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19 articles for “genotoxicity”
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Carbon Nanoparticles: Occupational Exposure and Genotoxic Effects
Abstract: The field of nanotechnology is revolutionizing today’s era by being the fastest emerging field. Though nanotechnology is the boon to the society, the potential toxicity of these nanoparticles should not be ignored as they can affect anyone from microbes to humans. The main focus of this paper is the toxicity of nanoparticles because people working in these areas, prone to nanoparticles are at high risk due to its toxic property. …
Published in Research and Reviews: A Journal of Toxicology · Vol. 5, Issue 1, 2015 · pp. 9–26 Read article
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Genotoxicity Evaluation of Hospital Waste Waters: A Study Monitored by E.coli WP2 Assay
Abstract: The major sources of health-care waste are hospitals. A variety of substances such as pharmaceuticals, radionuclide and solvents are used in hospitals for medical diagnostics, disinfection and research work. After application, some of these substances and excreted non-metabolized pharmaceuticals by the patients enter into the hospital effluents. Indeed, some of these substances found in wastewaters are genotoxic and are suspected to be a possible cause of the cancers observed in …
Published in Research and Reviews: A Journal of Toxicology · Vol. 3, Issue 1, 2013 · pp. 6–11 Read article
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A Review of Toxicity, Genotoxicity and Teratogenicity of Formaldehyde
Abstract: Formaldehyde (FA) is important chemical found outdoor and indoor source, it is commonly used in the production of industrial, laboratories and household fule. Most FA exposure occurs by inhalation or by skin or eye contact. It is rapidly absorbed by lungs, gastrointestinal tract and skin. FA easily reacts with amino group in molecular compounds such as proteins and nucleic acid; these reactions caused alterations in tissues and leading to toxicity …
Published in Research and Reviews: A Journal of Toxicology · Vol. 10, Issue 3, 2020 · pp. 9–18 Read article
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Comparative Evaluation of Genotoxicity in Peripheral Blood Mononuclear Cells in Oral Precancer and Cancer Patients Using Single Cell Gel Electrophoresis
Abstract: In the present study the comet assay was performed in peripheral mononuclear cells to evaluate DNA damage among tobacco chewers and smokers. The assay provides a quick, accurate and sensitive way to detect various forms of DNA damage in individual cells. The study comprises 50 oral cancer patients, 12 oral submucous fibrosis patients and 10 healthy controls. The length of the comet tail was used to determine the level of …
Published in Research and Reviews: Journal of Oncology and Hematology · Vol. 11, Issue 2, 2022 · pp. 26–34 Read article
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The Ames Test in Twenty-first Century
Abstract: Since the 19th century, industrial development has increased exposure to mutagens and possible carcinogens. In order to avoid these health risks, several techniques have been developed to recognize genotoxins. In the 1970s, Dr. Bruce Ames and colleagues, studying the histidine operon of Salmonella typhimurium, observed that histidine (−) auxotroph mutants were reverted to histidine (+) upon exposure to a mutagen. The researchers further observed that known carcinogens were mutagenic to …
Published in Research and Reviews: A Journal of Toxicology · Vol. 2, Issue 1, 2012 · pp. 23–37 Read article
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Role of MSG (Monosodium Glutamate) in DNA Breaks by Cellular Method: A review article
Abstract: - Monosodium glutamate (MSG) is a generally used food additive to enhance flavors. It has been found that though is one of the most common flavoring agents used worldwide, MSG’s accumulation in the body can cause genomic damages. These genomic damages can be identified through various methods such as Random Amplified Polymorphic DNA polymerase chain reaction (RAPD - PCR). Some herbal extracts have medicinal properties that can initiate DNA repair …
Published in Research & Reviews: A Journal of Bioinformatics · Vol. 10, Issue 2, 2023 · pp. 1–5 Read article
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Evaluation of Gamma Radiation Induced DNA Damage in Bombyx mori, using Single Cell Gel Electrophoresis (Comet Assay)
