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6 articles for “extracellular matrix (ECM)”
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Investigation on Plant Heparanase and its Inhibitors
Abstract: Heparanase is an endoglycosidase which cleaves heparan sulfate (HS) and hence participates in degradation and remodelling of extracellular matrix (ECM). It further regulates multiple biological activities that enhance tumour growth, angiogenesis and metastasis. Heparanase expression is enhanced in almost all cancers examined including various carcinomas, sarcomas and haematological malignancies. In the present article, heparanase enzyme in plants and its activity against inhibitors was described. Here the heparanase enzyme and the …
Published in Research and Reviews : A Journal of Life Sciences · Vol. 10, Issue 3, 2020 · pp. 19–27 Read article
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The Interaction of Extracellular Matrix and Growth Factors
Abstract: The extracellular matrix (ECM) regulates cell behavior by influencing cell proliferation, survival, shape, migration and differentiation. ECM assembly is regulated by the 3D environment and the cellular tension that is transmitted through integrins. The hematopoietic microenvironment is a complex structure in which stem cells, progenitor cells, stromal cells, growth factors, and ECM molecules each interact to direct the coordinated regulation of blood cell development. Hematopoietic growth factors are any of …
Published in Research and Reviews : A Journal of Life Sciences · Vol. 6, Issue 3, 2016 · pp. 9–23 Read article
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Rheumatoid Arthritis and Stem Cell Therapies Perspectives for It
Abstract: Rheumatoid arthritis (RA) is a chronic autoimmune disorder characterized by systemic inflammation, primarily affecting synovial joints, leading to joint destruction and systemic complications. The pathogenesis involves immune system dysregulation, autoantibody production, and enzymatic imbalances. Enzymes, including matrix metalloproteinases (MMPs), serine proteases, and kinases, play crucial roles in these processes. Their dysregulation contributes significantly to disease progression through the imbalance of pro-inflammatory cytokines, oxidative stress, and extracellular matrix (ECM) degradation. MMPs, …
Published in Research and Reviews : A Journal of Biotechnology · Vol. 15, Issue 2, 2025 · pp. 20–28 Read article
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In-Silico Docking of Rubia cordifolia Phytocompounds as Potential MMP-2 Inhibitors for Varicose Vein Management
Abstract: Varicose veins are one of the most common disorders, affecting the vein structure and function of lower limbs, yet there has been no absolute cure found yet. One of the underlying causes for worsening of the condition is the proteolytic activity of MMPs which are a group of enzymes that affect the extracellular matrix (ECM) surrounding the affected veins. Phytocompounds of Rubia cordifolia (Manjishta) were docked against the MMP-2 protein …
Published in International Journal of Biochemistry and Biomolecule Research · Vol. 3, Issue 2, 2025 · pp. 31–42 Read article
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Integrative Network Biology Analysis of GSE6011 Uncovers Molecular Signatures in Duchenne Muscular Dystrophy
Abstract: Duchenne muscular dystrophy (DMD) is a rare, severe neuromuscular disorder demonstrated by progressive skeletal muscle deterioration and premature mortality. Despite advances in supportive care, no definitive cure exists, highlighting the need to explore novel molecular targets. The current study aimed to uncover key dysregulated genes and molecular pathways in DMD through a dataset-specific network biology approach. Publicly available microarray data (GSE6011) from DMD quadriceps muscle biopsies of 22 patients and …
Published in Research and Reviews : Journal of Computational Biology · Vol. 14, Issue 3, 2025 · pp. 36–48 Read article
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Polymer Chemistry-Guided Development of Biomimetic Composite Scaffolds
Abstract: Polymer chemistry plays a fundamental role in advancing biomaterials for anatomical tissue engineering, particularly in the design of composite scaffolds that replicate the intrinsic characteristics of native tissues. The regeneration of damaged tissues, especially within anatomically complex structures such as bone, cartilage, and skin, necessitates biomaterials that closely emulate the hierarchical architecture and biological functions of native extracellular matrices (ECMs). The capacity to replicate both mechanical and biochemical cues of …
Published in Journal of Polymer & Composites · Vol. 14, Issue 1, 2026 · pp. 7–13 Read article