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12 articles for “amyloid”
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In Silico Analysis and Docking Study of the Active Phyto Compounds of Ginkgo Biloba Against Alzheimer's Amyloid-Beta Protein
Abstract: Objective: Alzheimer's disease, an age-related progressive neurological condition, arises due to the accumulation of amyloid-beta protein within the brain. In this study, an attempt was made to explore the potential of natural compounds derived from Ginkgo, known for their diverse medicinal properties, in the prevention of the disorder by employing molecular docking techniques, conducting drug-likeness prediction assessments, and performing ADME analysis. Methods: Amyloid beta protein was retrieved from the PDB …
Published in International Journal of Cell Biology and Cellular Functions · Vol. 1, Issue 2, 2023 Read article
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Study on Chemical Insights into Alzheimer's Disease: Amyloid Beta and Tau Protein Interactions
Abstract: Background: Alzheimers disease (AD) is the most prevalent form of dementia, affecting millions of individuals worldwide and posing significant challenges to healthcare systems. The disease is characterized by a gradual decline in cognitive functions, particularly memory, reasoning, and the ability to perform daily activities. Aim & objective: To study chemical insights in alzheimers disease, especially amyloid beta and tau protein interactions Results & discussion: The results of this review highlight …
Published in International Journal of Brain Sciences · Vol. 2, Issue 1, 2025 · pp. 37–46 Read article
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Kisunla (Donanemab): A Novel Breakthrough Illuminating a Path to Better Alzheimer’s Outcomes
Abstract: Background: Alzheimer’s disease (AD) is a progressive neurodegenerative condition marked by cognitive decline, memory loss, and loss of independence. Despite decades of extensive research, disease-modifying treatments have been limited in success. Recent therapeutic advancements have led to the development of monoclonal antibodies targeting amyloid-beta (Aβ) plaques, particularly the pyroglutamate-modified variant, a key pathological hallmark of AD. Objectives: This review aims to explore the therapeutic potential of Donanemab (Kisunla), a novel …
Published in Research and Reviews: A Journal of Neuroscience · Vol. 15, Issue 3, 2025 · pp. 37–45 Read article
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Samelisant, an H3 Receptor Agonist as an Anti-Alzheimer Potential – A Pilot Study on Molecular Docking
Abstract: Neurodegenerative diseases have become more prevalent and about 55 million of the population are affected by dementia globally. One of the most important neurodegenerative diseases is Alzheimer’s disease which is known for its effect on memory and cognitive impairment. Alzheimer’s disease (AD) is an area of intense scientific investigation due to its high prevalence and the lack of a definitive cure. Amyloid precursor protein plays a central role in Alzheimer’s …
Published in International Journal of Brain Sciences · Vol. 3, Issue 1, 2026 · pp. 15–26 Read article
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In Silico Analysis and Docking Study of the Active Phytocompounds of Bacopa monnieri Against Alzheimer Disease
Abstract: Objective: Alzheimer’s is a neurodegenerative disease and is the cause of 60–70% of cases of dementia. It infected a million people worldwide. An effort was undertaken to explore the potential of natural compounds found in Bacopa monnieri, a plant renowned for its extensive medicinal properties in Indian Ayurveda, to combat the disease. This was achieved through molecular docking studies, evaluation of drug-likeness, and comprehensive ADME (absorption, distribution, metabolism, and excretion) …
Published in Research and Reviews : Journal of Computational Biology · Vol. 13, Issue 2, 2024 · pp. 1–13 Read article
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Green Synthesis of Copper Nanoparticle for the Treatment of Neurodegenerative Disease
Abstract: The study of ecologically friendly CuNP synthesis is a growing area with potential applications in biomedical research and environmental remediation, as well as sustainable nanotechnology. Generally, reducing, and stabilizing agents such as microbes, plant extracts, or other natural sources are used. The green synthesis methodology guarantees the production of nanoparticles with desired characteristics for biomedical applications while simultaneously mitigating the environmental effect that comes with conventional chemical processes. CuNPs possess …
