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15 articles for “laboratory-on-a-chip”
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Experimental Studies to Record the Lithographically Fabricated Microstructures by Surface Profilometry and Scanning Electron Microscopy for Microfluidic Laboratory-on-a-Chip Systems
Abstract: In this research paper, the poly(methyl methacrylate) (PMMA) microfluidic laboratory-on-a-chip system is fabricated in the cleanroom laboratory by maskless lithography, hot embossing lithography and direct bonding technique. The microstructures of the lab-on-a-chip system are measured by surface stylus profilometer. Also, the images of microstructures of lab-on-a-chip system are captured by using scanning electron microscopy (SEM). This fabricated lab-on-a-chip system is useful in bioengineering applications.
Published in Journal of Polymer & Composites · Vol. 4, Issue 1, 2016 · pp. 27–36 Read article
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Short Experimental Report on Lithographic Technique in Microfluidics
Abstract: In this experimental work, a single SU-8 based glass microfluidic device is fabricated by the maskless lithography and indirect bonding technique. The sealing by indirect bonding technique is perform during the hard baking in maskless lithography. Dyed ethylene glycol is prepared as the working liquid. A CMOS camera catching 25 frames per second with a corresponding time-scale resolution of 0.04 second is used to record the surface-driven microfluidic flow of …
Published in Journal of Microwave Engineering and Technologies · Vol. 8, Issue 3, 2021 · pp. 1–5 Read article
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Passive Capillary Flow of Aqueous Working Liquids in the PMMA Microchannel Bends
Abstract: In this work, passive capillary flows or surface-driven capillary flows are recorded in polymethylmethacrylate (PMMA) microfluidic devices using aqueous ethanol and aqueous isopropyl alcohol (IPA) as chosen aqueous working liquids. Microchannel bends are the chosen microfluidic devices with the selected microchannel widths of 50, 120 and 200 micron. This work will be useful to fabricate the PMMA laboratory-on-a-chip systems for bioengineering applications.
Published in Journal of Catalyst & Catalysis · Vol. 5, Issue 1, 2018 · pp. 21–24 Read article
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Surface-Driven Capillary Flow of the Dyed Aqueous Ethanol in a single SU-8 based Glass Microfluidic Device integrated with the Arrays of Square Polyimide Micropillars
Abstract: In this work, a single SU-8 based glass microfluidic device is fabricated by the maskless lithography and indirect bonding technique. A particular polyimide layer at the selected portions and the arrays of square polyimide micropillars at the other portions are integrated on the microchannel bottom wall by the maskless lithography. Dyed aqueous ethanol (70% dyed water, 30% ethanol) is prepared as the working liquid in this work. A CMOS camera …
Published in Journal of Thin Films, Coating Science Technology & Application · Vol. 6, Issue 1, 2019 · pp. 33–37 Read article
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Experimental Demonstration on Microfluidic Capillary Flow of Red Dye in Photoresist based Glass Microfluidic Devices
Abstract: In this experimental work, a set of three individual SU-8 based glass microfluidic devices are fabricated by maskless lithography and indirect bonding technique in leakage-free conditions. Commercially available red coloured food dye is used as the selected working liquid. The microfluidic leakage in other set of two leaky microfluidic devices is experimentally demonstrated. Microfluidic devices should be fabricated at leakage-free conditions to achieve exact fluid flow characteristics. The effect of …
Published in Journal of Thin Films, Coating Science Technology & Application · Vol. 7, Issue 1, 2020 · pp. 1–7 Read article
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Experiments to Control the Surface-Driven Microfluidic Flow of Dyed Water in Straight PMMA Microchannels Fabricated by Maskless Lithography, Hot Embossing Lithography and Direct Bonding Technique
Abstract: Total six individual straight microchannels are fabricated by maskless lithography, hot embossing lithography and direct bonding technique using author’s own hands-on completely inside the cleanroom laboratory. Polymethylmethacrylate (PMMA) is the selected polymeric material to fabricate these straight microchannels. Dyed water is prepared as working liquid to record and study the microfluidic flow characteristics inside these fabricated microchannels. Air dielectric barrier discharge (DBD) plasma processing is the surface modification technique in …
Published in Journal of Thin Films, Coating Science Technology & Application · Vol. 7, Issue 1, 2020 · pp. 17–23 Read article
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Report on Microfluidic Flow of Dyed Working Liquids inside the Polymeric Devices
Abstract: In this experimental work, a single SU-8 based glass microfluidic device is engineered by the maskless lithography and indirect bonding technique. Also, total nine individual polymethylmethacrylate (PMMA) based microfluidic devices are fabricated by maskless lithography, hot embossing lithography, and direct bonding technique. Dyed ethylene glycol, dyed ethanol, and dyed aqueous isopropyl alcohol (50% water, 50% IPA) are prepared and used as working liquids to record each surface-driven microfluidic flow. The …
Published in Journal of Thin Films, Coating Science Technology & Application · Vol. 8, Issue 1, 2021 · pp. 22–29 Read article
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Short Review on the Effects of Plasma Processing Techniques in PMMA Microfluidic Device
