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245 articles for “agent evaluation”
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Phytochemical Screening and Biological Activity of Pomegranate Extracts
Abstract: Pomegranates are renowned for their abundance of bioactive compounds that exhibit potent antioxidant, anti-inflammatory, and antimicrobial properties, making them a subject of growing interest in natural medicine. This study aimed to compare the biological activities of ethanolic extracts derived from different parts of the pomegranate plant—specifically, the bark, peel, and leaves. A comprehensive investigation was conducted to evaluate their phytochemical composition and assess their antimicrobial, antioxidant, and anticancer properties. The …
Published in Research & Reviews: A Journal of Pharmacognosy · Vol. 12, Issue 2, 2025 · pp. 64–79 Read article
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In-silico screening of phytochemicals for identification of an alternative therapy for thyroid cancer
Abstract: Thyroid cancer remains a significant health concern globally, necessitating the exploration of novel therapeutic alternatives to improve treatment outcomes. This study targets COT kinase (Cancer Osaka Thyroid Kinase), a protein implicated in the progression of thyroid cancer, using molecular docking methods with various phytochemicals to identify potential therapeutic compounds. PyRx and Discovery Studio were employed to evaluate the interactions and binding affinities of a diverse set of natural compounds with …
Published in International Journal of Toxins and Toxics · Vol. 2, Issue 2, 2025 · pp. 31–55 Read article
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Studies on the Antioxidant Content and Antimicrobial Activity of Cucumber (Cucumis sativus) Peels Collected from Bagmari, Kolkata, West Bengal, India
Abstract: Cucumber (Cucumis sativus) is widely consumed across the globe, yet its peels are commonly discarded as waste, despite possessing a wealth of bioactive compounds. Recent studies have highlighted that these peels contain substantial amounts of antioxidants, antibacterial, anti-inflammatory, and anticarcinogenic properties, making them a promising candidate for value-added applications. In this study, methanolic extracts (80% v/v) of cucumber peels were systematically analyzed to assess their total phenolic content (TPC), total …
Published in Emerging Trends in Metabolites · Vol. 2, Issue 2, 2025 · pp. 6–14 Read article
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Formulation of Wonderful base pomegranate shampoo and evaluation of it
Abstract: The current study objective was to create and assess a herbal shampoo using natural ingredients that prioritized both efficacy and safty. The extracts of pomegranate (the active ingredient), curry leaves, hibiscus leaves, Fenugreek seeds and reetha were combined in varying amounts to make the shampoo. As ancient times, people are used herbal shampoos, which are cosmetic preparations made with traditional ayurvedic herbs, to clean their hair, scalp, and to beautify …
Published in Recent Trends in Cosmetics · Vol. 1, Issue 1, 2024 · pp. 23–36 Read article
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Protective Effects of Phyllanthus amarus and Sida acuta Extracts Against DoxorubicinInduced Toxicity in Chick Embryo Models
Abstract: Chemotherapy remains a cornerstone of cancer treatment, yet severe side effects, including cardiotoxicity often limit its clinical application. Doxorubicin, a widely used anticancer drug, is particularly associated with dose-dependent toxicities that impact the heart, liver, and kidneys. In search of complementary approaches to mitigate these adverse effects, this study evaluates the protective potential of hydro-alcoholic extracts from Phyllanthus amarus and Sida acuta, two medicinal plants with known antioxidant and anti-inflammatory …
Published in Research and Reviews: A Journal of Toxicology · Vol. 15, Issue 2, 2025 Read article
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Pathways in Drug Discovery and Development: From Molecular Targets to Market Approval
Abstract: A complicated, multidisciplinary, and resource-intensive process, the discovery and development of new pharmacological drugs is essential to the advancement of contemporary medicine. Finding and optimising lead chemicals comes after a disease-relevant biological target has been identified and validated. Through preclinical research in animal models, these leads are thoroughly assessed for toxicity, pharmacokinetics, safety, and efficacy. Clinical trials, which are carried out in several stages to evaluate safety, efficacy, ideal dosage, …
Published in Research & Reviews: A Journal of Drug Design & Discovery · Vol. 13, Issue 1, 2026 · pp. 01–04 Read article
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In Silico Screening of Terminalia chebula Phytocompounds as Potential Inhibitors of NTCP and DDB1 in Hepatitis B Virus Infection
Abstract: Hepatitis B virus (HBV) infection is a major global health concern, and chronic carriers are at risk of developing cirrhosis, hepatocellular carcinoma (HCC), and even death. Existing treatments can effectively inhibit viral replication, but they achieve little eradication of the virus because of covalently closed circular DNA (cccDNA) retention. In this investigation, bioactive compounds of Terminalia chebula, a plant known for its hepatoprotective and antiviral properties in traditional medicine, were …