Published in Research and Reviews : A Journal of Biotechnology · Vol. 14, Issue 1, 2024 · pp. 13–24 Read article
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Alcohol, Circadian Glymphatic Dysfunction, and Neurodegenerative Protein Accumulation: An Emerging Concern in the Indian Context
Abstract: Alcohol consumption has long been identified as a major public health issue, yet its deeper and more subtle effects on the human brain are only now coming into sharper focus. Traditional explanations often emphasize direct neuronal damage, but emerging research in neuroscience suggests a more intricate story. Recent findings indicate that alcohol not only harms brain cells but also disrupts the body’s internal biological clock—the circadian rhythm—which plays a critical …
Published in International Journal of Brain Sciences · Vol. 3, Issue 1, 2026 · pp. 1–4 Read article
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Role of Centella asiatica in Alzheimer’s Disease: A Comprehensive Review
Abstract: Alzheimer's disease (AD) is a progressive neurological illness that causes cognitive decline and memory loss and affects millions of people worldwide. As synthetic medications often prove ineffective or cause severe side effects, natural remedies are gaining attention. This review explores the potential of Centella asiatica, a herb traditionally used in oriental medicine, in the treatment of Alzheimer's disease. Triterpenoids, asiaticoside, and madecassoside are among the bioactive substances found in Centella …
Published in International Journal of Brain Sciences · Vol. 1, Issue 2, 2024 · pp. 1–7 Read article
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Detection and Classification of Alzheimer’s Disease Using Deep Learning Technique
Abstract: It is crucial that people with Alzheimer's disease (AD) receive a proper diagnosis to begin preventative action before irreparable brain damage develops. Most people who suffer from Alzheimer's disease (AD), a neurological condition that progresses, are older than 65. The area of interest (ROI) in the hippocampus has been extensively studied for several purposes, including neurological illness research, stress development monitoring, and memory function analysis. Moreover, a connection between Alzheimer's …
Published in Recent Trends in Sensor Research & Technology · Vol. 12, Issue 1, 2025 · pp. 15–20 Read article
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An Overview of Artificially Generated Neural Networks Inside the Brain’s Structure in an Alzheimer’s Disease Patient
Abstract: Alzheimer’s disease produces significant neuronal loss, while the precise mechanisms and timing are yet unknown. Other types of cell death, such necroptosis, parthanatosis, ferroptosis, and cuproptosis, need further investigation. Based on brain images of people with mild cognitive impairment, this study assesses artificial neural networks (ANNs) used to diagnose and predict Alzheimer’s disease (AD). This research was conducted considering growing recognition among researchers and medical professionals regarding the importance of …
Published in Research and Reviews: A Journal of Neuroscience · Vol. 15, Issue 2, 2025 Read article
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Neuroprotective Effects of Curcuma longa: A Review of Its Role in Neurodegenerative Diseases
Abstract: Curcuma longa (turmeric), a perennial herb notably utilized in traditional medication, has garnered big clinical attention due to its major bioactive compound, curcumin. Curcumin, well-known shows a couple of organic activities, together with antioxidant, anti-amyloidogenic, and neurodegenerative effects, making it a promising candidate for the management of neurodegenerative diseases (NDDs), which include Alzheimer’s illness, Parkinson’s disorder (PD), Huntington’s sickness (HD), and amyotrophic lateral sclerosis (ALS). This evaluate consolidates current findings …
Published in Research & Reviews: A Journal of Pharmacognosy · Vol. 12, Issue 3, 2025 · pp. 24–32 Read article
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Clinical metabolomics: Useful insights, perspectives, and challenges.
Abstract: Metabolomics provides a comprehensive snapshot of smallmolecule intermediates and end products of cellular processes and thereby links genotype, environment, and phenotype in human disease . Over the last decade, advances in liquid chromatography–mass spectrometry (LC–MS) and nuclear magnetic resonance (NMR) spectroscopy have enabled high-throughput profiling of thousands of metabolites from microliter volumes of clinical samples . Clinical metabolomics is now emerging as a tool for disease diagnosis, risk prediction, therapeutic …
Published in Emerging Trends in Metabolites · Vol. 3, Issue 1, 2026 · pp. 29–37 Read article