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International Journal of Biochemistry and Biomolecule Research Original Research

Multidimensional Impacts on Bryophyllum Pinnatum for the Potential of Obesity: A Review

  1. Varun Mishra Bachelor of Pharmacy (Final Year), Himachal Pharmacy College, Majhauli (Nalagarh)
  2. Sarbjot Singh Department of Pharmacology, Himachal Pharmacy College, Majhauli (Nalagarh)
  3. Rajneesh Kaur Department of Pharmaceutical Chemistry, Himachal Pharmacy College, Majhauli (Nalagarh)
  4. Brij Bhushan Department of Pharmaceutical Chemistry, Himachal Pharmacy College, Majhauli (Nalagarh)
  5. Shruti Jaswal Department of Pharmaceutics, Himachal Pharmacy College, Majhauli (Nalagarh)
  6. Anita Devi Department of Pharmaceutical Chemistry, Himachal Pharmacy College, Majhauli (Nalagarh)
  7. Anuneet Kaur Department of Pharmacology, Himachal Pharmacy College, Majhauli (Nalagarh), Himachal Pradesh, India

Abstract

Global public health concerns related to obesity are growing. Several comorbid illnesses, including cardiovascular disease (CVC), gastrointestinal disorders, type 2 diabetes (T2d), joint and muscle disorders, respiratory difficulties, and psychological disorders, are significantly more common in obese patients. The widespread misconception that obesity stems solely from a lack of self-control is gradually losing its stigma as awareness about fat-related issues grows. Instead of synthetic drugs herbal or medicinal plants are much beneficial in the treatment of obesity. Bryophyllum pinnatum leaves have been employed as an antibiotic in traditional medicine. So, in this paper we reviewed that plant have various pharmacological effects on the body with very less side effects and their active phytoconstituents have an soothing effect to get rid of obesity.

Keywords

References (60)

