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622 articles for “potential treatments”
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Systemic Lupus Erythematosus Revisited: A Milestones in Classification, Mechanistic Insights on Pathogenesis, Diagnosis, and Evolving Treatment Paradigms
Abstract: Systemic lupus erythematosus (SLE) is a prototypic, multi-systemic chronic inflammatory autoimmune disorder characterized by extreme clinical heterogeneity and the potential to involve virtually any organ or tissue. The condition is driven by a fundamental breakdown in immune tolerance, resulting in the overproduction of pathogenic autoantibodies and the formation of immune complexes that precipitate widespread inflammation and organ damage. This review aims to provide an exhaustive synthesis of recent developments in …
Published in Research and Reviews: A Journal of Pharmacology · Vol. 16, Issue 3, 2026 Read article
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A Computational Study to Elucidate the Phytochemicals as An Antagonist Against Pruritis in Psoriasis
Abstract: Objective: Psoriasis is a chronic, non-contagious, auto-immune skin disorder that causes inflammation, pain, and itching in the affected areas. The etiology of this condition is not entirely understood, and while there are treatments available to manage the symptoms, there is currently no cure. The Transient receptor potential cation channel, subfamily Vanillin, member 3 (TRPV3), present in keratinocytes, allegedly had a part in the development of psoriasis-related pain and itching. Specifically, …
Published in International Journal of Bioinformatics and Computational Biology · Vol. 1, Issue 2, 2023 · pp. 49–61 Read article
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Human Arginase I (Arg I)—A Potential Broad-spectrum Anti-cancer Agent: Perspectives and the Road Ahead
Abstract: Cancer is the second leading cause of morbidity and mortality globally. A variety of effective regimens are available for the treatment of different cancers, however, there is still a need for the development of safe and effective broad-spectrum anti-cancer agent(s). Towards this, amino acid-depleting enzymes have proven to be effective in the treatment of certain auxotrophic cancers. In this review, we have briefly discussed arginine metabolism and arginine depletion as …
Published in Research and Reviews: Journal of Oncology and Hematology · Vol. 9, Issue 3, 2020 · pp. 23–35 Read article
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METAL NANOPARTICLE: SYNTHESIS, PROPERTIES, AND THEIR DERMATOLOGICAL AND COSMETIC IMPACTS
Abstract: Nanoparticles (NPs) are materials with dimensions under 100 nm and various shapes, such as spheres and rods. Their advancement offers transformative potential in medical and healthcare fields. The increased application of NPs across molecular biology, chemistry, medicine, and material science reflects their growing importance. Due to their large surface area, NPs enhance substance delivery through the skin, benefiting cosmetic applications by improving penetration, efficacy, and targeted delivery of active ingredients.With …
Published in Recent Trends in Cosmetics · Vol. 2, Issue 2, 2025 · pp. 1–6 Read article
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Protective Effects of Phyllanthus amarus and Sida acuta Extracts Against DoxorubicinInduced Toxicity in Chick Embryo Models
Abstract: Chemotherapy remains a cornerstone of cancer treatment, yet severe side effects, including cardiotoxicity often limit its clinical application. Doxorubicin, a widely used anticancer drug, is particularly associated with dose-dependent toxicities that impact the heart, liver, and kidneys. In search of complementary approaches to mitigate these adverse effects, this study evaluates the protective potential of hydro-alcoholic extracts from Phyllanthus amarus and Sida acuta, two medicinal plants with known antioxidant and anti-inflammatory …
Published in Research and Reviews: A Journal of Toxicology · Vol. 15, Issue 2, 2025 Read article
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Fabrication and Characterization of Diacerein Loaded Nanosponge for Topical Delivery
Abstract: Diacerein, an anti-inflammatory drug, which comes under BCS class II, commonly used in treatment of osteoarthritis has limited by its poor solubility and bioavailability when administered topically. This study aimed to develop and evaluate diacerein-loaded nanosponges gel using varying concentrations of ethyl cellulose and polyvinyl alcohol (PVA) to enhance its delivery. Nanosponges were prepared using an emulsion solvent evaporation technique, with different ratios of ethyl cellulose (0.05-0.250%) and PVA (0.2-0.3%). …
Published in Research & Reviews: A Journal of Drug Formulation, Development and Production · Vol. 12, Issue 2, 2025 · pp. 26–46 Read article
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Multitarget Molecular Docking Using Curcuma longa Phytocompounds for Polycystic Ovary Syndrome Treatment