Abstract: Abstract: The plasma processing techniques are useful for surface modifications on polymer surfaces. The appropriate surface modification alters the level of static contact angles on the polymer surfaces. The surface-driven microfluidic flow of suitable working liquid is sensitive to the static contact angle of microchannel surfaces fabricated by different polymers. Therefore, plasma processing techniques are suitable to vary the flow speed of working liquids in microfluidics. In future, this review …
Published in Recent Trends in Fluid Mechanics · Vol. 6, Issue 1, 2019 · pp. 20–22 Read article
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Surface-Driven Capillary Flow of Dyed Aqueous Ethanol in the PMMA Microchannel Fabricated by Maskless Lithography, Hot Embossing Lithography and Direct Bonding Technique
Abstract: AbstractPolymethylmethacrylate (PMMA) as polymer is used to fabricate a dual sudden expansion microchannel by the maskless lithography, hot embossing lithography and direct bonding technique inside the cleanroom laboratory. Dyed aqueous ethanol (90% dyed water, 10% ethanol) is used as working liquid to record the surface-driven capillary flow in the fabricated microfluidic device using a CMOS camera catching 25 frames per second with a corresponding time-scale resolution of 0.04 second. This …
Published in Trends in Opto-electro & Optical Communication · Vol. 8, Issue 3, 2018 · pp. 37–40 Read article
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Optical Recording of Flow Phenomena in Photoresist based Microfluidic Devices
Abstract: AbstractIn this experimental work, a set of three individual SU-8 based glass microfluidic devices are fabricated by maskless lithography and indirect bonding technique without having any microfluidic leakage. Dyed ethanol (10% ethanol, 90% red dye) is prepared and used as dyed working liquid. The microfluidic leakage is observed in other set of two leaky microfluidic devices due to improper indirect bonding technique. The effect of surface-to-volume ratio on surface-driven capillary …
Published in Trends in Opto-electro & Optical Communication · Vol. 10, Issue 1, 2020 · pp. 36–42 Read article
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Design And Optimization Of Performance Parameters Of Indirect Solar Drying System
Abstract: The objective of the work being presented is to design and develop an indirect solar dryer in the renewable energy laboratory of Mechanical Engineering Department, I.I.T BHU Varanasi and evaluate its performance under the climatic conditions of Varanasi, U.P India. The main components of indirect solar dryer are flat plate solar collector, drying chamber, blower and other accessories of the drying system. Originally built Shukla-Sharma dryer for drying aonla was …
Published in Journal of Thermal Engineering and Applications · Vol. 8, Issue 1, 2021 · pp. 1–22 Read article
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Automated Blood Cell Counting and Disease Identification Using Image Processing: Implications for Polymer Composite- Based Biomedical Diagnostic Devices
Abstract: Accurate quantification of blood cells is central to clinical decision-making and to the performance of emerging polymer composite–based diagnostic platforms. This work presents a cost-effective, image-processing pipeline for automated counting of red blood cells (including overlapping cells), white blood cells, and platelets from Leishman-stained peripheral blood smears, and articulates its relevance to polymer composite microfluidic and biosensor devices. Implemented in Python with OpenCV, the workflow performs grayscale conversion, median/Gaussian denoising, …
Published in Journal of Polymer & Composites · Vol. 13, Issue 6, 2025 · pp. 262–270 Read article
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Polymeric Microfluidic Chips for Rapid Point-of-Care Diagnostic Testing
Abstract: Polymeric microfluidic chips have emerged as promising platforms for rapid point-of-care (POC) diagnostic testing by integrating sample preparation, fluid manipulation, biochemical reactions, and signal detection within compact and potentially low-cost devices. Their compatibility with materials such as polydimethylsiloxane (PDMS), polymethyl methacrylate (PMMA), cyclic olefin copolymer (COC), polystyrene (PS), polycarbonate (PC), and polymer–paper composites provide considerable flexibility in device design and manufacturing. Advances in soft lithography, injection moulding, hot embossing, laser …
Published in Journal of Polymer & Composites · Vol. 14, Issue 4, 2026 Read article
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Next Generation Immunoassays for Infectious Diseases of Animals
Abstract: Veterinary diagnostics has an essential role to play in the management and control of infectious diseases. Immunodiagnostics originated towards the end of 19th century with the advent of agglutination- and precipitation-based serological techniques. Progress in immunodiagnostics during the 20th century is marked by development of complement fixation test, and later, fluoro-, radio- and enzyme-immunoassays during 1950s, 1960s and 1970s, respectively. Various immunodiagnostic test formats were improved for their performance characteristics …
Published in Research and Reviews : A Journal of Immunology · Vol. 7, Issue 2, 2017 · pp. 22–43 Read article
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Recording on Passive Capillary Flow of Dyed Working Liquids in the Polymer based Microfluidic Devices Fabricated inside the Cleanroom Laboratory
Abstract: In this experimental work, author has fabricated total 13 individual microfluidic devices using the maskless lithography, hot embossing lithography, direct bonding technique, diamond like carbon (DLC) coating, and laboratory-made clamping inside the cleanroom laboratory using author’s own hands-on completely. Polymethylmethacrylate (PMMA) is the chosen polymer to fabricate the 10 individual microfluidic devices due to its plasticity and optical transparency. Dyed water, dyed ethylene glycol and dyed ethanol are the prepared …
Published in Journal of Thin Films, Coating Science Technology & Application · Vol. 7, Issue 3, 2020 · pp. 35–44 Read article