Published in Research & Reviews: A Journal of Drug Formulation, Development and Production · Vol. 13, Issue 1, 2026 · pp. 33–44 Read article
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Investigating Curcumin Phytocompounds as Prospective Parkinson's Disease Therapeutic Agents: A Computational Method that Targets LRRK2 Protein
Abstract: Objective: Parkinson’s Disease is the second stage predominant neurodegenerative illness. Primary aetiology is still unknown. One of the biggest battlegrounds in modern medicine is discovering the cause of Parkinson’s disease (PD), as well as the hunt for palliative treatments and, if feasible, a cure. The objective of this work is to identify the phytocompounds from curcumin (curcuma longa) for the treatment of PD. Curcumin, a well-researched phytochemical, has been suggested …
Published in Research and Reviews : Journal of Computational Biology · Vol. 12, Issue 3, 2023 · pp. 55–67 Read article
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Evaluation of the Aqueous Alcoholic Extract of Laxmi Taru for Its Anticancer Property: A Review
Abstract: Simarouba glauca is considered a very valuable medicinal herbal drug used to treat diarrhea and dysentery; hence, its bark is known as dysentery bark. Different parts of the tree treat different ailments. The bark and leaf extract of Laxmi taru (Simarouba glauca) is efficiently known for its anti-helmanthic, anti-parasitic, anti-dysentric, and anti-cancerous properties. Chemotherapy, which is most frequently used to treat cancer and is becoming more prevalent around the world, …
Published in Research & Reviews: A Journal of Drug Design & Discovery · Vol. 10, Issue 1, 2023 · pp. 28–32 Read article
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Development of Bio-Based Polymer Composites for Sustainable Construction Materials
Abstract: The demand for eco-friendly sustainable construction materials has gained significant interest in the development of bio-based polymer composites as ecologically suitable alternatives to traditional petrochemical-based polymer composites. The environmental problems associated with non-biodegradable, high-carbon-footprint polymer composites make their more bio-based counterparts an attractive option that offers both environmental and structural benefits. To evaluate environmental impact and industrial feasibility, a comprehensive life cycle assessment was performed. The methodology adopts optimized bio-based …
Published in Journal of Polymer & Composites · Vol. 13, Issue 4, 2025 · pp. 194–208 Read article
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Artificial Intelligence based hierarchical Cognitive Radio Network
Abstract: Faced with ever-increasingly complex communication network architectural difficulties and rising traffic demand across wireless systems, cognitive radio (CR) technology alone is insufficient for dynamic spectrum resource allocation in 5th-generation (5G) networks. A distributed cognitive cellular network is presented in this research work for an efficient real-time procedure, which merges artificial intelligence with CR technology into a sophisticated multi-agent system (MAS). It is a new approach to 5G cellular communication networks. …
Published in Journal of Artificial Intelligence Research & Advances · Vol. 8, Issue 2, 2021 · pp. 13–21 Read article
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A Comprehensive Review: Emerging Nanotechnology in Cancer Drug Delivery
Abstract: Nanotechnology has become a groundbreaking strategy in cancer therapy, especially in drug delivery systems, offering improved treatment effectiveness while minimizing the adverse effects associated with traditional methods. This review presents an in-depth analysis of recent progress in nanotechnology for cancer drug delivery, emphasizing the design, mechanisms, and practical applications of nanoparticle-based systems. Nanoparticles, such as liposomes, dendrimers, and gold nanoparticles, offer unique advantages, including improved drug solubility, targeted delivery to …
Published in Nano Trends – A Journal of Nano Technology & Its Applications · Vol. 27, Issue 1, 2025 · pp. 24–33 Read article
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Review of Simulation Techniques for Microscopic Mobility of Pedestrian Movement
Abstract: Simulation techniques are very useful for developing models or systems over time torepresent the real-world scenarios. The model represents the key characteristics orbehaviors/functions of the selected physical or abstract system or process. Simulationtechniques are useful when the real system cannot be engaged, because of inaccessibility,or dangerous or is unacceptable to engage or does not exist. Microscopic characteristicsof pedestrian traffic consider speeds, walking directions, distances between pedestrians,relative positions, passing behavior and …
Published in Trends in Transport Engineering and Applications · Vol. 1, Issue 1, 2014 · pp. 27–45 Read article
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Investigation of the Effects of Solpawa SBR-X TM Doses on Total Petroleum Hydrocarbon in Loam Soil at Different Depths
