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264 articles for “clinical applications”
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SiRNA-Based Multivalent Vaccines: A Systematic Review of Potential Risks, Benefits, and Future Applications
Abstract: Background: Small interfering RNA (SiRNA) technology represents a promising innovation in vaccine development, especially for multivalent vaccines that can target multiple pathogens or antigenic variants simultaneously. siRNA-based vaccines offer a unique mechanism to induce specific immune responses, presenting an adaptable and potentially powerful tool for tackling infectious diseases and cancer. Methods: This systematic review synthesizes recent studies on siRNA multivalent vaccines, focusing on their immunogenicity, safety, and effectiveness. We reviewed …
Published in International Journal of Vaccines · Vol. 2, Issue 1, 2025 · pp. 43–49 Read article
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Breast Cancer Detection Using Machine Learning: A Comparative Analysis of Supervised Learning Algorithms
Abstract: Globally, breast cancer remains a predominant cause of mortality among women, highlighting the urgent need for timely and precise diagnostic approaches. This research explores the application of machine learning algorithms—including Logistic Regression, SVM, Naïve Bayes, KNN, and Random Forest—on the Wisconsin Breast Cancer Dataset for effective tumor classification. Key pre-processing steps such as missing value handling, feature scaling, and dimensionality reduction were employed to improve model performance. The study evaluated …
Published in Research & Reviews: A Journal of Bioinformatics · Vol. 12, Issue 3, 2025 · pp. 46–52 Read article
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Polymer Nanocomposites As Emerging Platforms in Pharmaceutical Nanotechnology
Abstract: Nanotechnology allows the handling of materials in the 1–100 nm range, where distinct physicochemical phenomena, including quantum effects and higher surface-to-volume ratio, enable disruptive uses in pharmaceuticals and biomedicine. Significant challenges in solubility, stability and targeted biodistribution of therapeutics can be overcome by incorporating nanostructured polymers and polymer-based composites into drug delivery systems. PLGA nanoparticle and other nanocarriers, such as PLGA micelles, dendrimers, and hydrogels, have revealed promising effects on …
Published in Journal of Polymer & Composites · Vol. 14, Issue 1, 2026 · pp. 268–278 Read article
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Management of Kosthasakhashrita Kamala W.S.R. to Hepatocellular Jaundice – A Case Study
Abstract: Kosthasakhāśrit Kamala is a well-recognized clinical entity in Ayurveda and is widely correlated with modern hepatocellular jaundice. The condition arises primarily due to the vitiation of Pitta dosha within the Kostha (gastrointestinal tract), which subsequently spreads to the Sakha (peripheral tissues). Classical texts describe hallmark features such as Haridra Netra (yellowish discoloration of the eyes), yellowish hue of twak and nakha, pitta varṇa of mutra and sakrit (yellow urine and …
Published in Journal of AYUSH: Ayurveda, Yoga, Unani, Siddha and Homeopathy · Vol. 15, Issue 1, 2026 · pp. 1–8 Read article
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Recent Advancements in Nanobiocomposite-Based Wound Healing and Tissue Regeneration
Abstract: Haemostasis, inflammation, proliferation, remodeling, and other highly coordinated cellular and molecular activities are all part of the complex biological processes of wound healing and tissue regeneration. Following an injury, these stages cooperate to restore tissue integrity and function. However, this normal process is disturbed in many clinical circumstances, especially chronic wounds such diabetic ulcers, burns, and pressure sores. Prolonged inflammation, chronic microbial infection, diminished angiogenesis, and impaired extracellular matrix production …
Published in Journal of Polymer & Composites · Vol. 14, Issue 3, 2026 · pp. 297–318 Read article
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Breakthroughs in Biotechnology for the Regulation of Infectious Diseases
Abstract: Infectious diseases have a heavy impact on both public health and the world’s economies. In most diseases, antibiotic resistance has become widespread over time. A variety of diseases comprising pneumonia, tuberculosis, and gonorrhea go through the same evolutionary processes, which include the formation of drug-resistant pathogens in response to selection pressure from medications and their potential extinction when drug use is ceased. Since the occurrence of drug resistance in serious …
Published in Research and Reviews : A Journal of Biotechnology · Vol. 15, Issue 1, 2025 · pp. 1–25 Read article
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Bone Grafting in Dentistry: From Biological Principles to Contemporary Regenerative Applications
Abstract: Bone grafting plays a pivotal role in contemporary regenerative dentistry by enabling predictable reconstruction of alveolar bone defects resulting from periodontal disease, tooth extraction, trauma, or pathology. Adequate bone volume and quality are essential prerequisites for successful implant placement, periodontal regeneration, and long-term functional and esthetic outcomes. Bone graft materials act as biological or synthetic scaffolds that facilitate new bone formation through the primary mechanisms of osteogenesis, osteoinduction, osteoconduction, and …
