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59 articles for “Pathogenesis”
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Advances In HIV Research: Epidemiology, Pathogenesis, And Emerging Therapeutic Strategies
Abstract: Human Immunodeficiency Virus (HIV) remains a critical global health concern, infecting millions of individuals each year. The introduction of antiretroviral therapy (ART) has markedly improved disease outcomes by suppressing viral replication, restoring immune function, and extending patient longevity. Despite these advances, the complete eradication of HIV is hindered by the persistence of viral reservoirs, the emergence of drug-resistant strains, and disparities in healthcare accessibility. This review summarizes key developments in …
Published in International Journal of Pathogens · Vol. 3, Issue 1, 2026 · pp. 1–5 Read article
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Non-Small Cell Lung Cancer: Types, Pathogenesis, Diagnosis, and Novel Therapeutic Strategies
Abstract: Non-small cell lung cancer (NSCLC) is the most prevalent type of lung cancer, accounting for over 85% of all cases globally. It remains one of the primary causes of cancer-related death due to its rapid progression, few early symptoms, and late detection. The three main forms of non-small cell lung cancer (NSCLC) are adenocarcinoma, squamous cell carcinoma, and giant cell carcinoma; each has a unique histology, prognosis, and response to …
Published in Research and Reviews: A Journal of Pharmacology · Vol. 16, Issue 2, 2026 Read article
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Role of Impaired Digestion in Disease Pathogenesis: According to Unani System of Medicine
Abstract: The relationship between digestion and disease occupies a central position in Greco-Arab (Unani) medicine, as emphasized by classical physicians such as Ibn Sina and Al-Razi. In Unani medicine, digestion (Haḍm) is not confined to the gastrointestinal tract alone but represents a comprehensive physiological and metabolic process involving four sequential stages: gastric digestion (Haḍm-e-Mi‘dī), hepatic digestion (Haḍm-e-Kabidī), vascular digestion (Haḍm-e-‘Urūqī), and tissue digestion (Haḍm-e-‘Uḍwī). These stages are governed by Quwwat-e-Hāḍima (digestive …
Published in Research & Reviews : A Journal of Unani, Siddha and Homeopathy · Vol. 13, Issue 2, 2026 Read article
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Monkeypox Virus (MPXV): Epidemiology, Pathogenesis, and Control Strategies: Exploring the Recent Resurgence of Monkeypox, Its Transmission Dynamics, Clinical Manifestations, and Public Health Responses
Abstract: Monkeypox virus (MPXV) has re-emerged as a significant public health concern, with increasing cases reported worldwide. This zoonotic virus, primarily endemic to Central and West Africa, has demonstrated the potential for human-to-human transmission, leading to outbreaks in non-endemic regions. Unlike smallpox, which was eradicated through mass vaccination, monkeypox continues to persist due to the lack of widespread immunity and effective antiviral treatments. The resurgence of MPXV in recent years, particularly …
Published in International Journal of Virus Studies · Vol. 2, Issue 1, 2025 · pp. 29–34 Read article
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Comprehensive Review of Adenoid Cystic Carcinoma: Pathogenesis, Diagnosis, and Emerging Therapeutic Approaches
Abstract: Adenoid cystic carcinoma (ACC)is an infrequent neoplasm, highly malignant, that develops mainly in the salivary glands with the potential to exist in any secretory glandular sites, including the lacrimal glands, breast, and respiratory tract. ACC usually has a benign initial course, but conversely, it is notoriously aggressive in behavior with high incidence of perineural invasion, local recurrence, and distant metastasis, mostly to the lungs. The tumor’s molecular features are characterized …
Published in Research and Reviews: Journal of Oncology and Hematology · Vol. 14, Issue 3, 2025 · pp. 1–17 Read article
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A Comprehensive Review on Premature Hair Graying: Factor Contributing, Pathogenesis, Prevention Strategies, and Natural Therapeutic
Abstract: Premature graying of hair (PGH), also known as early canities, is an increasingly common dermatological concern characterized by the loss of natural hair pigmentation before the expected age. Hair color is primarily determined by the quantity and type of melanin synthesized by melanocytes within the hair follicle. Disruption in melanocyte function, survival, or melanin synthesis leads to hair graying. Multiple intrinsic and extrinsic factors contribute to PGH, including genetic predisposition, …
Published in Research and Reviews: A Journal of Health Professions · Vol. 16, Issue 1, 2026 · pp. 13–20 Read article
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Dermatophytoses: Taxonomy, Pathogenesis, Diagnosis, Resistance, and Management.