  1. Fruh SM, Graves RJ, Hauff C, Williams SG, Hall HR. Weight Bias and Stigma. Nursing Clinics of North America. 2021;56(4):479-493. doi:10.1016/j.cnur.2021.07.001
  2. Nam GE, Kim YH, Han K, Jung JH, Rhee EJ, Lee WY, et al. Obesity Fact Sheet in Korea, 2020: Prevalence of Obesity by Obesity Class from 2009 to 2018. Journal of Obesity & Metabolic Syndrome. 2021;30(2):141-148. doi:10.7570/jomes21056
  3. Seo MH, Lee WY, Kim SS, Kang JH, Kang JH, Kim KK, et al. 2018 Korean Society for the Study of Obesity Guideline for the Management of Obesity in Korea. Journal of Obesity & Metabolic Syndrome. 2019;28(1):40-45. doi:10.7570/jomes.2019.28.1.40
  4. Telci Caklili O, Cesur M, Mikhailidis DP, Rizzo M. Novel anti-obesity therapies and their different effects and safety profiles: A critical overview.
  5. Diabetes Metab Syndr Obes. 2023;16:1767–1774. doi:10.2147/DMSO.S392684.
  6. Kapoor N, Kalra S, Al Mahmeed W, Al-Rasadi K, Al-Alawi K, Banach M, et al. The Dual Pandemics of COVID-19 and Obesity: Bidirectional Impact. Diabetes Therapy. 2022;13(10):1723-1736. doi:10.1007/s13300-022-01311-2
  7. World Health Organization. Constitution of the world health organization.
  8. Swinburn BA, Kraak VI, Allender S, Atkins VJ, Baker PI, Bogard JR, et al. The Global Syndemic of Obesity, Undernutrition, and Climate Change: The Lancet Commission report. The Lancet. 2019;393(10173):791-846. doi:10.1016/s0140-6736(18)32822-8
  9. Nihalani N, Schwartz TL, Siddiqui UA, Megna JL. Weight Gain, Obesity, and Psychotropic Prescribing. Journal of Obesity. 2011;2011:1-9. doi:10.1155/2011/893629
  10. Cappuccio FP, Taggart FM, Kandala NB, Currie A, Peile E, Stranges S, et al. Meta-Analysis of Short Sleep Duration and Obesity in Children and Adults. Sleep. 2008;31(5):619-626. doi:10.1093/sleep/31.5.619
  11. Noh J. The Effect of Circadian and Sleep Disruptions on Obesity Risk. Journal of Obesity & Metabolic Syndrome. 2018;27(2):78-83. doi:10.7570/jomes.2018.27.2.78
  12. McAllister EJ, Dhurandhar NV, Keith SW, Aronne LJ, Barger J, Baskin M, et al. Ten Putative Contributors to the Obesity Epidemic. Critical Reviews in Food Science and Nutrition. 2009;49(10):868-913. doi:10.1080/10408390903372599
  13. Lim HJ, Xue H, Wang Y. Global trends in obesity. In: Handbook of Eating and Drinking: Interdisciplinary Perspectives. 2020:1217–1235.
  14. Bray GA, Kim KK, Wilding JPH, on behalf of the World Obesity Federation. Obesity: a chronic relapsing progressive disease process. A position statement of the World Obesity Federation. Obesity Reviews. 2017;18(7):715-723. doi:10.1111/obr.12551
  15. Burki T. European Commission classifies obesity as a chronic disease. The Lancet Diabetes & Endocrinology. 2021;9(7):418. doi:10.1016/s2213-8587(21)00145-5
  16. Rubino F, Batterham RL, Koch M, Mingrone G, le Roux CW, Farooqi IS, et al. Lancet Diabetes & Endocrinology Commission on the Definition and Diagnosis of Clinical Obesity. The Lancet Diabetes & Endocrinology. 2023;11(4):226-228. doi:10.1016/s2213-8587(23)00058-x
  17. Hall KD, Kahan S. Maintenance of Lost Weight and Long-Term Management of Obesity. Medical Clinics of North America. 2018;102(1):183-197. doi:10.1016/j.mcna.2017.08.012
  18. The Look AHEAD Research Group. Cardiovascular Effects of Intensive Lifestyle Intervention in Type 2 Diabetes. New England Journal of Medicine. 2013;369(2):145-154. doi:10.1056/nejmoa1212914
  19. Elhayany A, Lustman A, Abel R, Attal‐Singer J, Vinker S. A low carbohydrate Mediterranean diet improves cardiovascular risk factors and diabetes control among overweight patients with type 2 diabetes mellitus: A 1‐year prospective randomized intervention study.
  20. Diabetes Obes Metab. 2010;12(3):204–209. doi:10.1111/j.1463-1326.2009.01151.x.
  21. Harrington J, Felker GM, Januzzi JL, Lam CSP, Lingvay I, Pagidipati NJ, et al. Worth Their Weight? An Update on New and Emerging Pharmacologic Agents for Obesity and Their Potential Role for Persons with Cardiac Conditions. Current Cardiology Reports. 2024;26(3):61-71. doi:10.1007/s11886-023-02016-z
