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30 articles for “T2D”
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Exploring The Multitarget Pharmacological Mechanism of Diabex for T2dm by Combining Network Pharmacology and Molecular Docking Techniques
Abstract: Objective: Hyperglycemia brought on by an absolute or relative absence of insulin synthesis or action characterises a set of illnesses known as diabetes mellitus. Chronic hyperglycemia in diabetes mellitus has been linked to organ damage, heart, and blood vessels. The persistent metabolic condition Diabetes is a severe global issue with negative social, health, and economic effects. It is a type of metabolism disorder that interferes with food digestion in the …
Published in International Journal of Bioinformatics and Computational Biology · Vol. 1, Issue 3, 2023 · pp. 62–73 Read article
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Limitations to Therapeutic Approaches to T2DM in Light of Different HbA1C Values Suggested by Different Scientific Associations: A Review
Abstract: The present article provided a comprehensive review of international and national guidelines for managing Type-2 diabetes, with a focus on personalized treatment strategies. It discussed the recommended glycated haemoglobin targets and the initial treatment approach involving lifestyle modifications and the use of metformin. The present article underlined the necessity for treatment intensification due to the progressive nature of type-2 diabetes. It also emphasized the complexity of selecting additional antidiabetic medications, …
Published in Research and Reviews: A Journal of Medicine · Vol. 13, Issue 2, 2023 · pp. 13–26 Read article
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Role of Inflammatory Markers and Lipid Abnormalities in Glycemic Dysregulation Among Type 2 Diabetics
Abstract: Background: Diabetes mellitus (DM) is a chronic metabolic disorder characterized by systemic inflammation and associated with various complications in multiple organs. Type 2 diabetes mellitus (T2DM) specifically involves insulin resistance, hyperglycemia, and inflammatory responses. This study investigates the levels of various inflammatory markers and their correlation with glycaemic control in T2DM patients.Objective: To evaluate the levels of inflammatory markers (including NLR, PLR, SII, SIRI, CRP, IL-6, TNF-α, TGF-β, MCP-1, IL-4, …
Published in Emerging Trends in Metabolites · Vol. 2, Issue 2, 2025 Read article
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Screening of Mean Platelet Volume as a Prognostic Marker in Patients with Type 2 Diabetes Mellitus
Abstract: In this study platelets volume and its important role as a diagnostic marker was estimated in the prevalence of type 2 diabetes mellitus (T2DM) which are associated with mean platelet volume (MPV). The aim of the study was to investigate if platelets were activated in diabetes and its associated vascular complications by measuring the MPV in the diabetics compared to the non-diabetics, and to determine the correlation of MPV with …
Published in Research and Reviews : A Journal of Medical Science and Technology · Vol. 9, Issue 1, 2020 · pp. 47–52 Read article
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Evaluation of the Effects of Vitamin D Supplementation on Glycemic Control and Lipid Profile in Normoglycemic and STZ-Induced Type-2 Diabetic Rats
Abstract: The term diabetes mellitus describes a metabolic disorder of multiple aetiologies and is characterized by chronic hyperglycemia with disturbances of carbohydrate, fat and protein metabolism resulting from defects in insulin secretion, insulin action, or both. The current approaches for treatment of diabetes are mostly dependent on insulin and other oral standard drugs, which have their own drawbacks. Thus, micronutrients supplementation is gaining momentum as the quest for management of diabetes …
Published in Research and Reviews: A Journal of Pharmacology · Vol. 6, Issue 2, 2016 · pp. 24–34 Read article
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AI-Based Early Diagnosis & Prevention of Diabetes
Abstract: The worldwide burden of Diabetes Mellitus, especially Type 2 diabetes (T2D) has escalated to a critical level. Early detection of diabetes is essential to reduce long‑term complications and healthcare costs. This study explores the use of artificial intelligence (AI) techniques to improve the early diagnosis and prevention of diabetes. We developed an AI model using the Random Forest algorithm, the model predicts diabetes risk based on clinical and lifestyle variables …
Published in Research & Reviews: A Journal of Bioinformatics · Vol. 13, Issue 2, 2026 Read article
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Identification of the Dietary Risk Factors of Diabetes Mellitus Type 2 among Employees of Aligarh Muslim University Aligarh: An Observational Study
Abstract: Background: Type 2 diabetes mellitus is closely related to lifestyle factors such as diet, physical activities, alcohol, smoking, calorie intake as well as obesity and positive family history. Available data suggest that diet is the main culprit and a change in dietary habits and dietetics has a greater potential to improve T2DM. Aims and Objectives: To identify the dietary risk factors of T2DM and find out the association of established …
