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19 articles for “Stem cell transplantation.”
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Effect of Bone Marrow Derived Autologous Stem Cell Transplantation on Cerebral Metabolism of a 20-year-old Autistic Patient
Abstract: Autism is a neurodevelopmental disorder characterized by clinically significant impairment in social, occupational and other important areas of normal functioning. The autistic brain shows altered neurochemical metabolism, such as decreased glucose uptake, increased concentrations of lactate and reduced concentrations of N-acetyl-aspartate. Besides behavioral therapies and medications for autism-associated conditions such as seizures and gastrointestinal distress, there are no U.S. FDA approved pharmacological therapies to treat Autism’s core pathology. Stem cell …
Published in Research and Reviews: A Journal of Neuroscience · Vol. 3, Issue 3, 2013 · pp. 14–20 Read article
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The study on the isolation, culture, differentiation and transplantation of neural stem cells from brain of crossbred white rat in the neonatal period
Abstract: We have studied for isolating neural stem cells from brain tissue of neonatal crossbred white rat, culturing and transplanting into local cerebral ischemic reperfusion model rat. We performed digestion of brain tissue, primary culture and subculture of segregated cells, measured number of neurosphere and growth index and ratio of cell survival, and identified expression of nestine from cultured cells, investigated engraftment of NSCs into ill brain tissue after transplantation of …
Published in Research and Reviews: A Journal of Medicine · Vol. 12, Issue 2, 2022 · pp. 13–19 Read article
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A Review: Uses of Thalidomide in Cancer Treatment
Abstract: Thalidomide is an anti-angiogenetic agent, which was widely used in early 1950s and 1960s for the treatment of morning sickness in pregnant women. The drug has been banned in1960 as it caused severe birth defects in children whose mothers had used thalidomide during pregnancy. Though it caused severe adverse effects the drug has found to be effective in the treatment of leprosy and multiple myeloma. These days thalidomide has been …
Published in Research and Reviews: A Journal of Pharmacology · Vol. 8, Issue 1, 2018 · pp. 1–5 Read article
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Wiskott-Aldrich Syndrome: A Comprehensive Guide
Abstract: Wiskott-Aldrich Syndrome (WAS) is an uncommon genetic disorder inherited through the X chromosome, marked by a combination of immune system deficiencies, eczema, and low platelet counts. This syndrome primarily affects males, leading to significant morbidity and mortality due to recurrent infections, bleeding complications, and autoimmune diseases. Mutations in the WAS gene disrupt the production of the Wiskott-Aldrich Syndrome protein (WASp), crucial for the functioning of immune cells and platelet formation. …
Published in Research and Reviews : A Journal of Immunology · Vol. 14, Issue 2, 2024 · pp. 39–46 Read article
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Extranodal NK/T-Cell Lymphoma; Dilemma in Diagnosis and Management: A Review of Literature
Abstract: Natural killer (NK) cell neoplasms are rare malignancies. They are classified as extranodal NK-cell lymphoma, nasal type, and aggressive NK-cell leukaemia. Clinically they can be classified as nasal type, non-nasal type, and aggressive lymphoma/leukaemia. Stage I/II Nasal NK-cell lymphoma are treated by combined chemotherapy and radiotherapy. In case of stage III/IV nasal NK-cell lymphoma, as well as non-nasal and aggressive lymphomas/leukaemias, chemotherapy is the main treatment. In selected cases, allogenic …
Published in Research and Reviews: Journal of Oncology and Hematology · Vol. 3, Issue 3, 2014 · pp. 4–12 Read article
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Menstrual Blood Banking: A Future Need and Scope
Abstract: Stem cells abundant in menstrual blood possess the capacity to develop and differentiate into various cell types. The regenerative capacity of these stem cells derived from menstrual blood is comparable to that observed in stem cells present in umbilical cord blood and bone marrow. Every healthy woman experiences menstruation on average once every 28 to 30 days from the time of menstruation till menopausal. Menstrual blood banking involves storing menstrual …
Published in Research and Reviews : A Journal of Medical Science and Technology · Vol. 12, Issue 2, 2024 · pp. 35–39 Read article
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The Quiet Intruder: An Insidious Presentation of Primary Plasma Cell Leukemia and a Literature Review on Current Treatment Strategies
