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6 articles for “p53”
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Molecular Docking Studies of Wildtype P53 with Damnacanthal and Scopoletin- Phytochemicals Derived from Morinda Citrifolia
Abstract: Cancer is a prominent cause of mortality globally, and it has the potential to impact any region of the body. The tumor suppressor protein P53 plays a significant role in inhibiting tumor growth by regulating DNA repair, inducing cell cycle arrest, promoting senescence, and triggering apoptosis when confronted with genotoxic stress. P53 is found mutated in 50% of cancers where it loses its tumor suppressive properties and gains oncogenic properties …
Published in International Journal of Molecular Biotechnological Research · Vol. 1, Issue 2, 2023 · pp. 20–31 Read article
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Comparative Analysis of Ovarian Surface Epithelial Lesions with Corresponding Tubal Epithelial Changes with Reference to Ki67 and p53 Immunostains
Abstract: Ovarian surface epithelial cancers have high mortality due to late presentation. The ovarian surface epithelial tumours originate from fallopian tubal epithelium. Hence, ovarian surface epithelial tumours have good correlation with respect to genetic and immunohistological changes of fallopian tubes, especially fimbrial end epithelium. These changes are evident long before significant morphological changes in the ovaries appear. p53 and Ki67 are two important proliferative markers, and useful to evaluate ovarian surface …
Published in Research and Reviews : A Journal of Immunology · Vol. 9, Issue 2, 2019 · pp. 6–10 Read article
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Clinicopathological Study of Oral Malignant and Premalignant Lesions with p53 and p16 Immunostaining
Abstract: Oral cancer is a global problem, more in India. A study of 50 cases of oral lesions were conducted in a tertiary care hospital in Kolkata, India. Detailed clinical history was taken. Cytology, punch biopsy with histopathology and immunostaining with p53 and p16 were done in all the cases. A total of 31 cases (62.0%) were benign, 19 cases (38.0%) were malignant, with an age range of 26–69 years (mean …
Published in Research and Reviews: Journal of Oncology and Hematology · Vol. 8, Issue 2, 2019 · pp. 20–24 Read article
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In Silico Analysis of Potential Drug Targets in E. coli as Anticancer Agents
Abstract: Escherichia coli is a bacteria which grows as symbiotic and pathogenic organism in humans that expresses with genes causing several diseases. Manipulation and control of genes of E. coli can become a solution for cure of diseases like cancer. Based on QSAR studies, Partial partial charges are neutral for all selected ligands. The surface area, mass and volume for Capsaicin is predicted more compared to other selected ligands. As the …
Published in Research and Reviews : Journal of Computational Biology · Vol. 8, Issue 2, 2019 · pp. 10–18 Read article
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Uncommon Occurrence of Gastric Adenocarcinoma Occurring in a Patient with Common Variable Immunodeficiency Syndrome
Abstract: Common variable immunodeficiency (CVID) belongs to the diagnostic category of primary immunodeficiency (PID). They are characterized by a heterogeneous group of disorders that include recurrent infections, autoimmunity, granulomatous diseases and malignancies. The incidence of malignancy in CVID patients is around 1.5–20.7% and usually occurs during the 4th–6th decade of life. Non-hodgkin lymphoma is the most frequent malignancy, followed by epithelial tumors of stomach, breast, bladder and cervix. Patients with CVID …
Published in Research and Reviews: Journal of Oncology and Hematology · Vol. 7, Issue 1, 2018 · pp. 16–20 Read article
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Induction of G1 Phase Cell Cycle Arrest and Apoptosis in Breast Cancer MCF-7 Cells by Sulphonamide Derivative CID-6861424
Abstract: Breast cancer is most frequently detected and leading cause of cancer death in women worldwide. 80% of the breast cancer are estrogen receptor positive and the presently available drugs are ineffective either due to intrinsic resistance or due to acquired resistance. Sulfonamide compounds are a class of compounds showing activities like, antibacterial, antiviral including antitumor. In the present study we have investigated the anti-cancerous activity of sulfonamide derivative CID-6861424 on …
Published in Research and Reviews: A Journal of Toxicology · Vol. 9, Issue 2, 2019 · pp. 1–17 Read article