All articles
54 articles
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Comprehensive Review on Antimicrobial based Hydrogel for Wound Healing
Abstract: Chronic wounds present a significant clinical challenge due to their prolonged healing time, high risk of infection, and frequent recurrence. The development of novel wound dressings with both healing and antimicrobial properties is essential for effective wound management. This study focuses on the formulation and evaluation of an antimicrobial drug-loaded hydrogel designed to promote chronic wound healing. Chronic wounds are a growing concern in healthcare, often taking weeks or even …
Published in Research & Reviews: A Journal of Drug Formulation, Development and Production · Vol. 12, Issue 2, 2025 · pp. 72–88 Read article
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Formulation and Evaluation of Herbal Anti-inflammatory oil using Tamarindus Indica oil, Vitex Negundo oil and Ipomoea batatas oil
Abstract: The formulation and evaluation of a herbal anti-inflammatory oil derived from the leaves of Tamarindus indica (Tamarind) Ipomoea batatas (Sweet potato) Vitex negundo (Nirgundi) aim to explore the therapeutic potential of these plants in managing pain and inflammation. Tamarind leaves are rich in flavonoids like quercetin, which primarily provide anti-inflammatory benefits by inhibiting pro-inflammatory cytokines, though their analgesic effects are moderate. Nirgundi leaves contain eugenol, known for its strong analgesic …
Published in Research & Reviews: A Journal of Drug Formulation, Development and Production · Vol. 12, Issue 2, 2025 · pp. 01–06 Read article
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Fabrication and Characterization of Diacerein Loaded Nanosponge for Topical Delivery
Abstract: Diacerein, an anti-inflammatory drug, which comes under BCS class II, commonly used in treatment of osteoarthritis has limited by its poor solubility and bioavailability when administered topically. This study aimed to develop and evaluate diacerein-loaded nanosponges gel using varying concentrations of ethyl cellulose and polyvinyl alcohol (PVA) to enhance its delivery. Nanosponges were prepared using an emulsion solvent evaporation technique, with different ratios of ethyl cellulose (0.05-0.250%) and PVA (0.2-0.3%). …
Published in Research & Reviews: A Journal of Drug Formulation, Development and Production · Vol. 12, Issue 2, 2025 · pp. 26–46 Read article
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Orally Dispersible Tablet of Mesalazine: Formulation and Evaluation
Abstract: Oral disintegrating tablets (ODTs) become increasingly more and more popular, particularly among elderly and paediatric patients who have difficulties with swallowing. The 5-aminosalicylic acid compound oral mesalazine, frequently referred to as mesalamine, is used to treat mild to severe ulcerative colitis and has a high percentage of success in causing and establishing response. Mesalazine has a topical therapeutic action at the location of the suffering colonic mucosa. The medication’s disadvantage …
Published in Research & Reviews: A Journal of Drug Formulation, Development and Production · Vol. 12, Issue 2, 2025 · pp. 16–25 Read article
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Quantum Mechanics: Revolutionizing Pharmaceutical Sciences
Abstract: Quantum physics and pharmacy have generally been regarded as distinct areas—one investigates the microlevel behavior of non-living matter while the other concentrates on intricate biological systems. Nevertheless, progress in life sciences has increasingly depended on molecular-level insights, whereas quantum physics has advanced beyond basic principles to impact real-world uses. This intersection provides new opportunities for, pharmacy. Quantum entanglement, which allows for instantaneous relationships between particles, can be utilized for secure …
Published in Research & Reviews: A Journal of Drug Formulation, Development and Production · Vol. 12, Issue 1, 2025 · pp. 72–77 Read article
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Formulation, Evaluation and Development of Multipurpose Cream Containing kokum Butter
Abstract: The creation of the multipurpose polyherbal crack-healing cream, which shields the skin from cracks and can also serve as a multifunctional cream to shield the skin from other skin issues. The polyherbal cosmetic formulation can be used to give skin a protective barrier and is safe to use. Over the course of the study, this multipurpose polyherbal cream demonstrated good homogeneity, pH, consistency, spreadability, and lack of phase separation. This …
Published in Research & Reviews: A Journal of Drug Formulation, Development and Production · Vol. 12, Issue 1, 2025 · pp. 78–89 Read article
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Molecular Mechanisms of Drug Metabolism in Anesthesia: A Pharmacogenomic Perspective
Abstract: Pharmacogenomics studies how a person’s genetic profile affects their reaction to drugs, which is vital in anesthesia. Anesthetic pharmacology depends significantly on drug metabolism, which involves complex biochemical processes that manage the absorption, distribution, metabolism, and excretion (ADME) of anesthetic drugs. The cytochrome P450 (CYP) enzyme family plays a critical role in the metabolism of various anesthetic drugs, with genetic polymorphisms leading to inter-individual variability in drug responses. Specific CYP …