Abstract: Bombyx mori (B. mori) is the model insect used in the present study, which is commercially important compared to other Lepidopterans. Eggs of late embryonic stage (7 day old) of B. mori were exposed to different doses of gamma radiation to study the extent of DNA damage using comet assay which is a rapid technique to study the genotoxic effects. Test samples were exposed to varied doses of radiation (100, …
Published in Research and Reviews: A Journal of Toxicology · Vol. 11, Issue 1, 2024 · pp. 1–6 Read article
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Cytotoxic and Antigenotoxicity Activity of Hibiscus sabdariffa Extract Against Tobacco Smoke Extract in Allium cepa Cells
Abstract: The present study was objective to determine whether and to what extent Hibiscus sabdariffa (H. S) extract can reduced the genotoxic damage by Cigarette smoking extract on Allium cepa cells. For this purpose, we used onion bulbs were treated with %2 cigarette smoking extract for 12 h, then treated with concentrations 0.1, 0.01, 0.001 mg/ml of H.s extract for other 12 h; while negative control in water and positive control …
Published in Journal of Modern Chemistry & Chemical Technology · Vol. 14, Issue 2, 2023 · pp. 17–23 Read article
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Induction of Genetic Damage in Peripheral Erythrocytes of the Fish, Anabas testudineus Exposed to Sublethal Concentration of Acid Orange 7
Abstract: Acid orange 7, a synthetic organic compound, generally considered as pollutant, released from the process of chemical textile finishing process was exposed to the freshwater fish Anabas testudineus at sublethal concentration i.e., 0.27 gl-1 for 24, 72 and 96 h, maintaining ten animals per group along with the control. The median lethal concentration of acid orange 7 determined by Probit analysis was 2.7 gl-1 concentration. Sublethal exposure to the azo …
Published in Research and Reviews : A Journal of Life Sciences · Vol. 9, Issue 2, 2019 · pp. 83–96 Read article
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Molecular Docking Studies of Wildtype P53 with Damnacanthal and Scopoletin- Phytochemicals Derived from Morinda Citrifolia
Abstract: Cancer is a prominent cause of mortality globally, and it has the potential to impact any region of the body. The tumor suppressor protein P53 plays a significant role in inhibiting tumor growth by regulating DNA repair, inducing cell cycle arrest, promoting senescence, and triggering apoptosis when confronted with genotoxic stress. P53 is found mutated in 50% of cancers where it loses its tumor suppressive properties and gains oncogenic properties …
Published in International Journal of Molecular Biotechnological Research · Vol. 1, Issue 2, 2023 · pp. 20–31 Read article
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Crossroads of Ecology and Medicine: Evaluating Pollutant-Induced Risks to Biodiversity and Human Health
Abstract: Environmental pollution has emerged as a central challenge at the crossroads of ecology and human medicine. The rapid pace of industrialization, urbanization, and agricultural intensification has led to an unprecedented release of pollutants into the air, water, and soil—triggering cascading effects on ecosystems and human health. Pollutants such as particulate matter, heavy metals, pesticides, microplastics, endocrine-disrupting chemicals, and persistent organic pollutants not only degrade biodiversity but also exert multifaceted health …
Published in International Journal of Environmental Noise and Pollution Control · Vol. 3, Issue 1, 2025 · pp. 41–53 Read article
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Cytogenotoxicity Assessment of Asphalt Plant Discharge Water using Plant Assay
Abstract: The Allium cepa assay test was used to evaluate cytogenotoxic effects of asphalt plant discharge water at the concentrations of 10, 20, 30, 40, 50, 60, 70, 80, 90 and 100% (v/v) asphalt plant discharge water/distilled water. The distilled water served as the negative control. The analysis of the physicochemical properties and heavy metals concentrations showed that most parameters were higher than the established standards of WHO and FMENV. The …
Published in Journal of Water Pollution & Purification Research · Vol. 12, Issue 3, 2025 · pp. 100–110 Read article
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Prime Editing and Base Editing in Human Hematopoietic Stem Cells Toward Scarless Correction of Monogenic Blood Disorders
Abstract: Monogenic hematological disorders – such as sickle cell disease (SCD), β-thalassemia, and X-linked chronic granulomatous disease (X-CGD) – affect >400, 000 newborns worldwide each year, with a considerable burden in low-resource settings . Although donor-derived allogeneic hematopoietic stem-cell transplantation (HSCT) is widely regarded as curative, its application is limited due to issues of donor availability and graft-versus-host disease (GVHD) and conditioning-related toxicity. DSB-based conventional CRISPR-Cas9 strategies are limited by inefficient …