Published in Journal of AYUSH: Ayurveda, Yoga, Unani, Siddha and Homeopathy · Vol. 7, Issue 2, 2018 · pp. 20–25 Read article
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Impact of PPAR-γ2 pro12Ala Gene Polymorphism and Susceptibility of Type 2 Diabetes Mellitus in Patients Visiting Gondar University Teaching Hospital
Abstract: Type 2 diabetes mellitus (T2DM) is characterized by hyperglycemia that can occur through mechanisms such as; impaired insulin secretion, insulin resistance in peripheral tissues and increased glucose output by liver. Type 2 diabetes clearly represents a multifactorial disease, and several findings indicate that multiple genetic and environmental factors are important contributing factor involved in the pathogenesis of this disease. Recently great emphasis has been given to genetical factors to combat …
Published in Research and Reviews: A Journal of Microbiology and Virology · Vol. 5, Issue 2, 2015 · pp. 21–28 Read article
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Development of High Sugar Induced Hyperglycemia or Type 2 Diabetes in Zebrafish (Danio rerio) Model
Abstract: Type 2 diabetes (T2D) is the most common form of diabetes, accounting for about 90–95% of all diagnosed cases of diabetes in adult. It is mainly recognized by an increase in blood glucose levels, i.e., hyperglycemia. Earlier, zebrafish (Danio rerio) has been already used for the study of various metabolic diseases. In the present study, a validation study was done for the earlier developed acute hyperglycemia zebrafish model by using …
Published in Research and Reviews: A Journal of Health Professions · Vol. 8, Issue 3, 2018 · pp. 60–66 Read article
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Anthropometric Measurements as Cardio-Metabolic Risk Factors Did Not Associate with Echocardiography Determinants in Type 2 Diabetes
Abstract: Obesity and Type 2 diabetes (T2D) are risk factors for cardiovascular events. Anthropometric measurements are considered as independent risk factors for these events. This study aimed to assess the link between anthropometric measurements that are considered as risk factors for cardiovascular events and echocardiography determinants in T2D. A total number of 50 T2D patients (20 males and 30 females) with a median age of 58.8 years were included in this …
Published in Research and Reviews: A Journal of Health Professions · Vol. 5, Issue 1, 2015 · pp. 1–6 Read article
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Role of Plant-based Natural Products in the Treatment of Type 2 Diabetes
Abstract: Diabetes mellitus is caused by the elevation of blood sugar levels and has become a serious health concern worldwide with the number of cases steadily increasing annually. Due to the increased side effects and costs associated with the use of conventional drugs, alternative treatment methods that use natural compounds from medicinal plants have been researched. This review summarizes the recent advances and discoveries of plant based natural compounds used for …
Published in Journal of Modern Chemistry & Chemical Technology · Vol. 12, Issue 2, 2021 · pp. 1–14 Read article
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Frequency of Physical Activities by Type 2 Diabetes Mellitus Patients in Kashmir Valley
Abstract: The therapeutic regimen which is useful in the management of Type 2 diabetes (T2DM) profoundly includes physical activity and exercise. The paper focuses on the extent and type of physical exercise indulged by T2DM patients in Kashmir valley. The study was carried out in the major hospitals (both government and private) having Endocrinology department situated in Srinagar district as well as private health clinics. A total of 1000 diabetic adults …
Published in Research and Reviews: A Journal of Health Professions · Vol. 7, Issue 2, 2017 · pp. 41–46 Read article
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Evaluation of the Effect of Zinc Supplementation on Glycemic Control and Lipid Profile in Normoglycemic and Streptozotocin-induced Type-2 Diabetic Rats
Abstract: Diabetes mellitus is a chronic, progressive disease, which is accompanied by multiple complications. Hyperglycemia and dyslipidemia are common complications of diabetes mellitus. The current approaches for treatment of diabetes are mostly dependent on insulin and other oral standard drugs, which have their own put falls. Thus, micronutrients supplementation is gaining momentum as the quest for management of diabetes continues. Certain micronutrients increase insulin synthesis secretion and insulin sensitivity thereby improve …
Published in Research and Reviews : A Journal of Medical Science and Technology · Vol. 5, Issue 2, 2016 · pp. 41–51 Read article
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Recent Advances in Diabetes Management: A Gendered Approach in North India