Published in Research & Reviews: A Journal of Drug Formulation, Development and Production · Vol. 12, Issue 1, 2025 · pp. 90–95 Read article
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A Comprehensive Review of Analytical Method – Development and Method Validation of Digoxin Tablets
Abstract: The main objective of this review is to give an outline of the method development and validation process of digoxin, and this review covers the different types of spectroscopic and chromatographic techniques, such as HPLC, UHPLC-Tandem mass spectroscopy, TLC, and LC-MS. A novel method for the determination of digoxin in biological samples has been developed and validated, focusing on improving sensitivity, specificity, and reproducibility. The method was validated in terms …
Published in Research & Reviews: A Journal of Drug Formulation, Development and Production · Vol. 12, Issue 1, 2025 · pp. 47–58 Read article
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A Review of Analytical Method Development and Validation of Amiodarone Pharmaceutical Dosage Form
Abstract: The review provides an in-depth analysis of the analytical method development and validation process for amiodarone tablets. Method validation is crucial in the pharmaceutical industry for ensuring the quality and efficacy of tablets, as it ensures the accuracy, precision, and reliability of analytical techniques used in drug testing. It is a prerequisite for method development, adhering to good manufacturing practices, and optimizing processes. This review aims to consolidate and analyse …
Published in Research & Reviews: A Journal of Drug Formulation, Development and Production · Vol. 12, Issue 1, 2025 · pp. 59–71 Read article
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FDA Drug Approvals 2024: A Comprehensive Review
Abstract: The year 2024 has been pivotal for the pharmaceutical industry, with the U.S. Food and Drug Administration (FDA) granting approval to a diverse array of new drugs. These approvals highlight significant strides in therapeutic innovation, targeting a spectrum of diseases from rare genetic disorders to prevalent chronic conditions. This article provides a detailed examination of the FDA-approved drugs of 2024, focusing on their therapeutic indications, mechanisms of action, and the …
Published in Research & Reviews: A Journal of Drug Formulation, Development and Production · Vol. 12, Issue 1, 2025 · pp. 28–46 Read article
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Green Analytical Chemistry in Pharmaceuticals: Pathways to Sustainability and Compliance
Abstract: This review paper explores the integration of green analytical chemistry (GAC) in the pharmaceutical industry as a pathway to EU compliance and environmental sustainability. The review highlights a range of studies that focus on the application of green solvents, green extraction methods, biocatalysts, and energy-efficient techniques. Key findings suggest that employ eco-friendly solvents, such as ethanol and water and methods, like ultrasound-assisted extraction (UAE) and supercritical fluid extraction (SFE), significantly …
Published in Research & Reviews: A Journal of Drug Formulation, Development and Production · Vol. 12, Issue 1, 2025 · pp. 7–12 Read article
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Pharmaceutical Syrup Formulation Enhancing Bioavaibility and Patient Compliance
Abstract: Pharmaceutical syrup formulations are crucial for drug delivery, especially in pediatric and geriatric populations. However, challenges, such as bioavailability, stability, and patient compliance due to factors, like taste and viscosity, must be addressed. Strategies to enhance bioavailability include solubility enhancers, nanoparticle systems, and advanced techniques like solid dispersions and emulsions. Palatability plays a critical role in patient compliance, with flavoring agents, sweeteners, and texture modifications improving acceptability. Innovations, like controlled-release …
Published in Research & Reviews: A Journal of Drug Formulation, Development and Production · Vol. 12, Issue 1, 2025 · pp. 1–6 Read article
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Pharmacovigilance and drug safety current trends and challenges
Abstract: Pharmacovigilance and drug safety are critical areas of focus in healthcare, aimed at monitoring the safety and efficacy of pharmaceutical products throughout their lifecycle. This review explores current trends, emerging technologies, and challenges in pharmacovigilance, emphasizing their impact on public health and regulatory practices. With the increasing complexity of global pharmaceutical markets, pharmacovigilance systems are evolving to integrate real-time data analytics, artificial intelligence (AI), and machine learning (ML) to detect …
Published in Research & Reviews: A Journal of Drug Formulation, Development and Production · Vol. 12, Issue 1, 2025 · pp. 19–27 Read article
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Ethnopharmacological Insights: Uncovering Plant-Based Neuroprotective Treatments for Neurodegenerative Disorders
