Chronic kidney disease
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SGLT2 Inhibitors in Heart Failure and Chronic Kidney Disease: Expanding Therapeutic Horizons beyond Glycemic Control
Abstract: Heart failure (HF) and chronic kidney disease (CKD) are closely related clinical diseases that significantly increase morbidity and death worldwide. The co-occurrence of both conditions is frequently referred to as the "cardio-renal syndrome," in which the failure of one organ hastens the decline of the other. The original purpose of sodium–glucose cotransporter-2 (SGLT2) inhibitors was to treat type 2 diabetic mellitus (T2DM) by reducing blood sugar levels. Nevertheless, new data …
Published in Research and Reviews: A Journal of Pharmacology · Vol. 16, Issue 2, 2026 Read article
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A Comparative Study of Lipid Profile in Pre-Dialysis and Post-Dialysis End-Stage Renal Disease Patients
Abstract: Background: Chronic kidney disease (CKD) represents a major public health concern in India, with its prevalence increasing at an alarming rate. Individuals with CKD are at a substantially higher risk of developing cardiovascular disease (CVD), which remains the leading cause of mortality in this population. Dyslipidemia is particularly pronounced among patients with end-stage renal disease (ESRD); however, limited data are available regarding the impact of hemodialysis on lipid profile alterations. …
Published in Research and Reviews: A Journal of Medicine · Vol. 16, Issue 1, 2026 · pp. 25–31 Read article
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A Study to Assess the Risk Factors Associated with Sudden Death in Population on Hemodialysis
Abstract: Background: Patients with chronic kidney disease (CKD) receiving maintenance hemodialysis (HD) experience disproportionately high mortality, with sudden death remaining a leading cause. Multiple clinical, biochemical, and care-related factors influence outcomes, yet comprehensive risk stratification models and the role of dialysis timing and early nephrology care remain inadequately explored in resource-limited settings. Objectives: This study aimed to (i) identify clinical and biochemical risk factors associated with mortality in HD patients, (ii) …
Published in Research and Reviews : A Journal of Life Sciences · Vol. 16, Issue 1, 2026 · pp. 14–19 Read article
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Integration of Biomarkers in III and IV CKD Patients for Evaluation of Their Predictive Value for CVD in CKD Patients
Abstract: Background: Chronic kidney disease (CKD) is presently characterized by the presence of proteinuria and/or a diagnosis of renal impairment. The worldwide significance of CKD is underscored by the fact that its prevalence and incidence have doubled over the past three decades. This paper provides an overview of the existing evidence regarding biomarkers in individuals with CVD or CKD, with a particular focus on the emerging biomarkers (i.e., eGFR, sALB, UACR, …
Published in Research and Reviews: A Journal of Medicine · Vol. 15, Issue 3, 2025 · pp. 1–12 Read article
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A summary continuation analysis evaluating the prevalence and predictors of diabetic retinopathy in newly diagnosed type 2 diabetic patients.
Abstract: Context: Diabetic retinopathy (DR), the leading cause of acquired blindness in adults, affects approximately 93 million people globally. It is a serious complication of type 2 diabetes, resulting from prolonged damage to the blood vessels in the retina. Although largely preventable and treatable, DR continues to be the main cause of vision loss among working-age adults and significantly impacts quality of life. While most studies on DR in Nepal have …
Published in Research and Reviews : A Journal of Medical Science and Technology · Vol. 14, Issue 2, 2024 · pp. 21–30 Read article
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A Study on the Prevalence and Causative Factors of Anemia in Patients Undergoing Maintenance Hemodialysis
Abstract: Anemia is a common and serious issue in individuals with chronic kidney disease (CKD) who are on maintenance hemodialysis (MHD), greatly affecting their overall health and quality of life (QoL). Despite advancements in treatment, anemia remains a challenging issue in this population. This study investigates the prevalence of anemia and identifies the contributing factors in CKD patients on MHD with the aim of enhancing clinical management strategies. This study focused …
Published in Research and Reviews : A Journal of Medical Science and Technology · Vol. 14, Issue 1, 2024 · pp. 73–89 Read article
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A Study on the Incidence and Prevalence of Cardiovascular Morbidity and Mortality in Patients Undergoing Maintenance Hemodialysis
Abstract: Cardiovascular Disease (CVD) is a major complication for patients with end-stage renal disease (ESRD) on Hemodialysis (HD), with the mortality rate from CVD being nearly 20 times higher than in the general population. As Chronic Kidney Disease (CKD) advances, patients accumulate both traditional and kidney-specific cardiovascular risk factors, such as hypertension, diabetes, fluid overload, electrolyte imbalances, and uremic toxins. These factors contribute significantly to the increased cardiovascular morbidity and mortality …
Published in Research and Reviews : A Journal of Life Sciences · Vol. 14, Issue 3, 2024 · pp. 56–66 Read article
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Pregnancy Outcomes on Chronically Hemodialyzed Women in Arab World: A Systematic Review
Abstract: Pregnancy carries a major risk of difficulties, as highlighted by the present systemic study on pregnancy outcomes in persistently hemodialyzed women in the Arab world. The objective of this systematic review was to describe the pregnancy outcomes among chronically hemodialyzed pregnant women in Arab countries in terms of the incidence of pregnancy among women on maintenance hemodialysis and the incidence of maternal and fetal complications of pregnant women on hemodialysis. …
Published in International Journal of Midwifery Nursing And Practices · Vol. 2, Issue 1, 2024 · pp. 25–36 Read article
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Evaluation of Prescribing Pattern of Drugs in Hemodialysis Patients
Abstract: Background: Patients undergoing hemodialysis often exhibit a high level of dependency and frequently present with multiple co-morbid conditions Chronic kidney disease (CKD) poses a significant global public health challenge, with its association with numerous complications. Prescribing medications appropriately for individuals with CKD presents a substantial challenge. Objective: The study aimed to assess the prescribing patterns of drugs in hemodialysis patients. Results: Out of the total 82 selected patients, 42 (51%) …
Published in International Journal of Antibiotics · Vol. 1, Issue 2, 2024 · pp. 20–26 Read article
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Assessment of Finerenone Safety and Efficacy in Individuals with Type 2 Diabetes and Chronic Kidney Disease
Abstract: Background: In this work, we provide strong evidence for the safety and efficacy of finerenone in people with type 2 diabetes and chronic kidney disease. Our goal is to improve patients' quality of life and general well-being through our research. Aim: Finerenone exhibited a significant decrease in the likelihood of renal and cardiovascular (CV) events in individuals with both type 2 diabetes and chronic kidney disease. This exploratory subgroup analysis …
Published in International Journal of Antibiotics · Vol. 1, Issue 2, 2024 · pp. 06–09 Read article
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An Approach towards in Management of Chronic Kidney Disease
Abstract: The current international guidelines define and classify the chronic kidney disease (CKD) as decreased kidney function shown by decreased glomerular filtration rate (GFR). Glomerular filtration rate of 60 ml/min/1.73 m 2 for at least 3 months is a marker for kidney damage. The underlying causes for chronic kidney disease are proteinuria and hypertension. It is the main cause of CKD in many high-, middle- and low-income countries. In different countries, …
Published in Research and Reviews: A Journal of Pharmaceutical Science · Vol. 12, Issue 1, 2025 · pp. 9–15 Read article