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1953 articles for “phosphoinositol-3-kinase pathway” (ranking capped at the first 2,000 matches — narrow the search to see the rest)
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Chemical Profile and Toxicity of Fresh and Dry leaves of the Essential Oils of Vetiveria zizanioides (L.) Nash. From Southwest Nigeria
Abstract: The fresh and dry leaves of Vetiveria zizanioides (L.) Nash (Gramineae) plant was collected, air dried and authenticated at the University of Ibadan Herbarium with voucher number: UIH-23237. The plant's dried, fresh leaves were hydro distilled in a Clevenger device to extract the essential oils. The oils were characterized by Gas Chromatography-Mass Spectrometry (GC – MS) while the toxicity of the essential oils was tested using brine shrimps’ lethality assay. …
Published in Recent Trends in Cosmetics · Vol. 1, Issue 1, 2024 · pp. 44–49 Read article
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Chompound contaning oxadiazole derivatives and their potential therapeutic uses.
Abstract: Derivatives of oxadiazole or furadi azole rings constitute a significant class of heterocyclic substances. Oxadiazole is a heterocyclic, five-membered ring with two carbons, one oxygen atom, two nitrogen atoms, and two double bonds. They are produced by substituting two nitrogen (-N =) atoms for two methylene groups (= CH) in furan. The furan ring's aromaticity was significantly decreased by substituting these groups, resulting in a conjugated diene character. There were …
Published in Journal of Modern Chemistry & Chemical Technology · Vol. 15, Issue 1, 2024 · pp. 68–74 Read article
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Corrosion Measurement and Hardness Test of Magnesium-Tri Calcium Phosphate Composite Fabricated by Stir Casting
Abstract: Magnesium MMC is preferred in applications requiring high-quality materials and has replaced monolithic materials. Bio-implants traditionally used are titanium, steel, and nickel-titanium alloys, however, their removal necessitates surgery, which is costly and painful. While biodegradable 3D-printed implants are effective and eliminate the need for a second surgery, they remain expensive. After several studies to solve this issue, the development of biodegradable implants is considered. Magnesium possesses good biodegradable properties. An …
Published in Journal of Polymer & Composites · Vol. 13, Issue 3, 2025 · pp. 436–447 Read article
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Investigation and Optimization of Resistance Spot Welding Parameters for Stainless Steel
Abstract: The present work examines the significant impact of resistance spot welding (RSW) process parameters on the properties and efficacy of connections created in sheets of 316L stainless steel. This study examines the intricate relationship between welding parameters, investigating their influence on the microstructure, mechanical characteristics, and overall efficacy of welded connections. By employing a methodical experimental methodology, this study thoroughly investigates the impact of different factors in resistance spot welding …
Published in Journal of Thermal Engineering and Applications · Vol. 12, Issue 3, 2025 · pp. 15–21 Read article
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Drug Resistance in Targeted Cancer Treatment: Clinical Difficulties, Molecular Mechanisms, and Emerging Strategies
Abstract: Targeted cancer therapy, which selectively inhibits the molecular mechanisms responsible for tumor growth and development, has revolutionized modern oncology. Targeted therapies have lower systemic toxicity and better therapeutic efficacy when compared to traditional chemotherapy. However, the emergence of medication resistance often limits the long-term efficacy of these treatments, ultimately resulting in treatment failure and disease progression. Drug resistance develops through a number of intricate biological processes and can be innate …
Published in Research and Reviews: A Journal of Pharmaceutical Science · Vol. 17, Issue 1, 2026 · pp. 130–138 Read article
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Optimal Placement and Sizing of STATCOM for Loss Reduction and Voltage Profile Enhancement Using Genetic Algorithm
Abstract: Electric power distribution networks frequently experience significant power losses and voltage profile deterioration due to increasing load demand and inadequate reactive power compensation. This study investigates the enhancement of the Eleme distribution network in Rivers State through voltage upgrading and optimal deployment of a Static Synchronous Compensator (STATCOM). The existing network consists of a 5.56 km, 11 kV radial distribution system supplying seventeen distribution transformers with a cumulative load demand …
Published in Journal of Power Electronics and Power Systems · Vol. 16, Issue 2, 2026 Read article
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Integrating Network Pharmacology and Molecular Docking to Assess Rutin’s Pharmacological Properties