Abstract: The development of plant-based therapies for neurodegenerative diseases holds significant promise due to the therapeutic potential of natural compounds, such as Laurus nobilis, Aronia melanocarpa, and celastrol. This review identifies critical literature gaps in the current research, including inconsistent extraction methods, lack of clinical trials, insufficient documentation of long-term effects, limited mechanistic insights, and poor bioavailability. Addressing these gaps through standardization, rigorous clinical trials, advanced delivery systems, and comprehensive ethnopharmacological …
Published in Research & Reviews: A Journal of Drug Formulation, Development and Production · Vol. 12, Issue 1, 2025 · pp. 13–18 Read article
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A Research on Formulation and Evaluation of Clove Gel for Treatment of Scabies
Abstract: Scabies remains a pervasive global health issue, with a need for more effective topical treatments. This research focuses on the formulation and evaluation of a clove oil-based gel containing eugenol, the primary bioactive component, for the treatment of scabies. Eugenol’s well-documented antimicrobial, anti-inflammatory, and ant parasitic activities make it an ideal candidate for targeting Sarcoptes scabiei, the mite responsible for scabies. The formulation was prepared by incorporating clove oil and …
Published in Research & Reviews: A Journal of Drug Formulation, Development and Production · Vol. 11, Issue 3, 2024 · pp. 22–31 Read article
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Blockchain Technology for Strengthening the Indian Generic Medicine Supply Chain and Combating Counterfeit Drugs
Abstract: India is one of the leading distributors of generic medicines globally, but its supply chain faces numerous challenges including substandard medicines, counterfeiting, and inefficient logistics. Blockchain technology offers a promising solution by providing a secure, decentralized, and transparent platform to track and verify the entire drug supply chain from production to delivery. This paper investigates the potential of blockchain to mitigate counterfeit drug circulation, improve trust in Indian generic medicines, …
Published in Research & Reviews: A Journal of Drug Formulation, Development and Production · Vol. 11, Issue 3, 2024 · pp. 9–12 Read article
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Formulation and Evaluation of Saliva Substitute
Abstract: The development and evaluation of saliva substitutes play a vital role in managing xerostomia, a condition marked by insufficient saliva production that adversely affects oral health and overall well-being. This study investigates various formulations of saliva substitutes intended to replicate the functionality of natural saliva. The key goals are to assess their moisturizing effectiveness, physical and chemical properties, and in vitro performance. These formulations generally incorporate hydrators, lubricants, thickeners, and …
Published in Research & Reviews: A Journal of Drug Formulation, Development and Production · Vol. 11, Issue 3, 2024 · pp. 32–47 Read article
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Development of Sodium Alginate Beads of Telmisartan Using Emulsion Gelation Method: Formulation and In-Vitro Characterization
Abstract: Introduction: The antihypertensive medication Telmisartan (TEL) is a member of BCS class II, which is distinguished by limited oral rate and extent and water solubility. By localizing the medication release in the stomach, gastro-retentive floating bead devices may be able to address the issues related to partial absorption and the low solubility of TEL. The preparation of TEL floating alginate beads was the aim of this investigation. The current work …
Published in Research & Reviews: A Journal of Drug Formulation, Development and Production · Vol. 11, Issue 3, 2024 · pp. 13–21 Read article
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Accelerate Drug Development with Pharmacokinetic Softwares
Abstract: During continuously evolving technologies and mechanized equipments, there has been a tremendous growth in the pharmaceutical sector over the past few decades. New technologies, software, devices, and techniques are being developed or researched upon with each passing day. By leveraging pharmacokinetic software, researchers can efficiently analyze vast datasets from preclinical and clinical studies, extracting actionable insights that inform decision-making early in the development cycle. This predictive capability not only accelerates …
Published in Research & Reviews: A Journal of Drug Formulation, Development and Production · Vol. 11, Issue 3, 2024 · pp. 1–8 Read article
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Extraction and Compound Analysis of Bauhinia acuminata: Soxhlet Method and Identification
Abstract: In the present study, the extraction and compound analysis of Bauhinia acuminata using the Soxhlet method, coupled with identification techniques, were conducted. Bauhinia acuminata L., a member of the Leguminosae (Fabaceae) family in the Caesalpinioideae subfamily, is a shrub usually reaching a height of around 3 m. It is native to tropical Southeast Asia and commonly found in the tropical regions of India and China. Primarily grown for ornamental purposes, …
Published in Research & Reviews: A Journal of Drug Formulation, Development and Production · Vol. 11, Issue 2, 2024 · pp. 18–23 Read article