Abstract: Background: Diabetes Mellitus remains a major public health issue in India, with disproportionate burdens observed in North India and among women. Objectives: To examine gender and residence-based disparities in glycemic control, medication adherence, and healthcare access among adults with Type 2 Diabetes Mellitus (T2DM) in North India. Page 2 of 7 Methods: A cross-sectional study was conducted among 800 adults with T2DM across five North Indian states. Data on clinical …
Published in Research and Reviews: A Journal of Health Professions · Vol. 16, Issue 2, 2026 Read article
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Metabotropic Receptor Based Target for Insulin Resistance, Obesity, and Type 2 Diabetes Mellitus
Abstract: G protein coupled receptors (GPCRs) moreover called as metabotropic receptor addresses the greatest gathering of film proteins in the human genome. GPCRs share a regular essential characteristic of seven hydrophobic transmembrane (TM) sections (heptahelical structure), with an extracellular amino end and an intracellular carboxyl end their assistant and valuable closeness of GPCRs stays rather than the fundamental OK assortment of the ordinary GPCR ligands. GPCRs keep on being critical revelation …
Published in Trends in Drug Delivery · Vol. 5, Issue 1, 2018 · pp. 17–27 Read article
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IMPACT OF DIET AND CERTAIN FUNCTIONAL FOODS IN TYPE-II DIABETES MANAGEMENT
Abstract: Global health is greatly challenged by type 2 diabetes mellitus (T2DM), whose management mostly depends on dietary and lifestyle changes. This review study looks at how important diet and certain functional items are for managing type 2 diabetes. It offers a thorough summary of current scientific discoveries and clinical investigations that emphasize the contribution of dietary decisions and functional foods to better glycemic control, increased insulin sensitivity, and decreased risk …
Published in Research & Reviews : Journal of Food Science & Technology · Vol. 13, Issue 1, 2024 · pp. 9–15 Read article
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Practical approach for Type 2 Diabetes: Role of DPP4 Inhibitors
Abstract: Dipeptidyl peptidase-4 inhibitors (DPP-4Is) have become essential in managing type 2 diabetes mellitus (T2DM) due to their ability to enhance incretin hormone activity, which promotes insulin secretion and inhibits glucagon release. These agents effectively lower HbA1c levels by 0.5–1.0%, are weight-neutral, and have a low risk of hypoglycemia, making them suitable for a broad patient population, including the elderly. The antidiabetic market in India is vast. Gliptin as group row …
Published in Research and Reviews: A Journal of Pharmacology · Vol. 14, Issue 2, 2024 · pp. 20–26 Read article
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The Role of Pyruvate Dehydrogenase in Non-Alcoholic Fatty Liver Disease: Therapeutic Insights and Future Directions
Abstract: Non-alcoholic fatty liver disorders (NAFLD) are defined by the accumulation of excess fat in the liver that has no other cause, such as drinking alcohol. Pyruvate dehydrogenase has been established as an alternative treatment for this disorder. NAFLD pathogenesis is complex and includes oxidative stress inflammatory processes and mitochondrial dysfunction. Impaired liver fatty acid oxidation and glucose oxidation are significant individuals in developing NAFLD, and strategies to reverse these defects …
Published in Research and Reviews: A Journal of Pharmacology · Vol. 14, Issue 3, 2024 · pp. 44–51 Read article
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Multidimensional Impacts on Bryophyllum Pinnatum for the Potential of Obesity: A Review
Abstract: Global public health concerns related to obesity are growing. Several comorbid illnesses, including cardiovascular disease (CVC), gastrointestinal disorders, type 2 diabetes (T2d), joint and muscle disorders, respiratory difficulties, and psychological disorders, are significantly more common in obese patients. The widespread misconception that obesity stems solely from a lack of self-control is gradually losing its stigma as awareness about fat-related issues grows. Instead of synthetic drugs herbal or medicinal plants are …
Published in International Journal of Biochemistry and Biomolecule Research · Vol. 2, Issue 2, 2024 · pp. 42–51 Read article
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Evaluation of Medication Adherence in Patients with Type 2 Diabetes Mellitus: A Mixed- Methods Approach
Abstract: Background: Medication adherence refers to how closely an individual follows the prescribed medication regimen. It is essential for achieving desired therapeutic outcomes and improving patient health. Inadequate adherence can result in the deterioration of health conditions, higher mortality rates, and increased healthcare expenses. Diabetes mellitus, being a chronic condition, demands ongoing medical care not only to prevent the onset of serious complications but also to manage them effectively once they …
Published in International Journal of Community Health Nursing And Practices · Vol. 3, Issue 1, 2025 · pp. 28–35 Read article