  22. Green L, Taddei-Allen P. Shifting paradigms: Reframing coverage of antiobesity medications for plan sponsors. Journal of Managed Care & Specialty Pharmacy. 2023;29(5):564-568. doi:10.18553/jmcp.2023.29.5.564
  23. Gadde KM, Atkins KD. The limits and challenges of antiobesity pharmacotherapy. Expert Opinion on Pharmacotherapy. 2020;21(11):1319-1328. doi:10.1080/14656566.2020.1748599
  24. Li R, Song H, Shi W, Hu S, Yang Y, Tang J, et al. Galanin inhibits leptin expression and secretion in rat adipose tissue and 3T3-L1 adipocytes. Journal of Molecular Endocrinology. 2004;33(1):11-19. doi:10.1677/jme.0.0330011
  25. Murray CJL, Aravkin AY, Zheng P, Abbafati C, Abbas KM, Abbasi-Kangevari M, et al. Global burden of 87 risk factors in 204 countries and territories, 1990–2019: a systematic analysis for the Global Burden of Disease Study 2019. The Lancet. 2020;396(10258):1223-1249. doi:10.1016/s0140-6736(20)30752-2
  26. Okunogbe A, Nugent R, Spencer G, Powis J, Ralston J, Wilding J. Economic impacts of overweight and obesity: current and future estimates for 161 countries. BMJ Global Health. 2022;7(9):e009773. doi:10.1136/bmjgh-2022-009773
  27. Field AE, Coakley EH, Must A, Spadano JL, Laird N, Dietz WH, et al. Impact of Overweight on the Risk of Developing Common Chronic Diseases During a 10-Year Period. Archives of Internal Medicine. 2001;161(13):1581. doi:10.1001/archinte.161.13.1581
  28. Flier JS. Obesity Wars. Cell. 2004;116(2):337-350. doi:10.1016/s0092-8674(03)01081-x
  29. Moro CO, Basile G. Obesity and medicinal plants. Fitoterapia. 2000;71:S73-S82. doi:10.1016/s0367-326x(00)00177-5
  30. Lee JS, Lee MK, Ha TY, Bok SH, Park HM, Jeong KS, et al. Supplementation of whole persimmon leaf improves lipid profiles and suppresses body weight gain in rats fed high-fat diet. Food and Chemical Toxicology. 2006;44(11):1875-1883. doi:10.1016/j.fct.2006.06.014
  31. Nagaratna A, Hegde PL. A comprehensive review on Parnabeeja [Bryophyllum pinnatum (Lam.) Oken]. J Med Plants Stud. 2015;3(5):166–171.
  32. Abdi Beshir S, Ahmed Elnour A, Soorya A, Parveen Mohamed A, Sir Loon Goh S, Hussain N, et al. A narrative review of approved and emerging anti-obesity medications. Saudi Pharmaceutical Journal. 2023;31(10):101757. doi:10.1016/j.jsps.2023.101757
  33. Kishino E, Ito T, Fujita K, Kiuchi Y. A Mixture of the Salacia reticulata (Kotala himbutu) Aqueous Extract and Cyclodextrin Reduces the Accumulation of Visceral Fat Mass in Mice and Rats with High-Fat Diet–Induced Obesity. The Journal of Nutrition. 2006;136(2):433-439. doi:10.1093/jn/136.2.433
  34. Shrestha S, Bhattarai BR, Lee KH, Cho H. Mono- and disalicylic acid derivatives: PTP1B inhibitors as potential anti-obesity drugs. Bioorganic & Medicinal Chemistry. 2007;15(20):6535-6548. doi:10.1016/j.bmc.2007.07.010
  35. Barness LA, Opitz JM, Gilbert‐Barness E. Obesity: Genetic, molecular, and environmental aspects. American Journal of Medical Genetics Part A. 2007;143A(24):3016-3034. doi:10.1002/ajmg.a.32035
  36. Afzal- M, Ahmad K, Saleem S, Kazmi I, Anwar F. Effect of Bryophyllum pinnatum Lam. on N-diethylnitrosamine Induced Hepatic Injury in Rats. Biosciences Biotechnology Research Asia. 2012;9(2):747-755. doi:10.13005/bbra/1060
  37. Kamboj A, Saluja A. Bryophyllum pinnatum (Lam.) Kurz.: Phytochemical and pharmacological profile: A review. Pharmacognosy Reviews. 2009;3(6):364.
  38. Pal S, Chaudhuri AKN. Studies on the anti-ulcer activity of a Bryophyllum pinnatum leaf extract in experimental animals. Journal of Ethnopharmacology. 1991;33(1-2):97-102. doi:10.1016/0378-8741(91)90168-d
  39. Igwe SA, Akunyili DN. Analgesic Effects of Aqueous Extracts of the Leaves ofBryophyllum pinnatum. Pharmaceutical Biology. 2005;43(8):658-661. doi:10.1080/13880200500383108
  40. Pal S, Sen T, Chaudhuri AKN. Neuropsychopharmacological Profile of the Methanolic Fraction of Bryophyllum pinnatum Leaf Extract. Journal of Pharmacy and Pharmacology. 1999;51(3):313-318. doi:10.1211/0022357991772312