Abstract: Objectives: In the present research, the network pharmacology process was applied to determine the underlying mechanism of the pharmacological properties of Rutin. Network pharmacology was utilized to reveal the interactions between medications and the targets of illnesses, and it is capable of completely articulating the complexity between diseases and medications. The identification of diverse drug-target interactions using network pharmacology may be utilized to discover novel medications for difficult conditions like …
Published in International Journal of Molecular Biotechnological Research · Vol. 1, Issue 1, 2023 · pp. 20–33 Read article
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To evaluate the effectiveness of a structured educational program on knowledge about hypoglycemia and its management among diabetes patients living in selected urban slums of Durgapur, West Bengal
Abstract: INTRODUCTION: Diabetes Mellitus (DM) is a significant global health issue characterized by chronic hypoglycemia and an imbalance in the metabolism of carbohydrates, fats, and proteins. It has multiple underlying causes. Hyperglycemia refers to high blood glucose levels, while low blood glucose levels are known as hypoglycemia. Raising awareness about the signs and symptoms of diabetes among individuals with the condition can potentially minimize complications. OBJECTIVES: 1. To evaluate the initial …
Published in International Journal of Community Health Nursing And Practices · Vol. 1, Issue 1, 2023 Read article
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Molecular Docking and Pharmacokinetic Profiling of the Phytocompounds of Jatropha curcas as Antagonist for Salmonella typhi
Abstract: Background: Typhoid is an infection caused by the Gram-negative bacterium, Salmonella enterica serovar typhi. The study assessed the potential use of Jatropha curcas as a typhoid fever therapy alternative to traditional medications. The ability to uncover novel drug indications for currently available medications using in silico methods has increased thanks to the wealth of pharmacological and biological knowledge that is available. Objective: In this study, we assessed the potential inhibitory …
Published in International Journal of Cell Biology and Cellular Functions · Vol. 1, Issue 1, 2023 · pp. 67–81 Read article
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Efficient Fault Detection in Power Transmission: A Review of Three-Phase Line Fault Detection with Hybrid Energy using MATLAB
Abstract: In urban regions, the density of power demand has significantly increased recently. Large-scale subterranean power cable installations are beginning to take the place of overhead transmission lines everywhere in the world because of environmental concerns in highly populated areas. The present project's primary objective is to use MATLAB to create a simulation model that includes 3ph symmetrical and unsymmetrical defects. Some have proven to be effective in detecting errors while …
Published in International Journal of Electrical Power and Machine Systems · Vol. 1, Issue 1, 2023 · pp. 42–47 Read article
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Comparative Analysis on Concrete Strength Using Various Sizes of Aggregates and Combined Gradation
Abstract: This research delves into the effect of using various single coarse aggregate sizes and combinations of such by specific proportions. A thorough examination involving control specimens of 12mm, 20mm, and 25mm aggregates sizes, with combining proportions in the ratios – 5/8:3/8, 1/2:1/2, 3/8:5/8 have been conducted, shedding light on critical patterns that dictate concrete performance. The fine aggregate was properly zoned from the preliminary test. The design mix was calculated …
Published in Recent Trends in Civil Engineering & Technology · Vol. 14, Issue 1, 2024 · pp. 29–36 Read article
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Performance and Reliability Analysis of NAND Flash Memory through Characterization
Abstract: An extensive review of NAND flash memory technology is given in this study, with an emphasis on its design, guiding principles, and most recent developments. The importance of NAND flash memory in contemporary digital storage systems is discussed in general terms, emphasizing how widely used it is in everything from consumer electronics to business storage solutions. The underlying architecture of NAND flash memory, including the arrangement of memory cells, pages, …
Published in Journal of VLSI Design Tools and Technology · Vol. 14, Issue 2, 2024 · pp. 21–27 Read article
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Interaction of Bioactive Component of Aframomum melegueta on Molecular Docking
Abstract: Computational mimicry of the structure of large complexes created by di- and poly-interaction of molecules has been termed molecular docking. The purpose of molecular docking is the prediction of the three-dimensional structures of interest, this is due to that docking only produces plausible candidate structures. The docking was carried out between the bioactive compounds against 5α-reductase, 3β-hydroxy-steroid dehydrogenase, and 17β-hydroxy-steroid dehydrogenase of returned binding energy, BE (kcal/mol) between -5.9 and …
Published in International Journal of Biochemistry and Biomolecule Research · Vol. 2, Issue 1, 2024 · pp. 51–60 Read article
