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1877 articles for “Drug–protein interactions (DPIs)”
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Anti Covid-19 Drugs Suggested by Computational Methods: A Review
Abstract: Background and aims: Long COVID refers to the persistence of illness in individuals who have survived from COVID-19 infection. This article reviews long covid and the use of in silico techniques in drug development for COVID-19. Results: Many COVID-19 survivors have long COVID, which has become a burden in daily life. Various attempts have been undertaken to relieve symptoms and manage it, but there is no cure as of yet. …
Published in International Journal of Cell Biology and Cellular Functions · Vol. 1, Issue 1, 2023 · pp. 16–34 Read article
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Development and Assessment of Levetiracetam Microspheres Utilizing Synthetic and Natural Polymers: A Biomedical Engineering Perspective
Abstract: In the present study, comparative study of Levetiracetam loaded microspheres using Ethyl cellulose as synthetic and Sodium alginate as natural polymers was done. Solvent evaporation and ionic gelation technique has been successfully employed to produce Levetiracetam loaded ethyl cellulose and sodium alginate microspheres with optimal drug encapsulation that sustained the drug release over a period of time. Based on the pre-formulation studies E1 to E4 and S1 to S4 batches …
Published in International Journal of Biomedical Innovations and Engineering · Vol. 2, Issue 1, 2024 · pp. 1–18 Read article
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Using Multitarget Molecular Docking to Examine the Antiviral Potential of Clerodendrum Phlomidis against Measles
Abstract: Objective: Measles, a viral disease caused by a member of the Paramyxoviridae virus family, is highly contagious and characterized by a respiratory illness and a maculopapular rash on the skin. Children are the main victims of the illness. In the context of drug development, this study investigates the efficacy of phytocompounds derived from Clerodendrum phlomidis against the target protein of the measles virus. Methods: The 7SKS protein was retrieved from …
Published in International Journal of Molecular Biotechnological Research · Vol. 1, Issue 2, 2023 · pp. 32–42 Read article
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Exploring Chocolate’s Potential: A Review of Its Role in Drug Delivery and Health Benefits
Abstract: The abstract explores the versatile nature of chocolate, highlighting its role as a medium for drug delivery systems due to its resistance to microbial growth and rich nutritional profile. Medicated chocolate, infused with drugs, offers a palatable solution to enhance patient compliance, particularly among children, while stimulating serotonin production for added therapeutic benefits. Cocoa, abundant in polyphenols, contributes to chocolate's health advantages, including cholesterol reduction and cardiovascular health. Scientific evidence …
Published in Trends in Drug Delivery · Vol. 11, Issue 2, 2024 · pp. 16–24 Read article
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Development of a Machine Learning and Artificial Intelligence Based Model Aimed at Forecasting the Prognostic Impact of C-Reactive Protein in Myocarditis
Abstract: The specific role of inflammation markers in myocarditis remains uncertain. We investigated the diagnostic and prognostic significance of C-reactive protein (CRP) levels at the initial diagnosis among myocarditis patients. Our retrospective study enrolled patients clinically suspected (CS) or biopsy-proven (BP) with myocarditis, with available CRP data at diagnosis. We collected patient information, including clinical, laboratory, and imaging findings at diagnosis and follow-up visits. We utilized machine learning methods, specifically random …
Published in Research and Reviews: A Journal of Health Professions · Vol. 14, Issue 2, 2024 · pp. 12–24 Read article
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Drug Design and Process Chemistry: Bridging the Gap between Discovery and Manufacturing
Abstract: This review explores how drug discovery connects with process chemistry to enable large- scale pharmaceutical manufacturing. While drug discovery identifies and optimizes therapeutic compounds, process chemistry adapts these compounds for mass production, addressing challenges in scalability, cost, and quality. The article examines the role of early collaboration between drug designers and process chemists, recent innovations in green chemistry and flow chemistry, and case studies that illustrate successful scale-up strategies. Emerging …
Published in Trends in Drug Delivery · Vol. 12, Issue 1, 2025 · pp. 09–21 Read article
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Computational Analysis of Tinospora Cordifolia Phytochemicals as Potential Inhibitors of BRCA1-BRCT Domain Interaction in Breast Cancer
