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12 articles for “Thermostability”
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Thermal Comfort Analysis Thermostat Valve
Abstract: Recent analysis that has given performance on the basis of thermal analysis of thermostat valve. Play an important role in automobile Cooling system. And its performance can change according to its different temperature conditions. Thermostat valve has been extensively study with the primary direction it's Bring Down engine temperature and upgrade performance of engine. Thermostat valve play an important role in automobile cooling system for durable the engine temperature in …
Published in Journal of Refrigeration, Air conditioning, Heating and ventilation Read article
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Next-Generation mRNA Therapeutics: Self-Amplifying, Thermostable and Personalized mRNA Vaccines in the Era of Precision Medicine
Abstract: Messenger RNA (mRNA) technology has brought a major change in modern medicine, especially after its successful use in COVID-19 vaccines. However, early mRNA vaccines faced several problems such as low stability, strict cold storage requirements, and lack of personalized treatment. To overcome these challenges, next-generation mRNA technologies have been developed, including self-amplifying mRNA (saRNA), thermostable mRNA vaccines, and personalized mRNA vaccines. This article discusses the development of mRNA therapeutics, the …
Published in International Journal of Vaccines · Vol. 2, Issue 2, 2025 · pp. 38–54 Read article
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Metagenome-Informed Engineering of Monoclonal Antibodies: Mining Microbial Immunoglobulin-Like Domains for Ultra-Stable Therapeutics
Abstract: Metagenome-informed engineering represents an emerging strategy for improving the stability and functionality of monoclonal antibodies (mAbs) by leveraging the vast diversity of microbial immunoglobulin-like (Ig-like) domains (10,24). These domains, derived from uncultured bacteria and bacteriophages, exhibit exceptional thermostability, protease resistance, and structural resilience due to adaptation to extreme environments (29,30). This review highlights advances in metagenomic mining, structural characterization, and protein engineering that enable the integration of microbial Ig-like scaffolds …
Published in Research and Reviews : A Journal of Biotechnology · Vol. 16, Issue 1, 2026 Read article
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Integrative Structural-Functional Genomics of Fc and Fab: Precision Models for Monoclonal Antibody Stability and Anti-Aggregation Engineering
Abstract: Monoclonal antibodies (mAbs) represent the cornerstone of biotherapeutics, yet aggregation propensity compromises up to 50% of candidates during development, driven by Fab hypervariability and Fc vulnerabilities.(1,2) This review integrates functional genomics from OAS (4B+ sequences)(5) and structural databases (SAbDab: 10K+ structures)(6) with machine learning models achieving R=0.97 for SAP prediction.(11) We dissect biophysical mechanisms, benchmark predictive tools (DeepSP, ESM2), and engineering strategies (YTE, FW mutations) that enhance Tm by 5-10°C …
Published in International Journal of Molecular Biotechnological Research · Vol. 4, Issue 1, 2026 Read article
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Techno-economic Assessment of a Domestic Refrigerator with Aluminium-based Suction Line and Capillary Tube
Abstract: The present work reports the experimental performance evaluation of aluminum suction line-based domestic refrigerators. Furthermore, it compared domestic refrigerators with conventional copper capillary tubes and suction lines using R600a as a refrigerant. Performance parameters: energy consumption, ice-making time, and pull-down time was reduced significantly compared to conventional copper suction and capillary tube. Refrigerants having Ambient temperature for ice making test and pull down were initially set at 43°C and that …
Published in Journal of Polymer & Composites Read article
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Exploring the Future of Smart Homes: Voice Control Technologies and Applications
Abstract: With the use of voice commands, smartphones, and the Internet of Things, homeowners may utilise an intelligent house automation system, a technology-driven solution, to control and automate a variety of home systems and gadgets from a central hub. The system typically includes equipment such as smart thermostats, smart lighting, smart locks, security systems, and entertainment systems. With the increasing prevalence of IoT, smart homes have become increasingly popular, and automation …