Published in International Journal of Genetic Modifications and Recombinations · Vol. 4, Issue 1, 2026 · pp. 15–22 Read article
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Arsenic as a Cause of Cancer
Abstract: Inorganic Arsenic (iAs) is a pervasive and ubiquitous environmental toxin that has created world-wide human health problems. Populations exposed to high concentrations of arsenic-contaminated drinking water suffer serious health consequences ranging from acute toxicities to development of malignancies, including alarming cancer incidence and death rates. Epidemiologic studies have shown a relationship between chronic arsenic exposure and disease of the skin, lung, urinary bladder, and conceivably liver, kidney, and prostate in …
Published in Research and Reviews: Journal of Oncology and Hematology · Vol. 5, Issue 3, 2016 · pp. 8–21 Read article
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Study on Hospital Waste Management
Abstract: Hospital waste is “Any waste that is generated within the diagnosing, treatment or immunization of kith and kin one or animals or in research” in an exceedingly hospital. Hospital waste may be a special variety of waste created in little quantities carrying a high potential of infection and a couple of injury. If hospital waste is not effectively managed, there are substantial health consequences from a public health perspective. Hospital …
Published in Research and Reviews: A Journal of Toxicology · Vol. 12, Issue 2, 2022 · pp. 16–20 Read article
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Food Packaging Chemicals and Human Health: Molecular Toxicity, Exposure Pathways, and Regulatory Perspectives
Abstract: Food packaging plays a vital role in preserving food quality, extending shelf life, and ensuring safe transportation. However, increasing evidence indicates that chemicals from packaging materials can migrate into food during processing, storage, and consumption, resulting in chronic human exposure. Several food packaging chemicals, including bisphenols, phthalates, per- and polyfluoroalkyl substances (PFAS), styrene, heavy metals, and non-intentionally added substances (NIAS), have emerged as important xenobiotics due to their potential adverse …
Published in Research and Reviews: A Journal of Toxicology · Vol. 16, Issue 2, 2026 Read article
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Detrimental Effect of Mobile Phone Radiation on Living Organisms: An Update Review
Abstract: Mobile phone has raised the risk of the tissue-level damage for all living organisms not only for human and animals but plants as well. Numerous studies have documented various biological effects of EMR including changes in cell proliferation, enzyme activity, gene expression, cell-membrane permeability and ion homeostasis as well as oxidative stress and heat-shock response. A modulated field at 900 MHz strongly inhibited the growth of and, to some extent, …
Published in Research and Reviews : A Journal of Life Sciences · Vol. 3, Issue 2, 2013 · pp. 34–42 Read article
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Chromosomal Aberration and Mutagenicity Toxicological Studies of Beta-Sitosterol Isolated from Ocimum gratissimum (Lamiaceae)
Abstract: Ocimum gratissimum is an important medicinal plant belonging to the Lamiaceae family. Ocimum gratissimum is a small erect or straggling tree or large, woody, climbing shrub found almost throughout India including Andaman and Nicobar Islands. Stem have been used in antifertility treatment in the indigenous system of medicine, and further clinical tests substantiated their efficacy. The root bark contains diketones, fatty matter, rubber, dulcitol, Beta-sitosterol, phlobatannin and glycosidal tannins. Stem …
Published in Research & Reviews: A Journal of Pharmacognosy · Vol. 4, Issue 2, 2017 · pp. 1–6 Read article
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Quality Control of Ayurvedic Drugs
Abstract: Ayurveda is the ancient most system of medicine and most of Indian population uses Ayurvedic drugs in some form [1]. Their high cultural acceptability is due to the experienced safety and efficiency over centuries of use. Because of their unique effects and relatively low side effects, this medicine has been gaining popularity all over the world. British physicians travelled to India to observe rhinoplasty being performed using native methods [2]. …
Published in Research & Reviews: A Journal of Pharmacognosy · Vol. 3, Issue 3, 2016 · pp. 24–27 Read article