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16 articles for “scaffold techniques”
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Assessment of Decellularization Techniques for Fabrication of Tubular Submucosal Scaffolds from Small Intestine for Application in Oesophageal Tissue Engineering
Abstract: In this ground-breaking study, we sought to create superior tubular scaffolds for tissue engineering by utilizing small intestine submucosa (SIS), a remarkable biomaterial with outstanding therapeutic potential. We investigated two standard detergent-perfusion procedures, peracetic acid under perfusion and classic peracetic acid-agitation, to decellularize tubular SIS, with the goal of generating scaffolds with consistent and reliable properties for oesophageal tissue engineering. To assess biocompatibility, we employed metabolic research, microscopy, mechanical tests, …
Published in Journal of Polymer & Composites · Vol. 11, Issue 3, 2023 · pp. 30–38 Read article
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Bioconjugates and Biohybrid Polymers: Intricate Cellular Integration Methods and Sophisticated Biofunctionalization Techniques for Tailored Properties in Medical Contexts
Abstract: Bioconjugates are made when biological molecules are covalently linked to manufactured polymers. They can be used in many ways for imaging, diagnosis, and specific drug delivery. Getting perfect cellular fusion is very important for how well they work. Biomolecules can be attached to polymer scaffolds in a controlled way using techniques like click chemistry and site-specific conjugation. This makes sure that the molecules connect optimally with their biological targets. Using …
Published in Journal of Polymer & Composites · Vol. 12, Issue 3, 2024 · pp. 227–243 Read article
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Innovative 3D Printed Cell Scaffolds with Magnetized Nanocomposites for Targeted Cancer Therapy Drug Delivery
Abstract: In recent years, scaffolds have gained increasing attention in the field of tissue engineering, especially in cancer treatment. Nanocomposite scaffolds have emerged as promising candidates for delivering drugs to cancer cells. 3D printing technology has enabled the fabrication of customized scaffolds with precise pore size and complex geometries. This study explores the development of 3D printed scaffolds of nanostructured made of graphene oxide and Poly-Caprolactone (PCL) nanocomposites, which can be …
Published in Journal of Polymer & Composites · Vol. 11, Issue 3, 2023 · pp. 48–55 Read article
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Emerging Therapeutic Discovery Against Escherichia coli Infection by Rational Inhibition of Fatty Acid Responsive Transcription Factor: Theoretical Molecular Investigations of Some Metabolites as Inhibitors of Fatty Acid Metabolism Protein
Abstract: For the discovery of effective agent for overcoming resistance against Escherichia coli (E. coli) bacteria by modulating Fatty Acid Metabolism Protein (FadR)—a Fatty Acid Responsive Transcription Factor. The present study involved discovery of some metabolites of furan, furan-2-yl, macrolactin, and chromene scaffold via in silico structure-based drug design (SBDD) technique by utilizing the Maestro 9.1 software. The study will provide clues, motivate, and throw light on imperative aspects for the …
Published in Research and Reviews : Journal of Computational Biology · Vol. 7, Issue 3, 2018 · pp. 1–7 Read article
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Benzimidic Acid Derivatives as Potential Anti-Escherichia coli Agent for Preventing Nosocomial Infections
Abstract: Based on the global fame of benzimidic acid/benzoic acid derivatives in exhibiting antimicrobial activities against a variety of pathogens (particularly nosocomial infections), two novel compounds (S1 and S2) of benzimidic acid scaffold were rationally designed from a hydrazine derivative and fabricated using the conventional synthesis technique. Through sophisticated instruments, the molecules were comprehensively characterized and investigated for antibacterial activity against pathogenic Escherichia coli strain (MTCC 2961). The novel benzimidic compound …
Published in Research and Reviews : A Journal of Medical Science and Technology · Vol. 9, Issue 1, 2020 · pp. 11–15 Read article
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Use of NMR and Other Spectroscopy Techniques in Heterocyclic Oxadiazole Derivatives Studies: A Review
Abstract: It was possible to create a number of novel symmetrical 2,5-dialkyl-1,3,4-oxadiazoles with substituents including carboxymethylamino, isopropyloxycarbonylmethylamino, and bromine at the terminal positions of the alkyl groups. The multistep process that was devised used hydrazine hydrate, phosphorus oxychloride, and commercially available acid chlorides that varied in alkyl chain length and terminal substituent.Diisopropyliminodiacetate was an easy way to substitute the intermediate bromine-containing 2,5-dialkyl-1,3,4-oxadiazoles. This was followed by hydrolysis in an aqueous methanol …
Published in International Journal of Photochemistry and Photochemical Research · Vol. 2, Issue 1, 2024 · pp. 07–13 Read article
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Evaluation and Fabrication of 3D-Printed Bioactive β-TCP/PCL Scaffolds for Bone Tissue Engineering
Abstract: Bone is one of the tissue types that is transplanted the most worldwide. Each year, there are over four million procedures that incorporate the use of bone grafts or substitutes to help heal bone deficiencies. These treatments are still limited greatly, and there is always a demand for help because of trauma, cancer, infection, and arthritis. Because of this, researchers are targeting improvement in developing bioactive three-dimensional (3D) scaffolds that …
Published in Journal of Polymer & Composites · Vol. 14, Issue 4, 2026 · pp. 1–6 Read article
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Hydroxylated Chalcone Derivatives as Future Aldose Reductase Inhibitors: Discovery through Docking Technique
Abstract: The research endeavors molecular docking assisted exploration of ALR inhibitory perspectives of some B-ring substituted hydroxyl group (A-ring) containing chalcone compounds against human aldose reductase in complex with NADP+ and the inhibitor IDD594 (PDB ID: 1US0) by utilizing the iGEMDOCK (Genetic Evolutionary Method for Molecular Docking) software. The present investigation immensely focused on the human aldose reductase inhibitory perspectives of some hydroxylated chalcone compounds. The inhibition of the enzyme by …