Published in International Journal of Electrical Machine Analysis and Design · Vol. 2, Issue 1, 2024 · pp. 31–37 Read article
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Efficient Message Captivating Environment in IoT Home Networks
Abstract: The Internet of Things (IoT) concept involves connecting and monitoring physical objects via the internet, generating significant interest among researchers and users due to widespread internet availability. This concept encompasses a broad spectrum of devices, including internet-connected "smart" versions of traditional appliances, novel gadgets designed for an Internet-enabled environment, and Internet-enabled sensors transforming various sectors such as manufacturing, healthcare, transportation, and living spaces. Home automation, an IoT application, has significantly …
Published in International Journal of Mobile Computing Technology · Vol. 2, Issue 2, 2024 · pp. 8–16 Read article
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Optimization Strategies for Finned-Tube Gas Coolers in CO2 Heat Pump Systems: A Review
Abstract: In order to reduce CO2 emissions through increased energy use flexibility, this article examines existing energy solutions. It focuses on demand-side management tools such as electric vehicles and heat pumps, as well as storage possibilities. The aim is to shift to sustainable energy sources by striking a balance between non-renewables (coal, gas) and renewables (solar, wind). This is demonstrated by the notable decrease in the usage of oil-fired boilers and …
Published in Journal of Energy, Environment & Carbon Credits · Vol. 14, Issue 3, 2024 · pp. 11–20 Read article
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Dynamic Simulation of Load-Responsive Vapor Compression Refrigeration Systems
Abstract: Because of their dependable operation and effectiveness, vapor compression refrigeration systems, or vapor compression refrigeration (VCRS), have become popular in commercial, industrial, and residential settings. However, under different thermal loads, classic vapor compression refrigeration (VCR) systems may perform less well in that they are usually built for steady-state conditions and run at consistent speeds. In order to improve a load-responsive VCR system’s flexibility, energy efficiency, and response to changing cooling …
Published in Journal of Refrigeration, Air conditioning, Heating and ventilation · Vol. 12, Issue 2, 2025 · pp. 32–37 Read article
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GSM Based Intelligent Homes
Abstract: The advantages of an intelligent home system are numerous, ranging from the management of household duties and energy economy to the management of convenience and security. As a result of the continuing development of technology, it is becoming increasingly essential for modern households. Besides contributing to rendering living simpler, it leads to an improvement in the quality of our lives. Consequently, if you are interested in modernizing your home, you …
Published in International Journal of Electrical and Communication Engineering Technology · Vol. 3, Issue 2, 2025 · pp. 37–44 Read article
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Nanoparticle and Lipid-Based Vaccine Delivery Systems: A Systematic Review of Platforms, Stability, Pharmacokinetics, and Immune Modulation
Abstract: The rapid evolution of vaccine technologies over the past decade has highlighted the transformative role of nanoparticle (NP) and lipid-based delivery systems in modern immunization practices. These platforms – including polymeric nanoparticles, lipid nanoparticles (LNPs), liposomes, nanoemulsions, and solid lipid nanoparticles (SLNs) – enable enhanced antigen stability, improved cellular uptake, targeted antigen delivery, and potent immune activation. This systematic review critically examines the physicochemical foundations, manufacturing approaches, stability challenges, pharmacokinetic …
Published in Research and Reviews: A Journal of Toxicology · Vol. 16, Issue 1, 2026 · pp. 18–36 Read article
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The future of global immunisation strategies: an examination of vaccines
Abstract: Vaccination is still one of the best ways to improve public health, but worldwide immunization plans are facing new scientific, societal, and logistical problems. This article looks at the future of global immunization programs by looking at present and new vaccine technology, delivery systems, and policy frameworks. It looks at new technologies including mRNA platforms, thermostable vaccines, and new ways to distribute vaccinations that could help more people get them …
Published in International Journal of Vaccines · Vol. 3, Issue 1, 2026 · pp. 9–14 Read article