Comparative Analysis of Ovarian Surface Epithelial Lesions with Corresponding Tubal Epithelial Changes with Reference to Ki67 and p53 Immunostains

Srijita Biswas; Debashis Chakrabarty

doi:10.37591/rrjoi.v9i2.1578

Abstract

Ovarian surface epithelial cancers have high mortality due to late presentation. The ovarian surface epithelial tumours originate from fallopian tubal epithelium. Hence, ovarian surface epithelial tumours have good correlation with respect to genetic and immunohistological changes of fallopian tubes, especially fimbrial end epithelium. These changes are evident long before significant morphological changes in the ovaries appear. p53 and Ki67 are two important proliferative markers, and useful to evaluate ovarian surface tumours. In the present study, 58 cases of total ovarian lesions and corresponding fallopian tubes were examined. About 37 were benign (63.79%) and 21 (36.20%) were malignant. All the cases were correlated with clinical, histopathological and immunostaining scoring following standard methods. Malignant cases correlated with both p53 and Ki67 (P value less than 0.0001 (significant), but benign cases correlated well with p53 only (significant as P value less than 0.001). p53 and Ki67 immunostaining with histopathological correlation of tubal epithelium may well indicate the malignant potential of ipsilateral ovarian surface lesions and in future may be included in cancer screening for ovarian surface epithelial tumours. Keywords: Immunostaining, ovary, fallopian tube, histopathologyCite this ArticleS. Biswas, D. Chakrabarty, S.N. Banerjee, S. Mridha. Comparative analysis of ovarian surface epithelial lesions with corresponding tubal epithelial changes with reference to Ki67 and p53 immunostains. Research & Reviews: A Journal of Immunology. 2019; 9(2): 6–10p