Abstract: Breast cancer is a leading cause of cancer-related deaths worldwide, accounting for a significant proportion of mortality rates among women. Despite current therapeutic approaches, the disease remains characterized by molecular heterogeneity, making it challenging to develop effective treatments. This study explores the potential of Tinospora cordifolia, a medicinal plant, in breast cancer therapy. Guduchi, scientifically known as Tinospora cordifolia, boasts a centuries-long history of use in traditional medicine, with a …
Published in International Journal of Molecular Biotechnological Research · Vol. 3, Issue 1, 2025 · pp. 27–37 Read article
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Biochar-Filled Soy Protein Composites: Evaluating Thermal and Mechanical Properties for Sustainable Polymer Applications
Abstract: The growing demand for environmentally sustainable and biodegradable materials has intensified interest in alternative solutions for thermal insulation. This study explores the development of composite materials using mango seed shell biochar (MSSB) and soy protein isolate (SPI) as a biodegradable matrix-filler system. Mango seed shells, an abundant agro-industrial waste, were subjected to pyrolysis at 500°C for 2 hours to produce biochar. The resulting MSSB was incorporated into SPI with glycerol …
Published in Journal of Polymer & Composites · Vol. 13, Issue 3, 2025 · pp. 60–71 Read article
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Nano-Therapeutics in Diabetes Mellitus: Revolutionizing Diagnosis, Treatment, and Drug Delivery
Abstract: Diabetes mellitus is a chronic metabolic disorder in which blood glucose concentration remains high over an extended duration, resulting in significant lethal complications, including neuropathy, nephropathy and cardiovascular diseases. However, conventional diabetes management strategies, including insulin therapy and oral hypoglycemic agents, rarely exhibit poor bioavailability, high doses, off target delivery, etc. Nanotechnology has brought the rise of diabetes treatment revolution, by overcoming the challenges present in standard treatment, owing to …
Published in Trends in Drug Delivery · Vol. 12, Issue 2, 2025 · pp. 08–19 Read article
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Polymer Chemistry in Nutraceutical Composites: Exploring Natural Polymers and Binding Systems in a Bamboo-Enhanced Formulation
Abstract: Polymer chemistry underpins the development of advanced nutraceutical composites, blending natural polymers with functional ingredients for health benefits. This study examines a novel nutraceutical formulation comprising ragi (16.39 g/100g), wheat (12.29 g/100g), soybean (12.29 g/100g), buffalo milk (16.39 g/100g), buffalo butter (4.13 g/100g), bamboo extract (0.90 g/100g), and auxiliary components (37.61 g/100g, including fats, sugars, and proteins). Natural polymers—proteins from soybean and milk, polysaccharides from ragi and wheat—form a macromolecular …
Published in Journal of Polymer & Composites · Vol. 13, Issue 6, 2025 · pp. 878–884 Read article
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Innovations in Targeted Drug Discovery for Personalized Medicine
Abstract: Personalized medicine is revolutionizing modern healthcare by custoizing treatment plans to match an individual’s genetic makeup, protein expression, and metabomlic characteristics. Also referred to as precision medicine, this approach seeks to improve therapeutic outcomes, reduce adverse effects, and make efficient use of healthcare resources. The incorporation of various omics technologies—including genomics, proteomics, transcriptomics, metabolomics, and epigenomics—has greatly advanced our ability to understand disease biology and molecular variations specific to each …
Published in Research & Reviews: A Journal of Drug Design & Discovery · Vol. 12, Issue 3, 2025 · pp. 19–41 Read article
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Study of Behavior of Buckling Restrained Bearing Frame Along with Soil Structure Interaction
Abstract: Lateral forces due to earthquake are the major consideration for design of earthquake resisting structures, these forces can be resisted by various systems like braced frames, shear walls, moment frames, etc. Energy dissipation is one of the most convenient option for earthquake resistance, as it can absorb input energy from earthquake protecting the main structure. Past research revealed that the Buckling Restrained Braces (BRB) are the best type of energy …
Published in Journal of Construction Engineering, Technology & Management Read article
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Herbal Drug Used in the Treatment of Diabetes: A Review
Abstract: Background: Diabetes mellitus is a chronic disease that occurs at the point when the pancreas is not able to produce insulin, or when the body cannot utilize the insulin it produces. Diabetes mellitus is a complex metabolic disorder that affects various systems of body such as visual, circulatory, renal and nervous system. Human beings depend upon plants for their various needs such as food, fodder, fuel, timber, fibres, dyes, gums, …
Published in Research & Reviews : Journal of Herbal Science Read article
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Valeton Phytoconstituents from Curcuma Phaeocaulis as Prion Protein Mutant V210I Inhibitors: A Computational Docking and Virtual Screening Study