  41. Jaiswal S, Sawhney S. Correlation of epiphyllous bud differentiation with foliar senescence in crassulacean succulent Kalanchoe pinnata as revealed by thidiazuron and ethrel application. Journal of Plant Physiology. 2006;163(7):717-722. doi:10.1016/j.jplph.2005.08.001
  42. Akinpelu DA. Antimicrobial activity of Bryophyllum pinnatum leaves. Fitoterapia. 2000;71(2):193-194. doi:10.1016/s0367-326x(99)00135-5
  43. Okwu DE, Nnamdi FU. Two novel flavonoids from Bryophyllum pinnatum and their antimicrobial activity. J Chem Pharm Res. 2011;3(2):1–10.
  44. Aransiola EF, Daramola MO, Iwalewa EO, Seluwa AM, Olufowobi OO. Anti-diabetic effect of Bryophyllum pinnatum leaves. IJBB. 2014;8(1):89–93.
  45. Khan M, Patil PA, Shobha JC. Influence of Bryophyllum pinnatum (Lim.) leaf extract on wound healing in albino rats. J Nat Remedies. 2004;4(1):41–46. doi:10.18311/jnr/2004/380.
  46. Gesta S, Tseng YH, Kahn CR. Developmental Origin of Fat: Tracking Obesity to Its Source. Cell. 2007;131(2):242-256. doi:10.1016/j.cell.2007.10.004
  47. Balistreri CR, Caruso C, Candore G. The Role of Adipose Tissue and Adipokines in Obesity-Related Inflammatory Diseases. Mediators of Inflammation. 2010;2010:1-19. doi:10.1155/2010/802078
  48. Patel PS, Buras ED, Balasubramanyam A. The Role of the Immune System in Obesity and Insulin Resistance. Journal of Obesity. 2013;2013:1-9. doi:10.1155/2013/616193
  49. Kosteli A, Sugaru E, Haemmerle G, Martin JF, Lei J, Zechner R, et al. Weight loss and lipolysis promote a dynamic immune response in murine adipose tissue. Journal of Clinical Investigation. 2010;120(10):3466-3479. doi:10.1172/jci42845
  50. Hotamisligil GS, Arner P, Caro JF, Atkinson RL, Spiegelman BM. Increased adipose tissue expression of tumor necrosis factor-alpha in human obesity and insulin resistance. Journal of Clinical Investigation. 1995;95(5):2409-2415. doi:10.1172/jci117936
  51. Tsigos C, Kyrou I, Chala E, Tsapogas P, Stavridis JC, Raptis SA, et al. Circulating tumor necrosis factor alpha concentrations are higher in abdominal versus peripheral obesity. Metabolism. 1999;48(10):1332-1335. doi:10.1016/s0026-0495(99)90277-9
  52. Fernández-Sánchez A, Madrigal-Santillán E, Bautista M, Esquivel-Soto J, Morales-González Á, Esquivel-Chirino C, et al. Inflammation, Oxidative Stress, and Obesity. International Journal of Molecular Sciences. 2011;12(5):3117-3132. doi:10.3390/ijms12053117
  53. Gahlaut A, Pawar SD, Mandal TK, Dabur R. Evaluation of clinical efficacy of Bryophyllum pinnatum Salisb for treatment of lithiasis. Int J Pharm Pharm Sci. 2012;4(4):505–507.
  54. Gupta R, Lohani M, Arora S. Anti-inflammatory activity of the leaf extracts/fractions of Bryophyllum pinnatum Saliv. Syn. Int J Pharm Sci Rev Res. 2010;3(1):16–18.
  55. Mahata S, Maru S, Shukla S, Pandey A, Mugesh G, Das BC, et al. Anticancer property of Bryophyllum pinnata (Lam.) Oken. leaf on human cervical cancer cells. BMC Complementary and Alternative Medicine. 2012;12(1). doi:10.1186/1472-6882-12-15
  56. Bagul M, Srinivasa H, Anandjiwala S, Rajani M. Phytochemical evaluation and free radical scavenging activity of Nagakesara (stamen of Mesua ferrea Linn. var. ferrea). Indian Drugs. 2006;43(8):665–670.
  57. Harlalka G, Patil C, Patil M. Protective effect of Kalanchoe pinnata pers. (Crassulaceae) on gentamicin-induced nephrotoxicity in rats. Indian Journal of Pharmacology. 2007;39(4):201. doi:10.4103/0253-7613.36540
  58. Sreejayan, Rao MNA. Nitric Oxide Scavenging by Curcuminoids. Journal of Pharmacy and Pharmacology. 1997;49(1):105-107. doi:10.1111/j.2042-7158.1997.tb06761.x
  59. Jain VC, Patel NMb, Shah DP, Patel PK, Joshi BH. Antioxidant and antimicrobial activities of Bryophyllum calycinum salisb leaf. Pharmacologyonline. 2010;1:393–405.
  60. Muzitano MF, Tinoco LW, Guette C, Kaiser CR, Rossi-Bergmann B, Costa SS. The antileishmanial activity assessment of unusual flavonoids from Kalanchoe pinnata. Phytochemistry. 2006;67(18):2071-2077. doi:10.1016/j.phytochem.2006.06.027