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227 articles for “Genetics of the Disease”
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Uncommon Occurrence of Gastric Adenocarcinoma Occurring in a Patient with Common Variable Immunodeficiency Syndrome
Abstract: Common variable immunodeficiency (CVID) belongs to the diagnostic category of primary immunodeficiency (PID). They are characterized by a heterogeneous group of disorders that include recurrent infections, autoimmunity, granulomatous diseases and malignancies. The incidence of malignancy in CVID patients is around 1.5–20.7% and usually occurs during the 4th–6th decade of life. Non-hodgkin lymphoma is the most frequent malignancy, followed by epithelial tumors of stomach, breast, bladder and cervix. Patients with CVID …
Published in Research and Reviews: Journal of Oncology and Hematology · Vol. 7, Issue 1, 2018 · pp. 16–20 Read article
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Vaccine Candidates and Animal Models for Kala-Azar
Abstract: Kala-azar or Visceral Leishmaniasis (VL) is a serious human disease in tropical regions and rapidly emerging as an opportunistic infection in HIV patients. The available treatment against VL is associated with toxicity and drug resistance. Even though the development of vaccines against VL is received limited attention. The only successful immunization strategy in humans has been leishmanization, which is based on the development of durable immunity after recovery from infection …
Published in Research and Reviews : A Journal of Immunology · Vol. 5, Issue 1, 2015 · pp. 29–35 Read article
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Bacteriophage Therapy in Dairy Farming: A Potential Alternative to Antibiotics
Abstract: The widespread use of antibiotics in dairy farming to control bacterial infections has led to significant challenges, including the emergence of antibiotic-resistant bacteria and concerns over antibiotic residues in milk. Consequently, there is an increasing demand for alternative approaches to control bacterial infections in dairy cattle. One promising solution is bacteriophage therapy, which uses viruses that selectively infect and destroy bacteria. As a result, the need for new strategies to …
Published in Research and Reviews : Journal of Dairy Science and Technology · Vol. 13, Issue 2, 2024 · pp. 1–5 Read article
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A Review on Pierson Syndrome
Abstract: Pierson syndrome, also known as microcoria-congenital nephrosis syndrome, is a rare illness that mostly affects the kidney and eye. In 1963, Pierson et al. published the first description of this illness. A genetic mutation in the LAMB2 gene causes this disorder, which is responsible for producing the laminin-2 chain. The retina, neuromuscular junctions, glomerular and ocular basement membranes, and this laminin subunit are all significant components. Congenital nephrotic syndrome is …
Published in Research and Reviews: A Journal of Toxicology · Vol. 13, Issue 1, 2023 · pp. 10–14 Read article
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Type 2 Diabetic Dyslipidemia: A Review
Abstract: Diabetic dyslipidemia is a pathological condition where persistent rise in blood glucose level gives rise to derangement of lipids vis-a vis lipoproteins; which in turn increases the risk of cardiovascular diseases. Although both forms of diabetes mellitus that is, Diabetes mellitus Type-1 (insulin-dependent diabetes mellitus or IDDM) and Diabetes mellitus Type-2 (non-insulin-dependent diabetes mellitus or NIDDM) can alter lipid arrangement but Type-2 is more common (80–90%) form of diabetes mellitus, …
Published in Research and Reviews : A Journal of Medical Science and Technology · Vol. 10, Issue 2, 2021 · pp. 58–63 Read article
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3D-QSAR and Molecular Docking Studies of Triazol-Cycloalkanol Derivatives Used as Potent 3-Dehydroquinase II Inhibitors Against Mycobacterium tuberculosis
Abstract: Tuberculosis is a life threatening infectious disease caused by gram positive bacteria mycobacterium tuberculosis. Emergence of drug resistance, multi drug resistance and extensively drug resistance strain of mycobacterium make the situation more worst. It increases the mortality rate of tuberculosis patient, time duration and cost of treatment. Various inhibitors and drug molecules are designed to combat this fatal disease. Enzymes of shikimate pathway are responsible for production of essential amino …
Published in Research and Reviews : A Journal of Biotechnology · Vol. 5, Issue 3, 2015 · pp. 18–28 Read article
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The Eagle Eye Approach: Comprehensive Genomics Profile[CGP]