Abstract: Laboratory trials of environmental remediation products bring the hope of inventing such products to reality for many of today’s intractable environmental pollution conditions, paving the way for the field trials and subsequent large-scale field application. This laboratory study was conducted as the first phase of a 2-tiered adaptive trials of Solpawa® Bioremediation System (Solpawa-SBX) funded by the Nigerian Content Development and Monitoring Board (NCDMB). The study investigated the effectiveness of …
Published in Journal of Petroleum Engineering & Technology · Vol. 13, Issue 1, 2023 · pp. 64–72 Read article
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Formulation and Evaluation of Topical Antiacne Gel from Coriander and Garlic Extract
Abstract: Objective: To develop and evaluate a topical anti-acne gel formulated using aqueous extracts of coriander (Coriandrum sativum) and garlic (Allium sativum). The study aims to assess the antibacterial efficacy of the gel against acne-causing bacteria, specifically Propionibacterium acnes. Methods: 1.Extraction: Coriander Extract: Aqueous extraction was performed by soaking coriander seeds in distilled water, followed by filtration. Garlic Extract: Non-chemical extraction involved mixing crushed garlic with honey in a 1:1 ratio …
Published in Research & Reviews: A Journal of Pharmacognosy · Vol. 11, Issue 3, 2024 · pp. 10–15 Read article
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Reinventing Drug Delivery Through Cutting-Edge Nanotechnology
Abstract: Nanotechnology has emerged as a revolutionary platform in the field of drug delivery, offering novel strategies for the precise, efficient, and controlled delivery of therapeutic agents. The integration of nanocarriers, such as liposomes, polymeric nanoparticles, dendrimers, micelles, and inorganic nanoparticles, has significantly enhanced drug solubility, stability, bioavailability, and targeted delivery to specific tissues or cells. Targeted drug delivery systems based on nanotechnology minimize off-target effects, reduce systemic toxicity, and improve …
Published in Trends in Drug Delivery · Vol. 12, Issue 3, 2025 · pp. 44–61 Read article
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Screening of Pharmaceutically Significant Methioninase-Producing Fungi from the Satpura Range of Hoshangabad District and Its Large-Scale Production
Abstract: L-methioninase, an enzyme with notable anticancer properties, has emerged as a promising therapeutic agent due to its ability to selectively degrade methionine, a critical amino acid for the survival of methionine-dependent cancer cells. Methionine dependency, observed in many tumor cells, is a metabolic vulnerability that can be exploited for targeted cancer therapy. The Satpura Range in the Narmadapuram District, India, with its diverse microbial ecosystems, offers a rich reservoir for …
Published in Research & Reviews: A Journal of Bioinformatics · Vol. 12, Issue 2, 2025 · pp. 33–43 Read article
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Multi-Criteria Decision Making and Geoinformatics: Evaluating Tools for Alternative Road Network in Hilly Terrain
Abstract: Normal 0 false false false EN-US X-NONE X-NONE Mobility is the backbone of activity system of the human race. Road transportation network has been an essential infrastructure facility, which needs to be developed and regularly maintained to detain increasing population and economy. A road network should offer connectivity throughout the year without any natural and anthropogenic hindrance. In the Ladakh province of Jammu and Kashmir, where road is the largest …
Published in Journal of Remote Sensing & GIS · Vol. 3, Issue 3, 2012 · pp. 31–41 Read article
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Preliminary Evaluation for Phytochemicals in Tribulus Terrestris and Its Antibacterial Activity
Abstract: Medicinal herbs have a long history in improving human health and curing various diseases. A wide interest has been made for researchers using herbal material in identification of the active components and verification of their efficiency. We evaluated the aqueous and methanol extracts of Tribulus terrestris (T. terrestris) for the phytochemical content and its antimicrobial activity. Phytochemical screening of the extracts revealed the presence of alkaloids flavonoids, saponins, anthraquinone, terpenoids, …
Published in Research and Reviews: A Journal of Microbiology and Virology · Vol. 4, Issue 3, 2014 · pp. 1–6 Read article
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Molecular Pharmacokinetics and Structural Docking of Phenolic Acids for Targeting NF-κB Pathway Components in Inflammation and Fibrosis: A Computational Approach Toward Therapeutic Discovery
Abstract: Inflammation and Fibrosis are critical pathological processes associated with various chronic diseases, often mediated by the nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) signaling pathway. This study investigates the therapeutic potential of phenolic acids as modulators of the NF-κB pathway, aiming to identify novel ligands that can effectively interact with key components of this signaling cascade. A comprehensive computational approach was employed, utilizing molecular docking, pharmacological screening, and post-docking …
Published in International Journal of Cell Biology and Cellular Functions · Vol. 3, Issue 1, 2025 · pp. 14–31 Read article