Abstract: Introduction: Primary plasma cell leukemia (pPCL) is a rare and aggressive plasma cell dyscrasia, defined by ≥5% circulating plasma cells, with poor prognosis and rapid progression. Case Presentation: A 66-year-old African–American female with no prior medical history presented with one week of fatigue, dehydration, and polydipsia. Laboratory evaluation revealed leukocytosis, severe thrombocytopenia, acute kidney injury (creatinine 4.03 mg/dL), and hypercalcemia (13.0 mg/dL) with suppressed PTH. Imaging showed intra-abdominal lymphadenopathy without …
Published in Research and Reviews: Journal of Oncology and Hematology · Vol. 15, Issue 2, 2026 · pp. 1–5 Read article
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Stem Cell Therapy for Hemorrhagic Stroke: A Single Case Study Report
Abstract: Stroke is the leading cause of morbidity and mortality worldwide. Stem cell therapy holds a great promise where transplanted cells can migrate at the site of injury and trigger regeneration of neurons that can lead to functional improvement. The present study was carried out to evaluate the effect of autologous bone marrow and allogeneic cord blood stem cell transplantation in hemorrhagic stroke patients. In the present case report, autologous bone …
Published in Research and Reviews: A Journal of Neuroscience · Vol. 2, Issue 2, 2012 · pp. 22–26 Read article
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To Develop Self-instructional Module on ‘Umbilical Cord Stem Cell Collection, Preservation and Utilization’ and Evaluate its Effectiveness on Improving the Knowledge of Operational Level Nurses
Abstract: Umbilical cord stem cell based regenerative and cellular medicine has now become a fascination for all. The umbilical cord blood, donated by mothers after the birth of newborn, has become an accepted source of hematopoietic stem cells for bone marrow reconstitution. They play an important role in the treatment of blood and immune system related genetic diseases, cancers, and blood disorders. This study is aimed to assess the knowledge of …
Published in Research and Reviews: Journal of Oncology and Hematology · Vol. 9, Issue 3, 2020 · pp. 10–22 Read article
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Prime Editing and Base Editing in Human Hematopoietic Stem Cells Toward Scarless Correction of Monogenic Blood Disorders
Abstract: Monogenic hematological disorders – such as sickle cell disease (SCD), β-thalassemia, and X-linked chronic granulomatous disease (X-CGD) – affect >400, 000 newborns worldwide each year, with a considerable burden in low-resource settings . Although donor-derived allogeneic hematopoietic stem-cell transplantation (HSCT) is widely regarded as curative, its application is limited due to issues of donor availability and graft-versus-host disease (GVHD) and conditioning-related toxicity. DSB-based conventional CRISPR-Cas9 strategies are limited by inefficient …
Published in International Journal of Genetic Modifications and Recombinations · Vol. 4, Issue 1, 2026 · pp. 15–22 Read article
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An Overview of Fanconi Anemia: A Genetic Disorder
Abstract: Fanconi Anemia (FA) is a rare genetic disorder caused by DNA repair defects due to pathogenic variants in one of 21 genes. It is the primary cause of inherited bone marrow failure, marked by pancytopenia. Clinically, Fanconi Anemia (FA) is associated with congenital malformations in multiple systems, resulting in progressive bone marrow failure and heightened cancer risk, especially in the urogenital region and the head and neck. There are approximately …
Published in International Journal of Oncological Nursing and Practices · Vol. 2, Issue 2, 2024 · pp. 19–25 Read article
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Towards smart cancer care - AI enhanced monitoring and intervention
Abstract: According to estimates from the World Health Organization (WHO) for 2022, cancer is one of the leading causes of mortality, accounting for roughly 16% of all deaths globally. The goal of the cancer community is to improve the lives of those who are impacted by cancer and to cut the cancer death rate in half during the next several years. If cancer is identified early and treated, its impact on …
Published in Journal of Microwave Engineering and Technologies · Vol. 12, Issue 1, 2025 · pp. 38–44 Read article
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Revolutionizing Blood Cancer Treatment: Emerging Therapies and Future Perspectives
Abstract: Blood cancer inclusive of leukemia, lymphoma and multiple myeloma poses a significant threat in the world today because of its multifactorial process and its non-amenable to standard therapies. Some of such approaches are immunotherapy, gene-editing technology and targeted small molecule inhibitors that have altered the nature of treatments. CAR T cell therapy is a molecular targeted therapy for cancers and several clinical studies have reported a huge success. Also, the …