Abstract: Ancient Medicine methods had Precision medicine concept only in traditional Ayurvedic methods. Since modern medicine adopted both genetics and genomics profiling, precision medicine is playing a major role in cancer patients' lives. This oncology Medicine has been taken to the next level while the comprehensive genomic profiling (CGP) gave hope of capturing all possible key elements through Next generation sequencing molecular approaches that contribute to the cancers. The combination of …
Published in Research & Reviews: A Journal of Bioinformatics · Vol. 9, Issue 2, 2022 · pp. 1–6 Read article
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The Role of Artificial Intelligence and Machine Learning in Redefining Global Healthcare Systems and Advancing Medical Innovation
Abstract: Health Services are being revolutionized with AI and ML through improved accuracy, efficiency and accessibility in the delivery of health care. With AI and ML, it is now possible for health care professionals to assess varying amounts of complex clinical data in a relatively short amount of time, therefore, creating opportunities for early detection of disease, increasing the odds of accurate diagnosis, and improving the ability to make informed clinical …
Published in International Journal of Biomedical Innovations and Engineering · Vol. 4, Issue 1, 2026 · pp. 14–19 Read article
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An Ayurveda Management of High Level of Fecal Calprotectin – A Single Case Study
Abstract: Calprotectin is protein found in leucocytes. Calprotectin plays a crucial role in various physiological processes, including cell differentiation, immune modulation, tumor development, programmed cell death, and inflammatory responses. Gut inflammation due to various cause like genetic inheritance, changes in microbiota within intestine, defective immune regulation. Also, some infective such as salmonella, E. coli, Cytomegalovirus, Amoebiasis etc., and Non-infective such as Ischaemic colitis, Non-steroidal anti-inflammatory drugs, Colonic carcinoma etc., can mimic …
Published in Research and Reviews : A Journal of Ayurvedic Science, Yoga and Naturopathy · Vol. 11, Issue 3, 2024 · pp. 19–25 Read article
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Griscelli Syndrome Type 2: A Case Report on Its Diagnosis and Management
Abstract: Griscelli syndrome (GS) is an autosomal recessive disorder which is very rare and is characterized by dilution of pigments and variable immunodeficiency. Researchers have identified three types of this disorder which are distinguished by their genetic cause and pattern of signs and symptoms: Type 1, Type 2 and Type 3, caused by the mutation of MYO5A, RAB27A and MLPH genes respectively. Subtype 2 being the most common, is characterized by …
Published in Research and Reviews : A Journal of Immunology · Vol. 8, Issue 2, 2018 · pp. 5–7 Read article
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Investigating the Impact of Viral Infections on Pharmacokinetics and Pharmacodynamics of Antiviral Drugs
Abstract: The emergence and re-emergence of viral infections pose significant challenges to public health, necessitating a comprehensive understanding of how these infections impact the pharmacokinetics and pharmacodynamics of antiviral drugs. This review explores the intricate interactions between viral pathophysiology and the pharmacological effects of antiviral agents. Factors such as viral replication dynamics, host immune responses, and the genetic variability of both viruses and hosts significantly influence drug absorption, distribution, metabolism, and …
Published in International Journal of Virus Studies · Vol. 1, Issue 2, 2024 · pp. 23–30 Read article
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Type 2 Diabetes Mellitus: Existing Understanding and Expectations in India
Abstract: Increased fracture risk, which has been connected to type 1 diabetes in the past, has now become a top concern for those with type 2 diabetes. Depending on where the bone is located, how long you've had diabetes, and the study techniques, there has been evidence of a varying increase in fracture risk, ranging from 20% to 3-fold. An increased risk of fracture has been associated with a longer disease …
Published in Research and Reviews : A Journal of Biotechnology · Vol. 12, Issue 3, 2022 · pp. 12–17 Read article
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Pattern of Cancer in Punjab (Cancer Capital of India)
Abstract: The problems of the nature and possible treatment of malignant disease are studied in many laboratories and results are published in different journals. It is difficult for any worker to keep in touch with all the published work. Excellent summaries of papers were published for many years in the Cancer Review, the publication of which was unfortunately suspended about ten years ago. Since then abstracts have been available in the …
Published in Research and Reviews : A Journal of Biotechnology · Vol. 11, Issue 2, 2021 · pp. 4–11 Read article
