Role of MSG (Monosodium Glutamate) in DNA Breaks by Cellular Method: A review article

Anushka Mourya; Sarfaraz Hanfi; Alibha Rawat; Alka Tiwari; N. Ganesh

doi:10.37591/(rrjobi).v10i2.1446

Abstract

- Monosodium glutamate (MSG) is a generally used food additive to enhance flavors. It has been found that though is one of the most common flavoring agents used worldwide, MSG’s accumulation in the body can cause genomic damages. These genomic damages can be identified through various methods such as Random Amplified Polymorphic DNA polymerase chain reaction (RAPD - PCR). Some herbal extracts have medicinal properties that can initiate DNA repair mechanisms to counteract this damage. have purpose of this review paper is to evaluate the role of MSG in DNA damage, probably downstream diseases and DNA repair mechanisms that cells initiate to retract these effects, such as nucleotide excision repair ( NER) and base excision repair (BER) . Compound such as vitamin C, green tea extract, and Allium sativum have been shown to c counter effect on the health hazards caused by MSG by inhibiting oxidative stress, reducing bad effect, and to provide antioxidants. The retrieved information has shown that long-term consummation of MSG is associative with metabolic diseases, neurological and reproductive organ defects. Studies also noticed that MSG has the capability to induce geno-toxicity. The damages on the genes can have detrimental effect not only in the individual but also the descendent. Studies have been done to find the permanent change in the gene that can be caused by MSG, and the plan of action to reduce the MSG genetic defects.

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