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Effectiveness of Deep Breathing Exercise on Respiratory Parameters Among Post Extubated Patients Admitted in ICUs
Abstract: Introduction: Deep breathing exercises may be used to restore lung oxygenation ventilation function and are anticipated to enhance respiratory parameters. Aim: This study was done to examine the effectiveness of deep breathing exercise on respiratory parameters among post extubated patients. Methodology: A quasi experimental (pre-test, post-test control group) with quantitative approach study was conducted to assess the effect of deep breathing exercise on respiratory parameters among 30 post extubated patients …
Published in Research and Reviews: A Journal of Health Professions · Vol. 14, Issue 2, 2024 · pp. 25–31 Read article
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Anticancer Activity of Calotropis procera by Molecular Docking Analysis
Abstract: Cyclin-dependent kinase 2 (CDK2) is a protein synthesized by Calotropis procera. It is known to be responsible for causing cancer in the human body. Studies have presented the significance of the phytochemicals to inhibit the CDK2 protein. Adsorption, distribution, metabolism, and excretion (Swiss ADME) and PubChem were the pharmacological tools which were used to check molecular weight, which should be less than 500D, acceptors less than 10, and donors less …
Published in International Journal of Biochemistry and Biomolecule Research · Vol. 2, Issue 1, 2024 · pp. 01–07 Read article
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Review on Computer-Aided Drug Design in RAS Inhibitor Discovery
Abstract: This review explores the utilization of computer-aided drug design (CADD) methodologies in the discovery of inhibitors targeting the RAS pathway, a pivotal signaling cascade implicated in various cancers. Through an extensive examination of computational tools, methodologies, challenges, and recent advancements, this review aims to provide insights into the role of CADD in accelerating RAS inhibitor discovery. The discovery of effective inhibitors targeting the RAS pathway is of paramount importance in …
Published in Research & Reviews: A Journal of Drug Design & Discovery · Vol. 11, Issue 3, 2024 · pp. 7–14 Read article
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Effect of Particle Size Mix Ratio of Clay and Agro-Based Material for AGO and PMS Treatment on Microbial Growth
Abstract: The characteristics of possible microbes isolated and identified on adsorption process involving AGO and PMS as contaminants in fresh water medium was monitored using agro – based materials. The formulated adsorbent is made of clay with ago-based materials of Banana Ogoni Red (BOR) Banana Native (BN), Plantain Agbagba 1 (PA1), and Plantain Ogoni Red (POR). The particle size mixed ratio of clay to the various agro-based materials were 150𝜇𝑚 R5:5, …
Published in Journal of Thin Films, Coating Science Technology & Application · Vol. 11, Issue 2, 2024 · pp. 05–14 Read article
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Dasatinib Induced Pulmonary Hypertension
Abstract: Dasatinib (Das) is a second-generation tyrosine kinase inhibitor that is used in the treatment of chronic myelogenous leukemia (CML) in patients who are resistant or intolerant to imatinib, as well as in Philadelphia chromosome-positive acute lymphoblastic leukemia (Ph+ ALL) patients. Dasatinib-induced pulmonary arterial hypertension (PAH) is a known but rare adverse effect of dasatinib and is grouped under Group-1 PAH. The mechanism of PAH development is not fully known, but …
Published in Research and Reviews: A Journal of Pharmacology · Vol. 14, Issue 3, 2024 · pp. 92–95 Read article
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Botanical Blockade: Phytochemical Targeting Of Nf-Κb in Cancer Therapy
Abstract: The control of inflammation, corpuscle survival, proliferation, and allowed response are all influenced by the acute archetypal agent NF-κB. Its abnormal activity is typically seen in a range of malignancies, where it aids in bump advancement, metastasis, and treatment waste. The function of NF-κB in scar analysis is discussed in this product, along with significant phytochemicals that seem to be interested in targeting this pathway, based on recent investigation. It …
Published in Research & Reviews: A Journal of Pharmacognosy · Vol. 12, Issue 1, 2025 · pp. 13–21 Read article
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Performance Analysis of Biogas Production from Onion Leaves and Cow Dung Compositions
Abstract: Biogas could be obtained from agricultural byproducts; and onion leaves and cow dung is agricultural byproduct abundantly available in Aliero Northwestern Nigeria. This study entails biogas production from onion leaves, cow dung and their mixtures. The onion leaves and cow dung at equal proportions and the sum of their half (Mixture) were poured into three 25 l digesters for experimental investigations. The optimal biogas yields, the component composition of gases …
Published in Journal of Alternate Energy Sources & Technologies · Vol. 16, Issue 1, 2025 · pp. 1–9 Read article