumption, minimize waste generation, and accelerate analysis, aligning perfectly with the principles of green analytical chemistry. This comprehensive review aims to thoroughly explore the landscape of miniaturized analytical techniques, specifically highlighting their profound impact on fostering sustainable practices within the pharmaceutical sector. The review systematically …
Published in Research and Reviews: A Journal of Pharmaceutical Science · Vol. 17, Issue 1, 2026 · pp. 18–39 Read article
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RTL-to-GDSII Flow Optimization for Low-Power 32-bit RISC-V Processor
Abstract: This paper presents the implementation and optimization of a 32-bit RISC-V processor, transitioning from Register Transfer Level (RTL) design to final GDSII using Synopsys Fusion Compiler over 32nm technology node. The processor architecture is based on the RV32I base instruction set and incorporates a 5-stage pipeline to achieve a balanced trade-off between performance and design complexity. The design methodology involved RTL synthesis, gate-level netlist generation, and successive physical design stages …
Published in Journal of VLSI Design Tools and Technology · Vol. 15, Issue 3, 2025 · pp. 1–10 Read article
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Comparative Study of Bioactive Phytochemicals from Hexane Extract of Two Amaranthaceae Leafy Vegetables by GC-MS Method
Abstract: Amaranthus tricolor Linn and Amaranthus viridis Linn, belonging to the Amaranthaceae family, are popularly consumed leafy vegetables in India and many other countries globally. The bioactive components of Hexane extract from these two plants have been analysed using gas chromatography-mass spectrometry (GC–MS) technique. According to analysis, both species contain a total of nineteen important chemicals. Of these, ten were found in A. tricolour L. and nine in A. viridis L. …
Published in Journal of Polymer & Composites · Vol. 13, Issue 6, 2025 · pp. 7–17 Read article
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Stability-Indicating Rp-Hplc Development and Validation for the Estimation of Lercanidipine Hydrochloride Content in Tablet Dosage Form
Abstract: A sensitive, stability-revealing, and easy reverse-phase high-performance liquid chromatographic (RP-HPLC) technique was developed and rationalized to be in a position to determine Lercanidipine hydrochloride in ingested dosing preparations. It was separated by chromatography on a C 18 column using a mobile phase containing 10 mM potassium dihydrogen phosphate buffer and methanol (20:80, v/v; pH 4.0) at a flow rate of 1.0 mL/min and UV detected at 258 nm. The retention …
Published in Research & Reviews: A Journal of Drug Formulation, Development and Production · Vol. 13, Issue 1, 2026 · pp. 17–26 Read article
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Exploring Potential Phytochemicals for Myasthenia Gravis Treatment: A Molecular Docking and ADME Analysis Approach
Abstract: Objective: Muscle feebleness and exhaustion derived from a disruption in neuromuscular transference are hallmarks of the crippling autoimmune disease myasthenia gravis (MG). The drawbacks of the current MG therapy options are frequently partial efficacy and adverse effects. To investigate the potential of phytochemicals in MG control, in this work we integrated molecular docking with ADME (absorption, distribution, metabolism, and excretion) analysis using a computer method. We identified molecules exhibiting favorable …
Published in International Journal of Molecular Biotechnological Research · Vol. 2, Issue 2, 2024 · pp. 1–13 Read article
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Structural Behavior of Flexible and Semi-Rigid Beam-Column Joint Connections by FEM
Abstract: This study investigates the structural behavior of flexible and semi-rigid beam-column joint connections in cold-formed steel (CFS) structures, focusing on the use of Finite Element Modeling (FEM) to simulate their performance under various loading conditions. Traditional analysis methods often oversimplify beam-column connections, treating them as either perfectly rigid or fully flexible, which does not accurately capture real-world joint behavior. In reality, many beam-column joints exhibit semi-rigid characteristics, where the stiffness …
Published in Journal of Structural Engineering and Management · Vol. 12, Issue 3, 2025 Read article