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6 articles for “hepatocellular carcinoma”
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Comprehensive Review of Kojic Acid and Its Derivatives: Biological Activities, Safety, and Therapeutic Potential in Depigmentation
Abstract: There are several uses for kojic acid in human medicine, particularly in depigmentation. Additionally, derivatives of it are suggested to enhance efficacy, avoid side effects, and stop chemical degradation. With an eye toward human use and an attempt to clarify the action mechanisms, the goal of this study was to review the most recent scientific literature regarding the biological activities and safety information of kojic acid or its derivatives. During …
Published in Research and Reviews: A Journal of Pharmaceutical Science · Vol. 16, Issue 2, 2025 · pp. 45–53 Read article
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In Silico Screening of Terminalia chebula Phytocompounds as Potential Inhibitors of NTCP and DDB1 in Hepatitis B Virus Infection
Abstract: Hepatitis B virus (HBV) infection is a major global health concern, and chronic carriers are at risk of developing cirrhosis, hepatocellular carcinoma (HCC), and even death. Existing treatments can effectively inhibit viral replication, but they achieve little eradication of the virus because of covalently closed circular DNA (cccDNA) retention. In this investigation, bioactive compounds of Terminalia chebula, a plant known for its hepatoprotective and antiviral properties in traditional medicine, were …
Published in Research & Reviews: A Journal of Drug Formulation, Development and Production · Vol. 13, Issue 1, 2026 · pp. 33–44 Read article
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Vitamin D Mitigates Inflammation and Downregulates Importin α3 in Non-Alcoholic Fatty Liver Disease (NAFLD)
Abstract: Non-alcoholic fatty liver disease (NAFLD) affects about one-third of the population in the United States and Western countries, reaching up to 90% among obese individuals and those undergoing bariatric surgery. Characterized by hepatic fat accumulation, NAFLD progresses from simple steatosis to non-alcoholic steatohepatitis (NASH), fibrosis, and, in rare cases, hepatocellular carcinoma. Linked intricately with metabolic syndrome, including diabetes and obesity, NAFLD development involves insulin resistance and hyperinsulinemia. Experimental evidence consistently …
Published in International Journal of Cheminformatics · Vol. 4, Issue 1, 2026 Read article
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Vitamin D Mitigates Inflammation and Downregulates Importin α3 in Non-Alcoholic Fatty Liver Disease (NAFLD)
Abstract: Background: Pro-inflammatory cytokines, such as TNF-α, IL-1β, IL-6, and IL-8, seem to play a crucial role in the progression of NAFLD as they activate the transcription factor NF-кB. The activated NF-кBp50/RelA subunits are translocated to the nucleus by Importin α3 and Importin α4. Numerous studies have indicated a negative association between NAFLD and vitamin D levels. Low vitamin D levels have been correlated with histological severity, necro-inflammation, and fibrosis in …
Published in International Journal of Cheminformatics · Vol. 4, Issue 1, 2026 · pp. 1–16 Read article
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Awareness and Knowledge Regarding Hepatitis B Infection, Mode of Transmission and Prevention among People of Cameron Highlands, Malaysia
Abstract: The Hepatitis B virus (HBV) is a major cause of liver cirrhosis and hepatocellular carcinoma in humans. Every year 600,000 people die of illness related to HBV infection. This research is an attempt to study the awareness of HBV infection, modes of transmission and prevention among students, hospital personnel and public of Cameroon highlands of Malaysia. Majority of the hospital personnel are well aware of this infection and have adequate …
Published in Research and Reviews : A Journal of Immunology · Vol. 3, Issue 3, 2013 · pp. 11–17 Read article
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A Clinical Study based Observation on Prevalence of Altered Liver Enzymes among Patients of Hepatobiliary Diseases Attending National Institute of Unani Medicine, India
Abstract: Background: Hepatobiliary disease is a major health problem responsible for millions of deaths annually. As reported, more than 40 million deaths occur annually in South-East Asia Region due to hepatobiliary diseases. This study was conducted as a clinical trial to assess the efficacy of Unani formulation, from which the data on prevalence of altered liver enzymes among patients of hepatobiliary diseases in which the study participants were collected and compiled …
Published in Research and Reviews: A Journal of Medicine · Vol. 11, Issue 1, 2021 · pp. 5–11 Read article