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6 articles for “orally disintegrating tablets (odts)”
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Development and Optimization of Orally Disintegrating Tablets (ODTs) Containing Standardized Curcumin Extract for Enhanced Bioavailability and Patient Compliance
Abstract: This research centers on creating and perfecting orally disintegrating tablets with standardized curcumin extract to both increase its bioavailability and promote better patient adherence. Although curcumin has numerous therapeutic applications. It remains clinically ineffective due to its poor aqueous solubility and bioavailability constraints. The development of orally disintegrating tablets involved direct compression with various levels of superdisintegrants including sodium starch glycolate and cross povidone to address existing challenges. Research teams …
Published in Research & Reviews: A Journal of Drug Formulation, Development and Production · Vol. 12, Issue 3, 2025 · pp. 1–06 Read article
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Strategies for the Development and Optimization of Orally Disintegrating Tablets (ODTs) to Improve Bioavailability and Patient Compliance
Abstract: Background: Pharmaceutical scientists have developed Orally Disintegrating Tablets (ODTs) to advance patient drug acceptance and biological system availability through simplified medi-cation delivery especially for children and senior citizens and people who cannot swallow pills regularly. The oral disintegrating tablets dissolve in the mouth within thirty seconds or less (USP 701) while needing no additional liquid thus making them suitable for both emergency treatments. Objective: The research examines ODT development strategies …
Published in Research & Reviews: A Journal of Drug Design & Discovery · Vol. 13, Issue 2, 2026 Read article
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Orally Dispersible Tablet of Mesalazine: Formulation and Evaluation
Abstract: Oral disintegrating tablets (ODTs) become increasingly more and more popular, particularly among elderly and paediatric patients who have difficulties with swallowing. The 5-aminosalicylic acid compound oral mesalazine, frequently referred to as mesalamine, is used to treat mild to severe ulcerative colitis and has a high percentage of success in causing and establishing response. Mesalazine has a topical therapeutic action at the location of the suffering colonic mucosa. The medication’s disadvantage …
Published in Research & Reviews: A Journal of Drug Formulation, Development and Production · Vol. 12, Issue 2, 2025 · pp. 16–25 Read article
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Pediatric and Geriatric Formulation Tailoring Dosage Form for Age-Specific Needs
Abstract: This comprehensive review addresses the critical challenges and advancements in the formulation of oral medications for pediatric and geriatric populations, who often face unique pharmacokinetic and pharmacodynamic differences. The World Health Organization highlights that nearly 50% of long-term medications are not adhered to, with significant implications for health outcomes. Pediatric patients, due to their developmental stages, and geriatric patients, due to age-related physiological changes, require tailored drug formulations to enhance …
Published in Research & Reviews: A Journal of Drug Formulation, Development and Production · Vol. 12, Issue 2, 2025 · pp. 89–103 Read article
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Polymeric Ion-Exchange Complexes of Carbomer for Taste Masking and Enhanced Drug Bioavailability: A Physicochemical and In Vivo Study
Abstract: Famotidine (FAM) was recognized as a crystalline powder that varies in color from white to pale yellow and possesses an extremely bitter flavor. This study aimed to conceal the unpleasant flavor of FAM through employing unconventional ion-exchange resins sourced from Carbomer polymer Evaluation (Carbopol 974P). We used FTIR, DSC, and XRD to look at the drug-resin combination in its hard form to learn more about its physical and chemical properties. …
Published in Journal of Polymer & Composites · Vol. 14, Issue 1, 2026 · pp. 727–740 Read article
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Comparative Study on Oro Dispersible Tablets of Candesartan Cilexetil Formulated with Natural and Synthetic Disintegrants
Abstract: Candesartan cilexetil, a BCS class II drug with low aqueous solubility and poor bioavailability (15%), poses challenges for oral delivery. To address this limitation, the present study focuses on polymer-based inclusion complexation and composite formulation strategies to enhance solubility and dissolution behavior. The drug was incorporated into β-cyclodextrin (β-CD), a cyclic oligosaccharide polymer, by the kneading method in different drug-to-carrier ratios. Among these, the 1:1 molar ratio complex exhibited the …
Published in Journal of Polymer & Composites · Vol. 14, Issue 1, 2026 · pp. 687–695 Read article