Published in Research and Reviews: A Journal of Dentistry · Vol. 17, Issue 1, 2026 · pp. 6–13 Read article
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Comparative Analysis of the Structural Integrity and Dimensional Stability of Additively Manufactured Biopolymers vs. Thermoformed PETG: A 1-Year Retrospective Study on Polymer Performance in Orthodontic Applications
Abstract: Objective: This study aimed to evaluate the long-term dimensional accuracy and structural performance of direct 3D-printed biopolymers compared to conventional vacuum-formed Polyethylene Terephthalate Glycol (PETG) composites. The investigation focused on how different polymer processing methods (additive manufacturing vs. thermoforming) influence material thinning and resistance to occlusal stress. Methods: A retrospective analysis was conducted on 60 cases (n = 60) of post-orthodontic maintenance. The sample was divided into two cohorts: Group …
Published in Journal of Polymer & Composites · Vol. 14, Issue 3, 2026 · pp. 140–146 Read article
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Herbal Frontiers: The Role of Alternative Remedies in Combating Typhoid Fevers
Abstract: Typhoid fever, caused by Salmonella typhi, remains a major health challenge, particularly in developing regions where sanitation and healthcare resources are limited. With an estimated global incidence of 17 million cases annually, the disease poses a significant public health burden. The growing resistance to conventional antibiotics, such as fluoroquinolones and third-generation cephalosporins, exacerbates treatment challenges. This has spurred interest in alternative remedies, including herbal and homeopathic treatments.Herbal medicine offers a …
Published in Recent Trends in Infectious Diseases · Vol. 2, Issue 1, 2025 Read article
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Nutraceuticals Unveiled: Exploring the Science, Benefits, and Future of Functional Food
Abstract: The rapidly developing subject of nutraceuticals is critically examined in this review, with a focus on its scientific basis, proven health advantages, and possible future applications in the functional food industry. Key bioactive ingredients that contribute to the therapeutics effectiveness of functional foods, including flavonoids, polyphenols, carotenoids, probiotics, and essential fatty acids, have been identified and characterized as a result of recent developments in nutritional science. Both experimental and clinical …
Published in International Journal of Nutritions · Vol. 2, Issue 2, 2025 Read article
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Screening Phytocompounds of Tinospora cordifolia to Find Potential Drug Targets for Cystic Fibrosis
Abstract: This study aimed to evaluate the therapeutic potential of phytocompounds derived from Tinospora cordifolia in treating cystic fibrosis (CF), a genetic disorder caused by mutations in the CFTR gene that lead to severe respiratory and digestive complications. Phytocompounds were retrieved from the IMPPAT database and subjected to molecular docking simulations using PyRx to assess their binding affinity to the CFTR protein. The top-scoring compounds – sterol, magnoflorine, tembetarine, kaempferol, and …
Published in International Journal of Genetic Modifications and Recombinations · Vol. 3, Issue 1, 2025 · pp. 16–24 Read article
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Enhanced Diabetes Prediction: A Comparative Study of Machine Learning Models
Abstract: Excessively high blood glucose levels lead to diabetes, a condition that can be better managed with early detection, resulting in a longer life and improved health. Machine learning models are essential tools in diagnosing diabetes, especially when trained on appropriate and relevant datasets. In this study, a combination of ensemble methods and nine distinct machine learning algorithms were utilized to develop a predictive model for diabetes diagnosis based on a …
Published in Research & Reviews: A Journal of Bioinformatics · Vol. 12, Issue 2, 2025 · pp. 1–10 Read article
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Understanding Tennis Elbow: Causes, Symptoms, and Available Treatments
Abstract: Tennis Elbow, clinically termed lateral epicondylitis, stands as a prevalent musculoskeletal ailment affecting the outer part of the elbow. Despite its name, this condition isn't exclusive to tennis players; it often arises due to repetitive stress or overuse of the forearm muscles and tendons, leading to micro-tears and inflammation at the elbow's lateral epicondyle. The abstract focuses on elucidating the multifaceted aspects of Tennis Elbow, exploring its causes, symptoms, and …
Published in International Journal of Orthopedic Nursing and Practices · Vol. 1, Issue 2, 2023 · pp. 1–5 Read article
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A Brief Review On Nanoparticles Drug Delivery System Used In Cervical Cancer