Abstract: Dermatophytes, belonging to the family Arthrodermataceae, are keratinophilic fungi responsible for superficial mycoses. Dermatophytoses affect the skin, hair, and nails globally. Over the last few years, dermatophytic infections have seen a sharp rise in India, with the main causative agent being antifungal-resistant Trichophyton mentagrophytes genotype VIII. This review provides a detailed overview of dermatophytoses, including taxonomy, pathogenesis, epidemiology, diagnosis, and treatment. Dermatophytes belong to the kingdom Fungi, family Arthrodermataceae, with …
Published in International Journal of Fungi · Vol. 3, Issue 1, 2026 · pp. 28–37 Read article
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Revisiting the Role of Mindfulness-based Stress Reduction in the Management of Rheumatoid Arthritis
Abstract: Rheumatoid arthritis (RA) is a type of arthritis characterized by a chronic inflammatory disorder that primarily affects the lining of the synovial joints resulting in progressive disability in the movement of diarthrodial joints and arthralgia. It is a debilitating disease associated with premature death and socioeconomic burdens. Its pathogenesis is multifactorial with an individual course of progression where psychological stress is considered to be one of the risk factors associated …
Published in International Journal of Vaccines · Vol. 1, Issue 1, 2024 · pp. 19–28 Read article
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A Review on Diagnosis and Management of Conjunctivitis
Abstract: Conjunctivitis, typically recounted as crimson eye, is a super ocular circumstance affecting men and ladies of all ages. This abstract aims to summarize the findings of a comprehensive study that delves into the pathogenesis, clinical manifestations, and management strategies for conjunctivitis. A multifaceted approach was employed, including a systematic literature review of conjunctivitis-related studies, clinical observations, and interviews with leading ophthalmologists. The various cases were analysed to assess demographic patterns, …
Published in Recent Trends in Infectious Diseases · Vol. 1, Issue 2, 2024 · pp. 35–46 Read article
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Evaluation Tumor Necrosis Factor-α (TNF- α) Levels in Patients with Rheumatoid Arthritis
Abstract: Background: RA is an inflammatory, long-term autoimmune illness, that is impacted by external variables, according to a report from the World Health Organization. Women are 2-3 times more likely than men to develop RA, though this difference diminishes with older age at onset. Aim: The purpose of this study is to assess the significance of TNF-α concentrations in the predisposition to rheumatoid arthritis. Methods: The research project enrolled 100 patients …
Published in Research and Reviews : A Journal of Immunology · Vol. 14, Issue 2, 2024 · pp. 32–38 Read article
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Comprehensive Review on Postoperative Nausea and Vomiting Following General Anesthesia
Abstract: Postoperative nausea and vomiting, often known as PONV, is a common and uncomfortable consequence that occurs after general anesthesia. Patients of all ages are susceptible to experiencing this condition. Even though there have been advances in anaesthesia procedures and treatments, postoperative nausea and vomiting (PONV) continues to be a serious concern since it has the potential to cause patients to experience discomfort, delay their recovery, extend their hospital stays, and …
Published in International Journal of Advance in Molecular Engineering · Vol. 2, Issue 2, 2024 · pp. 20–26 Read article
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Leveraging Genome-Wide Association Studies for Precision Medicine in Cardiovascular Diseases
Abstract: Cardiovascular diseases (CVDs) are the leading cause of death globally, with complex etiologies involving genetic, environmental, and lifestyle factors. Genome-wide association studies (GWAS) have significantly advanced the understanding of genetic underpinnings of CVDs by identifying numerous risk loci and variants associated with various cardiovascular conditions. This review explores the potential of GWAS to drive precision medicine in cardiovascular diseases by linking genetic data with clinical outcomes, providing insights into disease …
Published in Research and Reviews : Journal of Computational Biology · Vol. 14, Issue 1, 2025 · pp. 35–39 Read article
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Virulence Factors in pathogens :mechanisms of infection & disease progression
Abstract: Pathogens, like bacteria, viruses, fungi, and parasites, have evolved specialized tools – known as virulence factors – that help them infect hosts, escape the immune system, and cause disease. These factors play a key role in determining how severe an infection becomes, how quickly it spreads, and how the body responds. Some pathogens use adhesins to stick to host cells, while others produce toxins that damage tissues or disrupt normal …
Published in International Journal of Pathogens · Vol. 2, Issue 1, 2025 · pp. 6–11 Read article
