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10 articles for “nucleoside”
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Modified Nucleosides “(ProTide)†as Potential Anti-HCV Therapeutics
Abstract: Hepatitis C virus (HCV) is among the most common causes of cirrhosis and chronic liver disease worldwide. As a result, many researchers are interested in designing and synthesis of a clinical treatment for HCV. Nucleoside monophosphates and monophosphonates play such an important role for treatments of incurable diseases such as hepatitis. For example, 2'-C-methyladenosine and 2'-C-methyl guanosine have shown activities against HCV in the replicon assay as well as against …
Published in Research and Reviews: A Journal of Pharmaceutical Science · Vol. 8, Issue 1, 2017 · pp. 32–39 Read article
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Ginger Extract Inhibits the Replication of T2 Bacteriophage by Inhibiting the Synthesis of Nucleosides
Abstract: Extracts of ginger inhibit the growth of bacteria and viruses of animal cells. At concentrations of 1, 2, 4, and 6 ml of a ginger extract per 100 ml of LB broth, E. coli replication was 104.6, 117.7, 117.7, and 122.8% of the control. At concentrations of 2, 4, and 6 ml of ginger extract per 100 ml of LB broth, the yield of T2 bacteriophage decreased by 36.2, 41.8, …
Published in Research and Reviews : A Journal of Biotechnology · Vol. 7, Issue 3, 2017 · pp. 20–27 Read article
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Application of Heterocyclic Compounds in Everyday Life
Abstract: Heterocyclic compounds are of very much interest in our daily life. They have high significance in our living system. Heterocyclic compounds have a wide range of applications in agrochemicals, pharmaceuticals, veterinary products etc. They are also used as starting material in the synthesis of organic compounds. These are also used in sanitizers, developers, anti-ordinates, corrosion inhibitors etc. Heterocyclic compounds are the cyclic compounds which contain one or more different atoms …
Published in Journal of Modern Chemistry & Chemical Technology · Vol. 9, Issue 1, 2018 · pp. 1–7 Read article
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In-Silico Design and Study of Novel Tetrahydro-β-Carbolines as Inhibitor of HIV-1 Reverse Transcriptase
Abstract: In the present study, we have designed 50 novel tetrahydro-β-carboline derivatives as non-nucleoside inhibitors of HIV-1 reverse transcriptase. Docking studies of designed analogs were performed by molecular modeling software AutoDock 4.2 using HIV-1 reverse transcriptase (PDB ID: 1RT2) as receptor. Lipinski rule of five parameters and toxicity parameters were derived through online servers Molinspiration and Osiris property explorer respectively. Docking parameters such as binding free energy and predicted inhibitory constant …
Published in Research & Reviews: A Journal of Drug Design & Discovery · Vol. 3, Issue 1, 2016 · pp. 19–30 Read article
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Stavudine Lamivudine Efavirenz Combination Therapy for Treatment of HIV Infection in Tertiary Care Hospital - A Retrospective Observational Study
Abstract: Highly Active Antiretroviral Therapy has transformed human immunodeficiency virus (HIV) infection into a chronic manageable disease. Compliance is the biggest challenge in low and middle income country like India where social and religious agenda play an important role. Efavirenz based HAART is current standard of care in management of HIV infected patients. The objective of the present study was to know efficacy of combination regimen of stavudine, lamivudine and efavirenz …
Published in Research and Reviews: A Journal of Pharmacology · Vol. 4, Issue 1, 2014 · pp. 17–22 Read article
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Inhibition of Replication of Adenovirus by 6-diazo-5-oxo-L-norleucine (DON)
Abstract: Normal 0 false false false EN-US X-NONE X-NONE The antibiotic known as 6-diazo-5-oxo-L-norleucine (DON) inhibits the growth of several types of Gram-positive and Gram-negative bacteria. DON has also been demonstrated to inhibit the replication of poliovirus, respiratory syncytial virus, mumps, and herpes simplex virus in cultured eukaryotic cells. DON is an analogue of glutamine and inhibits the synthesis of glycoproteins and purine nucleotides in cells that are treated with the …
Published in Research and Reviews: A Journal of Microbiology and Virology · Vol. 6, Issue 3, 2016 · pp. 31–37 Read article
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Case Report on Nevirapine Induced Exfoliative Dermatitis
Abstract: Nevirapine is the first drug of non-nucleoside reverse transcriptase inhibitors (NNRTI) class to treat seropositive patients, administered along with protease inhibitors and/or NRTIs. Nevirapine binds directly to reverse transcriptase (RT) and blocks the RNA-dependent and DNA-dependent polymerase enzyme. Exfoliative dermatitis is wide spread erythema and scaling of skin caused by pre-existing skin disorders, drugs and cancer, unknown causes. HIV infected patients are more prone to Exfoliative Dermatitis. This is a …
Published in Research and Reviews: A Journal of Medicine · Vol. 5, Issue 2, 2015 · pp. 7–10 Read article
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Inhibition of Replication of T2 Bacteriophage in Escherichia coli by 6-diazo-5-oxo-L-norleucine (DON)
Abstract: 800x600 Normal 0 false false false EN-US X-NONE X-NONE MicrosoftInternetExplorer4 The antibiotic known as 6-diazo-5-oxo-L-norleucine, DON, inhibits the growth of several types of Gram positive and Gram negative bacteria. It has also been demonstrated that DON inhibits the replication of poliovirus, respiratory syncytial virus, mumps and herpes simplex virus in cultured eukaryotic cells. At a concentration of 0.03 mM DON, the replication of Escherichia coli cells was inhibited by 11.0% …
Published in Research and Reviews: A Journal of Microbiology and Virology · Vol. 2, Issue 1, 2012 · pp. 9–19 Read article
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Cinnamon Extract and Cinnamaldehyde Inhibit the Replication of T2 Bacteriophage in E. coli: Potential for Use in Antiviral and Anticancer Therapy
Abstract: An extract of cinnamon inhibits the growth of bacteria, viruses and cancer cells. At concentrations of 1, 2, 4, and 8 ml per 100 ml of Luria-Bertani broth, cinnamon extract had virtually no effect on the growth of E. coli. At the same concentrations, however, the yield of T2 bacteriophage was 98, 76, 64.5, and 61.8% of the control. Addition of cinnamon extract 37 min before infection produced a yield …
Published in Research and Reviews : A Journal of Biotechnology · Vol. 9, Issue 3, 2019 · pp. 8–17 Read article
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Design Approach based Formulation of Deformable Liposomes and their In vitro Skin Permeation
Abstract: Leukemia is the common cause of disease and its worldwide incidence is increasing. Cytarabine pyrimidine nucleoside analogs most widely used for the treatment of leukemia, but the major obstacles to existing treatments are adverse effect and poor patient’s compliances. To provide sustained drug release with minimum side effects and to develop more patients affable formulation, the authors investigated the transdermal delivery of cytarabine through deformable liposomes. The present work demonstrated …
Published in Trends in Drug Delivery · Vol. 4, Issue 3, 2017 · pp. 14–25 Read article