Published in International Journal of Biomedical Innovations and Engineering · Vol. 3, Issue 2, 2025 Read article
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Hematopoietic Stem Cells: Sources and Therapeutic Potential for Autoimmune Diseases and Cancer
Abstract: Hematopoietic stem cells (HSCs) are a group of multipotent adult stem cells that are responsible for lifelong production of all types of functional blood cells comprising myeloid (monocytes, macrophages, granulocytes), megakaryocytes/platelets, red blood cells (erythrocyte), T-cells, B-cells, natural killer (NK) cells, mast cells and dendritic cells (DCs). HSCs have the capacity for self-renewal and differentiation into various tissues. These remarkable properties of HSCs make them an ideal tool for tissue …
Published in Research and Reviews: Journal of Oncology and Hematology · Vol. 1, Issue 3, 2012 · pp. 6–14 Read article
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Effects Of Chamomile In The Treatment Of Oral Mucositis Among Patients Undergoing Chemotherapy And Radiotherapy: A Systematic Review
Abstract: Background: The Most common inflammatory condition seen among patients undergoing chemotherapy and radiotherapy and in patients receiving hemopoietic stem cell transplant is Oral Mucositis. Many treatments were introduced to prevent oral mucositis where chamomile is one among them where it shows anti-inflammatory properties.Aim: To assess the efficacy of chamomile in the treatment of oral mucositis when compared to other treatments.Methods: A literature review search was performed using mesh terms like …
Published in Research and Reviews : A Journal of Life Sciences · Vol. 12, Issue 3, 2022 · pp. 22–28 Read article
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Supportive Therapy Play a Vital Role in the Treatment of Leukemia: A Review
Abstract: Leukemia is a major burden worldwide. The anomalous production of white blood cells (WBC) is responsible for producing leukemia; these cells are also known as blasts. A study indicated that thousands of patients are detected every year with leukemia risk worldwide. The risk factor including chemical exposure, ionizing radiations, cigarette smoking is the major causes for developing leukemia. There are four types of leukemia and number of genes involved are …
Published in Research and Reviews: A Journal of Pharmacology · Vol. 8, Issue 3, 2018 · pp. 1–8 Read article
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Stem Cell Therapy for Parkinson's Disease: Past, Present and Future
Abstract: Parkinson’s disease (PD) is one of the most common chronic progressive nervous system disorders of aging. Cell degeneration and death of dopamine neurons (DA neurons) in the substantial nigra, is the underlying feature of PD. Genetic studies showed much about the physiological processes associated with this disease. Replacing the cells lost by injury or disease has become a central idea aiming at the development of novel therapy for neurodegenerative diseases. …
Published in Research and Reviews: A Journal of Neuroscience · Vol. 9, Issue 1, 2019 · pp. 1–12 Read article
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Stem Cell Delivery Methods: Opportunities and Challenges
Abstract: There are many approaches to cell delivery, each with its own unique aspect and subtle pros and cons. Instead of solely looking at the objective results, the efficacy of these delivery systems should be evaluated on a case-by-case basis. Optimal cell therapy depends on successful delivery into the area of need, engraftment of a sufficient concentration of cells and prolonged survival of the transplanted cells. While cells have been delivered …
Published in Research and Reviews : A Journal of Biotechnology · Vol. 3, Issue 3, 2013 · pp. 32–40 Read article
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Improvement of Motor and Sensory–Motor Behaviors after the Human Amniotic Epithelial Cells Transplantation in 6-OHDA Lesioned Corpus Striatum of Wistar Albino Rats
Abstract: Deficits in apomorphine-induced rotation and rotarod in rat have been proposed as a nondrug-induced model of the akinesia associated with the Parkinson’s disease. In the present study, we examined the disabilities in the rotarod and apomorphine-induced rotations have been observed after the 6-hydroxydopamine-induced denervation in the striatum. These impaired activities have reversed after the Human Amniotic Epithelial (HAE) cells transplantation during long-term observation. The neuronal densities and diameter were reduced …
Published in Research and Reviews: A Journal of Neuroscience · Vol. 4, Issue 2, 2014 · pp. 34–45 Read article