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Host Invasion to Immune Evasion: Emerging Concepts in Pathogen Virulence Strategies
Abstract: Pathogens have evolved a wide repertoire of virulence strategies that allow them to invade host tissues, establish infection, and circumvent immune responses. From the initial steps of adhesion and colonization to complex molecular mimicry, antigenic variation, and immunomodulation, pathogens display remarkable adaptability. While traditional research has emphasized host cell entry and toxin production, emerging evidence highlights subtler and more dynamic strategies such as manipulation of host signaling pathways, subversion of …
Published in International Journal of Pathogens · Vol. 2, Issue 2, 2025 Read article
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The Invisible Engineers: How Viruses Change Cells at the Molecular Level
Abstract: Viruses are frequently thought of as simple parasites, yet at the molecular level, they are quite good at engineering and may change the way the cells they infect work. The Invisible Engineers: How Viruses Rewire Cells at the Molecular Scale looks into how viruses get into host cells, mess up intracellular circuits, and exploit molecular resources to make copies of themselves. This article talks about how viral proteins and nucleic …
Published in International Journal of Virus Studies · Vol. 3, Issue 2, 2026 · pp. 1–6 Read article
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The Role of Pyruvate Dehydrogenase in Non-Alcoholic Fatty Liver Disease: Therapeutic Insights and Future Directions
Abstract: Non-alcoholic fatty liver disorders (NAFLD) are defined by the accumulation of excess fat in the liver that has no other cause, such as drinking alcohol. Pyruvate dehydrogenase has been established as an alternative treatment for this disorder. NAFLD pathogenesis is complex and includes oxidative stress inflammatory processes and mitochondrial dysfunction. Impaired liver fatty acid oxidation and glucose oxidation are significant individuals in developing NAFLD, and strategies to reverse these defects …
Published in Research and Reviews: A Journal of Pharmacology · Vol. 14, Issue 3, 2024 · pp. 44–51 Read article
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A Comprehensive Review on Monkeypox Infection
Abstract: Monkeypox represents a zoonotic viral affliction instigated by the monkeypox virus, which is classified within the Poxviridae family and is distinct from the virus that causes chickenpox. Initially recognized in 1958, this infection has recently attracted international scrutiny due to its escalating incidence beyond traditional endemic territories. This review delivers an exhaustive examination of monkeypox, encompassing its epidemiology, viral morphology, modes of transmission, pathogenesis, clinical presentations, and therapeutic interventions. The …
Published in Recent Trends in Infectious Diseases · Vol. 2, Issue 1, 2025 · pp. 23–32 Read article
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Exploring the Therapeutic Potential of Phytohormones: Bridging Plant Immunity and Human Health
Abstract: This review highlights the multifaceted roles of phytohormones, including salicylic acid, abscisic acid, cytokinins, and brassinosteroids, emphasizing their contributions to plant immunity and potential therapeutic applications in human health. Phytohormones are critical regulators of plant growth, development, and defense, functioning as signaling molecules that activate and coordinate plant responses to biotic and abiotic stresses. Salicylic acid, in particular, is instrumental in systemic acquired resistance (SAR), a defense mechanism that strengthens …
Published in International Journal of Trends in Horticulture · Vol. 1, Issue 2, 2024 · pp. 20–23 Read article
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A Systematic Review on Diabetic Encephalopathy, Its Type & Biomarkers
Abstract: Diabetes and its complications become a major reason of morbidity and mortality associated with the changes of life style. Diabetic Encephalopathy is one of the complication of Diabetes Mellitus. The aim of this paper is to review the information on Diabetic Encephalopathy with emphasis on its etiology , pathogenesis and its treatment. Diabetic encephalopathy is the condition in which impairment of brain function occur. Diabetic encephalopathy is the complication of …
Published in Research and Reviews: A Journal of Pharmacology · Vol. 15, Issue 3, 2025 · pp. 98–117 Read article
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Brief Concept of Waja ul Mafasil and its Management in Unani System of Medicine: A Review
Abstract: Waja-ul-Mafasil (Osteoarthritis) also known as degenerative arthritis is a progressive joint disease, occurring in middle and later life. Osteoarthritis is a leading cause of disability worldwide despite its development in prevention, diagnosis, and treatment. A comprehensive description of Waja-ul-Mafasil is available in classical Unani literature. While going through the literature review of various compendiums written by Unani scholars, it is clear that this system of medicine had huge knowledge about …
Published in Research & Reviews : A Journal of Unani, Siddha and Homeopathy Read article