Published in Research and Reviews : Journal of Computational Biology · Vol. 8, Issue 1, 2019 · pp. 8–12 Read article
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Bio-Inspired FGPCs for Biomedical and Structural Applications
Abstract: Bio-inspired functionally graded polymer composites (FGPCs) represent a new class of smart materials that use gradient material distributions to enhance mechanical and biological properties, mimicking natural systems like bones, shells, and plant stems. FGPCs exhibit smooth gradient distributions across interfaces, which improves biocompatibility and reduces the risk of failure under complex loading and environmental conditions. In this study, bio-inspired FGPCs were designed, fabricated, and validated using a combined experimental and …
Published in Journal of Polymer & Composites · Vol. 14, Issue 2, 2026 · pp. 456–481 Read article
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Review of Hydroxyapatite Coating: Enhances Bioactivity and Osteoconductivity in Natural Hard Tissues
Abstract: Hydroxyapatite (HA or HAP) of biologically (produced from coral, cattle, or marine algae) or synthetic origin is used to repair and regenerate bone in the form of granules, blocks, and scaffolds, either alone or in a composite with polymers or other ceramics, or as a coating on dental or orthopedics implants. From the perspective of enhancing bioactivity, numerous methods for surface alteration and its combinations have been suggested. The composite …
Published in Journal of Thin Films, Coating Science Technology & Application · Vol. 9, Issue 2, 2022 · pp. 17–21 Read article
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Polymer Chemistry in Biomedical Applications: Advances and Innovations
Abstract: Polymers have revolutionized biomedical sciences by playing a crucial role in medical devices, drug delivery systems, and tissue engineering. It is important to note that their unique combination of biocompatibility, mechanical strength, and chemical versatility makes them essential for applications such as implants, prosthetics, and diagnostic tools. Biomedical polymers are categorized into natural types (e.g., collagen, chitosan) and synthetic variants (e.g., polyethylene glycol, polylactic acid), each offering distinct benefits depending …
Published in Journal of Polymer & Composites · Vol. 13, Issue 5, 2025 Read article
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Polymer-Based Nanocomposites: Synthesis, Properties, and Applications
Abstract: Polymer-based nanocomposites have emerged as a highly promising class of materials, offering enhanced mechanical, thermal, and electrical properties. By incorporating nanoscale fillers such as carbon nanotubes, graphene, and metal oxides into polymer matrices, these composites exhibit superior strength, conductivity, and durability compared to conventional polymer materials. Their tunable properties make them highly versatile, with applications spanning multiple industries, including biomedical engineering, electronics, and automotive manufacturing. The synthesis of polymer nanocomposites …
Published in Journal of Polymer & Composites · Vol. 13, Issue 6, 2025 · pp. 222–227 Read article
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Role of Modified Egg Membrane in Donor Site Wound Healing
Abstract: An ulcer is essentially a small gap or tear in the skin that struggles to heal properly, persisting either suddenly or over an extended period. These persistent ulcers can present significant challenges for individuals, prolonging their discomfort and recovery. Medical professionals employ various techniques to aid in healing, including using skin grafts from different body parts, specialized coverings, or temporary solutions to protect the wound.In our research, we explored an …
Published in Research & Reviews: A Journal of Bioinformatics · Vol. 11, Issue 2, 2024 · pp. 16–20 Read article
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The Emerging Golden Age of Astrophysics: Progress, Discoveries, and Future Directions
Abstract: The period between 2024 and 2026 has marked a transformative era in astrophysics, fundamentally reshaping our understanding of the universe and its underlying physical mechanisms. Significant advancements in observational astronomy, computational modeling, and space exploration technologies have enabled scientists to investigate cosmic phenomena with unprecedented precision. Among the most groundbreaking achievements, the James Webb Space Telescope (JWST) has provided high-resolution infrared observations that revealed the large-scale distribution of dark matter, …
Published in International Journal of Universe · Vol. 2, Issue 1, 2026 · pp. 6–9 Read article
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3D Printing of Polymer-Based Functionally Graded Materials: Recent Developments and Challenges
Abstract: Additive manufacturing (AM), specifically 3D printing, has become a useful technique for fabricating functionally graded materials (FGMs) because it can facilitate the spatial distribution of materials. Polymer FGMs (P-FGMs) have gained a great deal of interest due to their lightweight, customizable, multifunctional properties. In comparison to conventional fabrication, 3D printing allows better control of composition and microstructure, which results in materials with controlled mechanical, thermal, and biological properties. This review …
Published in Journal of Polymer & Composites · Vol. 14, Issue 2, 2026 · pp. 338–347 Read article
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Chemical and Electrocoagulation Methods for Polymer Synthesis and Composite Manufacturing: Recent Technological Advances and Extensive Application Analyses
Abstract: Recent years have seen big steps forward in the fields of polymer production and composite making, thanks to the development of new chemical and electrocoagulation techniques. This abstract gives a short summary of these new developments and goes into great detail about how they can be used. Chemical production of polymers has been an important part of materials science for a long time because it lets scientists precisely control the …
Published in Journal of Polymer & Composites · Vol. 12, Issue 3, 2024 · pp. 244–258 Read article