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A Review on Biotechnological Aspects of Conservation and Enhancements of Indian Snakeroot (Rauwolfia serpentina)
Abstract: Indian snakeroot (Rauwolfia serpentina) is one of the most important medicinal plants found in the Indian subcontinent, used in the treatment of various types of diseases. Recently it has been considered as a critically endangered plant by the International Union of the Conservation of Nature and Natural Resources (IUCN) due to its heavy exploitation in the past. The plant has a high demand in the international market due to its …
Published in Research & Reviews: A Journal of Drug Design & Discovery · Vol. 9, Issue 2, 2022 · pp. 30–38 Read article
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Composition and Therapeutic Applications of Goat Milk and Colostrum
Abstract: Goats are categorized under the small ruminants which required less fodder and a small area for shelter. Both goat milk (GM) and colostrum (GC) are secreted from the mammary glands of goats. The level of nutritional and bioactive components found to be at an elevated level in colostrum within 72 hours, which reach a normal level as the time increases from parturition. Recently an increased interest in goat milk and …
Published in Research and Reviews : Journal of Dairy Science and Technology · Vol. 10, Issue 2, 2021 · pp. 1–7 Read article
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Cancer Tumor Markers And Its Latest Trends
Abstract: Almost one in six deaths occurs due to abnormal cell division; these cells are termed cancer cells in general. Cancer cells collaborate to multiply and metastasize. Our aim is to awaken awareness in people to understand their bodies and motivate them for early diagnosis,as cancer is the second leading cause of death after cardiovascular disease. The human body is a marvellous creation in nature; in response to cancer, it creates …
Published in Research and Reviews: Journal of Oncology and Hematology · Vol. 13, Issue 3, 2024 · pp. 25–38 Read article
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Cancer biology and Sequencing technology: A new era for personalized patient care.
Abstract: Cancer is one of the most deadly diseases causing high mortality around the world. Lot of efforts are being made to be able to device a proper treatment for cancers. The majority treatments for various types of cancers comprise of surgery, radiation, chemotherapy, hormone therapy, immune therapy, and targeted therapy. These methods of treatment may not be fully able to get rid of cancer but able to extend the life …
Published in Research & Reviews: A Journal of Bioinformatics · Vol. 4, Issue 3, 2017 · pp. 1–14 Read article
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Biopharmaceuticals: A Review of Biopolymeric Drugs and Accessibility Challenges in India
Abstract: Advances in biotechnology have allowed us to produce biosynthesized proteins that have therapeutic benefits. The drug products having biotechnology derived proteins, i.e. Biopharmaceuticals, have evolved the treatment of several diseases. knowledge about biological systems have been explored scientifically, there have been significant efforts to utilize them for improving human lives. These biopharmaceutical products have a rapidly growing market which needs to be closely monitored to avoid any potential risks. This …
Published in Journal of Polymer & Composites · Vol. 12, Issue 5, 2024 · pp. 32–38 Read article
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Unraveling Metagenomics: A Comprehensive Diagnostic Approach for COVID-19
Abstract: The COVID-19 pandemic has brought attention to the need for rapid, accurate, and scalable diagnostic techniques. Metagenomics, a powerful technique that enables the comprehensive analysis of genetic material from complex microbial communities, has emerged as a promising diagnostic approach for COVID-19. This article elucidates the principles of metagenomic sequencing, highlighting its ability to detect viral RNA directly from clinical samples without prior knowledge of the pathogen. Furthermore, we discuss the …
Published in International Journal of Tropical Medicines · Vol. 1, Issue 2, 2024 · pp. 19–28 Read article
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Pathogenesis, Immune Response and Vaccine Development in Amoebiasis
Abstract: Worldwide, approximately fifty million cases of invasive E histolytica disease occur each year and resulting in more than 100,000 deaths. It is the second leading cause of mortality due to a protozoan parasitic infection after malaria. Entamoeba histolytica infection is associated with considerable morbidity and mortality in the form of intestinal and extra-intestinal amoebiasis especially in developing countries. Recent molecular studies have conclusively proved that there are morphologically similar species …
Published in Research and Reviews : A Journal of Immunology · Vol. 5, Issue 3, 2015 · pp. 30–35 Read article