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7 articles for “Site specificity”
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Comprehensive Overview of Carbohydrate Polymers
Abstract: Targeting drug delivery specifically to the colon has become increasingly crucial for treating various colonic diseases like colorectal cancer, amebiasis, ulcerative colitis, and Crohn’s disease. Numerous strategies have been developed for this purpose, including using enzymatically degradable polymers, employing prodrug-based approaches, coating drugs with polymers sensitive to time or pH changes, utilizing osmotically and pressure-controlled delivery systems. Polysaccharides activated by the colon's physiological environment show significant potential as they offer …
Published in International Journal of Membranes · Vol. 1, Issue 1, 2024 · pp. 8–21 Read article
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Advancing Gene Therapy: Next-Generation Viral Vector Engineering for Precision, Safety, and Scalability
Abstract: Gene therapy has emerged as a paradigm-shifting modality for the treatment of genetic disorders, malignancies, and rare diseases through the delivery of therapeutic nucleic acids aimed at correcting or modulating dysfunctional gene expression. Among the various delivery systems, viral vectors including adeno-associated viruses (AAVs), lentiviruses, adenoviruses, retroviruses, and herpes simplex viruses have proven indispensable owing to their high transduction efficiencies and adaptability. This review offers a comprehensive assessment of viral …
Published in International Journal of Virus Studies · Vol. 2, Issue 2, 2025 · pp. 37–55 Read article
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Forecasting Climate-Driven Healthcare Demand in Agricultural Regions: A Multi-Modal AI Approach
Abstract: The rapidly increasing instability of world climatic regimes has made past meteorological thresholds irrelevant, especially in the agricultural areas where monetary stability and well-being of humans are closely intertwined with an environmental situation. The more the frequency of 1 in every 1000-year events, i.e., heatwaves and catastrophic flooding increase, the greater the rural healthcare systems are in crisis, i.e., unable to predict a surge in demand because of data scarcity, …
Published in International Journal of Climate Conditions · Vol. 2, Issue 2, 2025 · pp. 28–38 Read article
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Emerging Therapies in Respiratory Tract Infections: Current Advances and Future Perspectives
Abstract: The impact of respiratory tract infections (RTI) as a global public health problem continues to be high morbidity and mortality rates. The development of novel therapeutic approaches stemmed from the fact that conventional treatment strategies, antibiotics, antivirals, antifungals etc. have become increasingly ineffective because of rise of antimicrobial resistance (AMR). Next generation therapies, such as novel antimicrobial agents, host directed therapies and novel drug delivery systems have come on the …
Published in Recent Trends in Infectious Diseases · Vol. 2, Issue 2, 2025 · pp. 17–25 Read article
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A study on Antibiotic Resistance: An Analysis of Molecular Mechanisms and Therapeutic Implications
Abstract: Antibiotic resistance (AR) represents one of the most critical existential threats to global public health, rapidly eroding the efficacy of established antimicrobial therapies and portending a return to the pre-antibiotic era. This analysis explores the intricate molecular landscape defining this crisis, focusing specifically on the primary mechanisms of action (MoA) utilized by major antibiotic classes—including cell wall inhibitors, protein synthesis inhibitors, and nucleic acid synthesis inhibitors—and the corresponding, diverse mechanisms …
Published in International Journal of Antibiotics · Vol. 3, Issue 1, 2026 · pp. 9–21 Read article
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Assessment of Quality of Life and Coping Strategies Used by Amputated Patients Attending Orthopedics OPD to Provide Rehabilitation Program: A Descriptive Study
Abstract: Introduction: Amputation is defined as the surgical removal of a body appendage such as limbs. It has a profound social, economic, physical and psychological impact on patients. Objectives of the study: To assess the quality of life and coping-strategies used by an amputated patient and to determine an association between the quality of life and coping-strategies with selected socio-demographic variables at Pt. B. D. Sharma, PGIMS, Rohtak. Material and Method: …
Published in International Journal of Orthopedic Nursing and Practices · Vol. 3, Issue 1, 2025 · pp. 23–39 Read article
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Investigating the Dietary Flexibility and Feeding Behavior of Clarias anguillaris and Auchenoglanis biscutatus in a Tropical River Ecosystem
Abstract: Studies on food and feeding habits of fishes are required to guide the selection of fish species for culture. The current study determined the food and feeding habits of Clarias anguillaris and Auchenoglanis biscutatus in the Lower River Benue at Makurdi, Nigeria. Fish samples were collected biweekly from local fishermen at the Wadata landing site who fished with different gears like gillnets, cast nets, hook and line, traps and lift …
Published in International Journal of Marine Life · Vol. 2, Issue 1, 2025 · pp. 1–9 Read article