Abstract: Objective: Creutzfeldt-Jakob disease (CJD), a neurological disorder that is sporadic, fatal, communicable, and worsens rapidly, is caused by abnormal folding of prion proteins. Identifying and assessing the potential of phytocompounds from the Curcuma phaeocaulis Valeton plant as a new therapeutic candidate aimed at the treatment of CJD is the objective of this research article. Methods: In this experiment, we assessed outcomes following an in-silico assessment to design a new oral …
Published in International Journal of Biochemistry and Biomolecule Research · Vol. 1, Issue 2, 2023 · pp. 1–16 Read article
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A Narrative Review on an Insight of Herbal Origin Drugs and Their Traditional Medicine Formulations for the Treatment of Nephrolithiasis
Abstract: Ethnopharmacological relevance. There is no satisfactory treatment at present to cure or prevent kidney stone recurrences using predictable medicines. There are several marketed formulations in Ayurveda, Unani and Homeopathic Traditional Medicines (TM) have potential lithotriptic effects and clinical applications. In India, prevalence rates of complementary and alternative medicine (CAM) for the treatment of nephrolithiasis are being estimated at 63.9%. Aim of the review This review article intended to scientifically documented …
Published in International Journal of Tropical Medicines · Vol. 1, Issue 1, 2024 · pp. 14–30 Read article
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Improving Parachute Efficiency: The Function of LS- Dyna in Fluid-structure Interaction Simulation
Abstract: As an accompaniment to assessment of DGA Aeronautical Systems created a simulation and model-building capability to gain a better understanding of the parachute dynamic behavior and to maximize the parachute systems flight tests. This work reports on the latest developments in Arbitrary Lagrangian mathematical (ALE) methods for analyzing the properties of the quasi-steady state descent phases and canopy inflation. Thus far, none of the simulations of the endless mass type …
Published in Journal of Experimental & Applied Mechanics · Vol. 15, Issue 1, 2024 · pp. 44–56 Read article
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To Rule Out the Efficacy of Haridradi Drugs in Respiratory Allergic Disorders in the Childrens.
Abstract: Allergic diseases in children have increased significantly in recent years and they are a major cause of morbidity in the children. Although there is a genetic predisposition, exposure to allergens i.e pollens, irritants, infections, diets and inhalant will determine the sensitization. At present, the best approach to the children who are at high risk for the development of allergies is to introduce environmental and dietary control and adopt early measures …
Published in Journal of AYUSH: Ayurveda, Yoga, Unani, Siddha and Homeopathy · Vol. 13, Issue 2, 2024 · pp. 53–60 Read article
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Anticancer Activity of Calotropis procera by Molecular Docking Analysis
Abstract: Cyclin-dependent kinase 2 (CDK2) is a protein synthesized by Calotropis procera. It is known to be responsible for causing cancer in the human body. Studies have presented the significance of the phytochemicals to inhibit the CDK2 protein. Adsorption, distribution, metabolism, and excretion (Swiss ADME) and PubChem were the pharmacological tools which were used to check molecular weight, which should be less than 500D, acceptors less than 10, and donors less …
Published in International Journal of Biochemistry and Biomolecule Research · Vol. 2, Issue 1, 2024 · pp. 01–07 Read article
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A Review on: Oral Thin Films: A New Approach to Effective and Easy Drug Delivery
Abstract: Oral Thin Film (OTF) is an advance drug delivery system in which drug is incorporated into dissolvable strip and place in oral cavity for rapid absorption. OTF is useful for patient such as pediatric and geriatric who have difficulty swallowing pills. It provides rapid action, precise dosage and improved bioavailability. OTFs consist of fast-dissolving films, extended-release films, and mucoadhesive films for various therapeutic applications. The manufacturing processes of OTFs such …
Published in Trends in Drug Delivery · Vol. 11, Issue 3, 2024 · pp. 22–41 Read article
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Pharma Tech: Leveraging Software for Drug Development & Clinical Research
Abstract: The pharmaceutical sector is progressively adopting software solutions to enhance the drug development process and optimize clinical research results. Drug development is a time-consuming, expensive, and intricate process that traditionally requires extensive laboratory research, preclinical testing, and several stages of clinical trials. Software tools are revolutionizing these stages by improving efficiency, minimizing errors, and speeding up timelines. During preclinical testing, predictive software tools are used to model toxicological effects and …
Published in International Journal of Bioinformatics and Computational Biology · Vol. 3, Issue 1, 2025 · pp. 11–19 Read article