Abstract: Objective: The primary goal of this research is to understand and describe specific aspects of molecular interaction, it includes studying various aspects such as binding affinity, binding mode, and stability of the ligand-protein complex. Molecular docking is a computational technique used to predict the preferred orientation of one molecule to a second when bound together to form a stable complex. In this study, molecular docking will be employed to stimulate …
Published in International Journal of Molecular Biotechnological Research · Vol. 2, Issue 1, 2024 · pp. 15–28 Read article
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Microneedles: A Modern Breakthrough in Drug Delivery Systems
Abstract: Microneedles (MNs) represent a revolutionary and transformative advancement in the realm of transdermal drug delivery systems, which are designed to facilitate the administration of therapeutic agents through the skin. These exceptionally small, micron-scale needles penetrate the stratum corneum, thereby enabling the direct delivery of pharmacological agents into the underlying dermis or the upper epidermis, consequently enhancing bioavailability while simultaneously circumventing the detrimental effects of first-pass metabolism and the degradation that …
Published in Trends in Drug Delivery · Vol. 12, Issue 3, 2025 · pp. 01–07 Read article
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Kinetics of Crystallization and Microstructural Evolution of Commercial Fluorophlogopite Machinable Glass- Ceramics in the System SrO∙4MgO∙Al2O3∙ 6SiO2∙2MgF2 with Varying in B2O3
Abstract: Glass materials based on fluorophlogopite stoichiometry with varying concentrations of B₂O₃ were synthesized using the melt-casting method, followed by heat treatment at different crystallization temperatures. The resulting glass and glass–ceramic samples were characterized using differential thermal analysis (DTA), scanning electron microscopy (SEM), X-ray diffraction (XRD), and Fourier-transform infrared (FT-IR) spectroscopy. Kinetic analysis revealed that the activation energies required for the formation of glass–ceramics were 192.77 kJ mol⁻¹ and 210.47 kJ …
Published in Journal of Thin Films, Coating Science Technology & Application · Vol. 12, Issue 3, 2025 · pp. 1–16 Read article
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Detection of Cancer using Machine Learning Algorithms
Abstract: Cancer is a group of diseases characterized by uncontrolled growth and spread of abnormal cells. There are over 100 types of cancer. And any part of the body can be affected. Cancer has become 2nd leading cause of death. Some hospitals offer cancer screening tests; the test results need to be evaluated by an oncologist. The cancer screening test are very expensive and not available in all of the hospital. …
Published in Trends in Machine design · Vol. 7, Issue 3, 2020 · pp. 9–16 Read article
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A Study on Cancer Related Fatigue and Quality of Life (QOL) among Women Undergoing Treatment for Various Cancers in Selected Tertiary Care Hospitals of Ludhiana, Punjab
Abstract: Cancer is a collection of illnesses marked by irregular cell proliferation that has the potential to infiltrate or metastasize to different areas of the body. Gynecological cancer specifically refers to the abnormal cell growth in the female reproductive tract, including various organs such as the endometrium, fallopian tubes, ovaries, uterus, cervix, vagina, and breast. These cancer cells have a tendency to multiply uncontrollably. The majority of individuals diagnosed with cancer …
Published in International Journal of Oncological Nursing and Practices · Vol. 1, Issue 1, 2023 · pp. 6–11 Read article
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Harnessing the Potential of Insectivorous Birds in Managing the Rice Leaf Folder, Cnaphalocrocis Medinalis in Paddy Ecosystems of Kerala
Abstract: This study evaluates the effectiveness of various treatments for managing leaf folder pests in rice crops during the maximum tillering stage, focusing on the role of insectivorous birds. The treatments included bird perches (T1), nylon nets (T2), Bt spray (T3), a combination of bird perch and Bt spray (T4), flubendiamide spray (T5), and a control group (T6). Results indicated significant differences in pest densities. T2 showed the highest mean density …
Published in International Journal of Insects · Vol. 1, Issue 2, 2024 · pp. 6–9 Read article
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Phytoremediation of Aquaculture Wastewater: Duckweed (Lemna minor L.) as a Phytoremediator
Abstract: Aquaculture systems discharge huge quantities of waste into the aquatic ecosystem, in the form of excretory products and excess feed. These have grave implications on physicochemical and biological quality of the receiving environment. The study aimed to determine potential of duckweed (Lemna minor L.) for phytoremediation of aquaculture effluent. Hundred grams (100 g) of duckweed was grown in 10 L aquaculture effluent for 7-, 14-, 21-, and 28-day retention period …
Published in International Journal of Pollution: Prevention & Control · Vol. 3, Issue 1, 2025 · pp. 13–19 Read article
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Role of Topical Onion Extract in Scar Management at Donor Site