Abstract: Among cervical tumor-related deaths worldwide, cervical cancer is a major cause. The limitations of traditional methods, such as chemotherapy and radiation therapy, stem from their adverse effects and increased susceptibility to medications. Despite being seen as innovative options, immune checkpoint inhibitors (ICIs) have rather low clinical response rates. Reliable treatments for patients with metastatic or recurring cervical cancer are currently lacking. Lately, nanomaterials including polymers, liposomes, and dendrimers have been …
Published in Research and Reviews : A Journal of Life Sciences · Vol. 15, Issue 1, 2025 · pp. 30–40 Read article
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Bio-Inspired Membranes in Oral Drug Delivery: A Pathway to Enhanced Permeability and Targeted Therapy
Abstract: Bio-inspired membranes in oral drug delivery represent a significant advancement in pharmaceutical technology, harnessing principles of natural biological systems to improve drug permeability, bioavailability, and targeted release. This review discusses the design, materials, and fabrication techniques used in bio-inspired membranes, with a focus on materials like chitosan, silk fibroin, and synthetic polymers that mimic biological structures. By exploring the mechanisms of drug permeation, such as mucoadhesion and selective permeability, bio-inspired …
Published in International Journal of Membranes · Vol. 1, Issue 2, 2024 · pp. 39–52 Read article
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Next Generation Sequencing (NGS) in Personalized Medicine: Emphasizing Public Health Beyond Reality
Abstract: NGS is a modern technology that allows researchers to quickly sequence large amounts of DNA or RNA, it is also known as massively parallel sequencing or deep sequencing. NGS has revolutionized genomic research and biological sciences by its speed, scale, accuracy, ultra-high throughput, and cost. NGS replaced the conventional sequencing method. A novel idea in healthcare is precision medicine, which involves adjusting medical care to each patient’s unique traits and …
Published in Recent Trends in Infectious Diseases · Vol. 2, Issue 1, 2025 · pp. 1–17 Read article
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Advances in Biological Systems Modeling for Predicting Drug Effects in Chronic Disease
Abstract: Biological systems modeling has emerged as a promising tool for understanding and predicting the effects of drugs in the treatment of chronic diseases. Chronic diseases, such as diabetes, cardiovascular diseases, and neurodegenerative disorders pose significant challenges to traditional drug development due to their complex, multifactorial nature. Systems biology approaches, which integrate computational modeling with experimental data, provide a holistic view of disease mechanisms and treatment responses. This review explores recent …
Published in Research and Reviews : Journal of Computational Biology · Vol. 14, Issue 1, 2025 · pp. 17–22 Read article
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Repurposing Liv-52 For Primary Sclerosing Cholangitis: A Computational Docking And Pharmacokinetic Study To Evaluate Its Bile Flow-Regulating Potential
Abstract: Primary Sclerosing Cholangitis (PSC) is a long-term liver disease where the bile ducts become inflamed and scarred over time. This scarring can block the flow of bile, leading to liver damage and, eventually, liver failure. The etiology of PSC remains largely unknown, and current treatment options are limited, highlighting the need for novel therapeutic strategies. This study aims to repurpose Liv-52, a traditional herbal formulation known for its hepatoprotective properties, …
Published in Research and Reviews : Journal of Computational Biology · Vol. 14, Issue 2, 2025 Read article
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Development of a Novel Therapeutic Approach Using RNA Interference for Targeting Viral Genes
Abstract: RNA interference (RNAi) is a ground breaking therapeutic strategy that holds immense promise for targeting viral genes in the treatment of viral infections. This approach leverages the natural gene-silencing mechanisms of RNAi to inhibit viral replication and expression at the molecular level, providing a precise and adaptable method to counteract viral pathogens, including influenza, HIV, and hepatitis viruses. Recent advancements in RNAi technology have enabled the development of highly specific …
Published in International Journal of Virus Studies · Vol. 1, Issue 2, 2024 · pp. 12–22 Read article
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A Novel Frontier On Biofeedback Enhanced Psychological Wellbeing For Metabolic Health In Human
Abstract: This article explores the emerging field of biofeedback and its application in optimizing metabolic health. Biofeedback involves the use of technology to monitor physiological processes and provide real-time feedback to individuals, empowering them to regulate their bodily functions. We delve into various biofeedback modalities and their potential benefits in managing metabolic disorders such as diabetes, obesity, and metabolic syndrome. Additionally, we discuss the underlying mechanisms of biofeedback, its effectiveness in …
Published in Research and Reviews: A Journal of Pharmacology · Vol. 15, Issue 1, 2025 · pp. 56–69 Read article