Abstract: Scarring is commonly caused by an imbalance between collagen synthesis and degradation. One promising approach to mitigate scar formation involves the use of onion extract, known for its ability to inhibit fibroblast activity, which plays a key role in the development of scars. Despite the widespread use of onion extract in various commercial scar treatment products, the exact molecular mechanisms through which it exerts its scar-reducing effects remain unclear.This study …
Published in Research and Reviews : Journal of Surgery · Vol. 13, Issue 2, 2024 · pp. 7–11 Read article
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Determining the Root Causes of Complications in Hemodialysis
Abstract: As with peritoneal dialysis and kidney transplantation, hemodialysis has been considered one of the most effective therapies for the replacement of kidney function. While this helps to save patients with the disease by decreasing morbidity /mortality/ rates, this medication has some side effects. These may manifest during the dialysis process alongside the ongoing treatment. Avoiding these barriers becomes crucial for improving the patients’ prognosis in this context.We are going to …
Published in Emerging Trends in Metabolites · Vol. 1, Issue 1, 2024 · pp. 27–47 Read article
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NanoBioAI: Utilizing Python to Investigate Magnetocaloric Effects in Magnetotactic Bacteria and Optimized Conditions for Thermotherapy
Abstract: The study presented in the research work represents a multidisciplinary approach, integrating biology, nanotechnology, and artificial intelligence. It specifically highlights the use of python computational power to investigate magnetocaloric effect (MCE) in magnetotactic bacteria (MTB), a phenomenon yet to be fully understood, characterized by reversible heating and cooling effects induced by magnetic fields. MTB are unique in that they contain embedded magnetic nanoparticles ranging from 10–100 nm in diameters. These …
Published in Journal of Artificial Intelligence Research & Advances · Vol. 11, Issue 2, 2024 · pp. 122–131 Read article
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To Investigate Hormonal Fluctuations in Male Rattus norvegicus after Treatment with 50% Methanolic Extract of Acacia arabica
Abstract: The use of medicinal plants in traditional and modern medicine has garnered significant interest for their therapeutic potential. Acacia arabica, commonly known as babul, is renowned for its bioactive compounds and diverse pharmacological properties. This study investigates the hormonal fluctuations induced by 50% methanolic extract of Acacia arabica in male Rattus norvegicus, aiming to explore its potential as a male contraceptive. Male contraception remains limited primarily to condoms and vasectomy, …
Published in Research & Reviews : Journal of Herbal Science · Vol. 13, Issue 3, 2024 · pp. 28–38 Read article
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Alteration in Metabolic Enzymes of Albino Rats under Cadmium Stress and their Modulation by Mentha Piperita
Abstract: Cadmium is a heavy metal posing severe risks to human health without any physiological function in the human body. Cadmium is found regularly in soil, rocks and ores, thus natural exposure is an important aspect, but increasing industrial application has put it in the category of bio-hazardous metals. Anticorrosive agents, stabilizer in PVC products, colour pigments, neutron-absorber in nuclear power plants, the fabrication of nickel-cadmium batteries and Phosphate fertilizers carry …
Published in Research and Reviews: A Journal of Toxicology · Vol. 3, Issue 3, 2013 · pp. 1–4 Read article
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Role of Food Supplements in Premalignant Lesions: A Literature Review
Abstract: Premalignant lesions of the oral cavity are histopathological alterations in the oral epithelium linked to a higher likelihood of malignant transformation. These lesions frequently present as leukoplakia (white patches), erythroplakia (red patches), oral lichen planus, and oral submucous fibrosis. Oral cancer, categorized among head and neck malignancies, is considered the sixth most common cancer globally. While tobacco and alcohol consumption remain the primary etiological factors, increasing evidence underscores the significant …
Published in Research and Reviews: A Journal of Dentistry · Vol. 16, Issue 3, 2025 · pp. 17–26 Read article
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In Silico Screening and Evaluation of Some Metabolites from Momordica charantia in the Treatment of Peptic Ulcers
Abstract: Peptic ulcers are also called as or duodenal ulcers or gastric ulcers that are open sores generally develop in the lining of the stomach due to food and climatic factors. H. pylori infections are potentially the most dangerous and are linked to several diseases like diabetes, cancer, cardiovascular diseases, etc. In the present study, in silico screening and evaluation of some metabolites from Momordica charantia like Momorcharin, Momordicin, Metformin, Pioglitazone, …
Published in Research and Reviews : Journal of Computational Biology Read article